GREMLIN Database
PSA - Proteasome subunit alpha
UniProt: Q9UXC6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 241 (193)
Sequences: 3868 (2186)
Seq/√Len: 157.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_N190_E5.5011.00
51_A195_A4.2801.00
41_G150_L3.0751.00
45_K185_D3.0361.00
41_G50_I2.9681.00
220_S223_T2.8751.00
149_K161_P2.6711.00
39_A79_S2.5321.00
76_V111_I2.4841.00
44_S191_T2.4461.00
188_V220_S2.4361.00
144_D147_V2.4351.00
44_S47_S2.4111.00
102_R108_P2.3621.00
181_N197_K2.2581.00
73_D102_R2.1841.00
42_I195_A2.1751.00
183_K190_E2.1331.00
50_I141_A2.1231.00
163_Q184_E2.1141.00
71_L74_D2.0771.00
75_H108_P2.0471.00
217_G226_F2.0231.00
45_K187_N1.9941.00
188_V192_I1.9721.00
48_V141_A1.9661.00
43_K161_P1.9101.00
46_S221_T1.8491.00
111_I142_G1.8191.00
186_L194_L1.7731.00
76_V114_L1.7421.00
123_Q126_T1.7171.00
192_I216_I1.6631.00
123_Q127_Q1.6601.00
51_A216_I1.6531.00
42_I191_T1.6361.00
77_G226_F1.6241.00
98_A114_L1.6051.00
46_S188_V1.5981.00
72_I98_A1.5831.00
110_S113_Y1.5571.00
94_A118_V1.5321.00
44_S188_V1.4871.00
166_A178_L1.4811.00
137_A155_P1.4691.00
183_K186_L1.4241.00
73_D108_P1.3921.00
109_V114_L1.3911.00
78_C91_I1.3901.00
69_V217_G1.3751.00
49_V218_Y1.3741.00
182_Y185_D1.3741.00
49_V192_I1.3741.00
78_C140_I1.3351.00
47_S188_V1.3341.00
97_I117_S1.3211.00
80_F87_G1.3091.00
143_I221_T1.3071.00
181_N194_L1.2921.00
139_V165_V1.2911.00
38_T170_G1.2881.00
49_V195_A1.2841.00
151_F161_P1.2661.00
48_V150_L1.2611.00
44_S220_S1.2401.00
49_V191_T1.2281.00
125_Y134_F1.2161.00
93_Y121_V1.2141.00
72_I78_C1.2031.00
192_I218_Y1.1991.00
56_K66_I1.1811.00
196_L214_V1.1801.00
93_Y97_I1.1791.00
189_E193_L1.1761.00
139_V167_I1.1681.00
43_K148_P1.1541.00
182_Y186_L1.1491.00
140_I153_T1.1371.00
47_S191_T1.1351.00
115_T159_Y1.1321.00
77_G219_A1.1311.00
101_H105_Y1.1241.00
177_F181_N1.1221.00
58_Q62_D1.0990.99
152_M165_V1.0980.99
97_I100_Q1.0820.99
38_T174_A1.0640.99
126_T135_G1.0590.99
227_L230_T1.0520.99
122_K153_T1.0400.99
220_S227_L1.0390.99
124_M128_H1.0280.99
43_K163_Q1.0250.99
100_Q104_I1.0210.99
177_F198_A1.0140.99
54_K215_E0.9850.99
70_F91_I0.9850.99
73_D76_V0.9720.99
69_V79_S0.9660.99
117_S121_V0.9660.99
96_N100_Q0.9530.99
198_A202_T0.9520.99
177_F194_L0.9430.98
90_L136_V0.9380.98
75_H145_K0.9330.98
91_I95_R0.9250.98
139_V150_L0.9210.98
186_L190_E0.9190.98
179_E205_P0.9110.98
227_L231_N0.9100.98
82_G86_D0.9040.98
193_L197_K0.9030.98
111_I149_K0.8800.98
81_A167_I0.8770.97
50_I79_S0.8690.97
143_I148_P0.8650.97
37_W53_E0.8650.97
50_I217_G0.8580.97
70_F89_V0.8540.97
109_V117_S0.8470.97
84_A87_G0.8440.97
193_L196_L0.8380.97
101_H113_Y0.8370.97
87_G136_V0.8310.97
109_V113_Y0.8300.97
118_V140_I0.8280.96
121_V124_M0.8280.96
186_L191_T0.8250.96
162_Y165_V0.8230.96
40_I178_L0.8160.96
70_F80_F0.8150.96
164_A178_L0.8130.96
197_K201_A0.8050.96
80_F85_S0.8020.96
75_H109_V0.8020.96
220_S225_L0.7950.96
187_N191_T0.7930.95
101_H110_S0.7920.95
189_E192_I0.7920.95
68_K182_Y0.7910.95
49_V188_V0.7880.95
110_S115_T0.7870.95
54_K213_T0.7840.95
107_E145_K0.7840.95
52_S81_A0.7810.95
212_N231_N0.7810.95
143_I147_V0.7690.95
223_T227_L0.7650.95
166_A174_A0.7610.94
72_I114_L0.7520.94
40_I195_A0.7460.94
96_N99_L0.7460.94
92_D95_R0.7430.94
101_H109_V0.7420.94
121_V134_F0.7410.94
196_L216_I0.7400.93
48_V51_A0.7330.93
55_R169_Q0.7280.93
50_I77_G0.7270.93
77_G217_G0.7250.93
112_D146_S0.7250.93
39_A139_V0.7250.93
35_K176_E0.7230.93
174_A198_A0.7180.92
40_I60_L0.7180.92
36_G88_R0.7160.92
118_V138_L0.7120.92
178_L198_A0.7100.92
78_C138_L0.7070.92
197_K200_S0.7010.92
99_L104_I0.6960.91
122_K138_L0.6930.91
68_K81_A0.6840.91
87_G91_I0.6830.90
99_L102_R0.6800.90
90_L118_V0.6780.90
67_E215_E0.6780.90
152_M162_Y0.6770.90
226_F230_T0.6770.90
169_Q207_E0.6760.90
189_E222_Q0.6730.90
216_I229_M0.6710.90
36_G142_G0.6700.90
207_E210_T0.6690.90
177_F197_K0.6690.90
110_S145_K0.6670.89
116_K120_D0.6590.89
84_A172_Y0.6590.89
59_S62_D0.6570.89
188_V191_T0.6570.89
200_S203_L0.6570.89
69_V77_G0.6540.88
59_S63_V0.6520.88
98_A105_Y0.6520.88
93_Y117_S0.6510.88
68_K169_Q0.6480.88
38_T61_L0.6470.88
157_G168_G0.6440.88
71_L75_H0.6420.88
97_I121_V0.6420.88
228_K231_N0.6410.87
125_Y153_T0.6390.87
137_A167_I0.6370.87
144_D149_K0.6230.86
115_T151_F0.6210.86
48_V219_A0.6180.86
143_I219_A0.6170.85
192_I229_M0.6170.85
74_D108_P0.6130.85
150_L162_Y0.6080.85
188_V227_L0.6050.84
158_Q165_V0.6020.84
196_L199_L0.5990.84
202_T207_E0.5970.84
95_R114_L0.5960.83
38_T199_L0.5960.83
166_A175_T0.5960.83
190_E194_L0.5950.83
118_V153_T0.5950.83
155_P167_I0.5930.83
39_A52_S0.5910.83
211_P231_N0.5900.83
69_V194_L0.5860.82
85_S204_K0.5860.82
170_G202_T0.5850.82
218_Y227_L0.5830.82
67_E92_D0.5830.82
141_A219_A0.5830.82
99_L107_E0.5820.82
83_L89_V0.5800.82
203_L208_K0.5790.82
99_L103_L0.5790.82
143_I223_T0.5790.82
120_D124_M0.5730.81
72_I94_A0.5720.81
166_A171_Y0.5700.81
143_I149_K0.5690.81
48_V148_P0.5680.80
55_R210_T0.5680.80
154_E158_Q0.5660.80
136_V178_L0.5640.80
151_F199_L0.5640.80
40_I51_A0.5630.80
100_Q103_L0.5620.80
127_Q156_S0.5620.80
102_R106_D0.5590.79
146_S149_K0.5590.79
62_D84_A0.5590.79
104_I120_D0.5570.79
112_D116_K0.5560.79
89_V118_V0.5550.79
145_K184_E0.5530.79
44_S49_V0.5520.78
38_T198_A0.5500.78
103_L114_L0.5450.78
222_Q225_L0.5440.77
40_I198_A0.5430.77
196_L209_L0.5400.77
41_G141_A0.5380.77
188_V218_Y0.5370.77
52_S69_V0.5360.76
55_R211_P0.5360.76
90_L121_V0.5360.76
53_E57_A0.5330.76
115_T140_I0.5290.76
111_I140_I0.5280.75
53_E208_K0.5280.75
126_T164_A0.5280.75
200_S212_N0.5260.75
177_F201_A0.5260.75
107_E118_V0.5230.75
152_M171_Y0.5220.75
201_A213_T0.5180.74
145_K149_K0.5170.74
66_I70_F0.5150.74
144_D151_F0.5150.74
86_D133_P0.5140.73
42_I51_A0.5140.73
135_G155_P0.5110.73
92_D172_Y0.5110.73
136_V167_I0.5100.73
170_G173_T0.5080.73
81_A158_Q0.5080.73
65_S76_V0.5070.72
190_E193_L0.5060.72
83_L86_D0.5060.72
170_G174_A0.5030.72
38_T211_P0.5010.72
76_V109_V0.5010.72
43_K180_K0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r3oB 1 0.9627 100 0.12 Contact Map
1j2pA 3 0.9668 100 0.12 Contact Map
4r3oA 1 0.9834 100 0.123 Contact Map
3h4pA 3 0.9336 100 0.124 Contact Map
1rypC 1 0.9751 100 0.125 Contact Map
1rypB 1 0.971 100 0.126 Contact Map
4r3oC 1 0.971 100 0.13 Contact Map
1rypF 1 0.9502 100 0.13 Contact Map
1yarA 3 0.917 100 0.132 Contact Map
4r3oF 1 0.9544 100 0.135 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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