GREMLIN Database
RFCS - Replication factor C small subunit
UniProt: Q9UXF5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (296)
Sequences: 21369 (12755)
Seq/√Len: 741.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
170_V190_E4.0081.00
12_E16_P4.0051.00
26_R168_D3.3911.00
9_L73_Y3.2841.00
165_K168_D3.0871.00
170_V174_I3.0201.00
304_A308_I2.9441.00
174_I186_Q2.4101.00
298_F302_E2.3941.00
166_K193_Y2.3601.00
166_K194_D2.3081.00
169_V193_Y2.2721.00
244_K247_Q2.2571.00
232_E236_M2.2191.00
174_I189_L2.2151.00
303_G306_D2.1941.00
217_S220_A2.1231.00
170_V189_L2.1021.00
288_L292_Y2.0851.00
308_I312_A2.0721.00
175_Y179_N2.0571.00
250_D254_T2.0371.00
171_N174_I2.0301.00
218_V222_F1.9971.00
287_V291_D1.9481.00
190_E194_D1.8991.00
257_I260_G1.8641.00
238_N242_Q1.8401.00
219_E222_F1.8081.00
282_S285_L1.8021.00
294_G298_F1.7961.00
295_E299_R1.7961.00
163_P200_M1.7861.00
185_D188_A1.7851.00
291_D295_E1.7841.00
22_I57_A1.7671.00
285_L288_L1.7441.00
57_A161_F1.7261.00
286_R290_L1.7201.00
297_E301_I1.7121.00
80_S124_A1.7031.00
99_V103_D1.7001.00
222_F225_L1.6941.00
243_G247_Q1.6921.00
231_K235_E1.6871.00
46_F161_F1.6761.00
231_K234_R1.6551.00
90_N94_E1.6451.00
232_E235_E1.6421.00
306_D309_Q1.6191.00
282_S286_R1.5821.00
45_L114_A1.5811.00
230_P234_R1.5731.00
266_I270_I1.5731.00
265_D269_Q1.5641.00
118_T152_I1.5441.00
229_Q232_E1.5401.00
260_G264_E1.5291.00
22_I60_A1.5231.00
183_E215_K1.5221.00
245_F248_A1.5111.00
279_I283_E1.4971.00
290_L294_G1.4871.00
18_T21_D1.4721.00
214_G222_F1.4521.00
259_Y263_G1.4441.00
166_K170_V1.4381.00
247_Q251_K1.4371.00
172_R175_Y1.4361.00
28_I159_F1.4301.00
219_E223_K1.4231.00
230_P236_M1.4081.00
245_F249_R1.4061.00
47_A158_L1.3991.00
305_D309_Q1.3821.00
278_E282_S1.3721.00
12_E15_R1.3701.00
257_I264_E1.3701.00
240_A273_E1.3671.00
196_T203_S1.3461.00
191_T194_D1.3421.00
20_D33_K1.3401.00
254_T258_T1.3361.00
164_L200_M1.3361.00
177_A208_Q1.3271.00
294_G297_E1.3271.00
260_G263_G1.3211.00
273_E276_S1.3191.00
177_A189_L1.3131.00
301_I304_A1.3011.00
166_K190_E1.3001.00
26_R171_N1.2971.00
74_F110_L1.2931.00
283_E287_V1.2931.00
229_Q236_M1.2811.00
258_T262_S1.2771.00
257_I261_L1.2721.00
280_Q283_E1.2711.00
292_Y296_T1.2661.00
307_E311_S1.2631.00
47_A160_R1.2591.00
172_R200_M1.2491.00
176_I179_N1.2391.00
293_I297_E1.2331.00
173_L189_L1.2211.00
276_S280_Q1.2091.00
295_E298_F1.2061.00
62_V108_V1.2051.00
304_A307_E1.2041.00
267_V270_I1.2011.00
173_L203_S1.1971.00
243_G246_T1.1961.00
237_I241_L1.1901.00
84_G87_V1.1881.00
167_E170_V1.1861.00
228_A231_K1.1801.00
292_Y295_E1.1801.00
110_L141_A1.1721.00
215_K222_F1.1701.00
186_Q190_E1.1641.00
184_Y211_S1.1631.00
168_D171_N1.1591.00
170_V193_Y1.1491.00
299_R302_E1.1471.00
29_I33_K1.1461.00
176_I204_I1.1281.00
22_I29_I1.1251.00
25_Q28_I1.1231.00
267_V271_H1.1221.00
233_V236_M1.1151.00
246_T250_D1.1051.00
284_E288_L1.1051.00
234_R238_N1.1011.00
191_T218_V1.0871.00
221_V225_L1.0851.00
271_H275_T1.0851.00
90_N93_K1.0721.00
184_Y189_L1.0711.00
248_A251_K1.0691.00
263_G266_I1.0641.00
251_K255_L1.0641.00
289_L292_Y1.0631.00
167_E190_E1.0591.00
9_L12_E1.0591.00
285_L289_L1.0571.00
264_E268_K1.0571.00
296_T299_R1.0501.00
243_G248_A1.0481.00
85_I89_R1.0461.00
183_E186_Q1.0411.00
262_S265_D1.0391.00
249_R253_R1.0311.00
174_I178_K1.0271.00
266_I269_Q1.0241.00
167_E171_N1.0231.00
166_K197_M1.0221.00
191_T195_I1.0151.00
59_L76_E1.0141.00
262_S266_I1.0111.00
308_I311_S1.0081.00
246_T249_R1.0071.00
298_F301_I1.0041.00
218_V221_V1.0031.00
47_A145_L1.0021.00
257_I263_G1.0001.00
288_L291_D0.9961.00
169_V203_S0.9911.00
243_G249_R0.9811.00
83_R120_D0.9751.00
101_P133_T0.9741.00
151_P155_R0.9731.00
238_N241_L0.9721.00
220_A223_K0.9711.00
33_K37_K0.9671.00
96_A128_T0.9651.00
19_L63_H0.9631.00
58_A139_I0.9621.00
300_I304_A0.9591.00
217_S221_V0.9581.00
228_A232_E0.9581.00
244_K249_R0.9501.00
63_H67_G0.9471.00
171_N175_Y0.9461.00
189_L193_Y0.9371.00
222_F226_G0.9331.00
188_A191_T0.9321.00
83_R118_T0.9291.00
197_M201_R0.9251.00
233_V237_I0.9181.00
13_K180_E0.9141.00
86_D90_N0.9121.00
248_A252_L0.9101.00
263_G267_V0.9081.00
253_R258_T0.9081.00
208_Q221_V0.9081.00
177_A184_Y0.9031.00
93_K96_A0.9001.00
55_T112_D0.8991.00
260_G266_I0.8991.00
230_P235_E0.8981.00
239_L247_Q0.8971.00
88_I92_V0.8851.00
182_A211_S0.8841.00
124_A128_T0.8831.00
173_L204_I0.8831.00
176_I180_E0.8731.00
291_D294_G0.8721.00
244_K248_A0.8681.00
214_G220_A0.8671.00
252_L255_L0.8641.00
185_D215_K0.8611.00
15_R73_Y0.8551.00
223_K227_L0.8451.00
255_L260_G0.8391.00
192_I207_L0.8371.00
216_I222_F0.8371.00
253_R257_I0.8361.00
169_V200_M0.8341.00
218_V224_V0.8331.00
305_D308_I0.8321.00
100_I103_D0.8301.00
221_V224_V0.8261.00
254_T259_Y0.8251.00
303_G308_I0.8251.00
296_T309_Q0.8241.00
284_E287_V0.8201.00
30_D33_K0.8201.00
17_K63_H0.8181.00
247_Q250_D0.8151.00
195_I225_L0.8141.00
265_D268_K0.8121.00
169_V173_L0.8111.00
249_R252_L0.8091.00
300_I307_E0.8091.00
61_L139_I0.8081.00
260_G271_H0.8081.00
255_L261_L0.8061.00
251_K254_T0.8051.00
309_Q312_A0.8041.00
302_E306_D0.8041.00
185_D217_S0.8031.00
235_E238_N0.8011.00
82_E95_F0.7931.00
65_L137_R0.7921.00
163_P197_M0.7921.00
269_Q272_R0.7911.00
85_I120_D0.7911.00
230_P233_V0.7901.00
78_N81_D0.7891.00
275_T279_I0.7851.00
231_K236_M0.7851.00
260_G267_V0.7851.00
145_L158_L0.7841.00
114_A138_F0.7791.00
265_D270_I0.7781.00
203_S207_L0.7781.00
301_I305_D0.7761.00
26_R30_D0.7761.00
27_E162_Y0.7741.00
13_K18_T0.7711.00
220_A224_V0.7711.00
272_R276_S0.7711.00
193_Y203_S0.7681.00
187_K218_V0.7671.00
285_L290_L0.7661.00
235_E239_L0.7661.00
234_R237_I0.7641.00
228_A234_R0.7641.00
260_G265_D0.7631.00
222_F227_L0.7601.00
282_S288_L0.7571.00
278_E283_E0.7571.00
303_G307_E0.7541.00
229_Q233_V0.7541.00
284_E290_L0.7521.00
45_L156_T0.7491.00
153_Q158_L0.7441.00
283_E286_R0.7401.00
261_L264_E0.7391.00
31_R34_K0.7341.00
214_G218_V0.7331.00
268_K271_H0.7331.00
123_Q126_R0.7311.00
13_K16_P0.7311.00
239_L243_G0.7231.00
244_K252_L0.7221.00
49_P52_T0.7191.00
250_D253_R0.7181.00
91_K95_F0.7161.00
278_E281_I0.7161.00
92_V95_F0.7161.00
114_A136_T0.7111.00
206_I209_A0.7091.00
79_A82_E0.7081.00
164_L168_D0.7071.00
285_L292_Y0.7011.00
274_I278_E0.6991.00
259_Y262_S0.6981.00
236_M239_L0.6971.00
215_K218_V0.6961.00
228_A236_M0.6961.00
278_E286_R0.6961.00
264_E267_V0.6921.00
192_I203_S0.6911.00
275_T278_E0.6881.00
17_K21_D0.6881.00
111_L136_T0.6861.00
270_I274_I0.6861.00
244_K253_R0.6821.00
217_S222_F0.6811.00
73_Y105_P0.6771.00
187_K190_E0.6771.00
114_A148_I0.6751.00
218_V225_L0.6751.00
217_S226_G0.6751.00
245_F251_K0.6751.00
192_I206_I0.6741.00
217_S224_V0.6701.00
83_R86_D0.6701.00
14_Y180_E0.6691.00
32_L159_F0.6651.00
294_G299_R0.6631.00
303_G309_Q0.6621.00
34_K213_Y0.6611.00
240_A243_G0.6601.00
264_E270_I0.6501.00
221_V226_G0.6501.00
99_V102_G0.6411.00
75_L107_K0.6411.00
114_A140_L0.6401.00
34_K37_K0.6361.00
302_E307_E0.6361.00
290_L293_I0.6351.00
220_A226_G0.6311.00
173_L192_I0.6301.00
261_L265_D0.6291.00
259_Y264_E0.6271.00
287_V290_L0.6261.00
296_T306_D0.6221.00
32_L61_L0.6181.00
229_Q234_R0.6151.00
282_S290_L0.6121.00
101_P104_I0.6091.00
198_G201_R0.6081.00
242_Q245_F0.6081.00
240_A245_F0.6071.00
228_A233_V0.6071.00
276_S279_I0.6051.00
221_V227_L0.6051.00
279_I282_S0.6031.00
89_R93_K0.6021.00
174_I177_A0.6011.00
300_I303_G0.6011.00
200_M203_S0.6001.00
126_R130_E0.5991.00
286_R293_I0.5971.00
44_L159_F0.5961.00
270_I273_E0.5951.00
164_L169_V0.5951.00
299_R303_G0.5941.00
31_R159_F0.5931.00
281_I285_L0.5911.00
87_V94_E0.5911.00
228_A235_E0.5901.00
136_T144_Y0.5851.00
127_R131_L0.5781.00
145_L160_R0.5771.00
138_F141_A0.5741.00
10_W76_E0.5721.00
58_A110_L0.5701.00
268_K272_R0.5691.00
302_E308_I0.5651.00
245_F252_L0.5651.00
237_I240_A0.5631.00
124_A130_E0.5611.00
172_R176_I0.5611.00
220_A225_L0.5611.00
117_M121_A0.5601.00
236_M240_A0.5591.00
137_R140_L0.5591.00
26_R29_I0.5591.00
199_D207_L0.5581.00
279_I286_R0.5581.00
180_E216_I0.5571.00
255_L259_Y0.5561.00
118_T121_A0.5561.00
306_D310_L0.5541.00
229_Q237_I0.5531.00
266_I271_H0.5511.00
75_L94_E0.5511.00
177_A207_L0.5511.00
55_T113_E0.5511.00
14_Y179_N0.5501.00
11_A66_Y0.5491.00
265_D272_R0.5471.00
108_V139_I0.5461.00
280_Q284_E0.5451.00
23_V172_R0.5441.00
87_V90_N0.5431.00
245_F253_R0.5421.00
283_E290_L0.5421.00
29_I57_A0.5411.00
299_R304_A0.5401.00
23_V175_Y0.5401.00
293_I298_F0.5401.00
31_R209_A0.5381.00
286_R289_L0.5381.00
240_A244_K0.5361.00
224_V227_L0.5341.00
85_I124_A0.5331.00
87_V91_K0.5331.00
273_E278_E0.5331.00
60_A63_H0.5331.00
218_V226_G0.5321.00
306_D311_S0.5311.00
9_L75_L0.5291.00
196_T199_D0.5291.00
215_K220_A0.5291.00
60_A64_D0.5281.00
175_Y178_K0.5271.00
258_T261_L0.5261.00
94_E99_V0.5261.00
239_L242_Q0.5251.00
209_A212_A0.5251.00
189_L203_S0.5231.00
83_R91_K0.5221.00
304_A309_Q0.5221.00
240_A249_R0.5211.00
300_I309_Q0.5201.00
29_I60_A0.5201.00
284_E289_L0.5191.00
259_Y266_I0.5181.00
298_F303_G0.5111.00
237_I242_Q0.5111.00
36_V61_L0.5111.00
287_V293_I0.5091.00
269_Q273_E0.5071.00
39_K65_L0.5071.00
229_Q235_E0.5071.00
81_D124_A0.5071.00
49_P142_C0.5041.00
127_R130_E0.5011.00
188_A210_A0.5011.00
92_V128_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1iqpA 5 0.9697 100 0.357 Contact Map
1sxjD 1 0.9394 100 0.36 Contact Map
2chqA 3 0.9424 100 0.366 Contact Map
1sxjC 1 0.9545 100 0.367 Contact Map
1sxjE 1 0.9121 100 0.434 Contact Map
1sxjB 1 0.9485 100 0.436 Contact Map
3u61B 3 0.9333 100 0.449 Contact Map
1jr3A 3 0.9697 100 0.455 Contact Map
3pvsA 4 0.9394 100 0.48 Contact Map
2chgA 1 0.6727 100 0.483 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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