GREMLIN Database
G1PDH - Glycerol-1-phosphate dehydrogenase [NAD(P)+]
UniProt: Q9UXE7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 351 (316)
Sequences: 14669 (10258)
Seq/√Len: 577.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
280_Y290_R3.2771.00
81_E85_R3.0921.00
211_C214_I2.9551.00
79_V106_A2.9551.00
317_T337_W2.8251.00
206_K295_K2.8021.00
18_H155_E2.6451.00
91_L103_T2.6241.00
51_D55_E2.5981.00
163_R269_E2.5831.00
113_E148_L2.5541.00
308_S311_E2.5521.00
313_I341_E2.5291.00
37_F90_L2.4931.00
74_D136_L2.4861.00
23_D26_I2.4601.00
162_R166_N2.4411.00
204_S225_M2.2961.00
207_H214_I2.2851.00
19_D155_E2.2521.00
189_R288_I2.2451.00
36_P64_E2.2391.00
82_V86_I2.2091.00
20_I23_D2.1401.00
93_G103_T2.1331.00
158_S215_I2.1261.00
44_K48_K2.1051.00
196_Y199_S2.0981.00
311_E314_K2.0961.00
291_N295_K2.0821.00
336_T339_S2.0781.00
33_V90_L2.0661.00
75_D78_M2.0651.00
54_I58_P2.0341.00
100_I116_S2.0091.00
82_V85_R2.0051.00
51_D54_I1.9801.00
254_A270_L1.9661.00
167_A269_E1.9381.00
253_F344_A1.9321.00
22_Y52_K1.9181.00
66_V86_I1.8481.00
294_K300_V1.8311.00
176_I197_T1.8041.00
58_P65_V1.7641.00
83_I112_L1.7581.00
207_H211_C1.7431.00
301_K304_D1.7251.00
206_K210_Q1.7221.00
40_V103_T1.7191.00
279_A289_I1.6901.00
73_L77_Y1.6451.00
260_I315_A1.6351.00
337_W341_E1.6161.00
333_R337_W1.6101.00
172_T201_A1.5921.00
312_V341_E1.5891.00
282_H331_G1.5831.00
74_D77_Y1.5831.00
27_Y30_Q1.5821.00
78_M81_E1.5781.00
25_S56_N1.5621.00
333_R339_S1.5491.00
76_V102_V1.5441.00
37_F92_L1.5381.00
42_G45_Y1.5351.00
38_L82_V1.5341.00
38_L83_I1.5221.00
287_K291_N1.5041.00
152_A227_M1.4871.00
173_I198_A1.4861.00
115_V149_A1.4861.00
155_E158_S1.4611.00
100_I125_G1.4601.00
214_I218_D1.4501.00
195_D199_S1.4481.00
76_V133_I1.4351.00
228_E235_V1.4171.00
283_G286_W1.4041.00
204_S207_H1.4011.00
273_L305_L1.4001.00
91_L107_A1.3931.00
167_A266_L1.3901.00
170_G293_L1.3781.00
161_P164_L1.3771.00
66_V82_V1.3691.00
290_R294_K1.3641.00
18_H224_R1.3631.00
13_R27_Y1.3531.00
54_I65_V1.3481.00
27_Y149_A1.3341.00
18_H158_S1.3341.00
265_I270_L1.3341.00
83_I110_N1.3171.00
52_K155_E1.3051.00
17_G23_D1.3001.00
77_Y81_E1.2881.00
55_E60_D1.2821.00
21_V52_K1.2771.00
93_G114_F1.2741.00
19_D22_Y1.2711.00
53_V94_I1.2661.00
135_G138_K1.2621.00
170_G298_F1.2531.00
90_L115_V1.2521.00
43_T47_K1.2471.00
55_E58_P1.2451.00
36_P89_S1.2441.00
76_V106_A1.2381.00
214_I217_K1.2351.00
157_L227_M1.2321.00
249_S275_T1.2311.00
169_I205_A1.2251.00
24_I53_V1.2161.00
288_I291_N1.2121.00
40_V106_A1.2001.00
76_V80_E1.1881.00
210_Q295_K1.1881.00
83_I88_P1.1851.00
276_I290_R1.1711.00
44_K47_K1.1691.00
80_E84_K1.1531.00
314_K317_T1.1491.00
253_F274_G1.1491.00
280_Y286_W1.1341.00
314_K318_I1.1331.00
83_I91_L1.1261.00
339_S342_K1.1261.00
21_V117_I1.1121.00
130_F143_K1.1101.00
210_Q214_I1.1091.00
182_W186_A1.1011.00
36_P66_V1.0991.00
280_Y283_G1.0991.00
17_G20_I1.0961.00
265_I273_L1.0931.00
160_S164_L1.0871.00
203_M225_M1.0801.00
169_I226_L1.0771.00
38_L88_P1.0761.00
36_P86_I1.0751.00
260_I314_K1.0731.00
316_L341_E1.0711.00
52_K56_N1.0711.00
62_K65_V1.0711.00
15_F27_Y1.0701.00
21_V156_I1.0701.00
81_E84_K1.0701.00
28_F90_L1.0691.00
165_I218_D1.0691.00
14_V231_I1.0581.00
313_I317_T1.0561.00
18_H215_I1.0541.00
45_Y49_I1.0511.00
93_G116_S1.0501.00
320_H323_R1.0461.00
78_M82_V1.0441.00
28_F33_V1.0351.00
45_Y48_K1.0331.00
23_D27_Y1.0281.00
338_S341_E1.0281.00
178_A332_D1.0231.00
46_T50_A1.0171.00
15_F149_A1.0071.00
260_I318_I1.0061.00
22_Y56_N1.0031.00
52_K55_E1.0001.00
121_P165_I0.9981.00
178_A289_I0.9951.00
250_E275_T0.9931.00
20_I151_I0.9901.00
313_I337_W0.9861.00
316_L319_A0.9851.00
155_E215_I0.9851.00
179_V236_A0.9851.00
15_F23_D0.9791.00
127_T150_I0.9731.00
103_T114_F0.9721.00
162_R209_F0.9681.00
73_L133_I0.9651.00
64_E67_E0.9641.00
312_V316_L0.9641.00
58_P64_E0.9601.00
291_N294_K0.9451.00
72_T75_D0.9411.00
192_Y196_Y0.9391.00
39_I65_V0.9351.00
254_A258_E0.9341.00
170_G272_G0.9331.00
29_S61_A0.9321.00
216_N225_M0.9311.00
157_L218_D0.9291.00
80_E109_R0.9261.00
196_Y200_L0.9221.00
315_A344_A0.9201.00
317_T321_T0.9191.00
207_H210_Q0.9181.00
21_V155_E0.9181.00
19_D153_D0.9181.00
279_A286_W0.9171.00
39_I54_I0.9171.00
45_Y50_A0.9161.00
68_I78_M0.9041.00
107_A112_L0.8971.00
90_L113_E0.8961.00
65_V68_I0.8871.00
165_I208_A0.8851.00
100_I118_P0.8831.00
88_P323_R0.8831.00
162_R297_G0.8811.00
74_D78_M0.8791.00
260_I311_E0.8711.00
26_I61_A0.8681.00
218_D228_E0.8671.00
41_T99_V0.8661.00
166_N209_F0.8661.00
201_A226_L0.8661.00
250_E271_V0.8651.00
127_T231_I0.8641.00
282_H332_D0.8641.00
266_L269_E0.8631.00
191_E194_G0.8621.00
41_T46_T0.8611.00
273_L276_I0.8601.00
175_K179_V0.8601.00
13_R30_Q0.8601.00
28_F115_V0.8591.00
181_D211_C0.8591.00
249_S335_L0.8581.00
36_P87_S0.8571.00
116_S147_P0.8561.00
287_K290_R0.8511.00
286_W290_R0.8471.00
68_I82_V0.8461.00
154_I224_R0.8451.00
102_V106_A0.8451.00
34_T89_S0.8421.00
165_I212_T0.8401.00
27_Y151_I0.8391.00
93_G100_I0.8391.00
25_S29_S0.8371.00
22_Y155_E0.8361.00
316_L320_H0.8351.00
316_L337_W0.8301.00
276_I293_L0.8261.00
318_I322_I0.8201.00
83_I106_A0.8141.00
169_I172_T0.8121.00
107_A114_F0.8071.00
197_T201_A0.8061.00
70_S98_K0.8031.00
253_F277_I0.8001.00
26_I29_S0.7991.00
193_Y196_Y0.7971.00
186_A189_R0.7971.00
300_V304_D0.7901.00
254_A271_V0.7901.00
249_S278_M0.7881.00
281_L339_S0.7871.00
72_T136_L0.7861.00
46_T51_D0.7801.00
201_A204_S0.7771.00
123_H172_T0.7761.00
40_V79_V0.7731.00
180_R218_D0.7701.00
290_R300_V0.7661.00
160_S168_G0.7621.00
58_P62_K0.7611.00
174_G275_T0.7601.00
27_Y31_L0.7601.00
145_K148_L0.7591.00
202_L206_K0.7581.00
272_G293_L0.7541.00
184_L187_K0.7521.00
313_I316_L0.7521.00
74_D137_Q0.7451.00
21_V153_D0.7451.00
76_V105_Y0.7411.00
284_I333_R0.7401.00
163_R167_A0.7391.00
176_I212_T0.7371.00
251_H267_H0.7351.00
318_I321_T0.7341.00
73_L136_L0.7341.00
79_V102_V0.7321.00
25_S60_D0.7311.00
277_I280_Y0.7281.00
198_A202_L0.7241.00
208_A212_T0.7241.00
77_Y80_E0.7211.00
207_H216_N0.7201.00
26_I30_Q0.7191.00
91_L112_L0.7191.00
193_Y232_S0.7121.00
334_G337_W0.7071.00
253_F340_A0.7071.00
204_S208_A0.7071.00
257_V270_L0.7061.00
62_K66_V0.7031.00
21_V53_V0.7011.00
338_S342_K0.6991.00
68_I79_V0.6991.00
237_M242_S0.6981.00
289_I293_L0.6971.00
18_H154_I0.6961.00
179_V191_E0.6931.00
202_L288_I0.6931.00
164_L167_A0.6921.00
212_T218_D0.6911.00
70_S75_D0.6911.00
252_L328_T0.6881.00
299_P304_D0.6871.00
206_K209_F0.6851.00
24_I117_I0.6851.00
310_E313_I0.6831.00
192_Y199_S0.6771.00
16_V224_R0.6761.00
158_S213_K0.6731.00
281_L333_R0.6731.00
328_T332_D0.6721.00
279_A285_N0.6721.00
200_L225_M0.6711.00
199_S203_M0.6701.00
49_I159_L0.6701.00
37_F89_S0.6701.00
228_E232_S0.6681.00
46_T54_I0.6681.00
42_G48_K0.6661.00
53_V56_N0.6641.00
46_T67_E0.6631.00
70_S264_G0.6621.00
56_N60_D0.6611.00
209_F297_G0.6601.00
311_E315_A0.6591.00
105_Y133_I0.6541.00
173_I177_I0.6541.00
332_D338_S0.6521.00
187_K208_A0.6471.00
249_S340_A0.6441.00
54_I67_E0.6431.00
38_L86_I0.6421.00
320_H337_W0.6411.00
176_I233_S0.6401.00
62_K68_I0.6381.00
302_A312_V0.6361.00
185_A189_R0.6321.00
166_N298_F0.6261.00
40_V99_V0.6261.00
116_S150_I0.6251.00
64_E86_I0.6241.00
15_F20_I0.6231.00
193_Y197_T0.6221.00
177_I198_A0.6211.00
261_H311_E0.6211.00
177_I285_N0.6191.00
14_V213_K0.6171.00
163_R266_L0.6161.00
164_L266_L0.6151.00
81_E137_Q0.6151.00
212_T215_I0.6091.00
242_S248_G0.6081.00
174_G250_E0.6071.00
209_F296_I0.6061.00
201_A229_A0.6051.00
200_L229_A0.6041.00
40_V91_L0.6041.00
46_T49_I0.6041.00
281_L335_L0.6021.00
317_T341_E0.6011.00
259_L315_A0.6001.00
162_R210_Q0.6001.00
211_C218_D0.5981.00
66_V88_P0.5971.00
52_K156_I0.5961.00
216_N224_R0.5951.00
108_F111_S0.5941.00
166_N297_G0.5921.00
75_D102_V0.5921.00
93_G99_V0.5921.00
72_T264_G0.5921.00
173_I296_I0.5911.00
76_V132_S0.5911.00
204_S226_L0.5881.00
139_P143_K0.5881.00
135_G142_V0.5881.00
51_D58_P0.5851.00
271_V274_G0.5851.00
319_A323_R0.5811.00
38_L68_I0.5811.00
114_F148_L0.5801.00
22_Y60_D0.5801.00
129_P238_G0.5781.00
256_A344_A0.5781.00
237_M240_A0.5771.00
62_K67_E0.5761.00
183_K186_A0.5741.00
316_L322_I0.5741.00
280_Y284_I0.5741.00
169_I296_I0.5731.00
203_M207_H0.5711.00
13_R149_A0.5691.00
157_L165_I0.5691.00
203_M206_K0.5640.99
140_V143_K0.5640.99
269_E299_P0.5640.99
315_A319_A0.5640.99
272_G298_F0.5630.99
15_F151_I0.5620.99
33_V113_E0.5620.99
39_I94_I0.5610.99
22_Y55_E0.5610.99
50_A54_I0.5580.99
40_V102_V0.5560.99
204_S217_K0.5550.99
265_I269_E0.5480.99
241_G330_L0.5470.99
24_I151_I0.5450.99
146_E230_L0.5450.99
275_T293_L0.5440.99
180_R215_I0.5430.99
253_F278_M0.5400.99
122_S157_L0.5400.99
307_L312_V0.5380.99
256_A318_I0.5360.99
278_M282_H0.5350.99
315_A318_I0.5350.99
252_L327_Y0.5340.99
25_S61_A0.5340.99
173_I292_R0.5340.99
217_K227_M0.5330.99
162_R200_L0.5320.99
293_L298_F0.5320.99
310_E314_K0.5300.99
335_L339_S0.5300.99
80_E106_A0.5280.99
162_R165_I0.5280.99
92_L115_V0.5280.99
181_D279_A0.5270.99
21_V56_N0.5260.99
105_Y131_A0.5260.99
285_N289_I0.5260.99
139_P267_H0.5260.99
208_A217_K0.5240.99
117_I151_I0.5230.99
25_S28_F0.5210.99
181_D184_L0.5210.99
269_E298_F0.5200.99
121_P227_M0.5200.99
204_S216_N0.5200.99
50_A94_I0.5190.99
249_S252_L0.5180.99
16_V228_E0.5180.99
261_H315_A0.5160.99
292_R296_I0.5160.99
176_I179_V0.5150.99
257_V265_I0.5140.99
294_K304_D0.5130.99
258_E270_L0.5120.99
205_A209_F0.5110.99
174_G271_V0.5110.99
47_K51_D0.5090.99
281_L336_T0.5090.99
176_I215_I0.5050.99
56_N61_A0.5040.99
320_H340_A0.5040.99
138_K141_S0.5040.99
315_A323_R0.5030.99
265_I305_L0.5020.99
139_P142_V0.5020.99
36_P88_P0.5020.99
41_T45_Y0.5020.99
293_L300_V0.5010.99
174_G248_G0.5010.99
79_V82_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bfjA 5 0.9288 100 0.148 Contact Map
3ox4A 2 0.9316 100 0.155 Contact Map
4fr2A 2 0.9288 100 0.162 Contact Map
1rrmA 2 0.9259 100 0.17 Contact Map
1vljA 2 0.963 100 0.175 Contact Map
1o2dA 1 0.9231 100 0.192 Contact Map
3iv7A 2 0.9345 100 0.193 Contact Map
3zdrA 2 0.9316 100 0.197 Contact Map
3w5sA 2 0.9288 100 0.202 Contact Map
4qgsA 2 0.9145 100 0.204 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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