GREMLIN Database
MOAC - Probable cyclic pyranopterin monophosphate synthase accessory protein
UniProt: Q9UXF7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 149 (137)
Sequences: 2832 (1681)
Seq/√Len: 143.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_K63_E5.4771.00
89_V113_L2.9571.00
91_S108_A2.8591.00
35_R123_Y2.7091.00
24_G132_P2.4921.00
23_E135_M2.4601.00
23_E88_R2.3451.00
34_K38_E2.1971.00
27_K130_K2.1251.00
24_G109_T2.0951.00
15_T98_K2.0421.00
54_G112_S1.9151.00
17_L94_K1.9081.00
25_F86_G1.9081.00
19_E92_K1.6991.00
21_E92_K1.6911.00
64_L111_I1.6871.00
26_I113_L1.6851.00
25_F88_R1.6701.00
29_K32_T1.5991.00
58_A108_A1.5751.00
33_I82_I1.5751.00
23_E133_Y1.5581.00
37_I82_I1.5351.00
15_T96_H1.5331.00
80_I87_I1.5271.00
36_I120_V1.5051.00
27_K128_N1.4941.00
117_W134_T1.4721.00
24_G113_L1.4451.00
82_I87_I1.4191.00
30_N34_K1.4091.00
72_P97_Y1.4061.00
83_E88_R1.4051.00
110_S132_P1.3971.00
28_L32_T1.3861.00
120_V127_E1.3801.00
19_E94_K1.3471.00
19_E138_D1.3421.00
37_I84_N1.3361.00
23_E90_R1.3311.00
35_R40_E1.3101.00
52_T67_L1.2861.00
45_N48_T1.2841.00
73_L93_V1.2621.00
54_G78_I1.2541.00
91_S109_T1.2381.00
64_L107_V1.2301.00
48_T51_K1.2281.00
25_F131_Y1.2091.00
72_P95_A1.2001.00
41_I46_V1.1871.00
9_D94_K1.1861.00
113_L129_G1.1841.00
5_A48_T1.1811.00
75_N94_K1.1551.00
81_K88_R1.1530.99
11_S74_E1.1450.99
21_E136_I1.1380.99
33_I85_S1.1350.99
106_L114_L1.1340.99
81_K90_R1.1290.99
35_R41_I1.1220.99
21_E90_R1.1190.99
74_E98_K1.1120.99
4_E51_K1.0980.99
26_I127_E1.0850.99
29_K124_E1.0820.99
54_G91_S1.0700.99
129_G132_P1.0640.99
87_I116_I1.0580.99
26_I116_I1.0250.99
71_I95_A1.0200.99
58_A73_L1.0110.99
109_T132_P0.9970.99
41_I123_Y0.9920.98
79_D90_R0.9890.98
128_N131_Y0.9820.98
73_L101_V0.9800.98
21_E91_S0.9790.98
49_V52_T0.9790.98
110_S129_G0.9700.98
11_S17_L0.9660.98
41_I120_V0.9630.98
46_V116_I0.9590.98
51_K79_D0.9410.98
15_T97_Y0.9320.98
58_A76_V0.9160.97
52_T56_M0.9130.97
45_N49_V0.9070.97
19_E136_I0.9070.97
11_S94_K0.9020.97
30_N85_S0.8910.97
5_A51_K0.8820.97
93_V101_V0.8730.97
28_L33_I0.8620.96
110_S113_L0.8510.96
27_K86_G0.8440.96
62_S70_L0.8410.96
90_R135_M0.8260.95
31_D34_K0.8220.95
36_I46_V0.8160.95
28_L127_E0.8150.95
12_Q17_L0.8140.95
65_L115_T0.8130.95
50_A115_T0.8120.95
80_I116_I0.7980.94
23_E131_Y0.7960.94
53_A115_T0.7900.94
78_I112_S0.7790.94
26_I89_V0.7780.94
117_W125_K0.7750.93
89_V112_S0.7740.93
34_K37_I0.7720.93
6_K75_N0.7670.93
55_I67_L0.7650.93
17_L96_H0.7640.93
5_A45_N0.7590.93
72_P98_K0.7540.93
86_G130_K0.7500.92
57_A111_I0.7460.92
79_D92_K0.7440.92
33_I37_I0.7420.92
47_I87_I0.7360.92
6_K77_D0.7360.92
128_N133_Y0.7360.92
83_E86_G0.7340.91
124_E127_E0.7310.91
32_T124_E0.7270.91
25_F130_K0.7210.91
71_I93_V0.7120.90
9_D75_N0.7030.90
127_E134_T0.6930.89
126_D134_T0.6910.89
33_I84_N0.6900.89
74_E96_H0.6860.88
6_K67_L0.6860.88
65_L122_K0.6840.88
76_V93_V0.6810.88
51_K77_D0.6730.88
14_E98_K0.6700.87
39_N45_N0.6550.86
42_E116_I0.6520.86
117_W120_V0.6520.86
125_K138_D0.6510.86
42_E123_Y0.6440.85
47_I80_I0.6420.85
77_D92_K0.6360.84
80_I89_V0.6350.84
73_L76_V0.6340.84
39_N48_T0.6340.84
107_V111_I0.6320.84
62_S71_I0.6280.84
49_V67_L0.6250.83
8_V122_K0.6220.83
62_S72_P0.6170.83
11_S96_H0.6170.83
89_V109_T0.6170.83
32_T120_V0.6150.82
117_W127_E0.6140.82
36_I87_I0.6120.82
33_I36_I0.6090.82
33_I86_G0.6060.82
29_K126_D0.6040.81
36_I41_I0.6020.81
29_K33_I0.6000.81
13_K125_K0.5950.80
32_T123_Y0.5940.80
57_A107_V0.5910.80
134_T137_D0.5910.80
22_A109_T0.5890.80
5_A49_V0.5820.79
10_I98_K0.5790.79
60_K64_L0.5750.78
42_E51_K0.5730.78
32_T36_I0.5690.77
93_V105_A0.5640.77
4_E48_T0.5640.77
5_A80_I0.5550.76
56_M61_T0.5550.76
57_A62_S0.5520.75
70_L73_L0.5470.75
45_N51_K0.5460.74
2_S79_D0.5450.74
12_Q15_T0.5420.74
46_V97_Y0.5390.73
58_A91_S0.5310.72
66_P115_T0.5310.72
56_M62_S0.5300.72
7_M10_I0.5300.72
103_M106_L0.5280.72
107_V114_L0.5250.72
28_L124_E0.5230.71
74_E97_Y0.5200.71
74_E95_A0.5200.71
53_A101_V0.5170.70
34_K84_N0.5150.70
70_L95_A0.5150.70
49_V56_M0.5110.69
46_V120_V0.5090.69
47_I51_K0.5060.69
129_G137_D0.5040.68
36_I40_E0.5030.68
58_A93_V0.5030.68
27_K85_S0.5020.68
42_E49_V0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eeyA 5 0.9933 100 0.058 Contact Map
4pyaA 3 0.8188 100 0.064 Contact Map
2ohdA 5 0.9195 100 0.071 Contact Map
4fdfA 5 0.9463 100 0.073 Contact Map
2eknA 5 0.9329 100 0.075 Contact Map
2iihA 4 0.9664 100 0.077 Contact Map
3bkrA 1 0.396 8.2 0.959 Contact Map
2cqaA 1 0.4899 5.3 0.963 Contact Map
3gjxB 1 0.3087 3.1 0.967 Contact Map
1f60A 1 0.8658 3 0.967 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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