GREMLIN Database
SPEE - Polyamine aminopropyl transferase
UniProt: Q9UXE4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 301 (268)
Sequences: 2368 (1491)
Seq/√Len: 91.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_K103_E6.1761.00
266_D278_K4.2911.00
23_K39_E3.9371.00
28_E113_K3.6741.00
106_V153_Y3.6691.00
182_R240_V3.4951.00
84_I93_L3.3651.00
81_S104_K3.2331.00
104_K136_N3.1871.00
115_I139_I3.1641.00
265_Y270_H3.1531.00
37_L117_F2.7851.00
112_E116_E2.7801.00
84_I96_V2.7781.00
93_L135_T2.7621.00
22_E39_E2.7481.00
93_L105_A2.5261.00
175_K179_E2.4481.00
144_K148_E2.4291.00
27_E34_H2.3701.00
26_A113_K2.2971.00
185_L189_G2.2741.00
106_V138_V2.2421.00
106_V136_N2.2281.00
29_K34_H2.2201.00
30_T35_V2.2051.00
181_L191_I2.1851.00
22_E41_T2.1431.00
93_L130_F2.1121.00
175_K214_E2.0701.00
266_D281_K2.0471.00
85_L142_G2.0471.00
96_V102_V2.0451.00
113_K116_E2.0121.00
72_L155_A2.0011.00
39_E45_K1.9691.00
105_A135_T1.9671.00
146_I184_I1.9451.00
75_L79_P1.9301.00
57_L124_E1.8741.00
146_I180_K1.8471.00
147_K180_K1.8191.00
97_L105_A1.7901.00
27_E36_T1.7881.00
82_V96_V1.7761.00
75_L155_A1.7741.00
30_T113_K1.7321.00
195_A236_V1.7301.00
140_T148_E1.7251.00
119_K131_E1.7241.00
144_K147_K1.7051.00
188_R241_R1.6851.00
31_P112_E1.6681.00
272_I275_S1.6601.00
150_K183_E1.6471.00
71_L155_A1.6361.00
149_T184_I1.6321.00
112_E139_I1.6141.00
217_K240_V1.5861.00
149_T152_K1.5771.00
116_E120_K1.5761.00
20_L41_T1.5631.00
156_I184_I1.5581.00
107_M137_L1.5181.00
278_K281_K1.5131.00
82_V102_V1.4891.00
69_H99_Y1.4611.00
115_I137_L1.4611.00
266_D269_S1.4571.00
79_P101_S1.4560.99
38_V48_I1.4470.99
143_L171_M1.4340.99
68_V92_T1.4340.99
278_K282_S1.4210.99
156_I185_L1.4170.99
212_I238_G1.3880.99
268_Y281_K1.3720.99
81_S186_N1.3680.99
68_V157_I1.3300.99
96_V105_A1.3260.99
156_I181_L1.2980.99
95_E98_K1.2880.99
84_I135_T1.2550.98
140_T144_K1.2170.98
37_L47_L1.1980.98
128_G132_D1.1970.98
188_R242_P1.1970.98
83_L108_V1.1960.98
158_L177_F1.1880.98
25_L121_Y1.1860.98
156_I189_G1.1790.98
56_T228_S1.1790.98
61_H279_N1.1600.97
59_D228_S1.1580.97
224_T235_F1.1490.97
26_A117_F1.1420.97
263_R282_S1.1380.97
128_G131_E1.1350.97
158_L191_I1.1350.97
170_Y174_T1.1250.97
73_L99_Y1.1200.97
38_V46_G1.1180.97
268_Y271_K1.1120.97
70_P222_S1.1120.97
37_L122_L1.1090.97
55_S89_E1.1060.97
83_L153_Y1.1040.97
72_L96_V1.1030.97
192_V222_S1.0970.96
81_S106_V1.0700.96
57_L122_L1.0670.96
187_E240_V1.0630.96
145_F153_Y1.0600.96
123_Y128_G1.0580.96
72_L99_Y1.0540.96
143_L180_K1.0360.95
212_I236_V1.0310.95
35_V117_F1.0240.95
138_V145_F1.0240.95
72_L102_V1.0210.95
80_K186_N1.0130.94
83_L146_I1.0120.94
209_Y213_K1.0010.94
146_I181_L1.0000.94
66_L273_S0.9990.94
223_Y232_L0.9800.93
97_L135_T0.9750.93
218_E244_L0.9690.93
209_Y219_A0.9650.93
96_V155_A0.9640.93
55_S125_W0.9620.93
30_T114_V0.9470.92
243_D247_E0.9450.92
205_Y221_A0.9410.92
60_E94_R0.9390.92
149_T153_Y0.9200.91
188_R240_V0.9170.91
132_D135_T0.9170.91
24_V36_T0.9170.91
176_E179_E0.8980.90
81_S152_K0.8960.90
68_V72_L0.8800.89
97_L132_D0.8760.89
72_L82_V0.8730.89
152_K186_N0.8730.89
248_D271_K0.8610.88
102_V105_A0.8580.88
66_L222_S0.8580.88
191_I238_G0.8570.88
179_E182_R0.8540.88
14_Y20_L0.8490.87
40_F44_G0.8480.87
64_H92_T0.8470.87
62_I279_N0.8430.87
187_E241_R0.8410.87
243_D246_S0.8400.87
130_F135_T0.8400.87
198_P233_W0.8370.87
269_S275_S0.8310.86
261_Q282_S0.8310.86
62_I224_T0.8240.86
107_M135_T0.8230.86
208_I211_T0.8220.86
245_L248_D0.8150.85
268_Y275_S0.8150.85
40_F46_G0.8130.85
96_V157_I0.8100.85
182_R217_K0.8050.84
69_H134_R0.7990.84
195_A234_G0.7980.84
155_A190_G0.7960.84
264_F269_S0.7950.84
158_L193_T0.7930.84
119_K130_F0.7920.83
108_V145_F0.7900.83
82_V157_I0.7840.83
79_P155_A0.7810.83
220_S245_L0.7800.83
202_L283_E0.7790.82
81_S151_E0.7770.82
113_K117_F0.7730.82
218_E239_G0.7720.82
241_R244_L0.7690.82
30_T87_G0.7690.82
75_L190_G0.7680.82
130_F137_L0.7660.81
28_E116_E0.7640.81
60_E64_H0.7640.81
93_L96_V0.7610.81
30_T64_H0.7540.80
19_H46_G0.7540.80
7_L10_W0.7540.80
92_T157_I0.7520.80
158_L181_L0.7490.80
193_T236_V0.7480.80
15_E200_F0.7480.80
162_D194_Q0.7470.80
55_S122_L0.7460.80
163_P173_Y0.7460.80
53_V228_S0.7440.79
28_E31_P0.7390.79
82_V155_A0.7310.78
61_H263_R0.7290.78
98_K262_L0.7280.78
67_L92_T0.7270.78
165_K169_S0.7260.78
218_E242_P0.7200.77
96_V99_Y0.7140.77
83_L145_F0.7120.76
70_P233_W0.7120.76
110_I141_D0.7100.76
63_Y159_D0.7080.76
65_E95_E0.7080.76
89_E92_T0.7070.76
197_S233_W0.7060.76
209_Y236_V0.7000.75
220_S243_D0.6980.75
69_H95_E0.6980.75
217_K239_G0.6980.75
10_W16_F0.6970.75
7_L38_V0.6920.74
206_V210_N0.6910.74
266_D275_S0.6890.74
207_T211_T0.6890.74
81_S156_I0.6870.74
180_K184_I0.6870.74
145_F149_T0.6860.74
55_S91_A0.6840.73
224_T264_F0.6780.73
219_A236_V0.6680.72
76_T79_P0.6680.72
179_E183_E0.6670.72
110_I229_F0.6650.71
36_T54_Q0.6640.71
56_T59_D0.6620.71
34_H51_G0.6610.71
81_S103_E0.6600.71
93_L107_M0.6560.70
193_T212_I0.6560.70
97_L134_R0.6540.70
24_V38_V0.6520.70
221_A234_G0.6510.70
31_P113_K0.6490.70
210_N213_K0.6490.70
109_D165_K0.6490.70
143_L176_E0.6450.69
37_L118_A0.6450.69
87_G95_E0.6430.69
274_F277_P0.6420.69
107_M115_I0.6410.69
67_L234_G0.6400.68
218_E243_D0.6390.68
75_L78_P0.6370.68
219_A238_G0.6350.68
241_R245_L0.6350.68
54_Q194_Q0.6350.68
205_Y234_G0.6330.68
54_Q162_D0.6330.68
211_T214_E0.6310.67
90_G130_F0.6300.67
78_P81_S0.6290.67
269_S273_S0.6290.67
173_Y194_Q0.6250.67
127_Q131_E0.6250.67
116_E119_K0.6250.67
30_T33_Q0.6240.67
183_E187_E0.6230.66
22_E40_F0.6190.66
30_T111_D0.6190.66
67_L235_F0.6190.66
118_A121_Y0.6180.66
160_L173_Y0.6180.66
239_G243_D0.6170.66
140_T145_F0.6170.66
54_Q63_Y0.6160.66
99_Y102_V0.6160.66
162_D173_Y0.6150.65
172_L178_Y0.6150.65
270_H274_F0.6140.65
71_L237_Y0.6140.65
26_A35_V0.6130.65
71_L190_G0.6130.65
102_V155_A0.6110.65
212_I221_A0.6070.64
175_K211_T0.6050.64
36_T48_I0.6030.64
218_E241_R0.6010.64
71_L222_S0.6000.64
90_G195_A0.6000.64
48_I53_V0.5980.63
89_E107_M0.5940.63
93_L129_A0.5930.63
151_E184_I0.5930.63
66_L269_S0.5930.63
65_E69_H0.5900.62
127_Q130_F0.5890.62
84_I87_G0.5870.62
54_Q64_H0.5860.62
71_L192_V0.5850.62
46_G53_V0.5750.60
35_V113_K0.5750.60
110_I114_V0.5750.60
267_G278_K0.5740.60
115_I130_F0.5730.60
87_G111_D0.5720.60
200_F230_D0.5700.60
180_K183_E0.5700.60
89_E109_D0.5670.59
152_K184_I0.5670.59
33_Q162_D0.5670.59
66_L224_T0.5660.59
107_M130_F0.5650.59
178_Y208_I0.5650.59
126_H129_A0.5640.59
165_K170_Y0.5630.59
223_Y234_G0.5630.59
198_P231_G0.5620.59
54_Q161_T0.5620.59
255_N259_D0.5610.58
84_I157_I0.5600.58
64_H125_W0.5600.58
205_Y262_L0.5600.58
194_Q233_W0.5600.58
33_Q111_D0.5590.58
151_E186_N0.5580.58
60_E63_Y0.5580.58
225_Y232_L0.5580.58
110_I142_G0.5580.58
212_I219_A0.5560.58
110_I172_L0.5560.58
63_Y162_D0.5550.58
223_Y280_I0.5510.57
171_M174_T0.5500.57
239_G242_P0.5490.57
147_K184_I0.5480.57
66_L264_F0.5480.57
181_L211_T0.5460.56
68_V96_V0.5450.56
26_A121_Y0.5440.56
147_K176_E0.5440.56
50_D111_D0.5430.56
69_H93_L0.5430.56
8_L11_Q0.5430.56
49_I109_D0.5410.56
75_L80_K0.5400.56
45_K124_E0.5400.56
142_G229_F0.5400.56
151_E187_E0.5390.55
196_T208_I0.5390.55
256_E261_Q0.5380.55
60_E90_G0.5350.55
8_L18_G0.5350.55
80_K282_S0.5350.55
163_P194_Q0.5330.55
158_L212_I0.5330.55
75_L99_Y0.5330.55
33_Q49_I0.5320.54
54_Q229_F0.5300.54
248_D257_R0.5290.54
244_L247_E0.5290.54
47_L122_L0.5280.54
74_S239_G0.5280.54
271_K275_S0.5260.54
124_E188_R0.5260.54
47_L92_T0.5250.53
255_N260_G0.5230.53
220_S274_F0.5230.53
17_H46_G0.5210.53
275_S280_I0.5200.53
241_R247_E0.5190.53
33_Q89_E0.5180.53
231_G264_F0.5160.52
79_P237_Y0.5160.52
78_P188_R0.5150.52
159_D194_Q0.5150.52
69_H107_M0.5130.52
16_F20_L0.5120.52
30_T117_F0.5110.52
163_P166_N0.5110.52
63_Y111_D0.5100.51
57_L90_G0.5100.51
106_V145_F0.5090.51
195_A204_V0.5090.51
24_V27_E0.5080.51
108_V140_T0.5080.51
74_S79_P0.5070.51
142_G158_L0.5070.51
54_Q196_T0.5070.51
161_T173_Y0.5060.51
123_Y126_H0.5060.51
52_K164_I0.5060.51
120_K131_E0.5060.51
76_T243_D0.5050.51
30_T153_Y0.5030.50
269_S272_I0.5030.50
179_E240_V0.5020.50
15_E19_H0.5020.50
91_A229_F0.5020.50
76_T188_R0.5020.50
276_L280_I0.5010.50
209_Y221_A0.5010.50
210_N214_E0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uirA 4 0.9934 100 0.376 Contact Map
1inlA 3 0.9203 100 0.414 Contact Map
2o07A 2 0.9236 100 0.42 Contact Map
1xj5A 4 0.9302 100 0.42 Contact Map
2cmgA 2 0.8704 100 0.424 Contact Map
2i7cA 2 0.9236 100 0.425 Contact Map
2pt6A 2 0.9236 100 0.43 Contact Map
2b2cA 2 0.8538 100 0.435 Contact Map
1mjfA 2 0.8738 100 0.437 Contact Map
1iy9A 3 0.907 100 0.442 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.009 seconds.