GREMLIN Database
Y776 - UPF0290 protein SSO0776
UniProt: Q9UXG3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 166 (157)
Sequences: 289 (245)
Seq/√Len: 19.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_F93_M6.9571.00
104_I108_G4.5251.00
110_V113_L4.5091.00
49_G106_R3.8611.00
18_F145_A3.8101.00
90_I125_I3.7381.00
117_D121_G3.5751.00
44_R48_D3.1630.99
59_L86_L2.7940.99
33_I52_F2.6100.98
66_G81_S2.2300.94
95_G110_V2.0920.92
50_K93_M2.0850.92
149_H153_N2.0840.92
25_P50_K2.0740.92
17_A87_F2.0740.92
18_F84_E2.0540.91
98_I144_L1.9750.90
58_A89_M1.9450.89
81_S85_S1.8240.86
62_G85_S1.7480.83
37_K45_L1.6410.79
95_G118_F1.6100.77
53_E96_A1.5910.77
33_I55_L1.5510.75
50_K165_P1.5450.74
48_D106_R1.5340.74
119_V141_I1.5240.73
21_N92_D1.5160.73
104_I110_V1.5050.72
107_G161_I1.5010.72
49_G107_G1.4580.70
46_F50_K1.4570.70
19_V37_K1.4470.69
42_G98_I1.4410.69
41_D101_R1.4350.69
58_A62_G1.4160.68
31_T35_F1.4100.67
57_V68_I1.3710.65
95_G113_L1.3660.65
109_R150_Q1.3280.62
60_T85_S1.3100.61
35_F52_F1.3050.61
60_T139_L1.3010.61
20_A24_G1.2830.60
72_F75_A1.2520.58
95_G98_I1.2320.57
16_P153_N1.2050.55
38_N45_L1.1940.54
109_R158_L1.1880.54
92_D95_G1.1680.52
83_L126_L1.1630.52
21_N24_G1.1510.51
16_P149_H1.1290.50
25_P156_A1.1260.50
61_F151_G1.1220.50
118_F122_A1.1090.49
84_E145_A1.0740.46
25_P161_I1.0680.46
46_F165_P1.0670.46
139_L154_Y1.0610.46
70_S81_S1.0590.45
36_G52_F1.0490.45
72_F142_C1.0310.44
11_I148_L1.0290.44
14_Y119_V1.0050.42
21_N91_G0.9990.42
41_D51_T0.9960.42
87_F125_I0.9880.41
120_L142_C0.9880.41
58_A92_D0.9870.41
94_I121_G0.9830.41
55_L59_L0.9790.40
21_N88_A0.9620.39
24_G92_D0.9600.39
38_N139_L0.9580.39
26_F68_I0.9210.37
94_I98_I0.9190.37
117_D128_L0.9150.37
125_I139_L0.9130.36
92_D118_F0.9120.36
118_F156_A0.9020.36
83_L129_M0.8990.36
67_V78_T0.8920.35
112_G163_N0.8900.35
63_T82_F0.8860.35
144_L163_N0.8790.34
102_L120_L0.8730.34
25_P88_A0.8660.34
153_N157_Y0.8650.34
82_F86_L0.8600.33
68_I102_L0.8560.33
60_T135_W0.8520.33
58_A91_G0.8480.33
57_V116_L0.8440.32
11_I132_N0.8270.32
83_L144_L0.8250.31
53_E69_I0.8200.31
15_L87_F0.8190.31
153_N156_A0.8100.31
118_F145_A0.8100.31
11_I138_F0.8090.31
141_I144_L0.7970.30
64_T68_I0.7950.30
72_F154_Y0.7840.29
65_V69_I0.7790.29
23_S82_F0.7760.29
157_Y165_P0.7730.29
105_P108_G0.7690.28
95_G156_A0.7680.28
34_D42_G0.7610.28
63_T79_L0.7570.28
14_Y18_F0.7530.28
25_P93_M0.7520.28
79_L82_F0.7450.27
37_K62_G0.7390.27
27_I123_S0.7390.27
62_G149_H0.7390.27
36_G68_I0.7360.27
8_L155_V0.7350.27
19_V78_T0.7280.26
156_A162_K0.7250.26
66_G95_G0.7250.26
88_A92_D0.7190.26
64_T78_T0.7180.26
14_Y123_S0.7180.26
135_W155_V0.7150.26
63_T85_S0.7150.26
33_I89_M0.7130.26
95_G164_V0.7120.26
11_I98_I0.7050.25
51_T115_Q0.7050.25
122_A155_V0.7050.25
21_N58_A0.7030.25
92_D122_A0.7020.25
61_F123_S0.7020.25
37_K160_K0.6980.25
21_N118_F0.6950.25
23_S45_L0.6930.25
120_L151_G0.6930.25
20_A53_E0.6890.24
21_N95_G0.6840.24
108_G165_P0.6750.24
16_P62_G0.6740.24
62_G152_T0.6710.24
55_L93_M0.6680.23
26_F61_F0.6640.23
118_F162_K0.6620.23
95_G117_D0.6610.23
43_R72_F0.6590.23
50_K55_L0.6560.23
61_F90_I0.6490.23
76_E89_M0.6480.23
86_L136_Y0.6450.22
19_V70_S0.6420.22
117_D152_T0.6420.22
97_F101_R0.6410.22
125_I141_I0.6380.22
77_W85_S0.6360.22
62_G122_A0.6340.22
32_P42_G0.6230.21
46_F111_L0.6230.21
64_T72_F0.6210.21
68_I78_T0.6200.21
68_I75_A0.6200.21
24_G145_A0.6160.21
124_L160_K0.6140.21
155_V159_L0.6090.21
22_G55_L0.6060.21
46_F137_Q0.6060.21
8_L75_A0.6040.21
34_D97_F0.6030.21
23_S52_F0.6020.21
20_A23_S0.6000.20
14_Y80_I0.5990.20
54_G114_D0.5990.20
47_G114_D0.5990.20
47_G100_R0.5990.20
47_G99_K0.5990.20
47_G54_G0.5990.20
99_K114_D0.5990.20
54_G99_K0.5990.20
54_G100_R0.5990.20
100_R114_D0.5990.20
149_H157_Y0.5970.20
52_F55_L0.5930.20
81_S113_L0.5920.20
70_S77_W0.5890.20
42_G45_L0.5870.20
34_D41_D0.5860.20
60_T140_F0.5860.20
24_G91_G0.5830.20
31_T158_L0.5780.20
78_T163_N0.5710.19
65_V150_Q0.5680.19
12_L69_I0.5650.19
55_L136_Y0.5630.19
65_V132_N0.5610.19
58_A109_R0.5590.19
111_L150_Q0.5560.19
66_G110_V0.5550.19
81_S133_I0.5520.19
24_G117_D0.5500.18
83_L125_I0.5450.18
79_L159_L0.5450.18
33_I86_L0.5440.18
52_F136_Y0.5420.18
45_L71_K0.5410.18
149_H160_K0.5380.18
151_G155_V0.5370.18
150_Q154_Y0.5320.18
61_F69_I0.5280.18
17_A153_N0.5260.18
23_S27_I0.5250.18
68_I135_W0.5250.18
38_N48_D0.5240.17
42_G104_I0.5230.17
33_I110_V0.5220.17
91_G118_F0.5200.17
110_V134_T0.5190.17
67_V104_I0.5160.17
60_T142_C0.5160.17
85_S122_A0.5150.17
46_F112_G0.5130.17
66_G103_G0.5130.17
82_F129_M0.5120.17
98_I126_L0.5110.17
68_I124_L0.5090.17
46_F106_R0.5080.17
72_F158_L0.5080.17
80_I83_L0.5030.17
80_I147_F0.5030.17
18_F58_A0.5020.17
145_A153_N0.5010.17
104_I111_L0.5010.17
45_L125_I0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4q2eA 2 0.8253 99.6 0.701 Contact Map
4lg3A 1 0.6566 9.1 0.954 Contact Map
4od4A 1 0.8976 5.8 0.958 Contact Map
1m56D 1 0.253 5.5 0.959 Contact Map
2mpnA 2 0.4036 3.8 0.962 Contact Map
1qleD 1 0.2349 3.4 0.963 Contact Map
3b9wA 3 0.9398 2 0.967 Contact Map
3j1zP 8 1 1.9 0.967 Contact Map
2bs2C 2 0.4337 1.9 0.967 Contact Map
2k1aA 1 0.241 1.4 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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