G1PDH - SULSO - GREMLIN Contacts

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G1PDH - Glycerol-1-phosphate dehydrogenase [NAD(P)+]

UniProt:	Q9UXE7	Sequences: MNVKEHVISLPRRVFVGHDIVYDISIYFSQLGVTPPFLIVTGTKYTKKIADKVIENLPKDAKYEVVEIDSATLDDVYMVEEVIKRISPSLLLGIGGGKVIDVTKYAAFRNSLEFVSIPTSPSHDGITSPFASIKGLQKPVSVKAKEPLAIIADIEILSLSPRRLINAGIGDTIGKIIAVRDWKLAAKLRGEYYGDYTASLALMSAKHAFQCTKIINKDIKYGVRMLMEALISSGVAMGMAGSTRPASGSEHLFAHAVELIHPEGILHGELVGLGTIIMAYLHGINWKIIRNRLKKIGFPVKAKDLGLSDEEVIKALTIAHTIRPERYTILGDRGLTWSSAEKIARVTKIID	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	351 (316)
Sequences:	14669 (10258)
Seq/√Len:	577.1

ECOLI - EUTG ADH2 YQHD FUCO YBDH GLDA ADHE
BACSU - GBSB YUGJ YUGK G1PDH
HALSA - G1PDH Q9HHR2 Q9HNB5
SULSO - G1PDH Q97VW4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
280_Y	290_R	3.277	1.00
81_E	85_R	3.092	1.00
211_C	214_I	2.955	1.00
79_V	106_A	2.955	1.00
317_T	337_W	2.825	1.00
206_K	295_K	2.802	1.00
18_H	155_E	2.645	1.00
91_L	103_T	2.624	1.00
51_D	55_E	2.598	1.00
163_R	269_E	2.583	1.00
113_E	148_L	2.554	1.00
308_S	311_E	2.552	1.00
313_I	341_E	2.529	1.00
37_F	90_L	2.493	1.00
74_D	136_L	2.486	1.00
23_D	26_I	2.460	1.00
162_R	166_N	2.441	1.00
204_S	225_M	2.296	1.00
207_H	214_I	2.285	1.00
19_D	155_E	2.252	1.00
189_R	288_I	2.245	1.00
36_P	64_E	2.239	1.00
82_V	86_I	2.209	1.00
20_I	23_D	2.140	1.00
93_G	103_T	2.133	1.00
158_S	215_I	2.126	1.00
44_K	48_K	2.105	1.00
196_Y	199_S	2.098	1.00
311_E	314_K	2.096	1.00
291_N	295_K	2.082	1.00
336_T	339_S	2.078	1.00
33_V	90_L	2.066	1.00
75_D	78_M	2.065	1.00
54_I	58_P	2.034	1.00
100_I	116_S	2.009	1.00
82_V	85_R	2.005	1.00
51_D	54_I	1.980	1.00
254_A	270_L	1.966	1.00
167_A	269_E	1.938	1.00
253_F	344_A	1.932	1.00
22_Y	52_K	1.918	1.00
66_V	86_I	1.848	1.00
294_K	300_V	1.831	1.00
176_I	197_T	1.804	1.00
58_P	65_V	1.764	1.00
83_I	112_L	1.758	1.00
207_H	211_C	1.743	1.00
301_K	304_D	1.725	1.00
206_K	210_Q	1.722	1.00
40_V	103_T	1.719	1.00
279_A	289_I	1.690	1.00
73_L	77_Y	1.645	1.00
260_I	315_A	1.635	1.00
337_W	341_E	1.616	1.00
333_R	337_W	1.610	1.00
172_T	201_A	1.592	1.00
312_V	341_E	1.589	1.00
282_H	331_G	1.583	1.00
74_D	77_Y	1.583	1.00
27_Y	30_Q	1.582	1.00
78_M	81_E	1.578	1.00
25_S	56_N	1.562	1.00
333_R	339_S	1.549	1.00
76_V	102_V	1.544	1.00
37_F	92_L	1.538	1.00
42_G	45_Y	1.535	1.00
38_L	82_V	1.534	1.00
38_L	83_I	1.522	1.00
287_K	291_N	1.504	1.00
152_A	227_M	1.487	1.00
173_I	198_A	1.486	1.00
115_V	149_A	1.486	1.00
155_E	158_S	1.461	1.00
100_I	125_G	1.460	1.00
214_I	218_D	1.450	1.00
195_D	199_S	1.448	1.00
76_V	133_I	1.435	1.00
228_E	235_V	1.417	1.00
283_G	286_W	1.404	1.00
204_S	207_H	1.401	1.00
273_L	305_L	1.400	1.00
91_L	107_A	1.393	1.00
167_A	266_L	1.390	1.00
170_G	293_L	1.378	1.00
161_P	164_L	1.377	1.00
66_V	82_V	1.369	1.00
290_R	294_K	1.364	1.00
18_H	224_R	1.363	1.00
13_R	27_Y	1.353	1.00
54_I	65_V	1.348	1.00
27_Y	149_A	1.334	1.00
18_H	158_S	1.334	1.00
265_I	270_L	1.334	1.00
83_I	110_N	1.317	1.00
52_K	155_E	1.305	1.00
17_G	23_D	1.300	1.00
77_Y	81_E	1.288	1.00
55_E	60_D	1.282	1.00
21_V	52_K	1.277	1.00
93_G	114_F	1.274	1.00
19_D	22_Y	1.271	1.00
53_V	94_I	1.266	1.00
135_G	138_K	1.262	1.00
170_G	298_F	1.253	1.00
90_L	115_V	1.252	1.00
43_T	47_K	1.247	1.00
55_E	58_P	1.245	1.00
36_P	89_S	1.244	1.00
76_V	106_A	1.238	1.00
214_I	217_K	1.235	1.00
157_L	227_M	1.232	1.00
249_S	275_T	1.231	1.00
169_I	205_A	1.225	1.00
24_I	53_V	1.216	1.00
288_I	291_N	1.212	1.00
40_V	106_A	1.200	1.00
76_V	80_E	1.188	1.00
210_Q	295_K	1.188	1.00
83_I	88_P	1.185	1.00
276_I	290_R	1.171	1.00
44_K	47_K	1.169	1.00
80_E	84_K	1.153	1.00
314_K	317_T	1.149	1.00
253_F	274_G	1.149	1.00
280_Y	286_W	1.134	1.00
314_K	318_I	1.133	1.00
83_I	91_L	1.126	1.00
339_S	342_K	1.126	1.00
21_V	117_I	1.112	1.00
130_F	143_K	1.110	1.00
210_Q	214_I	1.109	1.00
182_W	186_A	1.101	1.00
36_P	66_V	1.099	1.00
280_Y	283_G	1.099	1.00
17_G	20_I	1.096	1.00
265_I	273_L	1.093	1.00
160_S	164_L	1.087	1.00
203_M	225_M	1.080	1.00
169_I	226_L	1.077	1.00
38_L	88_P	1.076	1.00
36_P	86_I	1.075	1.00
260_I	314_K	1.073	1.00
316_L	341_E	1.071	1.00
52_K	56_N	1.071	1.00
62_K	65_V	1.071	1.00
15_F	27_Y	1.070	1.00
21_V	156_I	1.070	1.00
81_E	84_K	1.070	1.00
28_F	90_L	1.069	1.00
165_I	218_D	1.069	1.00
14_V	231_I	1.058	1.00
313_I	317_T	1.056	1.00
18_H	215_I	1.054	1.00
45_Y	49_I	1.051	1.00
93_G	116_S	1.050	1.00
320_H	323_R	1.046	1.00
78_M	82_V	1.044	1.00
28_F	33_V	1.035	1.00
45_Y	48_K	1.033	1.00
23_D	27_Y	1.028	1.00
338_S	341_E	1.028	1.00
178_A	332_D	1.023	1.00
46_T	50_A	1.017	1.00
15_F	149_A	1.007	1.00
260_I	318_I	1.006	1.00
22_Y	56_N	1.003	1.00
52_K	55_E	1.000	1.00
121_P	165_I	0.998	1.00
178_A	289_I	0.995	1.00
250_E	275_T	0.993	1.00
20_I	151_I	0.990	1.00
313_I	337_W	0.986	1.00
316_L	319_A	0.985	1.00
155_E	215_I	0.985	1.00
179_V	236_A	0.985	1.00
15_F	23_D	0.979	1.00
127_T	150_I	0.973	1.00
103_T	114_F	0.972	1.00
162_R	209_F	0.968	1.00
73_L	133_I	0.965	1.00
64_E	67_E	0.964	1.00
312_V	316_L	0.964	1.00
58_P	64_E	0.960	1.00
291_N	294_K	0.945	1.00
72_T	75_D	0.941	1.00
192_Y	196_Y	0.939	1.00
39_I	65_V	0.935	1.00
254_A	258_E	0.934	1.00
170_G	272_G	0.933	1.00
29_S	61_A	0.932	1.00
216_N	225_M	0.931	1.00
157_L	218_D	0.929	1.00
80_E	109_R	0.926	1.00
196_Y	200_L	0.922	1.00
315_A	344_A	0.920	1.00
317_T	321_T	0.919	1.00
207_H	210_Q	0.918	1.00
21_V	155_E	0.918	1.00
19_D	153_D	0.918	1.00
279_A	286_W	0.917	1.00
39_I	54_I	0.917	1.00
45_Y	50_A	0.916	1.00
68_I	78_M	0.904	1.00
107_A	112_L	0.897	1.00
90_L	113_E	0.896	1.00
65_V	68_I	0.887	1.00
165_I	208_A	0.885	1.00
100_I	118_P	0.883	1.00
88_P	323_R	0.883	1.00
162_R	297_G	0.881	1.00
74_D	78_M	0.879	1.00
260_I	311_E	0.871	1.00
26_I	61_A	0.868	1.00
218_D	228_E	0.867	1.00
41_T	99_V	0.866	1.00
166_N	209_F	0.866	1.00
201_A	226_L	0.866	1.00
250_E	271_V	0.865	1.00
127_T	231_I	0.864	1.00
282_H	332_D	0.864	1.00
266_L	269_E	0.863	1.00
191_E	194_G	0.862	1.00
41_T	46_T	0.861	1.00
273_L	276_I	0.860	1.00
175_K	179_V	0.860	1.00
13_R	30_Q	0.860	1.00
28_F	115_V	0.859	1.00
181_D	211_C	0.859	1.00
249_S	335_L	0.858	1.00
36_P	87_S	0.857	1.00
116_S	147_P	0.856	1.00
287_K	290_R	0.851	1.00
286_W	290_R	0.847	1.00
68_I	82_V	0.846	1.00
154_I	224_R	0.845	1.00
102_V	106_A	0.845	1.00
34_T	89_S	0.842	1.00
165_I	212_T	0.840	1.00
27_Y	151_I	0.839	1.00
93_G	100_I	0.839	1.00
25_S	29_S	0.837	1.00
22_Y	155_E	0.836	1.00
316_L	320_H	0.835	1.00
316_L	337_W	0.830	1.00
276_I	293_L	0.826	1.00
318_I	322_I	0.820	1.00
83_I	106_A	0.814	1.00
169_I	172_T	0.812	1.00
107_A	114_F	0.807	1.00
197_T	201_A	0.806	1.00
70_S	98_K	0.803	1.00
253_F	277_I	0.800	1.00
26_I	29_S	0.799	1.00
193_Y	196_Y	0.797	1.00
186_A	189_R	0.797	1.00
300_V	304_D	0.790	1.00
254_A	271_V	0.790	1.00
249_S	278_M	0.788	1.00
281_L	339_S	0.787	1.00
72_T	136_L	0.786	1.00
46_T	51_D	0.780	1.00
201_A	204_S	0.777	1.00
123_H	172_T	0.776	1.00
40_V	79_V	0.773	1.00
180_R	218_D	0.770	1.00
290_R	300_V	0.766	1.00
160_S	168_G	0.762	1.00
58_P	62_K	0.761	1.00
174_G	275_T	0.760	1.00
27_Y	31_L	0.760	1.00
145_K	148_L	0.759	1.00
202_L	206_K	0.758	1.00
272_G	293_L	0.754	1.00
184_L	187_K	0.752	1.00
313_I	316_L	0.752	1.00
74_D	137_Q	0.745	1.00
21_V	153_D	0.745	1.00
76_V	105_Y	0.741	1.00
284_I	333_R	0.740	1.00
163_R	167_A	0.739	1.00
176_I	212_T	0.737	1.00
251_H	267_H	0.735	1.00
318_I	321_T	0.734	1.00
73_L	136_L	0.734	1.00
79_V	102_V	0.732	1.00
25_S	60_D	0.731	1.00
277_I	280_Y	0.728	1.00
198_A	202_L	0.724	1.00
208_A	212_T	0.724	1.00
77_Y	80_E	0.721	1.00
207_H	216_N	0.720	1.00
26_I	30_Q	0.719	1.00
91_L	112_L	0.719	1.00
193_Y	232_S	0.712	1.00
334_G	337_W	0.707	1.00
253_F	340_A	0.707	1.00
204_S	208_A	0.707	1.00
257_V	270_L	0.706	1.00
62_K	66_V	0.703	1.00
21_V	53_V	0.701	1.00
338_S	342_K	0.699	1.00
68_I	79_V	0.699	1.00
237_M	242_S	0.698	1.00
289_I	293_L	0.697	1.00
18_H	154_I	0.696	1.00
179_V	191_E	0.693	1.00
202_L	288_I	0.693	1.00
164_L	167_A	0.692	1.00
212_T	218_D	0.691	1.00
70_S	75_D	0.691	1.00
252_L	328_T	0.688	1.00
299_P	304_D	0.687	1.00
206_K	209_F	0.685	1.00
24_I	117_I	0.685	1.00
310_E	313_I	0.683	1.00
192_Y	199_S	0.677	1.00
16_V	224_R	0.676	1.00
158_S	213_K	0.673	1.00
281_L	333_R	0.673	1.00
328_T	332_D	0.672	1.00
279_A	285_N	0.672	1.00
200_L	225_M	0.671	1.00
199_S	203_M	0.670	1.00
49_I	159_L	0.670	1.00
37_F	89_S	0.670	1.00
228_E	232_S	0.668	1.00
46_T	54_I	0.668	1.00
42_G	48_K	0.666	1.00
53_V	56_N	0.664	1.00
46_T	67_E	0.663	1.00
70_S	264_G	0.662	1.00
56_N	60_D	0.661	1.00
209_F	297_G	0.660	1.00
311_E	315_A	0.659	1.00
105_Y	133_I	0.654	1.00
173_I	177_I	0.654	1.00
332_D	338_S	0.652	1.00
187_K	208_A	0.647	1.00
249_S	340_A	0.644	1.00
54_I	67_E	0.643	1.00
38_L	86_I	0.642	1.00
320_H	337_W	0.641	1.00
176_I	233_S	0.640	1.00
62_K	68_I	0.638	1.00
302_A	312_V	0.636	1.00
185_A	189_R	0.632	1.00
166_N	298_F	0.626	1.00
40_V	99_V	0.626	1.00
116_S	150_I	0.625	1.00
64_E	86_I	0.624	1.00
15_F	20_I	0.623	1.00
193_Y	197_T	0.622	1.00
177_I	198_A	0.621	1.00
261_H	311_E	0.621	1.00
177_I	285_N	0.619	1.00
14_V	213_K	0.617	1.00
163_R	266_L	0.616	1.00
164_L	266_L	0.615	1.00
81_E	137_Q	0.615	1.00
212_T	215_I	0.609	1.00
242_S	248_G	0.608	1.00
174_G	250_E	0.607	1.00
209_F	296_I	0.606	1.00
201_A	229_A	0.605	1.00
200_L	229_A	0.604	1.00
40_V	91_L	0.604	1.00
46_T	49_I	0.604	1.00
281_L	335_L	0.602	1.00
317_T	341_E	0.601	1.00
259_L	315_A	0.600	1.00
162_R	210_Q	0.600	1.00
211_C	218_D	0.598	1.00
66_V	88_P	0.597	1.00
52_K	156_I	0.596	1.00
216_N	224_R	0.595	1.00
108_F	111_S	0.594	1.00
166_N	297_G	0.592	1.00
75_D	102_V	0.592	1.00
93_G	99_V	0.592	1.00
72_T	264_G	0.592	1.00
173_I	296_I	0.591	1.00
76_V	132_S	0.591	1.00
204_S	226_L	0.588	1.00
139_P	143_K	0.588	1.00
135_G	142_V	0.588	1.00
51_D	58_P	0.585	1.00
271_V	274_G	0.585	1.00
319_A	323_R	0.581	1.00
38_L	68_I	0.581	1.00
114_F	148_L	0.580	1.00
22_Y	60_D	0.580	1.00
129_P	238_G	0.578	1.00
256_A	344_A	0.578	1.00
237_M	240_A	0.577	1.00
62_K	67_E	0.576	1.00
183_K	186_A	0.574	1.00
316_L	322_I	0.574	1.00
280_Y	284_I	0.574	1.00
169_I	296_I	0.573	1.00
203_M	207_H	0.571	1.00
13_R	149_A	0.569	1.00
157_L	165_I	0.569	1.00
203_M	206_K	0.564	0.99
140_V	143_K	0.564	0.99
269_E	299_P	0.564	0.99
315_A	319_A	0.564	0.99
272_G	298_F	0.563	0.99
15_F	151_I	0.562	0.99
33_V	113_E	0.562	0.99
39_I	94_I	0.561	0.99
22_Y	55_E	0.561	0.99
50_A	54_I	0.558	0.99
40_V	102_V	0.556	0.99
204_S	217_K	0.555	0.99
265_I	269_E	0.548	0.99
241_G	330_L	0.547	0.99
24_I	151_I	0.545	0.99
146_E	230_L	0.545	0.99
275_T	293_L	0.544	0.99
180_R	215_I	0.543	0.99
253_F	278_M	0.540	0.99
122_S	157_L	0.540	0.99
307_L	312_V	0.538	0.99
256_A	318_I	0.536	0.99
278_M	282_H	0.535	0.99
315_A	318_I	0.535	0.99
252_L	327_Y	0.534	0.99
25_S	61_A	0.534	0.99
173_I	292_R	0.534	0.99
217_K	227_M	0.533	0.99
162_R	200_L	0.532	0.99
293_L	298_F	0.532	0.99
310_E	314_K	0.530	0.99
335_L	339_S	0.530	0.99
80_E	106_A	0.528	0.99
162_R	165_I	0.528	0.99
92_L	115_V	0.528	0.99
181_D	279_A	0.527	0.99
21_V	56_N	0.526	0.99
105_Y	131_A	0.526	0.99
285_N	289_I	0.526	0.99
139_P	267_H	0.526	0.99
208_A	217_K	0.524	0.99
117_I	151_I	0.523	0.99
25_S	28_F	0.521	0.99
181_D	184_L	0.521	0.99
269_E	298_F	0.520	0.99
121_P	227_M	0.520	0.99
204_S	216_N	0.520	0.99
50_A	94_I	0.519	0.99
249_S	252_L	0.518	0.99
16_V	228_E	0.518	0.99
261_H	315_A	0.516	0.99
292_R	296_I	0.516	0.99
176_I	179_V	0.515	0.99
257_V	265_I	0.514	0.99
294_K	304_D	0.513	0.99
258_E	270_L	0.512	0.99
205_A	209_F	0.511	0.99
174_G	271_V	0.511	0.99
47_K	51_D	0.509	0.99
281_L	336_T	0.509	0.99
176_I	215_I	0.505	0.99
56_N	61_A	0.504	0.99
320_H	340_A	0.504	0.99
138_K	141_S	0.504	0.99
315_A	323_R	0.503	0.99
265_I	305_L	0.502	0.99
139_P	142_V	0.502	0.99
36_P	88_P	0.502	0.99
41_T	45_Y	0.502	0.99
293_L	300_V	0.501	0.99
174_G	248_G	0.501	0.99
79_V	82_V	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bfjA	5	0.9288	100	0.148	Contact Map
3ox4A	2	0.9316	100	0.155	Contact Map
4fr2A	2	0.9288	100	0.162	Contact Map
1rrmA	2	0.9259	100	0.17	Contact Map
1vljA	2	0.963	100	0.175	Contact Map
1o2dA	1	0.9231	100	0.192	Contact Map
3iv7A	2	0.9345	100	0.193	Contact Map
3zdrA	2	0.9316	100	0.197	Contact Map
3w5sA	2	0.9288	100	0.202	Contact Map
4qgsA	2	0.9145	100	0.204	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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