GREMLIN Database
RL15E - 50S ribosomal protein L15e
UniProt: Q9UXD0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 216 (190)
Sequences: 340 (188)
Seq/√Len: 13.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_F146_H4.4001.00
138_P142_S4.1791.00
81_R84_R3.7840.99
62_V108_Y3.3660.99
15_S174_K2.9760.97
36_I64_V2.8570.96
110_N136_S2.8220.96
73_K167_K2.5600.93
57_Q137_H2.4600.91
4_S7_H2.3860.90
66_V128_Y2.3310.89
178_L181_T2.2890.88
3_L7_H2.2350.86
143_D146_H2.2200.86
9_I45_L2.2110.86
60_V111_L2.2030.86
46_N154_N2.1830.85
92_P99_I2.1030.83
27_L120_G2.0930.83
105_A158_V2.0640.82
51_L115_G1.9620.78
70_G90_Y1.9250.77
75_R87_V1.9040.76
175_S180_G1.8500.74
143_D147_K1.8150.72
68_R71_L1.8130.72
176_R180_G1.8120.72
163_T170_R1.7500.69
44_R63_R1.7340.69
64_V104_A1.7290.68
83_K95_G1.7080.67
115_G149_L1.6800.66
56_K143_D1.6750.66
176_R181_T1.6440.64
147_K150_Q1.6360.64
57_Q139_V1.6280.64
83_K187_N1.5800.61
96_Y128_Y1.5650.60
105_A159_F1.5620.60
29_K34_P1.5540.60
12_T19_K1.5200.58
29_K142_S1.4860.56
92_P98_W1.4830.56
21_S25_Q1.4820.56
128_Y168_K1.4620.55
98_W102_E1.4400.54
173_R181_T1.4350.54
97_R145_K1.4020.52
44_R67_R1.4010.52
35_S43_T1.3950.51
66_V113_V1.3910.51
4_S11_N1.3900.51
26_R43_T1.3700.50
102_E166_G1.3560.49
113_V132_M1.3470.49
42_P55_A1.3440.49
10_E14_N1.3430.49
13_W44_R1.3320.48
176_R179_K1.3290.48
98_W169_V1.3230.48
88_Y95_G1.3070.47
31_R170_R1.3010.46
26_R31_R1.2920.46
107_K162_L1.2880.46
47_R152_P1.2810.45
19_K47_R1.2800.45
120_G127_Y1.2390.43
172_L179_K1.2330.43
179_K182_V1.2130.42
178_L185_K1.2000.41
60_V108_Y1.1930.41
38_R87_V1.1910.41
133_V146_H1.1840.40
33_E37_V1.1340.38
88_Y103_R1.1310.38
13_W84_R1.1140.37
110_N120_G1.1050.36
14_N130_I1.1030.36
61_I108_Y1.1030.36
26_R170_R1.1030.36
13_W120_G1.0750.35
169_V181_T1.0690.35
97_R165_A1.0690.35
182_V185_K1.0450.33
153_S162_L1.0430.33
35_S65_R1.0320.33
120_G147_K1.0260.32
97_R182_V1.0250.32
40_A110_N1.0220.32
94_K102_E1.0090.32
10_E145_K0.9850.31
47_R50_S0.9830.30
66_V187_N0.9790.30
106_R145_K0.9730.30
24_R28_I0.9680.30
185_K189_K0.9660.30
126_K170_R0.9650.30
180_G185_K0.9570.29
20_K133_V0.9510.29
83_K93_A0.9460.29
24_R65_R0.9430.29
121_E126_K0.9430.29
14_N46_N0.9260.28
24_R38_R0.9220.28
95_G172_L0.9200.28
175_S179_K0.9190.28
4_S72_N0.9120.27
132_M166_G0.9060.27
97_R164_S0.9050.27
80_R87_V0.9030.27
79_G84_R0.8990.27
11_N137_H0.8900.26
115_G132_M0.8890.26
139_V142_S0.8780.26
16_E127_Y0.8770.26
98_W158_V0.8740.26
80_R123_G0.8670.26
76_P125_Y0.8620.25
72_N78_K0.8610.25
29_K33_E0.8540.25
5_M29_K0.8510.25
112_E158_V0.8430.25
36_I142_S0.8360.24
98_W166_G0.8310.24
36_I84_R0.8210.24
85_M106_R0.8200.24
47_R51_L0.8200.24
120_G165_A0.8180.24
56_K59_F0.8100.23
34_P81_R0.8080.23
46_N96_Y0.8080.23
151_D154_N0.8040.23
31_R160_R0.7970.23
109_P156_N0.7930.23
29_K182_V0.7900.22
48_A129_E0.7870.22
108_Y127_Y0.7790.22
178_L184_Y0.7780.22
115_G131_V0.7770.22
31_R68_R0.7710.22
164_S173_R0.7700.22
121_E133_V0.7660.22
9_I66_V0.7640.22
104_A108_Y0.7620.21
11_N14_N0.7570.21
44_R68_R0.7560.21
163_T171_G0.7550.21
97_R185_K0.7520.21
6_Y99_I0.7520.21
99_I176_R0.7490.21
107_K169_V0.7440.21
44_R160_R0.7400.21
37_V45_L0.7380.21
121_E140_I0.7370.21
19_K186_W0.7340.20
175_S178_L0.7340.20
125_Y149_L0.7300.20
66_V165_A0.7300.20
111_L188_R0.7280.20
12_T139_V0.7260.20
17_E32_K0.7240.20
45_L109_P0.7180.20
126_K156_N0.7170.20
150_Q180_G0.7150.20
5_M23_L0.7100.20
137_H144_P0.7090.20
40_A127_Y0.7090.20
23_L121_E0.7020.19
27_L128_Y0.6980.19
71_L92_P0.6970.19
79_G178_L0.6960.19
3_L91_S0.6950.19
37_V104_A0.6940.19
89_G181_T0.6940.19
161_G170_R0.6930.19
80_R89_G0.6920.19
110_N133_V0.6910.19
9_I145_K0.6890.19
34_P80_R0.6890.19
43_T183_R0.6870.19
48_A157_R0.6850.19
64_V125_Y0.6810.19
43_T123_G0.6800.19
157_R170_R0.6790.19
111_L132_M0.6780.19
74_P93_A0.6770.19
24_R60_V0.6760.19
65_R168_K0.6730.18
88_Y102_E0.6710.18
180_G187_N0.6700.18
118_Y176_R0.6700.18
110_N179_K0.6670.18
181_T184_Y0.6640.18
63_R68_R0.6640.18
79_G83_K0.6620.18
68_R111_L0.6610.18
143_D183_R0.6580.18
41_K106_R0.6550.18
13_W166_G0.6540.18
16_E21_S0.6490.18
139_V151_D0.6490.18
120_G136_S0.6490.18
70_G74_P0.6480.18
5_M17_E0.6480.18
164_S189_K0.6370.17
64_V127_Y0.6360.17
142_S182_V0.6340.17
107_K146_H0.6260.17
33_E127_Y0.6250.17
22_V72_N0.6250.17
27_L123_G0.6250.17
3_L78_K0.6230.17
75_R123_G0.6220.17
39_L191_K0.6210.17
44_R83_K0.6180.17
112_E155_R0.6180.17
26_R160_R0.6150.17
83_K173_R0.6120.17
45_L175_S0.6120.17
28_I82_P0.6110.17
8_Y23_L0.6070.16
105_A112_E0.6070.16
6_Y44_R0.6070.16
41_K71_L0.6010.16
79_G159_F0.6010.16
121_E125_Y0.6010.16
38_R128_Y0.6010.16
38_R148_W0.5990.16
62_V111_L0.5960.16
7_H187_N0.5950.16
3_L72_N0.5940.16
57_Q144_P0.5920.16
103_R160_R0.5900.16
86_G188_R0.5870.16
57_Q142_S0.5860.16
140_I177_G0.5830.16
75_R78_K0.5810.16
31_R44_R0.5800.16
59_F155_R0.5680.15
80_R85_M0.5660.15
46_N98_W0.5630.15
97_R173_R0.5600.15
154_N176_R0.5590.15
26_R67_R0.5550.15
70_G89_G0.5540.15
122_D148_W0.5540.15
138_P178_L0.5520.15
7_H34_P0.5510.15
31_R157_R0.5500.15
143_D150_Q0.5500.15
119_V128_Y0.5490.15
17_E24_R0.5450.15
63_R118_Y0.5440.15
43_T119_V0.5410.15
73_K135_P0.5400.15
13_W168_K0.5390.15
9_I192_E0.5390.15
15_S33_E0.5380.14
181_T185_K0.5360.14
123_G138_P0.5300.14
154_N162_L0.5300.14
5_M47_R0.5280.14
4_S55_A0.5280.14
3_L82_P0.5270.14
78_K155_R0.5240.14
109_P136_S0.5240.14
35_S64_V0.5220.14
104_A132_M0.5200.14
13_W164_S0.5180.14
42_P69_G0.5180.14
12_T18_W0.5180.14
44_R148_W0.5170.14
31_R122_D0.5170.14
70_G165_A0.5130.14
105_A125_Y0.5130.14
24_R156_N0.5120.14
173_R178_L0.5110.14
50_S89_G0.5110.14
97_R191_K0.5080.14
169_V173_R0.5080.14
58_G117_Y0.5060.14
76_P178_L0.5020.14
76_P79_G0.5010.14
65_R93_A0.5010.14
107_K121_E0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zf7Q 1 0.9028 100 0.128 Contact Map
3j39N 1 0.9028 100 0.129 Contact Map
4a17L 1 0.9028 100 0.138 Contact Map
4ujrA 1 0.9074 100 0.139 Contact Map
1vx7P 1 0.9028 100 0.141 Contact Map
3j61N 1 0.8611 100 0.15 Contact Map
1vq8M 1 0.8889 100 0.172 Contact Map
3j21M 1 0.8889 100 0.176 Contact Map
1ffkI 1 0.8889 100 0.186 Contact Map
4tp8P 1 0.3472 5.7 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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