GREMLIN Database
RL21 - 50S ribosomal protein L21e
UniProt: Q9UXE0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 101 (94)
Sequences: 484 (265)
Seq/√Len: 27.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_H10_T3.4001.00
18_K47_N2.5440.99
27_P30_S2.4650.99
6_K10_T2.3720.99
13_R90_R2.2260.98
74_Y94_L2.1190.97
34_V96_P1.9430.95
38_E72_R1.8820.94
81_G84_E1.8520.94
9_R64_G1.8500.94
67_I88_I1.8230.93
61_G64_G1.8180.93
31_K47_N1.7660.92
45_K60_Q1.7590.92
36_Y96_P1.6780.90
5_S10_T1.5990.88
10_T65_K1.5650.87
6_K11_R1.5300.85
19_S22_E1.5230.85
41_N96_P1.5010.84
77_S88_I1.4580.83
42_V93_H1.4520.82
49_S76_V1.4370.82
43_V63_V1.4230.81
11_R14_S1.4130.80
5_S73_A1.4010.80
82_D86_V1.3990.80
4_H11_R1.3870.79
18_K48_P1.3450.77
22_E25_A1.3280.76
37_K40_D1.3240.76
31_K95_V1.3180.76
39_G42_V1.3140.75
42_V61_G1.3080.75
68_G88_I1.2670.73
41_N65_K1.2560.72
45_K95_V1.1960.68
42_V89_V1.1840.67
15_L78_V1.1690.66
18_K27_P1.1690.66
68_G94_L1.1540.65
17_R98_N1.1380.64
63_V97_F1.1360.64
52_Q93_H1.1360.64
33_M39_G1.0880.61
44_V62_K1.0790.60
16_L64_G1.0670.59
22_E35_E1.0460.58
48_P65_K1.0350.57
43_V97_F1.0280.56
24_G76_V1.0270.56
17_R87_I1.0120.55
12_S60_Q1.0100.55
11_R19_S1.0080.55
90_R93_H0.9940.54
68_G85_K0.9780.52
21_R24_G0.9720.52
13_R49_S0.9580.51
30_S33_M0.9430.50
75_L88_I0.9420.50
16_L74_Y0.9400.50
45_K59_Y0.9380.49
32_L91_P0.9170.48
58_R81_G0.9060.47
70_R88_I0.9010.47
70_R94_L0.8820.45
4_H46_I0.8760.45
39_G90_R0.8720.44
27_P50_V0.8690.44
15_L57_R0.8590.43
92_E97_F0.8420.42
79_T87_I0.8370.42
26_V30_S0.8310.41
72_R86_V0.8310.41
26_V50_V0.8220.41
8_Y49_S0.8090.40
23_R81_G0.8020.39
31_K34_V0.7870.38
38_E71_G0.7770.37
42_V53_G0.7650.37
80_L85_K0.7530.36
42_V55_P0.7530.36
15_L98_N0.7500.36
41_N98_N0.7480.35
26_V81_G0.7230.34
26_V33_M0.7190.33
19_S92_E0.7100.33
24_G39_G0.7030.32
6_K84_E0.7030.32
43_V52_Q0.7010.32
30_S38_E0.6950.32
26_V29_L0.6940.32
44_V93_H0.6910.32
38_E46_I0.6890.31
80_L97_F0.6780.31
37_K62_K0.6760.31
50_V65_K0.6750.31
50_V79_T0.6710.30
4_H79_T0.6710.30
16_L20_P0.6650.30
22_E74_Y0.6460.29
4_H57_R0.6410.28
66_I72_R0.6380.28
6_K65_K0.6380.28
41_N51_H0.6340.28
13_R76_V0.6330.28
4_H51_H0.6220.27
9_R61_G0.6200.27
10_T46_I0.6170.27
61_G93_H0.6150.27
54_M93_H0.6110.27
57_R74_Y0.6070.26
17_R74_Y0.6000.26
75_L85_K0.6000.26
82_D85_K0.5930.26
21_R77_S0.5890.25
73_A79_T0.5860.25
9_R94_L0.5850.25
71_G74_Y0.5710.24
19_S77_S0.5690.24
40_D43_V0.5660.24
6_K17_R0.5590.24
18_K55_P0.5590.24
75_L80_L0.5550.23
29_L36_Y0.5400.23
53_G61_G0.5390.23
37_K87_I0.5380.23
13_R53_G0.5370.22
50_V72_R0.5340.22
14_S87_I0.5340.22
24_G77_S0.5290.22
7_G13_R0.5270.22
82_D89_V0.5260.22
75_L86_V0.5250.22
72_R79_T0.5220.22
9_R13_R0.5210.22
62_K65_K0.5100.21
67_I76_V0.5090.21
37_K77_S0.5070.21
5_S87_I0.5010.21
8_Y79_T0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vx7V 1 0.9604 100 0.064 Contact Map
3zf7U 1 0.9703 100 0.067 Contact Map
3j61T 1 0.9802 100 0.071 Contact Map
3j21R 1 0.9406 100 0.073 Contact Map
4ujrG 1 0.9703 100 0.077 Contact Map
3jywQ 1 0.9703 100 0.077 Contact Map
4a17P 1 0.9703 100 0.078 Contact Map
1vq8Q 1 0.9406 100 0.08 Contact Map
4w20T 1 0.9703 100 0.082 Contact Map
4w20Y 1 0.8812 63.9 0.91 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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