GREMLIN Database
MCM - Minichromosome maintenance protein MCM
UniProt: Q9UXG1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 686 (634)
Sequences: 2205 (1338)
Seq/√Len: 53.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
215_I259_V8.3011.00
569_S581_V7.0501.00
295_I314_A5.8991.00
288_D294_R5.3461.00
48_E102_G4.9081.00
285_L291_I4.8971.00
576_A585_D4.6061.00
278_D515_K4.3461.00
318_F575_M4.2641.00
195_A217_L4.2061.00
29_K51_D4.1781.00
316_A444_I3.8421.00
588_R591_N3.7621.00
397_D440_R3.5291.00
14_F17_F3.4261.00
313_L353_I3.3021.00
535_L587_E3.2901.00
509_D512_T3.2741.00
14_F18_L3.1871.00
285_L508_I3.1791.00
531_E583_R3.1651.00
309_L480_L3.1391.00
153_F172_P3.1341.00
529_T580_E3.1161.00
578_K585_D3.1101.00
285_L512_T3.0681.00
529_T532_A3.0401.00
217_L262_I2.9591.00
454_Y463_N2.9391.00
215_I233_V2.9341.00
313_L349_M2.8651.00
281_K284_D2.8021.00
52_V63_I2.7291.00
125_G197_I2.6761.00
15_I80_D2.6161.00
127_L195_A2.4821.00
344_T480_L2.4251.00
649_L662_I2.4171.00
16_E20_T2.4121.00
572_Y588_R2.4121.00
140_A182_L2.3241.00
97_H219_D2.3171.00
275_S278_D2.3041.00
14_F20_T2.3031.00
144_H149_C2.2951.00
110_R205_P2.2821.00
530_S534_N2.2411.00
149_C171_C2.2361.00
37_L45_L2.2331.00
476_L568_I2.2321.00
127_L231_V2.1971.00
143_K183_I2.1931.00
65_N119_K2.1891.00
18_L21_F2.1871.00
629_I633_I2.1361.00
281_K512_T2.1361.00
393_L443_V2.1131.00
308_E591_N2.0901.00
30_Y37_L2.0891.00
455_I458_R2.0871.00
137_I140_A2.0861.00
525_T574_K2.0501.00
420_A426_V2.0431.00
459_P462_D2.0211.00
578_K582_T1.9721.00
508_I512_T1.9701.00
323_K570_E1.9651.00
120_L260_S1.9381.00
279_E283_K1.9201.00
321_V332_G1.9181.00
534_N538_D1.9030.99
360_A396_A1.8950.99
299_I314_A1.8650.99
78_L96_V1.8580.99
643_A648_I1.8560.99
238_D258_K1.8480.99
429_A434_V1.8390.99
46_I101_V1.8310.99
276_E280_K1.8270.99
237_L255_I1.8240.99
296_I311_E1.8210.99
17_F21_F1.8140.99
29_K33_R1.8090.99
149_C157_E1.8000.99
315_L572_Y1.7930.99
519_Y577_L1.7730.99
353_I400_I1.7720.99
34_I37_L1.7690.99
283_K286_A1.7650.99
539_F590_I1.7540.99
312_A478_F1.7480.99
276_E279_E1.7430.99
486_E489_R1.7350.99
393_L401_A1.7340.99
311_E588_R1.7320.99
29_K35_N1.7290.99
99_R220_D1.7080.99
625_K630_I1.6850.99
572_Y585_D1.6760.99
405_E473_R1.6480.98
318_F520_A1.6470.98
348_Q423_Q1.6380.98
617_G623_R1.6300.98
199_E210_P1.6270.98
532_A586_A1.6240.98
583_R587_E1.6200.98
482_D488_D1.6110.98
524_V579_A1.5970.98
285_L294_R1.5860.98
367_G414_R1.5840.98
451_F455_I1.5790.98
363_T418_H1.5760.98
647_D650_K1.5550.98
123_I197_I1.5530.98
630_I634_D1.5530.98
15_I19_T1.5440.98
560_R567_R1.5380.98
621_S625_K1.5320.98
315_L597_L1.5310.97
44_S220_D1.5160.97
284_D287_K1.5040.97
44_S99_R1.5040.97
363_T367_G1.4990.97
535_L583_R1.4980.97
315_L568_I1.4960.97
196_V214_E1.4810.97
144_H171_C1.4770.97
234_T261_S1.4730.97
372_G405_E1.4660.97
520_A577_L1.4610.97
143_K181_R1.4590.97
232_K265_S1.4590.97
331_R567_R1.4590.97
456_S481_K1.4540.97
316_A442_A1.4500.97
530_S533_K1.4470.96
565_L586_A1.4130.96
149_C155_W1.4120.96
487_Q490_E1.4090.96
316_A400_I1.4090.96
367_G388_L1.3980.96
644_K647_D1.3800.95
274_I282_I1.3800.95
170_I177_P1.3770.95
197_I233_V1.3710.95
618_K623_R1.3640.95
569_S586_A1.3630.95
321_V525_T1.3460.95
211_R417_I1.3450.95
320_G574_K1.3440.95
286_A291_I1.3370.94
33_R42_K1.3350.94
14_F22_K1.3330.94
147_P155_W1.3300.94
535_L590_I1.3250.94
494_Y498_V1.3140.94
372_G473_R1.3080.94
501_G504_T1.3080.94
282_I512_T1.3060.94
20_T55_F1.3040.94
148_D179_Q1.3010.94
14_F21_F1.3000.94
153_F157_E1.2930.93
292_R572_Y1.2930.93
352_F510_I1.2920.93
636_L639_S1.2900.93
123_I257_M1.2890.93
630_I633_I1.2870.93
540_F544_R1.2850.93
651_E654_Q1.2830.93
168_P171_C1.2820.93
331_R405_E1.2800.93
314_A318_F1.2780.93
292_R588_R1.2760.93
292_R591_N1.2700.93
538_D542_E1.2680.93
620_K623_R1.2650.93
375_A428_I1.2570.92
27_Q32_E1.2540.92
147_P157_E1.2500.92
47_I74_L1.2500.92
100_I260_S1.2500.92
199_E207_G1.2350.92
322_P329_R1.2340.92
632_I636_L1.2320.92
539_F542_E1.2280.92
191_D563_E1.2230.91
18_L22_K1.2220.91
312_A476_L1.2200.91
658_E662_I1.2150.91
332_G417_I1.2130.91
419_E427_S1.2050.91
331_R473_R1.2030.91
81_H84_Q1.2020.91
122_T232_K1.2000.91
233_V259_V1.1980.91
586_A596_F1.1940.90
536_I565_L1.1930.90
293_D297_S1.1930.90
524_V577_L1.1900.90
290_W297_S1.1890.90
19_T84_Q1.1830.90
371_A386_Y1.1830.90
476_L592_I1.1820.90
405_E448_N1.1790.90
568_I572_Y1.1760.90
463_N479_I1.1740.90
320_G570_E1.1710.89
409_M423_Q1.1670.89
372_G560_R1.1600.89
150_M155_W1.1590.89
315_L571_A1.1590.89
110_R207_G1.1560.89
340_G346_K1.1510.89
288_D508_I1.1460.88
141_T183_I1.1440.88
657_I662_I1.1430.88
603_D607_G1.1410.88
195_A225_A1.1410.88
648_I662_I1.1400.88
131_T400_I1.1350.88
243_S246_K1.1350.88
621_S626_M1.1320.88
338_I444_I1.1310.88
367_G418_H1.1300.88
603_D606_S1.1270.88
292_R311_E1.1260.88
280_K284_D1.1260.88
649_L653_Q1.1250.87
630_I636_L1.1230.87
290_W294_R1.1200.87
467_P470_I1.1170.87
542_E545_K1.1170.87
500_S504_T1.1140.87
49_F60_A1.1100.87
389_E423_Q1.1060.87
625_K636_L1.1050.87
295_I513_L1.1050.87
645_V649_L1.1030.86
317_L357_A1.1010.86
413_D416_A1.1000.86
72_P75_E1.1000.86
657_I661_N1.1000.86
30_Y51_D1.0970.86
79_Y95_K1.0940.86
297_S307_W1.0940.86
321_V574_K1.0920.86
363_T423_Q1.0890.86
75_E98_V1.0810.85
335_H426_V1.0800.85
624_E634_D1.0770.85
535_L586_A1.0700.85
413_D418_H1.0700.85
652_A657_I1.0680.85
63_I70_I1.0680.85
370_A570_E1.0670.85
364_T367_G1.0630.84
218_E258_K1.0600.84
152_E186_K1.0590.84
19_T22_K1.0580.84
68_K238_D1.0570.84
433_I438_N1.0570.84
213_L257_M1.0560.84
286_A516_Y1.0500.84
420_A470_I1.0430.83
293_D307_W1.0370.83
183_I186_K1.0360.83
473_R560_R1.0360.83
197_I215_I1.0340.83
190_I219_D1.0340.83
294_R571_A1.0320.83
419_E425_T1.0310.82
107_I116_D1.0310.82
584_E587_E1.0280.82
47_I77_A1.0240.82
32_E36_E1.0240.82
207_G210_P1.0240.82
42_K45_L1.0210.82
331_R560_R1.0170.82
363_T368_S1.0130.81
626_M630_I1.0120.81
346_K404_D1.0120.81
207_G359_R1.0110.81
536_I566_I1.0100.81
633_I636_L1.0100.81
658_E661_N1.0080.81
652_A655_V1.0070.81
66_N69_I1.0040.81
625_K631_E1.0040.81
108_E111_K1.0010.81
406_I445_A0.9980.80
62_E70_I0.9920.80
61_Y65_N0.9900.80
28_N31_I0.9890.80
199_E389_E0.9870.80
276_E361_V0.9850.79
113_R116_D0.9850.79
48_E101_V0.9820.79
199_E227_P0.9820.79
366_K420_A0.9810.79
614_I617_G0.9810.79
112_I213_L0.9770.79
14_F19_T0.9720.79
629_I657_I0.9680.78
35_N39_A0.9660.78
363_T413_D0.9650.78
142_Y359_R0.9650.78
120_L234_T0.9630.78
586_A590_I0.9630.78
448_N473_R0.9610.78
406_I447_G0.9610.78
196_V429_A0.9600.78
634_D638_V0.9600.78
87_P91_R0.9590.78
42_K224_S0.9570.77
618_K626_M0.9560.77
339_I390_A0.9540.77
282_I516_Y0.9540.77
275_S515_K0.9530.77
317_L521_R0.9530.77
313_L336_I0.9460.77
136_R218_E0.9440.77
235_G257_M0.9420.76
331_R372_G0.9420.76
444_I592_I0.9400.76
405_E560_R0.9390.76
296_I299_I0.9340.76
396_A401_A0.9330.76
253_F388_L0.9310.76
396_A416_A0.9290.75
294_R508_I0.9280.75
291_I508_I0.9260.75
67_T519_Y0.9260.75
559_P596_F0.9240.75
473_R567_R0.9240.75
377_V386_Y0.9230.75
644_K648_I0.9200.75
389_E397_D0.9150.74
628_K635_S0.9140.74
232_K263_E0.9130.74
372_G567_R0.9120.74
418_H438_N0.9100.74
94_E100_I0.9100.74
388_L414_R0.9100.74
45_L78_L0.9080.74
359_R401_A0.9080.74
17_F22_K0.9080.74
351_Q362_Y0.9070.74
137_I189_L0.9050.73
262_I273_I0.9050.73
405_E567_R0.9050.73
625_K634_D0.9050.73
621_S629_I0.9040.73
207_G211_R0.9040.73
17_F30_Y0.9010.73
472_S558_T0.9000.73
198_Q210_P0.9000.73
333_D409_M0.8990.73
446_A452_G0.8960.73
36_E42_K0.8950.73
227_P395_L0.8940.72
142_Y168_P0.8930.72
339_I593_M0.8920.72
151_Q172_P0.8900.72
309_L344_T0.8880.72
625_K628_K0.8850.72
60_A64_I0.8820.71
175_G178_G0.8810.71
308_E588_R0.8810.71
422_E473_R0.8810.71
211_R499_H0.8800.71
369_T592_I0.8800.71
341_D347_S0.8790.71
71_L100_I0.8770.71
501_G507_I0.8770.71
314_A575_M0.8720.71
414_R418_H0.8710.71
143_K150_M0.8710.71
282_I577_L0.8700.70
653_Q656_G0.8670.70
392_A463_N0.8660.70
282_I515_K0.8650.70
409_M447_G0.8640.70
147_P181_R0.8630.70
278_D282_I0.8600.70
57_E61_Y0.8600.70
392_A397_D0.8590.69
293_D296_I0.8570.69
41_R98_V0.8570.69
646_K660_S0.8560.69
84_Q543_M0.8550.69
380_E383_T0.8540.69
652_A662_I0.8540.69
69_I85_L0.8530.69
340_G348_Q0.8520.69
32_E35_N0.8520.69
380_E432_G0.8510.69
303_I309_L0.8500.69
645_V651_E0.8500.69
446_A478_F0.8490.69
205_P335_H0.8490.69
625_K633_I0.8490.69
47_I52_V0.8480.68
194_K214_E0.8470.68
45_L485_G0.8450.68
141_T186_K0.8440.68
625_K629_I0.8440.68
18_L24_N0.8430.68
339_I597_L0.8430.68
646_K650_K0.8410.68
417_I452_G0.8410.68
426_V443_V0.8410.68
389_E558_T0.8410.68
333_D424_Q0.8370.67
453_R484_P0.8360.67
512_T515_K0.8360.67
603_D617_G0.8330.67
564_A570_E0.8320.67
46_I99_R0.8310.67
149_C401_A0.8310.67
318_F524_V0.8300.67
348_Q397_D0.8270.67
419_E429_A0.8260.66
147_P150_M0.8230.66
333_D499_H0.8220.66
283_K287_K0.8180.66
497_D501_G0.8180.66
191_D323_K0.8170.66
150_M157_E0.8160.65
623_R627_M0.8160.65
22_K28_N0.8120.65
569_S572_Y0.8110.65
379_R564_A0.8080.65
75_E97_H0.8070.65
423_Q427_S0.8070.65
463_N466_L0.8060.64
30_Y34_I0.8040.64
153_F156_P0.8010.64
343_G446_A0.8010.64
227_P345_A0.8000.64
130_V195_A0.8000.64
318_F574_K0.8000.64
449_P454_Y0.7990.64
22_K26_N0.7990.64
283_K519_Y0.7980.64
343_G347_S0.7960.64
501_G505_K0.7950.63
502_K506_N0.7940.63
232_K566_I0.7930.63
136_R142_Y0.7920.63
357_A389_E0.7920.63
16_E24_N0.7920.63
420_A563_E0.7910.63
363_T392_A0.7880.63
282_I291_I0.7870.63
642_C651_E0.7850.62
644_K652_A0.7840.62
88_T92_D0.7840.62
648_I656_G0.7830.62
316_A336_I0.7830.62
640_S655_V0.7820.62
423_Q431_A0.7780.62
47_I82_I0.7760.62
79_Y83_L0.7760.62
411_D414_R0.7750.61
210_P348_Q0.7730.61
348_Q403_I0.7710.61
618_K621_S0.7710.61
17_F51_D0.7690.61
625_K632_I0.7680.61
421_M443_V0.7670.61
621_S627_M0.7670.61
357_A360_A0.7670.61
110_R199_E0.7660.61
37_L41_R0.7630.60
626_M637_A0.7620.60
355_R369_T0.7620.60
403_I417_I0.7620.60
348_Q409_M0.7610.60
28_N32_E0.7610.60
303_I447_G0.7610.60
638_V642_C0.7610.60
142_Y253_F0.7580.60
648_I652_A0.7570.60
623_R629_I0.7560.60
293_D311_E0.7550.59
458_R463_N0.7550.59
198_Q207_G0.7530.59
413_D417_I0.7520.59
51_D55_F0.7500.59
634_D637_A0.7490.59
33_R37_L0.7480.59
129_K380_E0.7470.59
16_E19_T0.7470.59
619_P625_K0.7460.59
24_N574_K0.7450.58
307_W628_K0.7440.58
210_P397_D0.7440.58
401_A463_N0.7400.58
337_L477_I0.7390.58
34_I87_P0.7390.58
16_E23_G0.7360.57
397_D438_N0.7350.57
524_V574_K0.7340.57
347_S350_L0.7330.57
30_Y33_R0.7330.57
624_E628_K0.7330.57
640_S646_K0.7320.57
198_Q397_D0.7320.57
341_D346_K0.7310.57
433_I437_L0.7310.57
539_F594_R0.7300.57
632_I649_L0.7300.57
361_V558_T0.7290.57
647_D651_E0.7280.57
304_Y315_L0.7280.57
629_I635_S0.7280.57
87_P90_Q0.7270.57
127_L225_A0.7270.57
556_L559_P0.7250.56
513_L524_V0.7250.56
649_L654_Q0.7240.56
262_I548_S0.7200.56
350_L419_E0.7190.56
631_E635_S0.7180.56
199_E408_K0.7180.56
627_M633_I0.7160.55
112_I286_A0.7160.55
189_L492_A0.7160.55
353_I360_A0.7160.55
63_I133_V0.7150.55
340_G347_S0.7130.55
318_F517_I0.7130.55
624_E639_S0.7130.55
374_T392_A0.7110.55
67_T71_L0.7100.55
16_E22_K0.7090.55
79_Y313_L0.7080.55
118_G134_K0.7050.54
366_K418_H0.7050.54
152_E183_I0.7020.54
390_A479_I0.7010.54
635_S658_E0.7010.54
319_G340_G0.7010.54
493_N497_D0.6980.54
432_G473_R0.6980.54
18_L31_I0.6980.54
141_T152_E0.6970.53
303_I408_K0.6960.53
313_L393_L0.6960.53
629_I632_I0.6950.53
15_I22_K0.6950.53
373_L405_E0.6940.53
632_I652_A0.6940.53
332_G375_A0.6930.53
571_A597_L0.6920.53
130_V426_V0.6920.53
576_A582_T0.6910.53
332_G363_T0.6910.53
641_E644_K0.6910.53
377_V439_A0.6890.53
199_E419_E0.6890.53
135_E439_A0.6890.53
67_T236_I0.6880.52
121_I545_K0.6880.52
503_S506_N0.6880.52
23_G29_K0.6870.52
620_K624_E0.6870.52
63_I633_I0.6870.52
627_M632_I0.6860.52
646_K654_Q0.6860.52
407_D447_G0.6850.52
356_V360_A0.6820.52
312_A336_I0.6820.52
291_I597_L0.6820.52
128_V226_R0.6810.52
645_V648_I0.6810.52
375_A408_K0.6810.52
650_K657_I0.6800.52
333_D361_V0.6790.52
217_L224_S0.6790.52
49_F63_I0.6780.51
295_I540_F0.6780.51
292_R576_A0.6770.51
332_G574_K0.6770.51
642_C648_I0.6770.51
151_Q173_K0.6760.51
323_K442_A0.6760.51
540_F568_I0.6760.51
443_V456_S0.6740.51
598_E601_G0.6740.51
19_T24_N0.6740.51
112_I521_R0.6740.51
291_I576_A0.6730.51
19_T23_G0.6710.51
207_G423_Q0.6690.50
416_A452_G0.6670.50
572_Y591_N0.6670.50
458_R565_L0.6660.50
277_E294_R0.6660.50
315_L467_P0.6640.50
305_G452_G0.6630.50
410_R416_A0.6620.50
330_I417_I0.6610.50
469_T570_E0.6610.50
299_I349_M0.6600.49
342_P448_N0.6600.49
460_V464_I0.6590.49
71_L98_V0.6590.49
149_C153_F0.6590.49
139_K154_E0.6580.49
195_A262_I0.6580.49
363_T417_I0.6570.49
92_D121_I0.6570.49
45_L98_V0.6560.49
335_H366_K0.6560.49
205_P211_R0.6560.49
229_D436_K0.6560.49
342_P347_S0.6550.49
24_N29_K0.6550.49
110_R492_A0.6550.49
68_K72_P0.6550.49
226_R362_Y0.6540.49
371_A377_V0.6530.49
652_A656_G0.6530.49
641_E660_S0.6530.49
142_Y315_L0.6520.49
619_P632_I0.6520.49
149_C570_E0.6510.49
572_Y576_A0.6510.49
282_I326_E0.6510.49
335_H345_A0.6490.48
333_D416_A0.6480.48
640_S644_K0.6480.48
624_E632_I0.6470.48
210_P562_L0.6470.48
120_L341_D0.6470.48
201_P300_A0.6460.48
198_Q440_R0.6460.48
644_K660_S0.6450.48
633_I637_A0.6450.48
315_L575_M0.6450.48
354_S426_V0.6440.48
179_Q457_E0.6440.48
23_G26_N0.6440.48
367_G413_D0.6440.48
557_I561_Q0.6430.48
468_P478_F0.6430.48
534_N537_T0.6410.47
417_I470_I0.6410.47
619_P622_A0.6400.47
477_I561_Q0.6390.47
295_I575_M0.6390.47
370_A420_A0.6380.47
292_R575_M0.6380.47
343_G393_L0.6370.47
509_D528_I0.6360.47
645_V660_S0.6350.47
626_M633_I0.6350.47
15_I20_T0.6340.47
89_Y531_E0.6330.47
95_K102_G0.6310.46
620_K634_D0.6300.46
323_K330_I0.6280.46
370_A561_Q0.6280.46
628_K633_I0.6280.46
554_P596_F0.6270.46
406_I423_Q0.6270.46
88_T91_R0.6260.46
41_R45_L0.6260.46
621_S637_A0.6260.46
407_D449_P0.6260.46
437_L488_D0.6250.46
367_G375_A0.6250.46
371_A420_A0.6240.46
624_E630_I0.6240.46
403_I421_M0.6220.45
439_A449_P0.6220.45
366_K407_D0.6210.45
282_I345_A0.6200.45
487_Q565_L0.6200.45
210_P437_L0.6190.45
168_P180_F0.6190.45
311_E591_N0.6180.45
405_E422_E0.6180.45
62_E69_I0.6160.45
44_S49_F0.6150.45
17_F20_T0.6140.45
312_A413_D0.6140.45
364_T414_R0.6130.45
120_L137_I0.6130.45
294_R297_S0.6130.45
455_I463_N0.6130.45
288_D297_S0.6130.45
96_V100_I0.6120.44
385_E463_N0.6110.44
620_K627_M0.6100.44
306_H309_L0.6100.44
617_G632_I0.6090.44
98_V486_E0.6080.44
50_S369_T0.6070.44
416_A521_R0.6070.44
26_N30_Y0.6070.44
115_T530_S0.6060.44
274_I291_I0.6050.44
402_V406_I0.6050.44
323_K333_D0.6040.44
98_V504_T0.6040.44
351_Q355_R0.6040.44
152_E157_E0.6040.44
565_L593_M0.6040.44
210_P563_E0.6030.44
561_Q570_E0.6030.44
455_I502_K0.6020.43
465_N599_S0.6020.43
317_L565_L0.6020.43
15_I21_F0.6020.43
369_T447_G0.6010.43
482_D544_R0.6010.43
528_I566_I0.6000.43
292_R296_I0.6000.43
359_R393_L0.5990.43
199_E447_G0.5990.43
240_K491_L0.5980.43
191_D570_E0.5980.43
389_E562_L0.5980.43
620_K631_E0.5970.43
357_A388_L0.5960.43
340_G408_K0.5960.43
404_D448_N0.5950.43
375_A418_H0.5950.43
276_E521_R0.5950.43
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655_V661_N0.5950.43
365_G409_M0.5950.43
635_S646_K0.5940.43
641_E651_E0.5940.43
51_D514_R0.5930.42
252_V286_A0.5930.42
440_R472_S0.5920.42
405_E432_G0.5910.42
21_F24_N0.5910.42
300_A375_A0.5910.42
275_S282_I0.5900.42
316_A657_I0.5900.42
421_M429_A0.5900.42
618_K629_I0.5890.42
150_M153_F0.5880.42
341_D452_G0.5880.42
262_I398_G0.5880.42
309_L338_I0.5870.42
409_M413_D0.5870.42
337_L441_A0.5870.42
23_G27_Q0.5860.42
372_G430_K0.5860.42
430_K475_D0.5860.42
173_K176_K0.5860.42
388_L393_L0.5850.42
392_A401_A0.5850.42
117_I599_S0.5840.42
643_A647_D0.5840.42
343_G515_K0.5840.42
390_A558_T0.5830.41
369_T372_G0.5830.41
249_S253_F0.5830.41
233_V575_M0.5820.41
624_E629_I0.5810.41
377_V463_N0.5800.41
517_I520_A0.5800.41
375_A407_D0.5790.41
647_D653_Q0.5780.41
459_P553_S0.5780.41
632_I654_Q0.5780.41
40_Y197_I0.5780.41
230_R469_T0.5770.41
195_A233_V0.5770.41
192_W364_T0.5770.41
644_K651_E0.5760.41
197_I213_L0.5760.41
236_I260_S0.5760.41
101_V261_S0.5750.41
83_L90_Q0.5750.41
314_A420_A0.5740.41
425_T438_N0.5740.41
195_A296_I0.5740.41
207_G397_D0.5740.41
640_S648_I0.5730.40
213_L336_I0.5730.40
362_Y427_S0.5730.40
77_A568_I0.5720.40
379_R427_S0.5710.40
139_K188_K0.5710.40
198_Q427_S0.5700.40
227_P479_I0.5700.40
178_G371_A0.5690.40
653_Q662_I0.5690.40
359_R415_V0.5670.40
347_S421_M0.5660.40
597_L600_V0.5640.40
635_S638_V0.5640.40
49_F52_V0.5630.39
403_I454_Y0.5620.39
408_K447_G0.5620.39
348_Q440_R0.5610.39
648_I653_Q0.5610.39
141_T154_E0.5600.39
634_D640_S0.5600.39
405_E449_P0.5600.39
418_H423_Q0.5600.39
426_V469_T0.5590.39
33_R274_I0.5590.39
149_C168_P0.5580.39
331_R346_K0.5580.39
537_T565_L0.5570.39
366_K375_A0.5570.39
406_I409_M0.5560.39
112_I237_L0.5550.39
43_K219_D0.5550.39
625_K638_V0.5550.39
211_R415_V0.5550.39
392_A405_E0.5540.38
314_A479_I0.5530.38
31_I35_N0.5520.38
626_M636_L0.5520.38
418_H433_I0.5510.38
126_I300_A0.5510.38
254_D257_M0.5510.38
299_I304_Y0.5500.38
646_K655_V0.5500.38
23_G28_N0.5500.38
65_N580_E0.5490.38
322_P570_E0.5480.38
569_S631_E0.5480.38
118_G194_K0.5470.38
371_A394_V0.5470.38
625_K653_Q0.5460.38
241_Q245_V0.5460.38
40_Y582_T0.5460.38
419_E423_Q0.5460.38
639_S647_D0.5450.38
501_G506_N0.5450.38
215_I257_M0.5440.38
628_K646_K0.5440.38
425_T429_A0.5440.38
144_H485_G0.5430.37
426_V559_P0.5430.37
475_D560_R0.5430.37
629_I637_A0.5430.37
618_K638_V0.5430.37
405_E431_A0.5430.37
205_P438_N0.5430.37
38_V82_I0.5420.37
341_D449_P0.5420.37
282_I520_A0.5420.37
93_I96_V0.5410.37
318_F557_I0.5410.37
18_L28_N0.5410.37
449_P452_G0.5400.37
110_R210_P0.5380.37
395_L423_Q0.5380.37
142_Y570_E0.5370.37
230_R351_Q0.5370.37
452_G499_H0.5360.37
129_K314_A0.5360.37
356_V471_L0.5350.37
618_K625_K0.5350.37
83_L100_I0.5350.37
625_K635_S0.5340.37
199_E423_Q0.5340.37
538_D605_E0.5330.36
97_H282_I0.5330.36
619_P633_I0.5320.36
438_N445_A0.5320.36
416_A499_H0.5320.36
174_C177_P0.5310.36
242_D245_V0.5310.36
193_Q403_I0.5310.36
389_E395_L0.5310.36
342_P560_R0.5300.36
638_V644_K0.5300.36
312_A564_A0.5290.36
33_R36_E0.5290.36
204_V345_A0.5270.36
395_L517_I0.5270.36
633_I652_A0.5260.36
152_E155_W0.5260.36
433_I480_L0.5260.36
24_N27_Q0.5250.36
346_K350_L0.5250.36
15_I81_H0.5240.36
411_D496_L0.5240.36
347_S404_D0.5240.36
405_E446_A0.5230.35
620_K626_M0.5220.35
45_L60_A0.5210.35
624_E638_V0.5210.35
395_L447_G0.5210.35
635_S639_S0.5210.35
644_K653_Q0.5210.35
403_I406_I0.5200.35
117_I232_K0.5200.35
285_L288_D0.5200.35
204_V390_A0.5200.35
613_T617_G0.5200.35
113_R134_K0.5190.35
410_R428_I0.5190.35
56_N74_L0.5180.35
52_V131_T0.5180.35
208_Q211_R0.5170.35
430_K567_R0.5170.35
201_P237_L0.5170.35
79_Y82_I0.5170.35
138_Y263_E0.5160.35
502_K505_K0.5160.35
117_I548_S0.5150.35
392_A427_S0.5140.35
278_D519_Y0.5130.34
633_I640_S0.5130.34
39_A517_I0.5130.34
494_Y499_H0.5130.34
413_D423_Q0.5120.34
430_K560_R0.5120.34
134_K192_W0.5110.34
56_N152_E0.5110.34
139_K157_E0.5110.34
651_E655_V0.5100.34
380_E390_A0.5090.34
199_E440_R0.5090.34
368_S444_I0.5090.34
222_V339_I0.5090.34
274_I278_D0.5080.34
363_T375_A0.5080.34
646_K653_Q0.5070.34
655_V658_E0.5070.34
58_N289_P0.5070.34
637_A640_S0.5060.34
171_C174_C0.5060.34
390_A413_D0.5060.34
592_I597_L0.5050.34
98_V505_K0.5050.34
189_L371_A0.5050.34
368_S540_F0.5050.34
212_Q229_D0.5040.34
15_I32_E0.5040.34
396_A399_G0.5030.34
253_F327_D0.5030.34
197_I543_M0.5020.33
329_R332_G0.5020.33
112_I257_M0.5020.33
48_E509_D0.5010.33
640_S647_D0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ja84 1 0.8513 100 0.328 Contact Map
4fdgB 1 0.8586 100 0.335 Contact Map
3ja87 1 0.8673 100 0.359 Contact Map
3ja83 1 0.8397 100 0.361 Contact Map
3ja82 1 0.8746 100 0.364 Contact Map
3ja85 1 0.8601 100 0.373 Contact Map
4r7yA 3 0.8528 100 0.378 Contact Map
3ja86 1 0.8455 100 0.391 Contact Map
3f8tA 1 0.6574 100 0.513 Contact Map
1ltlA 4 0.3499 100 0.719 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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