PSA - SULSO - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

PSA - Proteasome subunit alpha

UniProt:	Q9UXC6	Sequences: MAFGPAAMGYDRAITIFSPDGSLYQVDYAFEAVKKGWTAIGIKSKSSVVIASEKRKAQSLLDVDSIEKVFLIDDHVGCSFAGLASDGRVLIDYARNIALQHRLIYDEPVSIDYLTKSVADVKQMYTQHGGVRPFGVALVIAGIDKSVPKLFMTEPSGQYMPYQAVAIGQGYYTATEFLEKNYKEDLNVEETILLALKALSATLKPNEKLTPNTVEIGYASTQTGLFLKMTNEDKNMYLQKL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	241 (193)
Sequences:	3868 (2186)
Seq/√Len:	157.3

HALSA - PSA PSB
SULSO - PSA PSB2 PSB1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
187_N	190_E	5.501	1.00
51_A	195_A	4.280	1.00
41_G	150_L	3.075	1.00
45_K	185_D	3.036	1.00
41_G	50_I	2.968	1.00
220_S	223_T	2.875	1.00
149_K	161_P	2.671	1.00
39_A	79_S	2.532	1.00
76_V	111_I	2.484	1.00
44_S	191_T	2.446	1.00
188_V	220_S	2.436	1.00
144_D	147_V	2.435	1.00
44_S	47_S	2.411	1.00
102_R	108_P	2.362	1.00
181_N	197_K	2.258	1.00
73_D	102_R	2.184	1.00
42_I	195_A	2.175	1.00
183_K	190_E	2.133	1.00
50_I	141_A	2.123	1.00
163_Q	184_E	2.114	1.00
71_L	74_D	2.077	1.00
75_H	108_P	2.047	1.00
217_G	226_F	2.023	1.00
45_K	187_N	1.994	1.00
188_V	192_I	1.972	1.00
48_V	141_A	1.966	1.00
43_K	161_P	1.910	1.00
46_S	221_T	1.849	1.00
111_I	142_G	1.819	1.00
186_L	194_L	1.773	1.00
76_V	114_L	1.742	1.00
123_Q	126_T	1.717	1.00
192_I	216_I	1.663	1.00
123_Q	127_Q	1.660	1.00
51_A	216_I	1.653	1.00
42_I	191_T	1.636	1.00
77_G	226_F	1.624	1.00
98_A	114_L	1.605	1.00
46_S	188_V	1.598	1.00
72_I	98_A	1.583	1.00
110_S	113_Y	1.557	1.00
94_A	118_V	1.532	1.00
44_S	188_V	1.487	1.00
166_A	178_L	1.481	1.00
137_A	155_P	1.469	1.00
183_K	186_L	1.424	1.00
73_D	108_P	1.392	1.00
109_V	114_L	1.391	1.00
78_C	91_I	1.390	1.00
69_V	217_G	1.375	1.00
49_V	218_Y	1.374	1.00
182_Y	185_D	1.374	1.00
49_V	192_I	1.374	1.00
78_C	140_I	1.335	1.00
47_S	188_V	1.334	1.00
97_I	117_S	1.321	1.00
80_F	87_G	1.309	1.00
143_I	221_T	1.307	1.00
181_N	194_L	1.292	1.00
139_V	165_V	1.291	1.00
38_T	170_G	1.288	1.00
49_V	195_A	1.284	1.00
151_F	161_P	1.266	1.00
48_V	150_L	1.261	1.00
44_S	220_S	1.240	1.00
49_V	191_T	1.228	1.00
125_Y	134_F	1.216	1.00
93_Y	121_V	1.214	1.00
72_I	78_C	1.203	1.00
192_I	218_Y	1.199	1.00
56_K	66_I	1.181	1.00
196_L	214_V	1.180	1.00
93_Y	97_I	1.179	1.00
189_E	193_L	1.176	1.00
139_V	167_I	1.168	1.00
43_K	148_P	1.154	1.00
182_Y	186_L	1.149	1.00
140_I	153_T	1.137	1.00
47_S	191_T	1.135	1.00
115_T	159_Y	1.132	1.00
77_G	219_A	1.131	1.00
101_H	105_Y	1.124	1.00
177_F	181_N	1.122	1.00
58_Q	62_D	1.099	0.99
152_M	165_V	1.098	0.99
97_I	100_Q	1.082	0.99
38_T	174_A	1.064	0.99
126_T	135_G	1.059	0.99
227_L	230_T	1.052	0.99
122_K	153_T	1.040	0.99
220_S	227_L	1.039	0.99
124_M	128_H	1.028	0.99
43_K	163_Q	1.025	0.99
100_Q	104_I	1.021	0.99
177_F	198_A	1.014	0.99
54_K	215_E	0.985	0.99
70_F	91_I	0.985	0.99
73_D	76_V	0.972	0.99
69_V	79_S	0.966	0.99
117_S	121_V	0.966	0.99
96_N	100_Q	0.953	0.99
198_A	202_T	0.952	0.99
177_F	194_L	0.943	0.98
90_L	136_V	0.938	0.98
75_H	145_K	0.933	0.98
91_I	95_R	0.925	0.98
139_V	150_L	0.921	0.98
186_L	190_E	0.919	0.98
179_E	205_P	0.911	0.98
227_L	231_N	0.910	0.98
82_G	86_D	0.904	0.98
193_L	197_K	0.903	0.98
111_I	149_K	0.880	0.98
81_A	167_I	0.877	0.97
50_I	79_S	0.869	0.97
143_I	148_P	0.865	0.97
37_W	53_E	0.865	0.97
50_I	217_G	0.858	0.97
70_F	89_V	0.854	0.97
109_V	117_S	0.847	0.97
84_A	87_G	0.844	0.97
193_L	196_L	0.838	0.97
101_H	113_Y	0.837	0.97
87_G	136_V	0.831	0.97
109_V	113_Y	0.830	0.97
118_V	140_I	0.828	0.96
121_V	124_M	0.828	0.96
186_L	191_T	0.825	0.96
162_Y	165_V	0.823	0.96
40_I	178_L	0.816	0.96
70_F	80_F	0.815	0.96
164_A	178_L	0.813	0.96
197_K	201_A	0.805	0.96
80_F	85_S	0.802	0.96
75_H	109_V	0.802	0.96
220_S	225_L	0.795	0.96
187_N	191_T	0.793	0.95
101_H	110_S	0.792	0.95
189_E	192_I	0.792	0.95
68_K	182_Y	0.791	0.95
49_V	188_V	0.788	0.95
110_S	115_T	0.787	0.95
54_K	213_T	0.784	0.95
107_E	145_K	0.784	0.95
52_S	81_A	0.781	0.95
212_N	231_N	0.781	0.95
143_I	147_V	0.769	0.95
223_T	227_L	0.765	0.95
166_A	174_A	0.761	0.94
72_I	114_L	0.752	0.94
40_I	195_A	0.746	0.94
96_N	99_L	0.746	0.94
92_D	95_R	0.743	0.94
101_H	109_V	0.742	0.94
121_V	134_F	0.741	0.94
196_L	216_I	0.740	0.93
48_V	51_A	0.733	0.93
55_R	169_Q	0.728	0.93
50_I	77_G	0.727	0.93
77_G	217_G	0.725	0.93
112_D	146_S	0.725	0.93
39_A	139_V	0.725	0.93
35_K	176_E	0.723	0.93
174_A	198_A	0.718	0.92
40_I	60_L	0.718	0.92
36_G	88_R	0.716	0.92
118_V	138_L	0.712	0.92
178_L	198_A	0.710	0.92
78_C	138_L	0.707	0.92
197_K	200_S	0.701	0.92
99_L	104_I	0.696	0.91
122_K	138_L	0.693	0.91
68_K	81_A	0.684	0.91
87_G	91_I	0.683	0.90
99_L	102_R	0.680	0.90
90_L	118_V	0.678	0.90
67_E	215_E	0.678	0.90
152_M	162_Y	0.677	0.90
226_F	230_T	0.677	0.90
169_Q	207_E	0.676	0.90
189_E	222_Q	0.673	0.90
216_I	229_M	0.671	0.90
36_G	142_G	0.670	0.90
207_E	210_T	0.669	0.90
177_F	197_K	0.669	0.90
110_S	145_K	0.667	0.89
116_K	120_D	0.659	0.89
84_A	172_Y	0.659	0.89
59_S	62_D	0.657	0.89
188_V	191_T	0.657	0.89
200_S	203_L	0.657	0.89
69_V	77_G	0.654	0.88
59_S	63_V	0.652	0.88
98_A	105_Y	0.652	0.88
93_Y	117_S	0.651	0.88
68_K	169_Q	0.648	0.88
38_T	61_L	0.647	0.88
157_G	168_G	0.644	0.88
71_L	75_H	0.642	0.88
97_I	121_V	0.642	0.88
228_K	231_N	0.641	0.87
125_Y	153_T	0.639	0.87
137_A	167_I	0.637	0.87
144_D	149_K	0.623	0.86
115_T	151_F	0.621	0.86
48_V	219_A	0.618	0.86
143_I	219_A	0.617	0.85
192_I	229_M	0.617	0.85
74_D	108_P	0.613	0.85
150_L	162_Y	0.608	0.85
188_V	227_L	0.605	0.84
158_Q	165_V	0.602	0.84
196_L	199_L	0.599	0.84
202_T	207_E	0.597	0.84
95_R	114_L	0.596	0.83
38_T	199_L	0.596	0.83
166_A	175_T	0.596	0.83
190_E	194_L	0.595	0.83
118_V	153_T	0.595	0.83
155_P	167_I	0.593	0.83
39_A	52_S	0.591	0.83
211_P	231_N	0.590	0.83
69_V	194_L	0.586	0.82
85_S	204_K	0.586	0.82
170_G	202_T	0.585	0.82
218_Y	227_L	0.583	0.82
67_E	92_D	0.583	0.82
141_A	219_A	0.583	0.82
99_L	107_E	0.582	0.82
83_L	89_V	0.580	0.82
203_L	208_K	0.579	0.82
99_L	103_L	0.579	0.82
143_I	223_T	0.579	0.82
120_D	124_M	0.573	0.81
72_I	94_A	0.572	0.81
166_A	171_Y	0.570	0.81
143_I	149_K	0.569	0.81
48_V	148_P	0.568	0.80
55_R	210_T	0.568	0.80
154_E	158_Q	0.566	0.80
136_V	178_L	0.564	0.80
151_F	199_L	0.564	0.80
40_I	51_A	0.563	0.80
100_Q	103_L	0.562	0.80
127_Q	156_S	0.562	0.80
102_R	106_D	0.559	0.79
146_S	149_K	0.559	0.79
62_D	84_A	0.559	0.79
104_I	120_D	0.557	0.79
112_D	116_K	0.556	0.79
89_V	118_V	0.555	0.79
145_K	184_E	0.553	0.79
44_S	49_V	0.552	0.78
38_T	198_A	0.550	0.78
103_L	114_L	0.545	0.78
222_Q	225_L	0.544	0.77
40_I	198_A	0.543	0.77
196_L	209_L	0.540	0.77
41_G	141_A	0.538	0.77
188_V	218_Y	0.537	0.77
52_S	69_V	0.536	0.76
55_R	211_P	0.536	0.76
90_L	121_V	0.536	0.76
53_E	57_A	0.533	0.76
115_T	140_I	0.529	0.76
111_I	140_I	0.528	0.75
53_E	208_K	0.528	0.75
126_T	164_A	0.528	0.75
200_S	212_N	0.526	0.75
177_F	201_A	0.526	0.75
107_E	118_V	0.523	0.75
152_M	171_Y	0.522	0.75
201_A	213_T	0.518	0.74
145_K	149_K	0.517	0.74
66_I	70_F	0.515	0.74
144_D	151_F	0.515	0.74
86_D	133_P	0.514	0.73
42_I	51_A	0.514	0.73
135_G	155_P	0.511	0.73
92_D	172_Y	0.511	0.73
136_V	167_I	0.510	0.73
170_G	173_T	0.508	0.73
81_A	158_Q	0.508	0.73
65_S	76_V	0.507	0.72
190_E	193_L	0.506	0.72
83_L	86_D	0.506	0.72
170_G	174_A	0.503	0.72
38_T	211_P	0.501	0.72
76_V	109_V	0.501	0.72
43_K	180_K	0.500	0.71

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4r3oB	1	0.9627	100	0.12	Contact Map
1j2pA	3	0.9668	100	0.12	Contact Map
4r3oA	1	0.9834	100	0.123	Contact Map
3h4pA	3	0.9336	100	0.124	Contact Map
1rypC	1	0.9751	100	0.125	Contact Map
1rypB	1	0.971	100	0.126	Contact Map
4r3oC	1	0.971	100	0.13	Contact Map
1rypF	1	0.9502	100	0.13	Contact Map
1yarA	3	0.917	100	0.132	Contact Map
4r3oF	1	0.9544	100	0.135	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0077 seconds.