RFCS - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

RFCS - Replication factor C small subunit

UniProt:	Q9UXF5	Sequences: MSTKVEEILWAEKYRPKTLDDIVNQREIIDRLKKFVKEKNMPHLLFAGPPGTGKTTAALALVHDLYGDNYTEYFLELNASDERGIDVIRNKVKEFARTVIPGDIPFKVVLLDEADNMTADAQQALRRTMELYTENTRFILACNYLSKIIEPIQSRTALFRFYPLKKEDVVNRLIYIAKNEKAEYDQKALETIYDITMGDMRKSINILQAASAYGKISVEAVFKVLGLAQPKEVREMINLALQGKFTQARDKLRTLLITYGLSGEDIVKQIHREITSSEIQISEELRVLLLDYIGETEFRIIEGADDEIQLSALLAKMAIYGNKYIGSENR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	330 (296)
Sequences:	21369 (12755)
Seq/√Len:	741.3

ECOLI - DPO3X RARA RUVB HOLB
BACSU - DPO3X YRVN RUVB HOLB YJOB YEAC
HALSA - RFCS Q9HN59 RFCL Q9HPV0 Q9HPG1 PAN2 PAN1 Q9HNK6 Q9HSH7
SULSO - RFCS RFCL Q97ZJ7 Q97V06 Q97W74 PAN

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
170_V	190_E	4.008	1.00
12_E	16_P	4.005	1.00
26_R	168_D	3.391	1.00
9_L	73_Y	3.284	1.00
165_K	168_D	3.087	1.00
170_V	174_I	3.020	1.00
304_A	308_I	2.944	1.00
174_I	186_Q	2.410	1.00
298_F	302_E	2.394	1.00
166_K	193_Y	2.360	1.00
166_K	194_D	2.308	1.00
169_V	193_Y	2.272	1.00
244_K	247_Q	2.257	1.00
232_E	236_M	2.219	1.00
174_I	189_L	2.215	1.00
303_G	306_D	2.194	1.00
217_S	220_A	2.123	1.00
170_V	189_L	2.102	1.00
288_L	292_Y	2.085	1.00
308_I	312_A	2.072	1.00
175_Y	179_N	2.057	1.00
250_D	254_T	2.037	1.00
171_N	174_I	2.030	1.00
218_V	222_F	1.997	1.00
287_V	291_D	1.948	1.00
190_E	194_D	1.899	1.00
257_I	260_G	1.864	1.00
238_N	242_Q	1.840	1.00
219_E	222_F	1.808	1.00
282_S	285_L	1.802	1.00
294_G	298_F	1.796	1.00
295_E	299_R	1.796	1.00
163_P	200_M	1.786	1.00
185_D	188_A	1.785	1.00
291_D	295_E	1.784	1.00
22_I	57_A	1.767	1.00
285_L	288_L	1.744	1.00
57_A	161_F	1.726	1.00
286_R	290_L	1.720	1.00
297_E	301_I	1.712	1.00
80_S	124_A	1.703	1.00
99_V	103_D	1.700	1.00
222_F	225_L	1.694	1.00
243_G	247_Q	1.692	1.00
231_K	235_E	1.687	1.00
46_F	161_F	1.676	1.00
231_K	234_R	1.655	1.00
90_N	94_E	1.645	1.00
232_E	235_E	1.642	1.00
306_D	309_Q	1.619	1.00
282_S	286_R	1.582	1.00
45_L	114_A	1.581	1.00
230_P	234_R	1.573	1.00
266_I	270_I	1.573	1.00
265_D	269_Q	1.564	1.00
118_T	152_I	1.544	1.00
229_Q	232_E	1.540	1.00
260_G	264_E	1.529	1.00
22_I	60_A	1.523	1.00
183_E	215_K	1.522	1.00
245_F	248_A	1.511	1.00
279_I	283_E	1.497	1.00
290_L	294_G	1.487	1.00
18_T	21_D	1.472	1.00
214_G	222_F	1.452	1.00
259_Y	263_G	1.444	1.00
166_K	170_V	1.438	1.00
247_Q	251_K	1.437	1.00
172_R	175_Y	1.436	1.00
28_I	159_F	1.430	1.00
219_E	223_K	1.423	1.00
230_P	236_M	1.408	1.00
245_F	249_R	1.406	1.00
47_A	158_L	1.399	1.00
305_D	309_Q	1.382	1.00
278_E	282_S	1.372	1.00
12_E	15_R	1.370	1.00
257_I	264_E	1.370	1.00
240_A	273_E	1.367	1.00
196_T	203_S	1.346	1.00
191_T	194_D	1.342	1.00
20_D	33_K	1.340	1.00
254_T	258_T	1.336	1.00
164_L	200_M	1.336	1.00
177_A	208_Q	1.327	1.00
294_G	297_E	1.327	1.00
260_G	263_G	1.321	1.00
273_E	276_S	1.319	1.00
177_A	189_L	1.313	1.00
301_I	304_A	1.301	1.00
166_K	190_E	1.300	1.00
26_R	171_N	1.297	1.00
74_F	110_L	1.293	1.00
283_E	287_V	1.293	1.00
229_Q	236_M	1.281	1.00
258_T	262_S	1.277	1.00
257_I	261_L	1.272	1.00
280_Q	283_E	1.271	1.00
292_Y	296_T	1.266	1.00
307_E	311_S	1.263	1.00
47_A	160_R	1.259	1.00
172_R	200_M	1.249	1.00
176_I	179_N	1.239	1.00
293_I	297_E	1.233	1.00
173_L	189_L	1.221	1.00
276_S	280_Q	1.209	1.00
295_E	298_F	1.206	1.00
62_V	108_V	1.205	1.00
304_A	307_E	1.204	1.00
267_V	270_I	1.201	1.00
173_L	203_S	1.197	1.00
243_G	246_T	1.196	1.00
237_I	241_L	1.190	1.00
84_G	87_V	1.188	1.00
167_E	170_V	1.186	1.00
228_A	231_K	1.180	1.00
292_Y	295_E	1.180	1.00
110_L	141_A	1.172	1.00
215_K	222_F	1.170	1.00
186_Q	190_E	1.164	1.00
184_Y	211_S	1.163	1.00
168_D	171_N	1.159	1.00
170_V	193_Y	1.149	1.00
299_R	302_E	1.147	1.00
29_I	33_K	1.146	1.00
176_I	204_I	1.128	1.00
22_I	29_I	1.125	1.00
25_Q	28_I	1.123	1.00
267_V	271_H	1.122	1.00
233_V	236_M	1.115	1.00
246_T	250_D	1.105	1.00
284_E	288_L	1.105	1.00
234_R	238_N	1.101	1.00
191_T	218_V	1.087	1.00
221_V	225_L	1.085	1.00
271_H	275_T	1.085	1.00
90_N	93_K	1.072	1.00
184_Y	189_L	1.071	1.00
248_A	251_K	1.069	1.00
263_G	266_I	1.064	1.00
251_K	255_L	1.064	1.00
289_L	292_Y	1.063	1.00
167_E	190_E	1.059	1.00
9_L	12_E	1.059	1.00
285_L	289_L	1.057	1.00
264_E	268_K	1.057	1.00
296_T	299_R	1.050	1.00
243_G	248_A	1.048	1.00
85_I	89_R	1.046	1.00
183_E	186_Q	1.041	1.00
262_S	265_D	1.039	1.00
249_R	253_R	1.031	1.00
174_I	178_K	1.027	1.00
266_I	269_Q	1.024	1.00
167_E	171_N	1.023	1.00
166_K	197_M	1.022	1.00
191_T	195_I	1.015	1.00
59_L	76_E	1.014	1.00
262_S	266_I	1.011	1.00
308_I	311_S	1.008	1.00
246_T	249_R	1.007	1.00
298_F	301_I	1.004	1.00
218_V	221_V	1.003	1.00
47_A	145_L	1.002	1.00
257_I	263_G	1.000	1.00
288_L	291_D	0.996	1.00
169_V	203_S	0.991	1.00
243_G	249_R	0.981	1.00
83_R	120_D	0.975	1.00
101_P	133_T	0.974	1.00
151_P	155_R	0.973	1.00
238_N	241_L	0.972	1.00
220_A	223_K	0.971	1.00
33_K	37_K	0.967	1.00
96_A	128_T	0.965	1.00
19_L	63_H	0.963	1.00
58_A	139_I	0.962	1.00
300_I	304_A	0.959	1.00
217_S	221_V	0.958	1.00
228_A	232_E	0.958	1.00
244_K	249_R	0.950	1.00
63_H	67_G	0.947	1.00
171_N	175_Y	0.946	1.00
189_L	193_Y	0.937	1.00
222_F	226_G	0.933	1.00
188_A	191_T	0.932	1.00
83_R	118_T	0.929	1.00
197_M	201_R	0.925	1.00
233_V	237_I	0.918	1.00
13_K	180_E	0.914	1.00
86_D	90_N	0.912	1.00
248_A	252_L	0.910	1.00
263_G	267_V	0.908	1.00
253_R	258_T	0.908	1.00
208_Q	221_V	0.908	1.00
177_A	184_Y	0.903	1.00
93_K	96_A	0.900	1.00
55_T	112_D	0.899	1.00
260_G	266_I	0.899	1.00
230_P	235_E	0.898	1.00
239_L	247_Q	0.897	1.00
88_I	92_V	0.885	1.00
182_A	211_S	0.884	1.00
124_A	128_T	0.883	1.00
173_L	204_I	0.883	1.00
176_I	180_E	0.873	1.00
291_D	294_G	0.872	1.00
244_K	248_A	0.868	1.00
214_G	220_A	0.867	1.00
252_L	255_L	0.864	1.00
185_D	215_K	0.861	1.00
15_R	73_Y	0.855	1.00
223_K	227_L	0.845	1.00
255_L	260_G	0.839	1.00
192_I	207_L	0.837	1.00
216_I	222_F	0.837	1.00
253_R	257_I	0.836	1.00
169_V	200_M	0.834	1.00
218_V	224_V	0.833	1.00
305_D	308_I	0.832	1.00
100_I	103_D	0.830	1.00
221_V	224_V	0.826	1.00
254_T	259_Y	0.825	1.00
303_G	308_I	0.825	1.00
296_T	309_Q	0.824	1.00
284_E	287_V	0.820	1.00
30_D	33_K	0.820	1.00
17_K	63_H	0.818	1.00
247_Q	250_D	0.815	1.00
195_I	225_L	0.814	1.00
265_D	268_K	0.812	1.00
169_V	173_L	0.811	1.00
249_R	252_L	0.809	1.00
300_I	307_E	0.809	1.00
61_L	139_I	0.808	1.00
260_G	271_H	0.808	1.00
255_L	261_L	0.806	1.00
251_K	254_T	0.805	1.00
309_Q	312_A	0.804	1.00
302_E	306_D	0.804	1.00
185_D	217_S	0.803	1.00
235_E	238_N	0.801	1.00
82_E	95_F	0.793	1.00
65_L	137_R	0.792	1.00
163_P	197_M	0.792	1.00
269_Q	272_R	0.791	1.00
85_I	120_D	0.791	1.00
230_P	233_V	0.790	1.00
78_N	81_D	0.789	1.00
275_T	279_I	0.785	1.00
231_K	236_M	0.785	1.00
260_G	267_V	0.785	1.00
145_L	158_L	0.784	1.00
114_A	138_F	0.779	1.00
265_D	270_I	0.778	1.00
203_S	207_L	0.778	1.00
301_I	305_D	0.776	1.00
26_R	30_D	0.776	1.00
27_E	162_Y	0.774	1.00
13_K	18_T	0.771	1.00
220_A	224_V	0.771	1.00
272_R	276_S	0.771	1.00
193_Y	203_S	0.768	1.00
187_K	218_V	0.767	1.00
285_L	290_L	0.766	1.00
235_E	239_L	0.766	1.00
234_R	237_I	0.764	1.00
228_A	234_R	0.764	1.00
260_G	265_D	0.763	1.00
222_F	227_L	0.760	1.00
282_S	288_L	0.757	1.00
278_E	283_E	0.757	1.00
303_G	307_E	0.754	1.00
229_Q	233_V	0.754	1.00
284_E	290_L	0.752	1.00
45_L	156_T	0.749	1.00
153_Q	158_L	0.744	1.00
283_E	286_R	0.740	1.00
261_L	264_E	0.739	1.00
31_R	34_K	0.734	1.00
214_G	218_V	0.733	1.00
268_K	271_H	0.733	1.00
123_Q	126_R	0.731	1.00
13_K	16_P	0.731	1.00
239_L	243_G	0.723	1.00
244_K	252_L	0.722	1.00
49_P	52_T	0.719	1.00
250_D	253_R	0.718	1.00
91_K	95_F	0.716	1.00
278_E	281_I	0.716	1.00
92_V	95_F	0.716	1.00
114_A	136_T	0.711	1.00
206_I	209_A	0.709	1.00
79_A	82_E	0.708	1.00
164_L	168_D	0.707	1.00
285_L	292_Y	0.701	1.00
274_I	278_E	0.699	1.00
259_Y	262_S	0.698	1.00
236_M	239_L	0.697	1.00
215_K	218_V	0.696	1.00
228_A	236_M	0.696	1.00
278_E	286_R	0.696	1.00
264_E	267_V	0.692	1.00
192_I	203_S	0.691	1.00
275_T	278_E	0.688	1.00
17_K	21_D	0.688	1.00
111_L	136_T	0.686	1.00
270_I	274_I	0.686	1.00
244_K	253_R	0.682	1.00
217_S	222_F	0.681	1.00
73_Y	105_P	0.677	1.00
187_K	190_E	0.677	1.00
114_A	148_I	0.675	1.00
218_V	225_L	0.675	1.00
217_S	226_G	0.675	1.00
245_F	251_K	0.675	1.00
192_I	206_I	0.674	1.00
217_S	224_V	0.670	1.00
83_R	86_D	0.670	1.00
14_Y	180_E	0.669	1.00
32_L	159_F	0.665	1.00
294_G	299_R	0.663	1.00
303_G	309_Q	0.662	1.00
34_K	213_Y	0.661	1.00
240_A	243_G	0.660	1.00
264_E	270_I	0.650	1.00
221_V	226_G	0.650	1.00
99_V	102_G	0.641	1.00
75_L	107_K	0.641	1.00
114_A	140_L	0.640	1.00
34_K	37_K	0.636	1.00
302_E	307_E	0.636	1.00
290_L	293_I	0.635	1.00
220_A	226_G	0.631	1.00
173_L	192_I	0.630	1.00
261_L	265_D	0.629	1.00
259_Y	264_E	0.627	1.00
287_V	290_L	0.626	1.00
296_T	306_D	0.622	1.00
32_L	61_L	0.618	1.00
229_Q	234_R	0.615	1.00
282_S	290_L	0.612	1.00
101_P	104_I	0.609	1.00
198_G	201_R	0.608	1.00
242_Q	245_F	0.608	1.00
240_A	245_F	0.607	1.00
228_A	233_V	0.607	1.00
276_S	279_I	0.605	1.00
221_V	227_L	0.605	1.00
279_I	282_S	0.603	1.00
89_R	93_K	0.602	1.00
174_I	177_A	0.601	1.00
300_I	303_G	0.601	1.00
200_M	203_S	0.600	1.00
126_R	130_E	0.599	1.00
286_R	293_I	0.597	1.00
44_L	159_F	0.596	1.00
270_I	273_E	0.595	1.00
164_L	169_V	0.595	1.00
299_R	303_G	0.594	1.00
31_R	159_F	0.593	1.00
281_I	285_L	0.591	1.00
87_V	94_E	0.591	1.00
228_A	235_E	0.590	1.00
136_T	144_Y	0.585	1.00
127_R	131_L	0.578	1.00
145_L	160_R	0.577	1.00
138_F	141_A	0.574	1.00
10_W	76_E	0.572	1.00
58_A	110_L	0.570	1.00
268_K	272_R	0.569	1.00
302_E	308_I	0.565	1.00
245_F	252_L	0.565	1.00
237_I	240_A	0.563	1.00
124_A	130_E	0.561	1.00
172_R	176_I	0.561	1.00
220_A	225_L	0.561	1.00
117_M	121_A	0.560	1.00
236_M	240_A	0.559	1.00
137_R	140_L	0.559	1.00
26_R	29_I	0.559	1.00
199_D	207_L	0.558	1.00
279_I	286_R	0.558	1.00
180_E	216_I	0.557	1.00
255_L	259_Y	0.556	1.00
118_T	121_A	0.556	1.00
306_D	310_L	0.554	1.00
229_Q	237_I	0.553	1.00
266_I	271_H	0.551	1.00
75_L	94_E	0.551	1.00
177_A	207_L	0.551	1.00
55_T	113_E	0.551	1.00
14_Y	179_N	0.550	1.00
11_A	66_Y	0.549	1.00
265_D	272_R	0.547	1.00
108_V	139_I	0.546	1.00
280_Q	284_E	0.545	1.00
23_V	172_R	0.544	1.00
87_V	90_N	0.543	1.00
245_F	253_R	0.542	1.00
283_E	290_L	0.542	1.00
29_I	57_A	0.541	1.00
299_R	304_A	0.540	1.00
23_V	175_Y	0.540	1.00
293_I	298_F	0.540	1.00
31_R	209_A	0.538	1.00
286_R	289_L	0.538	1.00
240_A	244_K	0.536	1.00
224_V	227_L	0.534	1.00
85_I	124_A	0.533	1.00
87_V	91_K	0.533	1.00
273_E	278_E	0.533	1.00
60_A	63_H	0.533	1.00
218_V	226_G	0.532	1.00
306_D	311_S	0.531	1.00
9_L	75_L	0.529	1.00
196_T	199_D	0.529	1.00
215_K	220_A	0.529	1.00
60_A	64_D	0.528	1.00
175_Y	178_K	0.527	1.00
258_T	261_L	0.526	1.00
94_E	99_V	0.526	1.00
239_L	242_Q	0.525	1.00
209_A	212_A	0.525	1.00
189_L	203_S	0.523	1.00
83_R	91_K	0.522	1.00
304_A	309_Q	0.522	1.00
240_A	249_R	0.521	1.00
300_I	309_Q	0.520	1.00
29_I	60_A	0.520	1.00
284_E	289_L	0.519	1.00
259_Y	266_I	0.518	1.00
298_F	303_G	0.511	1.00
237_I	242_Q	0.511	1.00
36_V	61_L	0.511	1.00
287_V	293_I	0.509	1.00
269_Q	273_E	0.507	1.00
39_K	65_L	0.507	1.00
229_Q	235_E	0.507	1.00
81_D	124_A	0.507	1.00
49_P	142_C	0.504	1.00
127_R	130_E	0.501	1.00
188_A	210_A	0.501	1.00
92_V	128_T	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1iqpA	5	0.9697	100	0.357	Contact Map
1sxjD	1	0.9394	100	0.36	Contact Map
2chqA	3	0.9424	100	0.366	Contact Map
1sxjC	1	0.9545	100	0.367	Contact Map
1sxjE	1	0.9121	100	0.434	Contact Map
1sxjB	1	0.9485	100	0.436	Contact Map
3u61B	3	0.9333	100	0.449	Contact Map
1jr3A	3	0.9697	100	0.455	Contact Map
3pvsA	4	0.9394	100	0.48	Contact Map
2chgA	1	0.6727	100	0.483	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0099 seconds.