GREMLIN Database
THSB - Thermosome subunit beta
UniProt: Q9V2T8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 554 (468)
Sequences: 5309 (2213)
Seq/√Len: 102.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_I143_K4.6031.00
149_A505_A4.4481.00
145_I505_A4.2061.00
157_T186_K3.8931.00
495_D498_K3.8771.00
144_T147_E3.8171.00
487_N490_T3.6321.00
487_N494_E3.5711.00
435_V443_I3.4981.00
354_A371_G3.4011.00
161_R182_D3.3731.00
182_D186_K3.3481.00
494_E499_L3.0951.00
247_L336_G3.0691.00
421_E508_K2.9921.00
116_K448_N2.9861.00
454_I472_L2.9771.00
483_W495_D2.9381.00
136_K439_E2.8561.00
157_T189_A2.8121.00
69_N74_I2.8041.00
138_E512_V2.8041.00
463_L486_L2.7401.00
486_L491_G2.7351.00
138_E516_T2.6791.00
468_K493_P2.6081.00
287_D291_A2.6041.00
113_L134_Y2.5311.00
134_Y516_T2.4941.00
219_T382_I2.4851.00
428_L443_I2.4451.00
239_R355_L2.4141.00
451_E473_R2.3271.00
135_K520_T2.2851.00
475_L484_Y2.2541.00
145_I420_V2.2341.00
144_T427_R2.2341.00
288_K291_A2.2171.00
143_K147_E2.1591.00
140_I431_Y2.1571.00
471_Q474_S2.1491.00
429_R447_A2.1451.00
417_G496_M2.1251.00
245_I353_A2.1121.00
86_K89_V2.1091.00
39_K111_G2.0801.00
39_K43_E2.0661.00
303_I318_A2.0561.00
487_N499_L2.0451.00
165_L178_E2.0201.00
178_E182_D2.0111.00
146_Q509_M1.9921.00
139_E143_K1.9731.00
46_K111_G1.9601.00
446_Y516_T1.9511.00
337_R349_D1.9501.00
159_V162_K1.9351.00
113_L446_Y1.9321.00
141_A424_I1.9261.00
241_E355_L1.9221.00
240_I243_A1.9171.00
463_L491_G1.9101.00
35_I39_K1.8991.00
105_T511_A1.8341.00
431_Y434_Q1.8301.00
183_L380_I1.8291.00
190_Q223_Y1.8231.00
114_A522_V1.8101.00
184_V397_L1.8071.00
244_K352_Y1.8061.00
431_Y443_I1.8031.00
353_A369_V1.7821.00
36_A40_A1.7801.00
150_Q497_W1.7761.00
247_L330_L1.7701.00
28_K32_R1.7411.00
140_I427_R1.7361.00
494_E501_V1.7331.00
413_A502_I1.7221.00
458_A463_L1.7201.00
42_E111_G1.7191.00
129_I439_E1.7071.00
325_S328_E1.6981.00
66_T395_R1.6931.00
183_L219_T1.6861.00
157_T182_D1.6831.00
427_R430_K1.6671.00
134_Y446_Y1.6611.00
144_T148_I1.6601.00
112_E115_K1.6231.00
131_V135_K1.6111.00
24_R527_D1.6061.00
395_R398_R1.6021.00
96_D395_R1.5861.00
33_A36_A1.5731.00
242_N294_A1.5691.00
346_T349_D1.5681.00
451_E455_M1.5671.00
240_I297_V1.5571.00
330_L369_V1.5561.00
188_V408_I1.5481.00
422_I454_I1.5411.00
69_N395_R1.5351.00
120_L441_L1.5211.00
132_S439_E1.5191.00
242_N352_Y1.5181.00
117_A134_Y1.5161.00
299_C330_L1.5091.00
142_L146_Q1.5061.00
420_V424_I1.4931.00
298_I369_V1.4911.00
471_Q475_L1.4721.00
471_Q492_N1.4711.00
452_G456_I1.4651.00
360_K363_E1.4521.00
339_I345_L1.4461.00
141_A450_I1.4241.00
64_D388_R1.4221.00
142_L513_K1.4221.00
430_K433_P1.4151.00
428_L447_A1.4141.00
116_K119_D1.4041.00
143_K146_Q1.4001.00
419_A423_E1.3921.00
247_L338_V1.3901.00
140_I144_T1.3771.00
425_A473_R1.3771.00
458_A465_P1.3660.99
214_G218_D1.3600.99
39_K115_K1.3580.99
120_L125_I1.3570.99
450_I512_V1.3570.99
210_K391_D1.3520.99
290_A316_I1.3500.99
242_N354_A1.3440.99
246_A345_L1.3380.99
409_R506_L1.3370.99
36_A81_Q1.3300.99
43_E111_G1.3240.99
240_I295_N1.3240.99
422_I473_R1.3110.99
137_A446_Y1.3080.99
38_V522_V1.2980.99
140_I443_I1.2880.99
380_I397_L1.2870.99
331_A338_V1.2860.99
384_G390_V1.2840.99
484_Y493_P1.2800.99
141_A428_L1.2780.99
253_E304_D1.2710.99
426_K430_K1.2690.99
96_D402_G1.2650.99
440_Q444_E1.2560.99
35_I114_A1.2390.99
220_Q381_L1.2370.99
247_L331_A1.2350.99
150_Q159_V1.2320.99
496_M501_V1.2320.99
382_I393_T1.2170.99
153_T159_V1.2080.99
145_I509_M1.2010.99
423_E476_H1.2000.99
444_E448_N1.1910.99
158_D161_R1.1670.98
148_I151_P1.1670.98
382_I390_V1.1600.98
410_D506_L1.1590.98
415_A419_A1.1590.98
69_N169_G1.1570.98
112_E452_G1.1520.98
352_Y373_K1.1480.98
218_D381_L1.1440.98
244_K294_A1.1370.98
137_A443_I1.1370.98
246_A350_L1.1340.98
163_V413_A1.1330.98
68_T392_E1.1330.98
341_N344_E1.1330.98
431_Y435_V1.1320.98
311_L318_A1.1300.98
294_A352_Y1.1290.98
125_I441_L1.1250.98
96_D398_R1.1200.98
423_E477_E1.1170.98
309_H313_K1.1160.98
333_A372_A1.1120.98
115_K452_G1.1060.98
454_I458_A1.1040.98
319_V367_V1.0930.97
161_R164_A1.0910.97
74_I395_R1.0800.97
23_S530_A1.0770.97
83_P528_I1.0720.97
509_M513_K1.0610.97
91_I106_A1.0520.97
415_A497_W1.0520.97
83_P530_A1.0500.97
395_R402_G1.0440.97
38_V88_L1.0440.97
357_E363_E1.0410.97
188_V206_V1.0390.97
154_I158_D1.0390.97
436_G443_I1.0380.97
444_E447_A1.0360.97
397_L401_L1.0310.96
136_K140_I1.0250.96
243_A296_V1.0250.96
43_E46_K1.0250.96
414_V505_A1.0210.96
243_A353_A1.0210.96
470_M474_S1.0130.96
92_A107_V1.0070.96
225_I333_A1.0060.96
463_L468_K1.0050.96
437_G440_Q0.9940.96
49_Y108_I0.9910.96
147_E427_R0.9870.95
298_I322_A0.9840.95
470_M473_R0.9820.95
71_G104_K0.9810.95
364_D367_V0.9790.95
157_T161_R0.9770.95
468_K486_L0.9730.95
504_P507_V0.9710.95
186_K223_Y0.9710.95
247_L327_L0.9700.95
457_L488_L0.9670.95
483_W497_W0.9670.95
70_D73_T0.9660.95
154_I159_V0.9650.95
289_I292_T0.9630.95
70_D399_D0.9620.95
161_R178_E0.9610.95
247_L299_C0.9570.95
25_T29_E0.9560.95
142_L509_M0.9520.94
49_Y105_T0.9520.94
136_K435_V0.9490.94
438_K441_L0.9490.94
231_V317_L0.9440.94
392_E395_R0.9440.94
357_E370_E0.9430.94
424_I450_I0.9430.94
407_V411_G0.9390.94
436_G439_E0.9370.94
25_T33_A0.9320.94
286_V314_K0.9320.94
240_I296_V0.9320.94
497_W502_I0.9310.94
46_K456_I0.9290.94
345_L349_D0.9290.94
216_V393_T0.9270.94
425_A451_E0.9250.94
105_T453_L0.9220.93
297_V311_L0.9210.93
401_L405_A0.9210.93
60_D77_K0.9200.93
249_D345_L0.9180.93
104_K399_D0.9170.93
145_I424_I0.9140.93
288_K343_D0.9140.93
42_E46_K0.9130.93
339_I349_D0.9120.93
113_L522_V0.9120.93
148_I424_I0.9080.93
38_V114_A0.9010.93
398_R402_G0.9010.93
179_Y217_N0.9010.93
47_S56_K0.8980.92
289_I297_V0.8970.92
103_T399_D0.8950.92
163_V403_T0.8910.92
35_I118_E0.8880.92
446_Y450_I0.8860.92
288_K346_T0.8840.92
144_T423_E0.8790.92
463_L488_L0.8780.92
353_A356_V0.8770.92
533_K537_S0.8710.91
292_T347_S0.8680.91
184_V380_I0.8660.91
161_R165_L0.8610.91
423_E483_W0.8580.91
392_E396_A0.8570.91
432_A444_E0.8560.91
186_K190_Q0.8560.91
164_A404_V0.8530.90
23_S532_G0.8520.90
68_T395_R0.8510.90
160_L164_A0.8500.90
426_K429_R0.8490.90
423_E484_Y0.8490.90
144_T424_I0.8480.90
249_D340_S0.8470.90
133_G137_A0.8450.90
160_L189_A0.8440.90
358_E365_K0.8420.90
452_G455_M0.8410.90
211_K364_D0.8400.90
222_V226_V0.8390.90
505_A509_M0.8380.90
522_V528_I0.8370.90
35_I115_K0.8360.90
492_N499_L0.8350.89
115_K513_K0.8330.89
148_I420_V0.8330.89
423_E472_L0.8330.89
422_I425_A0.8300.89
301_K323_K0.8280.89
243_A356_V0.8230.89
415_A483_W0.8230.89
435_V439_E0.8220.89
243_A352_Y0.8210.89
49_Y453_L0.8200.89
210_K394_E0.8180.89
58_L529_V0.8180.89
289_I294_A0.8170.88
32_R36_A0.8160.88
146_Q505_A0.8160.88
420_V505_A0.8150.88
133_G442_A0.8150.88
129_I489_F0.8100.88
116_K449_A0.8090.88
43_E47_S0.8070.88
306_V310_Y0.8050.88
423_E426_K0.8050.88
50_G53_G0.8050.88
46_K459_E0.8020.88
459_E465_P0.8010.87
138_E446_Y0.8010.87
170_S178_E0.8000.87
92_A106_A0.8000.87
286_V310_Y0.7980.87
422_I451_E0.7970.87
430_K434_Q0.7950.87
458_A486_L0.7880.87
424_I427_R0.7860.86
60_D64_D0.7850.86
355_L370_E0.7830.86
23_S531_A0.7820.86
250_A336_G0.7800.86
158_D162_K0.7760.86
244_K293_G0.7750.86
486_L492_N0.7730.86
510_N513_K0.7730.86
472_L493_P0.7720.85
302_G321_R0.7710.85
135_K139_E0.7710.85
88_L91_I0.7690.85
359_R370_E0.7690.85
487_N501_V0.7680.85
534_K537_S0.7680.85
287_D314_K0.7650.85
249_D338_V0.7640.85
425_A450_I0.7620.85
162_K500_G0.7620.85
448_N451_E0.7590.85
141_A427_R0.7580.84
187_A221_L0.7570.84
433_P444_E0.7550.84
138_E142_L0.7550.84
75_L107_V0.7550.84
240_I289_I0.7530.84
164_A185_V0.7520.84
76_D93_K0.7520.84
136_K443_I0.7520.84
163_V407_V0.7510.84
208_I382_I0.7460.83
434_Q440_Q0.7460.83
290_A314_K0.7440.83
136_K431_Y0.7440.83
532_G537_S0.7430.83
252_L307_A0.7420.83
188_V401_L0.7400.83
37_A82_H0.7390.83
445_A448_N0.7370.83
531_A534_K0.7350.83
187_A219_T0.7320.82
80_L528_I0.7320.82
476_H484_Y0.7320.82
144_T428_L0.7290.82
71_G399_D0.7270.82
110_A515_A0.7270.82
134_Y137_A0.7260.82
68_T74_I0.7230.82
60_D66_T0.7230.82
55_D69_N0.7230.82
125_I438_K0.7200.81
434_Q437_G0.7190.81
80_L530_A0.7190.81
494_E498_K0.7180.81
429_R444_E0.7160.81
188_V404_V0.7160.81
253_E302_G0.7120.81
165_L181_A0.7100.80
415_A496_M0.7100.80
532_G536_G0.7100.80
68_T169_G0.7090.80
41_I88_L0.7070.80
429_R448_N0.7070.80
252_L289_I0.7070.80
129_I436_G0.7040.80
146_Q149_A0.7020.80
490_T494_E0.7010.80
428_L431_Y0.7010.80
426_K477_E0.7010.80
184_V400_A0.6970.79
80_L83_P0.6970.79
495_D499_L0.6960.79
140_I147_E0.6950.79
485_G496_M0.6940.79
507_V511_A0.6920.79
365_K368_F0.6920.79
248_L252_L0.6910.79
451_E469_L0.6910.79
410_D509_M0.6900.78
86_K405_A0.6890.78
434_Q443_I0.6870.78
243_A295_N0.6870.78
169_G395_R0.6850.78
121_L130_I0.6850.78
148_I427_R0.6820.78
170_S508_K0.6810.78
503_E508_K0.6810.78
296_V369_V0.6800.77
294_A350_L0.6780.77
454_I469_L0.6770.77
426_K473_R0.6760.77
187_A191_V0.6750.77
34_N114_A0.6750.77
253_E307_A0.6740.77
324_K328_E0.6740.77
25_T80_L0.6740.77
414_V420_V0.6720.77
423_E427_R0.6700.76
46_K452_G0.6700.76
73_T395_R0.6690.76
68_T89_V0.6680.76
301_K321_R0.6650.76
148_I415_A0.6640.76
146_Q410_D0.6630.76
109_L515_A0.6600.75
71_G100_A0.6570.75
433_P440_Q0.6540.75
350_L400_A0.6540.75
141_A144_T0.6540.75
244_K289_I0.6530.75
390_V393_T0.6520.74
334_T351_G0.6510.74
331_A336_G0.6490.74
467_D471_Q0.6490.74
461_A488_L0.6480.74
69_N171_K0.6470.74
440_Q443_I0.6460.74
426_K484_Y0.6450.74
510_N514_A0.6450.74
212_H390_V0.6450.74
511_A515_A0.6450.74
37_A84_T0.6450.74
372_A375_P0.6430.73
232_V308_Q0.6390.73
141_A512_V0.6390.73
119_D123_K0.6360.73
130_I446_Y0.6360.73
82_H86_K0.6350.72
95_Q514_A0.6330.72
213_G217_N0.6330.72
147_E150_Q0.6320.72
233_H320_R0.6310.72
234_P287_D0.6310.72
328_E332_R0.6300.72
151_P154_I0.6300.72
245_I334_T0.6290.72
361_V366_M0.6290.72
458_A468_K0.6280.72
34_N528_I0.6280.72
232_V303_I0.6280.72
154_I193_E0.6280.72
162_K165_L0.6280.72
467_D470_M0.6260.71
134_Y442_A0.6250.71
35_I125_I0.6250.71
458_A469_L0.6250.71
77_K236_M0.6250.71
532_G535_S0.6240.71
429_R451_E0.6220.71
284_E288_K0.6220.71
354_A372_A0.6210.71
362_G366_M0.6200.71
160_L404_V0.6190.71
138_E513_K0.6180.70
441_L447_A0.6170.70
484_Y494_E0.6160.70
98_E510_N0.6160.70
129_I132_S0.6140.70
61_S534_K0.6140.70
39_K118_E0.6130.70
292_T297_V0.6120.70
298_I330_L0.6110.70
206_V467_D0.6110.70
66_T77_K0.6110.70
437_G441_L0.6100.69
487_N492_N0.6090.69
360_K364_D0.6090.69
288_K344_E0.6090.69
28_K247_L0.6080.69
477_E483_W0.6070.69
529_V532_G0.6070.69
451_E464_D0.6060.69
223_Y371_G0.6050.69
425_A447_A0.6040.69
414_V502_I0.6040.69
471_Q484_Y0.6020.68
476_H498_K0.6020.68
302_G320_R0.6020.68
475_L493_P0.6020.68
45_L104_K0.6020.68
318_A326_D0.6020.68
230_E233_H0.6010.68
66_T289_I0.6000.68
73_T399_D0.6000.68
120_L445_A0.5990.68
114_A443_I0.5990.68
246_A294_A0.5980.68
170_S396_A0.5970.68
29_E32_R0.5970.68
117_A446_Y0.5970.68
111_G115_K0.5960.68
31_L526_D0.5960.68
468_K488_L0.5950.68
71_G103_T0.5950.68
231_V236_M0.5950.68
244_K292_T0.5940.67
335_G351_G0.5940.67
213_G383_R0.5940.67
96_D399_D0.5940.67
246_A336_G0.5920.67
117_A133_G0.5910.67
245_I356_V0.5910.67
403_T407_V0.5890.67
153_T491_G0.5890.67
252_L258_E0.5880.67
147_E476_H0.5880.67
88_L522_V0.5880.67
137_A158_D0.5880.67
285_K289_I0.5870.67
111_G114_A0.5860.66
310_Y313_K0.5860.66
100_A103_T0.5840.66
246_A289_I0.5840.66
121_L489_F0.5840.66
86_K90_Q0.5830.66
415_A484_Y0.5830.66
241_E371_G0.5820.66
57_M522_V0.5820.66
170_S217_N0.5820.66
87_L518_A0.5800.66
42_E45_L0.5800.66
161_R206_V0.5800.66
34_N57_M0.5790.65
126_H524_R0.5790.65
453_L457_L0.5790.65
341_N349_D0.5780.65
290_A293_G0.5770.65
448_N473_R0.5770.65
239_R357_E0.5760.65
254_V257_P0.5750.65
23_S528_I0.5750.65
136_K147_E0.5730.65
23_S28_K0.5730.65
92_A110_A0.5720.65
46_K90_Q0.5690.64
419_A472_L0.5690.64
247_L334_T0.5690.64
472_L475_L0.5680.64
76_D250_A0.5670.64
471_Q493_P0.5670.64
113_L138_E0.5670.64
422_I469_L0.5660.64
169_G392_E0.5660.64
213_G216_V0.5660.64
163_V411_G0.5650.64
296_V317_L0.5650.64
190_Q378_V0.5650.64
166_T503_E0.5650.64
382_I397_L0.5640.63
321_R326_D0.5630.63
241_E354_A0.5620.63
132_S520_T0.5620.63
213_G381_L0.5620.63
67_I533_K0.5610.63
49_Y104_K0.5610.63
292_T295_N0.5590.63
357_E361_V0.5580.63
230_E327_L0.5570.63
134_Y138_E0.5570.63
240_I356_V0.5570.63
168_L180_L0.5560.62
23_S32_R0.5560.62
451_E466_I0.5550.62
170_S514_A0.5540.62
105_T109_L0.5540.62
415_A423_E0.5530.62
183_L382_I0.5520.62
59_V80_L0.5520.62
125_I437_G0.5480.61
243_A455_M0.5480.61
40_A48_T0.5470.61
141_A447_A0.5470.61
108_I311_L0.5460.61
186_K189_A0.5460.61
284_E287_D0.5450.61
140_I424_I0.5450.61
39_K42_E0.5450.61
252_L285_K0.5440.61
249_D301_K0.5440.61
151_P450_I0.5440.61
456_I459_E0.5430.61
229_K358_E0.5430.61
193_E376_K0.5420.60
188_V207_Q0.5420.60
105_T507_V0.5410.60
104_K108_I0.5400.60
165_L190_Q0.5400.60
410_D505_A0.5390.60
72_A76_D0.5380.60
467_D472_L0.5380.60
102_G507_V0.5380.60
139_E430_K0.5370.60
367_V370_E0.5360.60
359_R368_F0.5350.59
215_S218_D0.5350.59
109_L113_L0.5340.59
220_Q370_E0.5330.59
113_L516_T0.5330.59
322_A368_F0.5320.59
533_K536_G0.5320.59
100_A399_D0.5320.59
506_L509_M0.5320.59
384_G393_T0.5310.59
63_G163_V0.5310.59
432_A447_A0.5310.59
249_D324_K0.5310.59
184_V404_V0.5310.59
24_R44_A0.5300.59
49_Y52_R0.5300.59
349_D428_L0.5280.58
448_N452_G0.5270.58
251_S301_K0.5260.58
114_A249_D0.5260.58
254_V304_D0.5250.58
385_G524_R0.5250.58
120_L523_L0.5230.58
60_D63_G0.5230.58
28_K31_L0.5220.58
252_L286_V0.5220.58
26_Y215_S0.5220.58
24_R27_G0.5210.57
331_A334_T0.5210.57
40_A81_Q0.5200.57
44_A48_T0.5190.57
417_G501_V0.5170.57
157_T529_V0.5170.57
34_N522_V0.5170.57
387_E391_D0.5170.57
330_L334_T0.5150.57
397_L403_T0.5150.57
346_T355_L0.5150.57
228_D304_D0.5150.57
128_T131_V0.5140.56
384_G523_L0.5140.56
79_D334_T0.5140.56
337_R346_T0.5130.56
366_M369_V0.5130.56
334_T524_R0.5130.56
32_R35_I0.5120.56
152_V179_Y0.5120.56
83_P401_L0.5120.56
69_N522_V0.5120.56
475_L490_T0.5110.56
41_I80_L0.5110.56
98_E409_R0.5110.56
59_V531_A0.5100.56
231_V367_V0.5100.56
448_N466_I0.5090.56
233_H236_M0.5090.56
360_K365_K0.5090.56
419_A454_I0.5070.55
152_V407_V0.5060.55
146_Q151_P0.5050.55
253_E258_E0.5040.55
245_I369_V0.5040.55
95_Q106_A0.5040.55
405_A501_V0.5030.55
424_I431_Y0.5030.55
371_G376_K0.5030.55
300_Q327_L0.5020.55
163_V404_V0.5020.55
128_T520_T0.5020.55
297_V304_D0.5010.55
472_L476_H0.5000.54
244_K347_S0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a6dB 2 0.9061 100 0.07 Contact Map
3ko1A 5 0.9097 100 0.077 Contact Map
3j1bA 4 0.9188 100 0.083 Contact Map
3p9dA 1 0.9495 100 0.083 Contact Map
1q3qA 4 0.935 100 0.083 Contact Map
3ruvA 6 0.9314 100 0.089 Contact Map
1a6dA 2 0.9079 100 0.093 Contact Map
3p9dE 1 0.9278 100 0.095 Contact Map
3iygA 1 0.926 100 0.095 Contact Map
3p9dD 2 0.926 100 0.096 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0138 seconds.