GREMLIN Database
PSB2 - Proteasome subunit beta 2
UniProt: Q9UXF3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 208 (188)
Sequences: 4338 (2462)
Seq/√Len: 179.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_T164_E5.0331.00
29_A169_A3.7341.00
19_G28_L3.1041.00
23_N159_K3.0641.00
22_V25_G2.7091.00
123_R135_E2.6601.00
17_T58_T2.4051.00
22_V165_A2.3961.00
19_G124_L2.3851.00
155_E171_R2.3691.00
162_L193_H2.3661.00
81_S87_P2.3091.00
55_I90_I2.2151.00
193_H196_G2.1901.00
162_L166_A2.1521.00
137_N158_P2.1111.00
157_N164_E2.0931.00
28_L116_G2.0551.00
50_Y53_D2.0381.00
20_I169_A1.9861.00
24_D194_S1.9151.00
90_I117_G1.9081.00
26_V116_G1.8811.00
162_L198_E1.8361.00
52_T81_S1.8171.00
21_R135_E1.8161.00
160_M168_L1.8041.00
23_N161_T1.7951.00
55_I93_I1.7651.00
114_L139_V1.7491.00
193_H198_E1.7351.00
54_K87_P1.7301.00
102_S105_K1.7181.00
125_F135_E1.7011.00
27_I169_A1.6231.00
27_I166_A1.5761.00
20_I165_A1.5711.00
89_S92_G1.5681.00
155_E168_L1.5631.00
102_S106_Y1.5541.00
73_L97_L1.5421.00
27_I191_K1.5421.00
166_A191_K1.5041.00
22_V162_L1.4831.00
77_Y93_I1.4541.00
157_N160_M1.4461.00
22_V193_H1.4211.00
112_Q129_Y1.4201.00
156_Y159_K1.4181.00
24_D162_L1.4161.00
94_A133_I1.4061.00
166_A189_V1.4051.00
25_G165_A1.3891.00
16_T144_G1.3691.00
190_A199_E1.3661.00
21_R137_N1.3461.00
59_T66_L1.3231.00
167_D171_R1.3151.00
48_V190_A1.2961.00
46_R188_I1.2861.00
88_I93_I1.2861.00
57_I70_Y1.2801.00
57_I115_I1.2651.00
52_T87_P1.2341.00
156_Y160_M1.2281.00
29_A189_V1.2101.00
104_T109_Y1.2101.00
151_V172_A1.2051.00
140_A152_L1.2031.00
69_I111_V1.1741.00
151_V155_E1.1721.00
72_V76_I1.1681.00
76_I79_Y1.1391.00
25_G162_L1.1331.00
163_D167_D1.1321.00
170_K187_V1.1301.00
76_I96_R1.1181.00
27_I165_A1.1171.00
195_K198_E1.1081.00
72_V100_V1.1031.00
32_R188_I1.0951.00
34_A45_V1.0931.00
171_R174_F1.0651.00
80_N84_K1.0621.00
114_L141_T1.0571.00
21_R122_P1.0551.00
26_V124_L1.0521.00
49_L70_Y1.0501.00
118_Y194_S1.0471.00
33_R40_V1.0411.00
51_I57_I1.0381.00
119_D123_R1.0250.99
36_A41_A1.0210.99
101_L113_I1.0170.99
51_I77_Y1.0010.99
16_T148_A0.9970.99
167_D170_K0.9930.99
96_R100_V0.9900.99
90_I123_R0.9840.99
128_D132_D0.9770.99
126_N139_V0.9730.99
152_L172_A0.9630.99
18_V152_L0.9630.99
170_K189_V0.9630.99
103_A107_F0.9610.99
138_Y152_L0.9590.99
188_I199_E0.9540.99
172_A176_A0.9500.99
28_L56_G0.9490.99
56_G192_I0.9480.99
56_G190_A0.9340.99
48_V58_T0.9260.99
115_I127_L0.9170.99
70_Y74_K0.9150.99
75_N79_Y0.9130.99
52_T55_I0.9120.99
101_L127_L0.9110.99
100_V103_A0.9050.99
164_E167_D0.8950.99
28_L58_T0.8850.98
60_A141_T0.8830.98
163_D166_A0.8620.98
56_G197_H0.8580.98
66_L111_V0.8540.98
79_Y83_T0.8430.98
180_D183_T0.8380.98
28_L190_A0.8290.98
54_K88_I0.8270.98
88_I92_G0.8260.98
160_M164_E0.8250.98
126_N136_E0.8200.97
78_H81_S0.8190.97
148_A172_A0.8190.97
79_Y82_I0.8180.97
26_V122_P0.8120.97
105_K110_I0.8120.97
32_R186_G0.8100.97
49_L59_T0.8080.97
49_L68_F0.7980.97
118_Y122_P0.7940.97
164_E168_L0.7930.97
89_S120_D0.7870.97
114_L124_L0.7850.97
151_V168_L0.7790.97
171_R175_S0.7790.97
33_R184_G0.7780.97
162_L165_A0.7770.97
97_L115_I0.7740.96
55_I115_I0.7690.96
75_N78_H0.7690.96
17_T30_A0.7670.96
153_E179_R0.7600.96
57_I113_I0.7600.96
54_K120_D0.7560.96
80_N92_G0.7510.96
15_T31_D0.7490.96
94_A125_F0.7490.96
174_F177_I0.7450.96
27_I162_L0.7350.95
80_N88_I0.7320.95
35_S40_V0.7300.95
90_I115_I0.7260.95
116_G192_I0.7230.95
176_A180_D0.7200.95
160_M165_A0.7200.95
78_H82_I0.7170.95
98_A133_I0.7170.95
65_D108_P0.7160.95
138_Y149_M0.7140.94
30_A60_A0.7130.94
86_G120_D0.7120.94
62_S65_D0.7100.94
50_Y199_E0.7100.94
48_V56_G0.7090.94
69_I97_L0.7090.94
112_Q141_T0.7000.94
97_L113_I0.7000.94
63_V66_L0.6960.94
33_R143_S0.6960.94
136_E139_V0.6910.93
47_K156_Y0.6870.93
111_V152_L0.6850.93
23_N158_P0.6770.93
180_D184_G0.6770.93
190_A197_H0.6750.93
26_V29_A0.6710.92
140_A148_A0.6680.92
18_V39_F0.6670.92
18_V169_A0.6620.92
80_N89_S0.6590.92
192_I197_H0.6560.92
61_G65_D0.6550.92
106_Y130_L0.6520.91
72_V96_R0.6490.91
20_I29_A0.6480.91
151_V175_S0.6450.91
162_L191_K0.6440.91
194_S199_E0.6410.91
88_I96_R0.6360.90
129_Y141_T0.6320.90
17_T114_L0.6290.90
89_S94_A0.6290.90
30_A48_V0.6250.90
66_L70_Y0.6220.89
51_I74_K0.6220.89
161_T165_A0.6210.89
118_Y192_I0.6190.89
53_D87_P0.6180.89
99_N103_A0.6170.89
13_K150_G0.6120.89
59_T113_I0.6120.89
91_K95_T0.6110.88
163_D195_K0.5980.87
19_G116_G0.5980.87
73_L96_R0.5980.87
92_G95_T0.5970.87
170_K174_F0.5970.87
144_G148_A0.5890.87
61_G131_G0.5870.86
64_A132_D0.5840.86
97_L127_L0.5830.86
77_Y99_N0.5820.86
42_N45_V0.5800.86
170_K173_V0.5790.86
104_T127_L0.5770.85
120_D123_R0.5720.85
47_K60_A0.5720.85
51_I93_I0.5720.85
59_T64_A0.5700.85
69_I101_L0.5700.85
121_Q194_S0.5700.85
22_V191_K0.5690.85
62_S68_F0.5680.85
32_R173_V0.5670.85
78_H83_T0.5650.84
72_V75_N0.5600.84
132_D139_V0.5600.84
78_H86_G0.5560.83
95_T133_I0.5540.83
177_I180_D0.5530.83
79_Y150_G0.5520.83
191_K198_E0.5490.83
36_A178_K0.5490.83
87_P121_Q0.5490.83
18_V29_A0.5470.82
76_I100_V0.5460.82
131_G142_G0.5450.82
33_R180_D0.5450.82
48_V188_I0.5430.82
107_F111_V0.5420.82
37_G42_N0.5410.82
103_A167_D0.5400.82
125_F133_I0.5360.81
100_V109_Y0.5330.81
191_K194_S0.5310.80
138_Y156_Y0.5290.80
23_N53_D0.5290.80
118_Y196_G0.5280.80
143_S147_V0.5250.80
46_R49_L0.5250.80
60_A132_D0.5250.80
126_N134_T0.5240.80
36_A39_F0.5200.79
140_A145_S0.5190.79
81_S85_Y0.5180.79
24_D193_H0.5170.79
22_V27_I0.5170.79
95_T98_A0.5170.79
149_M179_R0.5160.79
108_P112_Q0.5150.78
120_D194_S0.5140.78
71_D146_P0.5130.78
166_A170_K0.5100.78
11_I98_A0.5090.78
21_R158_P0.5080.78
151_V171_R0.5070.77
75_N80_N0.5050.77
64_A178_K0.5050.77
57_I73_L0.5030.77
144_G147_V0.5020.77
196_G199_E0.5000.76
15_T60_A0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1rypC 1 1 100 0.123 Contact Map
1j2pA 3 0.9904 100 0.123 Contact Map
4r3oC 1 1 100 0.131 Contact Map
4r3oB 1 0.9808 100 0.137 Contact Map
4r3oE 1 0.9856 100 0.139 Contact Map
3h4pA 3 0.9856 100 0.139 Contact Map
1rypE 1 0.9856 100 0.142 Contact Map
1rypB 1 0.9904 100 0.142 Contact Map
4r3oA 1 0.9904 100 0.149 Contact Map
1rypF 1 0.9808 100 0.149 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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