GREMLIN Database
RRP4 - Exosome complex component Rrp4
UniProt: Q9UXC4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 249 (212)
Sequences: 760 (515)
Seq/√Len: 35.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_V90_V5.4051.00
78_G90_V5.0931.00
17_V60_V5.0751.00
92_I98_A4.7901.00
128_A141_L4.7591.00
31_P35_Y4.7091.00
31_P34_P4.4141.00
131_E142_S2.8211.00
32_W35_Y2.7101.00
213_K217_E2.4221.00
124_D150_R2.3901.00
70_P139_P2.3310.99
221_K224_T2.2260.99
81_E97_K2.1870.99
19_P48_V2.1780.99
108_R116_L2.1670.99
35_Y46_T2.1220.99
158_D193_R2.0840.99
211_I215_E2.0490.99
74_D186_I2.0460.99
76_V156_V2.0240.98
75_I148_L1.9870.98
115_D118_R1.8820.97
76_V80_V1.8750.97
17_V44_Y1.8700.97
88_W117_R1.8000.97
125_Y156_V1.7450.96
22_L42_K1.7280.96
228_K231_I1.7090.95
211_I214_I1.6550.95
161_P183_G1.6460.94
69_Y162_V1.5830.93
105_L167_V1.5780.93
197_T204_E1.5650.93
221_K229_Q1.5610.93
77_I151_V1.5530.93
226_R230_F1.5520.92
87_G102_A1.5340.92
160_M215_E1.4900.91
31_P36_I1.4890.91
54_K58_F1.4800.91
214_I217_E1.4740.90
80_V120_L1.4660.90
132_N138_D1.4630.90
226_R229_Q1.4500.90
221_K225_D1.4410.89
23_L36_I1.4360.89
224_T229_Q1.4330.89
167_V174_M1.4270.89
120_L123_G1.4130.88
33_S151_V1.4050.88
218_S222_G1.3820.87
120_L185_S1.3760.87
221_K230_F1.3640.87
43_Y126_V1.3530.86
74_D130_I1.3500.86
141_L188_V1.3380.85
47_V62_P1.3230.85
149_G167_V1.3110.84
90_V126_V1.3060.84
101_P133_F1.2960.84
105_L108_R1.2780.83
19_P100_L1.2540.81
98_A128_A1.2460.81
32_W43_Y1.2300.80
63_L124_D1.2210.80
75_I127_I1.2070.79
214_I218_S1.2020.79
147_D153_N1.2020.79
217_E226_R1.1950.78
156_V159_I1.1930.78
22_L44_Y1.1860.78
178_L207_L1.1740.77
52_D61_I1.1430.75
184_C188_V1.1400.75
219_H223_L1.1330.74
88_W163_K1.1220.74
210_A214_I1.1010.72
106_L145_G1.1000.72
105_L143_V1.0730.70
154_G178_L1.0620.69
46_T132_N1.0620.69
74_D182_S1.0570.69
184_C227_I1.0510.69
73_N124_D1.0480.68
50_L186_I1.0450.68
43_Y127_I1.0380.68
139_P190_N1.0360.67
196_A208_I1.0340.67
207_L210_A1.0290.67
84_E89_V1.0270.67
174_M206_I1.0220.66
140_V143_V1.0020.65
34_P144_K0.9890.64
36_I160_M0.9810.63
54_K117_R0.9660.62
22_L43_Y0.9640.62
73_N231_I0.9620.62
43_Y199_P0.9560.61
98_A103_S0.9540.61
153_N198_C0.9390.60
27_E159_I0.9360.59
83_V87_G0.9320.59
27_E80_V0.9310.59
73_N129_R0.9300.59
118_R185_S0.9270.59
147_D185_S0.9270.59
185_S199_P0.9220.58
30_I181_K0.9210.58
77_I104_N0.9190.58
60_V158_D0.9140.58
148_L166_R0.9080.57
225_D228_K0.9080.57
81_E202_F0.9070.57
109_S143_V0.9020.57
209_E215_E0.8920.56
88_W116_L0.8910.56
217_E229_Q0.8900.56
104_N133_F0.8890.56
224_T227_I0.8860.55
133_F139_P0.8840.55
70_P209_E0.8840.55
66_S189_A0.8820.55
151_V195_W0.8760.54
120_L130_I0.8740.54
78_G91_D0.8650.53
13_P39_I0.8650.53
105_L116_L0.8590.53
210_A227_I0.8570.53
70_P198_C0.8530.52
89_V222_G0.8500.52
60_V129_R0.8500.52
212_R228_K0.8470.52
21_E160_M0.8430.52
53_V58_F0.8410.51
93_K98_A0.8350.51
52_D183_G0.8300.50
213_K230_F0.8290.50
58_F121_D0.8280.50
90_V98_A0.8260.50
21_E197_T0.8250.50
107_G116_L0.8200.50
105_L114_E0.8170.49
72_I132_N0.8130.49
83_V150_R0.8100.49
134_D137_I0.8080.49
44_Y85_I0.8020.48
223_L226_R0.8010.48
214_I223_L0.7960.48
106_L143_V0.7930.47
120_L126_V0.7880.47
45_S91_D0.7870.47
108_R114_E0.7860.47
83_V102_A0.7840.46
209_E216_N0.7820.46
47_V64_E0.7820.46
76_V201_R0.7780.46
224_T230_F0.7750.46
196_A205_E0.7710.45
129_R144_K0.7690.45
21_E59_E0.7660.45
23_L79_L0.7630.45
84_E196_A0.7630.45
106_L109_S0.7590.44
221_K228_K0.7580.44
88_W114_E0.7570.44
105_L118_R0.7530.44
51_F98_A0.7520.44
79_L129_R0.7520.44
135_R153_N0.7520.44
101_P140_V0.7510.44
217_E222_G0.7430.43
44_Y69_Y0.7430.43
66_S125_Y0.7420.43
40_N50_L0.7420.43
42_K205_E0.7410.43
84_E117_R0.7400.43
17_V23_L0.7370.42
20_G123_G0.7300.42
186_I194_I0.7270.42
156_V164_V0.7250.41
102_A116_L0.7220.41
143_V149_G0.7220.41
33_S140_V0.7200.41
24_A48_V0.7190.41
127_I185_S0.7180.41
104_N126_V0.7080.40
46_T55_D0.7050.40
157_I216_N0.7030.40
73_N125_Y0.7030.40
88_W120_L0.7010.39
125_Y162_V0.6950.39
73_N86_Y0.6910.39
109_S127_I0.6870.38
221_K226_R0.6870.38
223_L227_I0.6840.38
120_L128_A0.6830.38
108_R118_R0.6810.38
209_E217_E0.6800.38
33_S66_S0.6790.38
177_T185_S0.6780.38
102_A124_D0.6740.37
53_V193_R0.6710.37
62_P100_L0.6710.37
162_V174_M0.6670.37
217_E223_L0.6640.36
105_L120_L0.6630.36
216_N228_K0.6580.36
36_I41_S0.6580.36
224_T228_K0.6550.36
103_S127_I0.6540.36
77_I158_D0.6530.36
77_I214_I0.6520.36
32_W36_I0.6510.35
225_D230_F0.6490.35
131_E144_K0.6460.35
137_I179_T0.6440.35
62_P170_K0.6440.35
217_E221_K0.6420.35
38_K41_S0.6410.35
25_E52_D0.6410.35
74_D159_I0.6360.34
144_K147_D0.6300.34
86_Y187_F0.6290.34
23_L230_F0.6280.34
24_A72_I0.6280.34
92_I173_S0.6260.34
158_D176_E0.6250.33
105_L127_I0.6230.33
169_G174_M0.6230.33
107_G194_I0.6190.33
48_V66_S0.6170.33
95_P127_I0.6170.33
218_S229_Q0.6150.33
83_V119_Y0.6130.33
92_I133_F0.6090.32
44_Y101_P0.6070.32
69_Y95_P0.6070.32
130_I166_R0.6050.32
131_E143_V0.6020.32
120_L184_C0.6020.32
41_S134_D0.5990.31
155_I208_I0.5980.31
79_L163_K0.5920.31
19_P123_G0.5880.31
93_K155_I0.5870.31
14_R44_Y0.5820.30
87_G99_Y0.5820.30
216_N223_L0.5810.30
100_L126_V0.5810.30
24_A27_E0.5810.30
52_D178_L0.5800.30
148_L151_V0.5770.30
98_A132_N0.5730.30
86_Y118_R0.5710.29
114_E127_I0.5700.29
52_D75_I0.5690.29
139_P171_N0.5690.29
134_D194_I0.5660.29
40_N202_F0.5660.29
80_V83_V0.5650.29
54_K127_I0.5640.29
222_G226_R0.5640.29
115_D198_C0.5620.29
58_F62_P0.5610.29
60_V155_I0.5580.28
222_G231_I0.5570.28
81_E92_I0.5550.28
65_G156_V0.5540.28
207_L211_I0.5530.28
21_E50_L0.5530.28
101_P172_K0.5520.28
28_F43_Y0.5520.28
44_Y196_A0.5510.28
86_Y104_N0.5480.28
139_P153_N0.5470.28
171_N212_R0.5470.28
80_V124_D0.5460.28
144_K229_Q0.5450.28
120_L150_R0.5450.28
97_K175_Y0.5420.27
148_L164_V0.5410.27
27_E224_T0.5400.27
63_L147_D0.5390.27
77_I173_S0.5370.27
137_I140_V0.5370.27
58_F177_T0.5360.27
57_Q145_G0.5330.27
31_P76_V0.5330.27
91_D94_A0.5330.27
206_I211_I0.5320.27
205_E208_I0.5290.26
90_V205_E0.5290.26
124_D129_R0.5280.26
14_R157_I0.5280.26
106_L147_D0.5250.26
125_Y143_V0.5220.26
211_I219_H0.5210.26
61_I183_G0.5190.26
30_I59_E0.5180.26
127_I142_S0.5180.26
96_Y101_P0.5170.26
121_D124_D0.5170.26
18_V108_R0.5140.26
133_F137_I0.5120.25
105_L187_F0.5120.25
34_P137_I0.5100.25
57_Q129_R0.5090.25
219_H222_G0.5090.25
49_G78_G0.5080.25
35_Y185_S0.5070.25
21_E66_S0.5060.25
16_I20_G0.5050.25
135_R138_D0.5040.25
118_R121_D0.5030.25
120_L142_S0.5020.25
132_N135_R0.5010.25
17_V159_I0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nn6G 1 0.8394 100 0.297 Contact Map
4ifdG 1 0.8755 100 0.301 Contact Map
2je6I 3 0.8233 100 0.315 Contact Map
2z0sA 1 0.6988 100 0.356 Contact Map
2ba0A 1 0.8715 100 0.368 Contact Map
4ifdH 1 0.8795 100 0.43 Contact Map
2nn6H 1 0.8594 100 0.449 Contact Map
2ja9A 2 0.6667 100 0.481 Contact Map
2nn6I 1 0.6305 99.9 0.65 Contact Map
3m7nA 1 0.6506 99.9 0.668 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0081 seconds.