GREMLIN Database
CDC62 - ORC1-type DNA replication protein 2
UniProt: Q9UXF8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 413 (364)
Sequences: 1661 (1211)
Seq/√Len: 63.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
280_S287_H5.1071.00
222_L261_A4.9051.00
278_E287_H4.7601.00
134_F138_H4.5341.00
44_L62_V4.0961.00
320_L371_I4.0801.00
102_C152_L3.9101.00
36_H224_D3.5251.00
312_H341_Y3.3601.00
133_V141_L3.2421.00
40_K215_P3.1721.00
234_F272_G3.1541.00
310_D313_Q3.0911.00
134_F137_I3.0251.00
168_Y202_S2.9611.00
312_H352_P2.9321.00
80_G151_A2.7441.00
278_E290_K2.7241.00
137_I141_L2.6831.00
34_L74_A2.5761.00
202_S206_H2.4431.00
154_E191_N2.4341.00
114_E117_N2.3781.00
114_E118_A2.3731.00
37_R217_Y2.3501.00
239_V283_V2.3301.00
234_F238_A2.3161.00
37_R40_K2.2591.00
19_I272_G2.2291.00
155_F188_F2.2021.00
245_Q249_N2.1821.00
77_R99_H2.1541.00
132_E136_M2.1301.00
156_G191_N2.0481.00
357_Q360_E2.0281.00
25_L233_A2.0211.00
47_I62_V2.0101.00
25_L229_R2.0081.00
200_D203_I2.0061.00
137_I140_Y1.9731.00
22_K273_E1.9661.00
130_A138_H1.9131.00
194_H198_K1.8841.00
48_F79_F1.8111.00
168_Y205_D1.8071.00
75_T214_F1.7761.00
62_V187_I1.7390.99
246_F289_K1.7110.99
223_Y227_K1.7020.99
217_Y262_R1.6870.99
303_I307_S1.6790.99
172_R206_H1.6740.99
218_K221_E1.6610.99
338_E358_V1.6570.99
168_Y206_H1.6530.99
332_I337_L1.6530.99
217_Y225_I1.6500.99
227_K241_D1.6440.99
41_I75_T1.6410.99
223_Y245_Q1.6320.99
250_T253_Y1.6300.99
45_G82_N1.6160.99
202_S205_D1.5930.99
129_S133_V1.5850.99
25_L31_P1.5850.99
205_D208_A1.5660.99
287_H291_A1.5390.99
111_I166_E1.5100.98
268_L291_A1.4790.98
274_I287_H1.4690.98
131_Q135_K1.4580.98
101_N168_Y1.4510.98
138_H141_L1.4440.98
214_F217_Y1.4380.98
22_K276_E1.4230.98
168_Y172_R1.4220.98
44_L95_V1.4210.98
239_V245_Q1.4200.98
335_G383_R1.4170.98
271_A283_V1.4110.98
226_L264_A1.4090.98
48_F52_L1.3950.97
392_P395_K1.3830.97
66_G71_G1.3730.97
191_N259_G1.3720.97
271_A291_A1.3570.97
136_M140_Y1.3380.97
134_F141_L1.3340.97
129_S134_F1.3160.96
97_Y151_A1.3050.96
130_A134_F1.3030.96
185_S189_I1.2900.96
164_T168_Y1.2880.96
246_F250_T1.2870.96
219_S249_N1.2860.96
128_L141_L1.2810.96
112_S173_L1.2800.96
251_Y267_T1.2770.96
41_I78_L1.2720.96
245_Q253_Y1.2670.96
395_K399_D1.2590.95
267_T292_N1.2530.95
321_I396_R1.2460.95
191_N214_F1.2390.95
48_F341_Y1.2380.95
306_L396_R1.2350.95
171_V174_Y1.2340.95
249_N253_Y1.2290.95
337_L387_V1.2220.95
129_S137_I1.2210.95
309_L365_L1.2180.94
193_S260_N1.2170.94
133_V138_H1.2170.94
334_M358_V1.2090.94
217_Y229_R1.2080.94
320_L337_L1.2040.94
288_A293_S1.2030.94
108_L112_S1.1990.94
62_V119_L1.1920.94
128_L132_E1.1910.94
226_L244_L1.1860.94
51_L147_H1.1820.94
102_C111_I1.1800.93
37_R229_R1.1790.93
229_R265_I1.1730.93
61_R209_R1.1710.93
264_A272_G1.1620.93
129_S138_H1.1560.93
30_V328_K1.1420.92
128_L137_I1.1390.92
332_I336_T1.1370.92
62_V212_I1.1290.92
222_L226_L1.1280.92
76_V189_I1.1280.92
35_P228_Y1.1260.92
224_D227_K1.1250.92
205_D260_N1.1250.92
341_Y352_P1.1250.92
319_A322_R1.1150.91
223_Y248_S1.1130.91
272_G275_A1.1120.91
65_L211_L1.0990.91
155_F191_N1.0940.91
116_A122_P1.0940.91
397_L401_I1.0930.91
84_E97_Y1.0930.91
106_R110_L1.0930.91
283_V288_A1.0900.90
260_N263_I1.0890.90
126_R129_S1.0880.90
217_Y260_N1.0830.90
335_G384_T1.0810.90
196_I211_L1.0790.90
311_L315_I1.0770.90
128_L133_V1.0710.90
261_A264_A1.0680.89
214_F262_R1.0620.89
323_A365_L1.0620.89
240_D282_V1.0610.89
43_E290_K1.0540.89
39_E140_Y1.0470.89
129_S132_E1.0440.88
242_E245_Q1.0400.88
268_L288_A1.0390.88
197_Y202_S1.0340.88
149_I287_H1.0290.88
135_K138_H1.0260.87
66_G69_G1.0230.87
67_R265_I1.0210.87
48_F187_I1.0150.87
63_V112_S1.0150.87
69_G154_E1.0100.87
101_N154_E1.0090.87
111_I115_I1.0090.87
338_E341_Y1.0070.87
309_L368_I1.0030.86
41_I184_I0.9980.86
238_A241_D0.9970.86
137_I278_E0.9960.86
164_T203_I0.9940.86
123_I127_G0.9920.86
64_I76_V0.9920.86
251_Y292_N0.9860.85
338_E355_H0.9830.85
70_T221_E0.9820.85
269_S273_E0.9810.85
130_A140_Y0.9760.85
271_A287_H0.9760.85
136_M139_E0.9750.85
39_E239_V0.9750.85
40_K214_F0.9730.85
117_N149_I0.9720.85
69_G153_D0.9710.84
259_G262_R0.9670.84
342_I370_I0.9660.84
291_A294_T0.9650.84
47_I186_Y0.9640.84
266_E269_S0.9630.84
137_I142_D0.9610.84
155_F195_S0.9600.84
63_V190_V0.9580.84
151_A189_I0.9580.84
167_I188_F0.9560.84
102_C312_H0.9550.83
133_V137_I0.9410.83
250_T289_K0.9370.82
214_F259_G0.9290.82
130_A139_E0.9280.82
37_R265_I0.9210.81
131_Q138_H0.9200.81
116_A120_K0.9170.81
313_Q364_K0.9120.81
248_S252_G0.9120.81
47_I212_I0.9120.81
133_V136_M0.9110.80
359_Y385_T0.9100.80
131_Q134_F0.9070.80
357_Q361_Y0.9060.80
171_V209_R0.9020.80
155_F237_N0.8990.80
274_I291_A0.8890.79
394_D398_D0.8890.79
68_T191_N0.8880.79
126_R132_E0.8870.79
158_F166_E0.8840.78
116_A121_L0.8820.78
243_V288_A0.8760.78
286_D289_K0.8720.77
164_T172_R0.8700.77
366_K371_I0.8690.77
270_L273_E0.8650.77
243_V247_I0.8570.76
203_I206_H0.8570.76
18_I21_H0.8540.76
252_G259_G0.8510.76
217_Y259_G0.8490.76
72_K154_E0.8470.75
168_Y203_I0.8380.75
319_A344_L0.8370.75
62_V322_R0.8360.74
105_H112_S0.8360.74
388_S396_R0.8350.74
268_L271_A0.8340.74
353_R361_Y0.8320.74
42_K275_A0.8320.74
153_D259_G0.8270.74
61_R152_L0.8260.74
201_R367_V0.8240.73
188_F193_S0.8240.73
342_I346_R0.8230.73
189_I217_Y0.8220.73
192_E209_R0.8210.73
212_I289_K0.8180.73
108_L158_F0.8180.73
46_F118_A0.8180.73
98_V118_A0.8160.73
333_T370_I0.8150.73
57_K61_R0.8150.73
47_I188_F0.8130.72
155_F158_F0.8130.72
21_H25_L0.8120.72
129_S141_L0.8120.72
66_G72_K0.8120.72
348_F371_I0.8070.72
107_T147_H0.8020.71
261_A289_K0.8010.71
37_R225_I0.8010.71
188_F191_N0.8000.71
196_I361_Y0.8000.71
37_R260_N0.7990.71
333_T336_T0.7970.71
168_Y199_L0.7970.71
76_V206_H0.7890.70
384_T387_V0.7880.70
325_N328_K0.7870.70
118_A205_D0.7860.70
64_I139_E0.7850.70
355_H359_Y0.7830.69
63_V155_F0.7830.69
252_G269_S0.7800.69
134_F199_L0.7790.69
217_Y265_I0.7770.69
390_S395_K0.7760.69
217_Y222_L0.7750.69
202_S208_A0.7740.69
153_D225_I0.7730.68
80_G97_Y0.7680.68
100_I111_I0.7680.68
229_R261_A0.7670.68
315_I335_G0.7630.67
320_L387_V0.7590.67
110_L113_Q0.7590.67
354_R360_E0.7570.67
132_E135_K0.7550.67
76_V196_I0.7530.66
21_H29_Y0.7520.66
20_K24_K0.7510.66
104_R167_I0.7500.66
302_I370_I0.7490.66
171_V206_H0.7470.66
146_I158_F0.7460.66
326_K349_N0.7450.66
101_N260_N0.7450.66
329_A332_I0.7400.65
187_I307_S0.7400.65
285_L289_K0.7370.65
170_L173_L0.7350.65
115_I333_T0.7340.64
100_I118_A0.7320.64
127_G141_L0.7320.64
129_S136_M0.7300.64
246_F285_L0.7220.63
154_E262_R0.7220.63
372_N390_S0.7180.63
24_K29_Y0.7180.63
309_L370_I0.7160.63
33_N228_Y0.7160.63
306_L391_L0.7150.62
38_E394_D0.7120.62
64_I225_I0.7110.62
18_I272_G0.7110.62
352_P356_T0.7100.62
37_R262_R0.7100.62
167_I202_S0.7080.62
46_F224_D0.7080.62
69_G225_I0.7070.62
266_E270_L0.7060.61
127_G130_A0.7050.61
242_E247_I0.7050.61
284_L287_H0.7050.61
39_E42_K0.7030.61
225_I261_A0.6980.61
105_H114_E0.6970.60
203_I357_Q0.6950.60
352_P371_I0.6910.60
248_S264_A0.6910.60
212_I278_E0.6890.60
67_R193_S0.6880.59
133_V140_Y0.6870.59
102_C341_Y0.6870.59
362_L373_T0.6840.59
106_R308_Y0.6810.59
389_L393_L0.6800.59
226_L248_S0.6800.59
345_S348_F0.6780.58
130_A133_V0.6780.58
55_D206_H0.6760.58
323_A340_E0.6760.58
144_R158_F0.6730.58
28_D246_F0.6730.58
76_V115_I0.6720.58
100_I115_I0.6720.58
247_I263_I0.6690.57
77_R97_Y0.6680.57
227_K371_I0.6670.57
96_K146_I0.6670.57
65_L190_V0.6660.57
130_A141_L0.6620.57
199_L208_A0.6590.56
126_R134_F0.6580.56
115_I122_P0.6550.56
44_L136_M0.6550.56
306_L322_R0.6540.56
306_L339_E0.6540.56
173_L190_V0.6530.56
64_I187_I0.6530.56
235_N374_R0.6510.55
48_F288_A0.6460.55
42_K81_K0.6430.54
247_I289_K0.6430.54
254_D310_D0.6410.54
49_K86_I0.6410.54
81_K149_I0.6400.54
20_K235_N0.6390.54
393_L401_I0.6390.54
111_I116_A0.6370.54
310_D315_I0.6350.53
243_V283_V0.6330.53
26_S30_V0.6320.53
72_K153_D0.6320.53
275_A283_V0.6320.53
265_I273_E0.6320.53
73_T154_E0.6310.53
244_L248_S0.6310.53
251_Y254_D0.6300.53
355_H361_Y0.6300.53
353_R357_Q0.6290.53
61_R115_I0.6290.53
42_K46_F0.6280.53
395_K398_D0.6280.53
81_K85_D0.6270.53
227_K230_V0.6250.52
359_Y362_L0.6240.52
167_I205_D0.6240.52
65_L191_N0.6230.52
31_P229_R0.6220.52
220_M223_Y0.6220.52
231_D377_G0.6210.52
188_F247_I0.6200.52
216_P291_A0.6200.52
79_F83_F0.6180.52
335_G387_V0.6170.51
115_I150_V0.6170.51
149_I207_I0.6140.51
224_D371_I0.6140.51
222_L265_I0.6130.51
130_A137_I0.6120.51
275_A291_A0.6110.51
251_Y264_A0.6100.51
102_C203_I0.6090.50
49_K53_A0.6090.50
63_V173_L0.6050.50
146_I237_N0.6030.50
111_I170_L0.6030.50
320_L389_L0.6020.50
152_L290_K0.6000.49
316_L358_V0.6000.49
222_L264_A0.5970.49
37_R214_F0.5970.49
264_A275_A0.5950.49
37_R222_L0.5930.49
203_I209_R0.5920.49
68_T367_V0.5910.48
261_A310_D0.5900.48
223_Y240_D0.5890.48
69_G259_G0.5890.48
170_L202_S0.5890.48
317_L389_L0.5880.48
312_H315_I0.5880.48
218_K293_S0.5880.48
242_E272_G0.5880.48
102_C167_I0.5870.48
24_K31_P0.5860.48
387_V392_P0.5850.48
259_G273_E0.5830.47
76_V228_Y0.5830.47
172_R205_D0.5820.47
60_E188_F0.5800.47
127_G138_H0.5800.47
290_K294_T0.5790.47
43_E46_F0.5780.47
74_A171_V0.5780.47
36_H260_N0.5780.47
127_G131_Q0.5750.47
231_D239_V0.5750.47
57_K185_S0.5740.46
134_F170_L0.5740.46
67_R323_A0.5740.46
38_E149_I0.5730.46
325_N397_L0.5710.46
19_I22_K0.5710.46
139_E306_L0.5690.46
251_Y265_I0.5690.46
131_Q139_E0.5680.46
85_D220_M0.5670.46
238_A245_Q0.5670.46
284_L343_S0.5670.46
339_E400_Y0.5660.46
274_I294_T0.5660.46
112_S174_Y0.5650.45
23_D27_P0.5640.45
191_N217_Y0.5640.45
74_A216_P0.5640.45
214_F260_N0.5630.45
51_L60_E0.5630.45
158_F314_L0.5610.45
218_K242_E0.5600.45
68_T230_V0.5590.45
188_F209_R0.5590.45
375_Q385_T0.5580.45
206_H209_R0.5560.44
67_R310_D0.5550.44
338_E342_I0.5550.44
100_I333_T0.5540.44
111_I205_D0.5530.44
164_T206_H0.5530.44
100_I106_R0.5530.44
172_R175_D0.5530.44
117_N371_I0.5530.44
241_D319_A0.5510.44
302_I396_R0.5500.44
61_R192_E0.5490.44
341_Y345_S0.5470.43
20_K39_E0.5470.43
320_L377_G0.5470.43
247_I288_A0.5470.43
319_A378_K0.5470.43
192_E200_D0.5460.43
289_K292_N0.5450.43
260_N267_T0.5430.43
192_E198_K0.5420.43
339_E354_R0.5420.43
312_H345_S0.5410.43
339_E343_S0.5410.43
252_G264_A0.5400.43
100_I331_E0.5400.43
317_L365_L0.5390.42
264_A268_L0.5380.42
170_L247_I0.5350.42
40_K221_E0.5350.42
226_L229_R0.5340.42
53_A135_K0.5340.42
53_A302_I0.5330.42
123_I133_V0.5320.42
44_L395_K0.5300.41
306_L309_L0.5300.41
65_L158_F0.5290.41
275_A335_G0.5280.41
63_V171_V0.5260.41
371_I379_G0.5250.41
34_L244_L0.5240.41
216_P259_G0.5230.41
235_N238_A0.5220.41
43_E284_L0.5210.40
120_K140_Y0.5200.40
221_E288_A0.5190.40
191_N262_R0.5190.40
246_F292_N0.5180.40
284_L398_D0.5170.40
117_N400_Y0.5170.40
258_N269_S0.5170.40
99_H151_A0.5160.40
67_R190_V0.5160.40
127_G134_F0.5160.40
184_I197_Y0.5150.40
191_N222_L0.5120.39
76_V185_S0.5120.39
279_G290_K0.5110.39
34_L396_R0.5110.39
304_D379_G0.5110.39
55_D139_E0.5110.39
330_D372_N0.5100.39
112_S161_T0.5090.39
239_V243_V0.5090.39
261_A265_I0.5090.39
48_F205_D0.5090.39
20_K85_D0.5090.39
70_T101_N0.5080.39
43_E142_D0.5070.39
274_I383_R0.5070.39
316_L374_R0.5050.39
388_S401_I0.5040.39
81_K290_K0.5030.38
315_I341_Y0.5030.38
74_A105_H0.5020.38
143_R371_I0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qbyA 1 0.8838 100 0.358 Contact Map
4xgcA 1 0.7482 100 0.366 Contact Map
2v1uA 1 0.9225 100 0.367 Contact Map
1w5sA 1 0.9225 100 0.432 Contact Map
2qbyB 1 0.8717 100 0.443 Contact Map
4xgcD 1 0.9153 100 0.462 Contact Map
1fnnA 1 0.9007 100 0.466 Contact Map
3te6A 1 0.6538 100 0.582 Contact Map
4xgcE 1 0.8136 100 0.634 Contact Map
4ko8A 3 0.6271 100 0.682 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0119 seconds.