SPEE - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

SPEE - Polyamine aminopropyl transferase

UniProt:	Q9UXE4	Sequences: MFGWHWLLEWQTPYEFHGHLIEKVLAEEKTPYQHVTLVEFTRFGKGLIIDGKVQSTLYDEHIYHELLVHPLLLSLTKPPKSVLILGGGEGATLREVLKYKSVEKAVMVDIDEKVIEFAKKYLYEWHQGAFEDKRTNLVITDGLKFIKETKEKYDAIILDLTDPIKNSTSYMLYTKEFYEKLREILNERGGIVTQATSPSFSLEVYVTIYNTIKEVFKEASASYTYMASFDGLWGFVYGGVRPDLLSEDEVDSKINERIDGQLRFYDGYSHKISFSLPKNIKSEFQKITKISTEKDPIYVPA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	301 (268)
Sequences:	2368 (1491)
Seq/√Len:	91.1

ECOLI - SPEE
BACSU - SPEE
SULSO - SPEE

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
80_K	103_E	6.176	1.00
266_D	278_K	4.291	1.00
23_K	39_E	3.937	1.00
28_E	113_K	3.674	1.00
106_V	153_Y	3.669	1.00
182_R	240_V	3.495	1.00
84_I	93_L	3.365	1.00
81_S	104_K	3.233	1.00
104_K	136_N	3.187	1.00
115_I	139_I	3.164	1.00
265_Y	270_H	3.153	1.00
37_L	117_F	2.785	1.00
112_E	116_E	2.780	1.00
84_I	96_V	2.778	1.00
93_L	135_T	2.762	1.00
22_E	39_E	2.748	1.00
93_L	105_A	2.526	1.00
175_K	179_E	2.448	1.00
144_K	148_E	2.429	1.00
27_E	34_H	2.370	1.00
26_A	113_K	2.297	1.00
185_L	189_G	2.274	1.00
106_V	138_V	2.242	1.00
106_V	136_N	2.228	1.00
29_K	34_H	2.220	1.00
30_T	35_V	2.205	1.00
181_L	191_I	2.185	1.00
22_E	41_T	2.143	1.00
93_L	130_F	2.112	1.00
175_K	214_E	2.070	1.00
266_D	281_K	2.047	1.00
85_L	142_G	2.047	1.00
96_V	102_V	2.045	1.00
113_K	116_E	2.012	1.00
72_L	155_A	2.001	1.00
39_E	45_K	1.969	1.00
105_A	135_T	1.967	1.00
146_I	184_I	1.945	1.00
75_L	79_P	1.930	1.00
57_L	124_E	1.874	1.00
146_I	180_K	1.847	1.00
147_K	180_K	1.819	1.00
97_L	105_A	1.790	1.00
27_E	36_T	1.788	1.00
82_V	96_V	1.776	1.00
75_L	155_A	1.774	1.00
30_T	113_K	1.732	1.00
195_A	236_V	1.730	1.00
140_T	148_E	1.725	1.00
119_K	131_E	1.724	1.00
144_K	147_K	1.705	1.00
188_R	241_R	1.685	1.00
31_P	112_E	1.668	1.00
272_I	275_S	1.660	1.00
150_K	183_E	1.647	1.00
71_L	155_A	1.636	1.00
149_T	184_I	1.632	1.00
112_E	139_I	1.614	1.00
217_K	240_V	1.586	1.00
149_T	152_K	1.577	1.00
116_E	120_K	1.576	1.00
20_L	41_T	1.563	1.00
156_I	184_I	1.558	1.00
107_M	137_L	1.518	1.00
278_K	281_K	1.513	1.00
82_V	102_V	1.489	1.00
69_H	99_Y	1.461	1.00
115_I	137_L	1.461	1.00
266_D	269_S	1.457	1.00
79_P	101_S	1.456	0.99
38_V	48_I	1.447	0.99
143_L	171_M	1.434	0.99
68_V	92_T	1.434	0.99
278_K	282_S	1.421	0.99
156_I	185_L	1.417	0.99
212_I	238_G	1.388	0.99
268_Y	281_K	1.372	0.99
81_S	186_N	1.368	0.99
68_V	157_I	1.330	0.99
96_V	105_A	1.326	0.99
156_I	181_L	1.298	0.99
95_E	98_K	1.288	0.99
84_I	135_T	1.255	0.98
140_T	144_K	1.217	0.98
37_L	47_L	1.198	0.98
128_G	132_D	1.197	0.98
188_R	242_P	1.197	0.98
83_L	108_V	1.196	0.98
158_L	177_F	1.188	0.98
25_L	121_Y	1.186	0.98
156_I	189_G	1.179	0.98
56_T	228_S	1.179	0.98
61_H	279_N	1.160	0.97
59_D	228_S	1.158	0.97
224_T	235_F	1.149	0.97
26_A	117_F	1.142	0.97
263_R	282_S	1.138	0.97
128_G	131_E	1.135	0.97
158_L	191_I	1.135	0.97
170_Y	174_T	1.125	0.97
73_L	99_Y	1.120	0.97
38_V	46_G	1.118	0.97
268_Y	271_K	1.112	0.97
70_P	222_S	1.112	0.97
37_L	122_L	1.109	0.97
55_S	89_E	1.106	0.97
83_L	153_Y	1.104	0.97
72_L	96_V	1.103	0.97
192_V	222_S	1.097	0.96
81_S	106_V	1.070	0.96
57_L	122_L	1.067	0.96
187_E	240_V	1.063	0.96
145_F	153_Y	1.060	0.96
123_Y	128_G	1.058	0.96
72_L	99_Y	1.054	0.96
143_L	180_K	1.036	0.95
212_I	236_V	1.031	0.95
35_V	117_F	1.024	0.95
138_V	145_F	1.024	0.95
72_L	102_V	1.021	0.95
80_K	186_N	1.013	0.94
83_L	146_I	1.012	0.94
209_Y	213_K	1.001	0.94
146_I	181_L	1.000	0.94
66_L	273_S	0.999	0.94
223_Y	232_L	0.980	0.93
97_L	135_T	0.975	0.93
218_E	244_L	0.969	0.93
209_Y	219_A	0.965	0.93
96_V	155_A	0.964	0.93
55_S	125_W	0.962	0.93
30_T	114_V	0.947	0.92
243_D	247_E	0.945	0.92
205_Y	221_A	0.941	0.92
60_E	94_R	0.939	0.92
149_T	153_Y	0.920	0.91
188_R	240_V	0.917	0.91
132_D	135_T	0.917	0.91
24_V	36_T	0.917	0.91
176_E	179_E	0.898	0.90
81_S	152_K	0.896	0.90
68_V	72_L	0.880	0.89
97_L	132_D	0.876	0.89
72_L	82_V	0.873	0.89
152_K	186_N	0.873	0.89
248_D	271_K	0.861	0.88
102_V	105_A	0.858	0.88
66_L	222_S	0.858	0.88
191_I	238_G	0.857	0.88
179_E	182_R	0.854	0.88
14_Y	20_L	0.849	0.87
40_F	44_G	0.848	0.87
64_H	92_T	0.847	0.87
62_I	279_N	0.843	0.87
187_E	241_R	0.841	0.87
243_D	246_S	0.840	0.87
130_F	135_T	0.840	0.87
198_P	233_W	0.837	0.87
269_S	275_S	0.831	0.86
261_Q	282_S	0.831	0.86
62_I	224_T	0.824	0.86
107_M	135_T	0.823	0.86
208_I	211_T	0.822	0.86
245_L	248_D	0.815	0.85
268_Y	275_S	0.815	0.85
40_F	46_G	0.813	0.85
96_V	157_I	0.810	0.85
182_R	217_K	0.805	0.84
69_H	134_R	0.799	0.84
195_A	234_G	0.798	0.84
155_A	190_G	0.796	0.84
264_F	269_S	0.795	0.84
158_L	193_T	0.793	0.84
119_K	130_F	0.792	0.83
108_V	145_F	0.790	0.83
82_V	157_I	0.784	0.83
79_P	155_A	0.781	0.83
220_S	245_L	0.780	0.83
202_L	283_E	0.779	0.82
81_S	151_E	0.777	0.82
113_K	117_F	0.773	0.82
218_E	239_G	0.772	0.82
241_R	244_L	0.769	0.82
30_T	87_G	0.769	0.82
75_L	190_G	0.768	0.82
130_F	137_L	0.766	0.81
28_E	116_E	0.764	0.81
60_E	64_H	0.764	0.81
93_L	96_V	0.761	0.81
30_T	64_H	0.754	0.80
19_H	46_G	0.754	0.80
7_L	10_W	0.754	0.80
92_T	157_I	0.752	0.80
158_L	181_L	0.749	0.80
193_T	236_V	0.748	0.80
15_E	200_F	0.748	0.80
162_D	194_Q	0.747	0.80
55_S	122_L	0.746	0.80
163_P	173_Y	0.746	0.80
53_V	228_S	0.744	0.79
28_E	31_P	0.739	0.79
82_V	155_A	0.731	0.78
61_H	263_R	0.729	0.78
98_K	262_L	0.728	0.78
67_L	92_T	0.727	0.78
165_K	169_S	0.726	0.78
218_E	242_P	0.720	0.77
96_V	99_Y	0.714	0.77
83_L	145_F	0.712	0.76
70_P	233_W	0.712	0.76
110_I	141_D	0.710	0.76
63_Y	159_D	0.708	0.76
65_E	95_E	0.708	0.76
89_E	92_T	0.707	0.76
197_S	233_W	0.706	0.76
209_Y	236_V	0.700	0.75
220_S	243_D	0.698	0.75
69_H	95_E	0.698	0.75
217_K	239_G	0.698	0.75
10_W	16_F	0.697	0.75
7_L	38_V	0.692	0.74
206_V	210_N	0.691	0.74
266_D	275_S	0.689	0.74
207_T	211_T	0.689	0.74
81_S	156_I	0.687	0.74
180_K	184_I	0.687	0.74
145_F	149_T	0.686	0.74
55_S	91_A	0.684	0.73
224_T	264_F	0.678	0.73
219_A	236_V	0.668	0.72
76_T	79_P	0.668	0.72
179_E	183_E	0.667	0.72
110_I	229_F	0.665	0.71
36_T	54_Q	0.664	0.71
56_T	59_D	0.662	0.71
34_H	51_G	0.661	0.71
81_S	103_E	0.660	0.71
93_L	107_M	0.656	0.70
193_T	212_I	0.656	0.70
97_L	134_R	0.654	0.70
24_V	38_V	0.652	0.70
221_A	234_G	0.651	0.70
31_P	113_K	0.649	0.70
210_N	213_K	0.649	0.70
109_D	165_K	0.649	0.70
143_L	176_E	0.645	0.69
37_L	118_A	0.645	0.69
87_G	95_E	0.643	0.69
274_F	277_P	0.642	0.69
107_M	115_I	0.641	0.69
67_L	234_G	0.640	0.68
218_E	243_D	0.639	0.68
75_L	78_P	0.637	0.68
219_A	238_G	0.635	0.68
241_R	245_L	0.635	0.68
54_Q	194_Q	0.635	0.68
205_Y	234_G	0.633	0.68
54_Q	162_D	0.633	0.68
211_T	214_E	0.631	0.67
90_G	130_F	0.630	0.67
78_P	81_S	0.629	0.67
269_S	273_S	0.629	0.67
173_Y	194_Q	0.625	0.67
127_Q	131_E	0.625	0.67
116_E	119_K	0.625	0.67
30_T	33_Q	0.624	0.67
183_E	187_E	0.623	0.66
22_E	40_F	0.619	0.66
30_T	111_D	0.619	0.66
67_L	235_F	0.619	0.66
118_A	121_Y	0.618	0.66
160_L	173_Y	0.618	0.66
239_G	243_D	0.617	0.66
140_T	145_F	0.617	0.66
54_Q	63_Y	0.616	0.66
99_Y	102_V	0.616	0.66
162_D	173_Y	0.615	0.65
172_L	178_Y	0.615	0.65
270_H	274_F	0.614	0.65
71_L	237_Y	0.614	0.65
26_A	35_V	0.613	0.65
71_L	190_G	0.613	0.65
102_V	155_A	0.611	0.65
212_I	221_A	0.607	0.64
175_K	211_T	0.605	0.64
36_T	48_I	0.603	0.64
218_E	241_R	0.601	0.64
71_L	222_S	0.600	0.64
90_G	195_A	0.600	0.64
48_I	53_V	0.598	0.63
89_E	107_M	0.594	0.63
93_L	129_A	0.593	0.63
151_E	184_I	0.593	0.63
66_L	269_S	0.593	0.63
65_E	69_H	0.590	0.62
127_Q	130_F	0.589	0.62
84_I	87_G	0.587	0.62
54_Q	64_H	0.586	0.62
71_L	192_V	0.585	0.62
46_G	53_V	0.575	0.60
35_V	113_K	0.575	0.60
110_I	114_V	0.575	0.60
267_G	278_K	0.574	0.60
115_I	130_F	0.573	0.60
87_G	111_D	0.572	0.60
200_F	230_D	0.570	0.60
180_K	183_E	0.570	0.60
89_E	109_D	0.567	0.59
152_K	184_I	0.567	0.59
33_Q	162_D	0.567	0.59
66_L	224_T	0.566	0.59
107_M	130_F	0.565	0.59
178_Y	208_I	0.565	0.59
126_H	129_A	0.564	0.59
165_K	170_Y	0.563	0.59
223_Y	234_G	0.563	0.59
198_P	231_G	0.562	0.59
54_Q	161_T	0.562	0.59
255_N	259_D	0.561	0.58
84_I	157_I	0.560	0.58
64_H	125_W	0.560	0.58
205_Y	262_L	0.560	0.58
194_Q	233_W	0.560	0.58
33_Q	111_D	0.559	0.58
151_E	186_N	0.558	0.58
60_E	63_Y	0.558	0.58
225_Y	232_L	0.558	0.58
110_I	142_G	0.558	0.58
212_I	219_A	0.556	0.58
110_I	172_L	0.556	0.58
63_Y	162_D	0.555	0.58
223_Y	280_I	0.551	0.57
171_M	174_T	0.550	0.57
239_G	242_P	0.549	0.57
147_K	184_I	0.548	0.57
66_L	264_F	0.548	0.57
181_L	211_T	0.546	0.56
68_V	96_V	0.545	0.56
26_A	121_Y	0.544	0.56
147_K	176_E	0.544	0.56
50_D	111_D	0.543	0.56
69_H	93_L	0.543	0.56
8_L	11_Q	0.543	0.56
49_I	109_D	0.541	0.56
75_L	80_K	0.540	0.56
45_K	124_E	0.540	0.56
142_G	229_F	0.540	0.56
151_E	187_E	0.539	0.55
196_T	208_I	0.539	0.55
256_E	261_Q	0.538	0.55
60_E	90_G	0.535	0.55
8_L	18_G	0.535	0.55
80_K	282_S	0.535	0.55
163_P	194_Q	0.533	0.55
158_L	212_I	0.533	0.55
75_L	99_Y	0.533	0.55
33_Q	49_I	0.532	0.54
54_Q	229_F	0.530	0.54
248_D	257_R	0.529	0.54
244_L	247_E	0.529	0.54
47_L	122_L	0.528	0.54
74_S	239_G	0.528	0.54
271_K	275_S	0.526	0.54
124_E	188_R	0.526	0.54
47_L	92_T	0.525	0.53
255_N	260_G	0.523	0.53
220_S	274_F	0.523	0.53
17_H	46_G	0.521	0.53
275_S	280_I	0.520	0.53
241_R	247_E	0.519	0.53
33_Q	89_E	0.518	0.53
231_G	264_F	0.516	0.52
79_P	237_Y	0.516	0.52
78_P	188_R	0.515	0.52
159_D	194_Q	0.515	0.52
69_H	107_M	0.513	0.52
16_F	20_L	0.512	0.52
30_T	117_F	0.511	0.52
163_P	166_N	0.511	0.52
63_Y	111_D	0.510	0.51
57_L	90_G	0.510	0.51
106_V	145_F	0.509	0.51
195_A	204_V	0.509	0.51
24_V	27_E	0.508	0.51
108_V	140_T	0.508	0.51
74_S	79_P	0.507	0.51
142_G	158_L	0.507	0.51
54_Q	196_T	0.507	0.51
161_T	173_Y	0.506	0.51
123_Y	126_H	0.506	0.51
52_K	164_I	0.506	0.51
120_K	131_E	0.506	0.51
76_T	243_D	0.505	0.51
30_T	153_Y	0.503	0.50
269_S	272_I	0.503	0.50
179_E	240_V	0.502	0.50
15_E	19_H	0.502	0.50
91_A	229_F	0.502	0.50
76_T	188_R	0.502	0.50
276_L	280_I	0.501	0.50
209_Y	221_A	0.501	0.50
210_N	214_E	0.500	0.50

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1uirA	4	0.9934	100	0.376	Contact Map
1inlA	3	0.9203	100	0.414	Contact Map
2o07A	2	0.9236	100	0.42	Contact Map
1xj5A	4	0.9302	100	0.42	Contact Map
2cmgA	2	0.8704	100	0.424	Contact Map
2i7cA	2	0.9236	100	0.425	Contact Map
2pt6A	2	0.9236	100	0.43	Contact Map
2b2cA	2	0.8538	100	0.435	Contact Map
1mjfA	2	0.8738	100	0.437	Contact Map
1iy9A	3	0.907	100	0.442	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0089 seconds.