GREMLIN Database
KTHY1 - Probable thymidylate kinase 1
UniProt: Q9UXG7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (183)
Sequences: 4653 (3474)
Seq/√Len: 256.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_K179_Q3.6971.00
25_H181_I3.1651.00
33_N82_D3.1191.00
123_L169_A2.9001.00
21_L177_L2.7991.00
124_D152_R2.4491.00
23_K27_E2.4171.00
171_K175_E2.3751.00
129_V132_S2.1371.00
152_R156_L2.1021.00
172_D175_E2.0541.00
167_V176_V2.0481.00
70_I74_W2.0321.00
35_I82_D1.9771.00
37_T71_H1.9451.00
139_F142_E1.9111.00
19_A85_I1.9061.00
19_A36_V1.8871.00
18_L180_A1.8251.00
32_L83_L1.8171.00
124_D156_L1.8081.00
3_K83_L1.7951.00
23_K36_V1.7891.00
18_L177_L1.7691.00
29_K185_Q1.7681.00
165_Y183_I1.7351.00
156_L166_V1.6941.00
126_P170_S1.6881.00
13_S125_L1.6351.00
25_H29_K1.6221.00
177_L181_I1.6141.00
91_F163_N1.5771.00
121_I183_I1.5601.00
122_L164_F1.5031.00
125_L129_V1.4951.00
23_K85_I1.4891.00
109_M112_S1.4821.00
4_L86_L1.4611.00
18_L21_L1.4501.00
122_L166_V1.3781.00
48_L51_K1.3751.00
159_A166_V1.3501.00
157_K161_E1.3351.00
153_E157_K1.3261.00
56_D73_N1.2981.00
6_A86_L1.2971.00
25_H177_L1.2951.00
121_I180_A1.2891.00
22_L184_I1.2801.00
47_K67_D1.2791.00
149_A153_E1.2721.00
25_H185_Q1.2721.00
11_D130_A1.2671.00
7_I22_L1.2631.00
100_L143_E1.2541.00
123_L180_A1.2521.00
181_I185_Q1.2491.00
129_V170_S1.2471.00
145_I149_A1.2461.00
108_K161_E1.2441.00
24_E28_S1.2351.00
35_I77_K1.2321.00
10_I148_L1.2021.00
77_K82_D1.1991.00
6_A91_F1.1991.00
91_F120_V1.1961.00
21_L174_N1.1911.00
49_I63_L1.1751.00
119_M165_Y1.1671.00
130_A134_I1.1591.00
167_V183_I1.1551.00
90_Y111_N1.1531.00
128_E149_A1.1521.00
72_V115_P1.1511.00
69_E73_N1.1501.00
65_A111_N1.1501.00
61_V65_A1.1381.00
157_K160_K1.1381.00
21_L173_K1.1381.00
127_I145_I1.1341.00
8_E92_S1.1321.00
105_Q109_M1.1121.00
158_L164_F1.1061.00
51_K55_N1.1021.00
177_L180_A1.0991.00
126_P129_V1.0981.00
17_T173_K1.0941.00
179_Q182_K1.0881.00
20_N24_E1.0861.00
122_L159_A1.0791.00
125_L130_A1.0771.00
29_K181_I1.0671.00
43_E46_I1.0661.00
56_D69_E1.0651.00
146_K149_A1.0631.00
134_I137_D1.0601.00
122_L156_L1.0501.00
58_I106_W1.0491.00
146_K150_K1.0431.00
106_W113_Y1.0421.00
116_K162_Y1.0361.00
36_V85_I1.0141.00
183_I186_K1.0141.00
121_I165_Y1.0121.00
108_K112_S1.0111.00
27_E34_V1.0091.00
173_K177_L1.0021.00
179_Q183_I1.0011.00
23_K34_V0.9941.00
37_T86_L0.9811.00
122_L152_R0.9801.00
65_A90_Y0.9761.00
46_I67_D0.9721.00
178_E182_K0.9671.00
175_E179_Q0.9621.00
18_L173_K0.9591.00
65_A93_S0.9571.00
67_D71_H0.9551.00
124_D166_V0.9511.00
24_E27_E0.9351.00
58_I113_Y0.9341.00
127_I152_R0.9231.00
131_I134_I0.9171.00
64_F141_F0.9161.00
119_M183_I0.9121.00
90_Y116_K0.9041.00
25_H178_E0.8971.00
95_A99_A0.8911.00
91_F164_F0.8881.00
111_N114_F0.8831.00
99_A150_K0.8781.00
131_I145_I0.8771.00
168_D171_K0.8761.00
29_K32_L0.8661.00
33_N80_D0.8631.00
121_I167_V0.8591.00
48_L55_N0.8580.99
25_H28_S0.8520.99
94_I158_L0.8410.99
6_A163_N0.8400.99
182_K185_Q0.8400.99
21_L24_E0.8360.99
132_S136_N0.8340.99
100_L147_S0.8280.99
65_A107_I0.8230.99
39_E71_H0.8220.99
4_L89_Y0.8220.99
58_I73_N0.8140.99
95_A154_K0.8080.99
156_L159_A0.8070.99
120_V163_N0.8020.99
75_L84_I0.8010.99
16_T20_N0.7980.99
94_I104_E0.7960.99
20_N36_V0.7930.99
10_I130_A0.7930.99
125_L169_A0.7880.99
103_D107_I0.7840.99
11_D148_L0.7830.99
101_G150_K0.7730.99
167_V180_A0.7630.99
61_V107_I0.7590.99
108_K116_K0.7570.99
53_G64_F0.7570.99
131_I135_K0.7520.99
108_K162_Y0.7500.99
7_I180_A0.7500.99
154_K157_K0.7500.99
175_E178_E0.7470.99
27_E33_N0.7440.99
72_V75_L0.7370.98
40_P68_R0.7370.98
99_A151_V0.7350.98
150_K153_E0.7340.98
182_K186_K0.7240.98
56_D59_L0.7200.98
34_V82_D0.7190.98
18_L22_L0.7190.98
7_I19_A0.7140.98
128_E145_I0.7120.98
71_H86_L0.7120.98
159_A164_F0.7110.98
62_L110_V0.7040.98
20_N23_K0.7040.98
94_I108_K0.7040.98
46_I70_I0.7000.98
60_L100_L0.6960.98
10_I122_L0.6940.98
105_Q108_K0.6830.98
89_Y115_P0.6800.97
121_I184_I0.6800.97
176_V179_Q0.6770.97
34_V85_I0.6720.97
112_S116_K0.6710.97
99_A147_S0.6710.97
104_E154_K0.6700.97
96_Y147_S0.6680.97
7_I18_L0.6670.97
104_E157_K0.6640.97
77_K80_D0.6590.97
6_A164_F0.6570.97
31_K34_V0.6560.97
143_E147_S0.6560.97
34_V83_L0.6540.97
61_V110_V0.6530.97
103_D106_W0.6480.97
68_R93_S0.6470.97
76_S80_D0.6440.96
3_K118_D0.6440.96
147_S151_V0.6400.96
16_T38_R0.6390.96
59_L66_A0.6380.96
104_E108_K0.6380.96
158_L162_Y0.6340.96
50_E54_W0.6340.96
4_L78_I0.6320.96
12_G134_I0.6290.96
46_I49_I0.6270.96
173_K176_V0.6270.96
62_L113_Y0.6240.96
59_L69_E0.6160.95
18_L169_A0.6140.95
27_E36_V0.6060.95
38_R47_K0.6060.95
39_E68_R0.6060.95
110_V113_Y0.6020.95
127_I149_A0.6000.95
65_A114_F0.5990.95
120_V164_F0.5930.94
93_S107_I0.5840.94
64_F94_I0.5830.94
7_I121_I0.5810.94
40_P64_F0.5790.94
5_I118_D0.5780.94
64_F67_D0.5670.93
100_L141_F0.5660.93
128_E132_S0.5650.93
98_G103_D0.5650.93
94_I111_N0.5630.93
7_I123_L0.5630.93
18_L176_V0.5620.93
8_E96_Y0.5580.92
77_K84_I0.5520.92
68_R111_N0.5520.92
90_Y93_S0.5460.92
95_A151_V0.5450.92
22_L177_L0.5450.92
92_S155_Y0.5440.91
44_D48_L0.5410.91
37_T84_I0.5400.91
18_L123_L0.5370.91
106_W109_M0.5350.91
109_M113_Y0.5350.91
41_F50_E0.5340.91
78_I81_A0.5300.90
56_D70_I0.5290.90
13_S130_A0.5290.90
93_S97_Q0.5280.90
127_I130_A0.5220.90
105_Q161_E0.5200.90
45_I48_L0.5190.89
38_R42_S0.5160.89
61_V93_S0.5160.89
93_S111_N0.5140.89
45_I70_I0.5120.89
40_P92_S0.5120.89
45_I52_I0.5110.89
91_F162_Y0.5080.88
8_E122_L0.5070.88
171_K176_V0.5060.88
92_S96_Y0.5050.88
99_A103_D0.5020.88
38_R87_D0.5010.88
133_R169_A0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3czpA 2 0.8466 100 0.377 Contact Map
2plrA 2 0.9894 100 0.393 Contact Map
2yogA 1 0.9365 100 0.402 Contact Map
1nn5A 2 0.963 100 0.417 Contact Map
1gtvA 2 0.9418 100 0.422 Contact Map
1p6xA 3 0.9894 100 0.433 Contact Map
3czqA 3 0.8783 100 0.439 Contact Map
4edhA 2 0.9947 100 0.441 Contact Map
1osnA 4 0.9524 100 0.448 Contact Map
4eaqA 2 0.9788 100 0.454 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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