GREMLIN Database
RRP41 - Exosome complex component Rrp41
UniProt: Q9UXC2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 248 (214)
Sequences: 7818 (3704)
Seq/√Len: 253.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_K27_E3.4121.00
35_L152_D3.2381.00
56_A145_A3.1401.00
197_L233_R3.1091.00
32_K48_E2.9761.00
58_V149_A2.8021.00
231_L234_E2.8011.00
48_E53_K2.7941.00
191_I221_A2.6191.00
168_K213_E2.5851.00
26_D223_K2.4631.00
56_A129_T2.4571.00
39_K51_N2.3491.00
175_L224_G2.3451.00
144_M228_I2.3331.00
34_E48_E2.3091.00
36_G152_D2.2861.00
210_T213_E2.2091.00
159_D196_S2.2081.00
147_S160_L2.1811.00
224_G227_I2.1401.00
42_D86_F2.1331.00
33_I47_F2.0321.00
230_N234_E1.9971.00
55_I132_L1.9891.00
211_P215_R1.9771.00
54_A131_I1.9281.00
66_P69_L1.9101.00
33_I148_L1.9001.00
167_G177_L1.8441.00
193_M225_I1.8431.00
197_L230_N1.8401.00
160_L233_R1.8231.00
178_N181_E1.8121.00
168_K186_E1.7641.00
173_I216_Q1.7511.00
111_L146_A1.7471.00
167_G185_G1.7371.00
159_D197_L1.6991.00
75_A108_R1.6981.00
223_K227_I1.6821.00
151_A236_L1.6771.00
38_L57_A1.6741.00
25_P172_V1.5471.00
169_A174_I1.5351.00
173_I220_L1.5011.00
159_D198_N1.4871.00
168_K173_I1.4821.00
219_D223_K1.4631.00
162_A225_I1.4611.00
31_I49_M1.4551.00
28_L175_L1.4491.00
211_P222_V1.4451.00
160_L229_Y1.4431.00
33_I144_M1.4421.00
47_F141_V1.4331.00
222_V226_N1.4231.00
233_R237_K1.4121.00
46_I53_K1.4111.00
110_A202_L1.3941.00
170_D184_W1.3781.00
33_I235_A1.3471.00
119_L154_G1.3331.00
191_I218_F1.3301.00
226_N230_N1.3101.00
227_I230_N1.3021.00
180_T184_W1.2751.00
175_L220_L1.2711.00
74_R118_E1.2671.00
33_I231_L1.2611.00
213_E216_Q1.2491.00
49_M141_V1.2331.00
227_I231_L1.2201.00
129_T142_S1.2011.00
60_G64_M1.1991.00
111_L150_L1.1991.00
120_F156_P1.1681.00
38_L41_A1.1491.00
42_D154_G1.1441.00
108_R112_E1.1361.00
225_I229_Y1.1361.00
58_V127_V1.1271.00
143_L163_G1.1251.00
151_A155_I1.1171.00
88_T91_R1.1051.00
127_V146_A1.1001.00
163_G192_A1.0991.00
129_T146_A1.0891.00
26_D220_L1.0871.00
97_S100_E1.0841.00
61_P64_M1.0761.00
47_F145_A1.0661.00
67_R70_S1.0641.00
31_I228_I1.0621.00
165_A188_D1.0611.00
50_G135_D1.0531.00
151_A157_M1.0521.00
152_D239_K1.0421.00
58_V153_A1.0381.00
229_Y233_R1.0351.00
212_D216_Q1.0301.00
169_A184_W1.0171.00
45_A148_L1.0101.00
56_A146_A1.0091.00
215_R219_D0.9931.00
107_I129_T0.9911.00
114_A159_D0.9911.00
82_H96_P0.9901.00
60_G123_T0.9871.00
97_S101_I0.9861.00
173_I217_A0.9661.00
85_P93_N0.9641.00
35_L235_A0.9641.00
164_V175_L0.9531.00
211_P219_D0.9431.00
193_M222_V0.9391.00
147_S151_A0.9351.00
166_V221_A0.9321.00
41_A59_Y0.9311.00
231_L235_A0.9221.00
174_I181_E0.9151.00
115_V150_L0.9141.00
148_L235_A0.9131.00
114_A147_S0.9071.00
115_V125_I0.9071.00
172_V216_Q0.9061.00
43_G58_V0.9051.00
147_S233_R0.8971.00
74_R117_V0.8951.00
171_G186_E0.8871.00
69_L74_R0.8861.00
86_F90_E0.8851.00
85_P88_T0.8851.00
42_D59_Y0.8791.00
140_L163_G0.8751.00
173_I213_E0.8731.00
166_V220_L0.8711.00
230_N233_R0.8681.00
166_V175_L0.8600.99
166_V173_I0.8580.99
223_K226_N0.8580.99
66_P71_L0.8560.99
147_S157_M0.8520.99
62_K123_T0.8520.99
67_R71_L0.8510.99
219_D222_V0.8490.99
96_P101_I0.8370.99
139_R165_A0.8370.99
60_G154_G0.8320.99
114_A161_I0.8310.99
35_L148_L0.8300.99
110_A192_A0.8210.99
42_D60_G0.8200.99
144_M232_E0.8140.99
134_A138_S0.8110.99
41_A57_A0.8100.99
186_E208_S0.7940.99
228_I232_E0.7930.99
82_H87_S0.7860.99
87_S91_R0.7840.99
54_A129_T0.7840.99
31_I231_L0.7830.99
59_Y126_D0.7820.99
31_I144_M0.7780.99
233_R236_L0.7780.99
86_F89_D0.7780.99
143_L161_I0.7770.99
28_L227_I0.7760.99
63_E67_R0.7690.99
29_R176_D0.7680.99
47_F144_M0.7660.99
78_R100_E0.7630.99
220_L224_G0.7590.99
234_E237_K0.7580.99
27_E30_S0.7480.99
160_L196_S0.7410.98
164_V224_G0.7400.98
54_A142_S0.7390.98
105_K112_E0.7370.98
134_A179_E0.7340.98
85_P91_R0.7310.98
60_G119_L0.7270.98
148_L232_E0.7240.98
43_G149_A0.7210.98
49_M140_L0.7210.98
166_V189_M0.7200.98
87_S90_E0.7160.98
68_H71_L0.7150.98
172_V181_E0.7140.98
75_A105_K0.7130.98
120_F123_T0.7120.98
38_L55_I0.7110.98
139_R190_P0.7100.98
61_P126_D0.7080.98
75_A107_I0.7040.98
46_I132_L0.7030.98
151_A233_R0.7020.98
56_A127_V0.7000.98
216_Q219_D0.6990.98
86_F91_R0.6990.98
54_A141_V0.6980.98
60_G153_A0.6950.98
144_M163_G0.6940.98
162_A228_I0.6920.98
37_V53_K0.6910.98
48_E51_N0.6900.98
101_I104_S0.6880.98
34_E37_V0.6880.98
60_G155_I0.6850.97
165_A190_P0.6840.97
182_D188_D0.6840.97
200_V218_F0.6770.97
215_R222_V0.6750.97
35_L45_A0.6720.97
169_A172_V0.6700.97
144_M162_A0.6660.97
57_A130_E0.6650.97
99_R103_L0.6640.97
140_L143_L0.6620.97
166_V191_I0.6570.97
32_K46_I0.6570.97
23_R181_E0.6550.97
60_G63_E0.6540.97
198_N226_N0.6520.97
54_A145_A0.6510.97
212_D215_R0.6500.97
41_A44_S0.6440.96
103_L139_R0.6370.96
114_A158_R0.6290.96
140_L190_P0.6280.96
105_K108_R0.6280.96
61_P123_T0.6270.96
61_P67_R0.6220.96
36_G43_G0.6180.95
164_V228_I0.6130.95
40_N89_D0.6110.95
45_A145_A0.6070.95
78_R126_D0.6070.95
75_A117_V0.6060.95
103_L137_G0.6040.95
37_V46_I0.6040.95
180_T183_M0.6040.95
71_L122_R0.6010.95
38_L45_A0.6010.95
203_F222_V0.5990.95
51_N135_D0.5990.95
166_V217_A0.5980.94
189_M205_L0.5940.94
161_I196_S0.5930.94
81_Y103_L0.5920.94
85_P90_E0.5900.94
63_E123_T0.5900.94
236_L239_K0.5890.94
164_V225_I0.5890.94
157_M160_L0.5880.94
91_R94_P0.5860.94
85_P89_D0.5840.94
49_M164_V0.5830.94
192_A202_L0.5830.94
63_E124_A0.5820.94
81_Y142_S0.5790.93
187_A209_M0.5790.93
216_Q220_L0.5770.93
151_A160_L0.5770.93
34_E46_I0.5740.93
214_F218_F0.5730.93
60_G125_I0.5720.93
147_S159_D0.5720.93
114_A201_T0.5710.93
72_P115_V0.5700.93
125_I150_L0.5700.93
51_N133_Q0.5680.93
189_M200_V0.5680.93
44_S55_I0.5660.93
59_Y128_F0.5640.93
107_I143_L0.5640.93
43_G152_D0.5630.93
129_T145_A0.5600.92
234_E238_S0.5600.92
85_P92_K0.5590.92
144_M148_L0.5570.92
179_E182_D0.5510.92
124_A133_Q0.5510.92
77_L117_V0.5510.92
119_L155_I0.5510.92
131_I136_A0.5500.92
44_S57_A0.5500.92
186_E213_E0.5480.91
220_L223_K0.5470.91
105_K109_E0.5470.91
133_Q136_A0.5450.91
161_I201_T0.5410.91
58_V145_A0.5410.91
116_L119_L0.5410.91
138_S141_V0.5400.91
61_P66_P0.5390.91
226_N229_Y0.5340.90
52_T136_A0.5330.90
49_M144_M0.5310.90
79_V146_A0.5310.90
64_M67_R0.5300.90
235_A238_S0.5290.90
69_L72_P0.5280.90
196_S233_R0.5270.90
187_A207_G0.5270.90
176_D181_E0.5230.90
197_L226_N0.5230.90
71_L125_I0.5210.89
40_N51_N0.5190.89
47_F54_A0.5180.89
68_H74_R0.5170.89
52_T141_V0.5160.89
209_M213_E0.5150.89
45_A152_D0.5130.89
123_T131_I0.5120.89
137_G182_D0.5100.88
93_N96_P0.5080.88
162_A232_E0.5030.88
219_D226_N0.5030.88
82_H128_F0.5020.88
63_E66_P0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2je6B 2 0.9435 100 0.126 Contact Map
2wnrB 1 0.8952 100 0.149 Contact Map
3m7nD 1 0.9556 100 0.153 Contact Map
2po1A 1 0.9516 100 0.159 Contact Map
4ifdB 1 0.9637 100 0.172 Contact Map
2nn6F 1 0.8831 100 0.174 Contact Map
2nn6C 1 0.9556 100 0.174 Contact Map
2nn6B 1 0.9355 100 0.174 Contact Map
2po1B 1 0.9516 100 0.177 Contact Map
2nn6E 1 0.9718 100 0.183 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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