GREMLIN Database
RRP42 - Exosome complex component Rrp42
UniProt: Q9UXC0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 275 (220)
Sequences: 5295 (2550)
Seq/√Len: 171.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_L167_N3.8521.00
33_K36_D3.8111.00
48_K60_T3.5601.00
268_E271_K3.2051.00
57_K62_M3.1751.00
67_T164_A3.1001.00
41_S57_K3.0711.00
195_Y232_D2.9691.00
30_D214_D2.9491.00
211_V261_T2.9321.00
35_T260_S2.8321.00
195_Y231_P2.8091.00
65_A160_A2.7931.00
51_D93_L2.7181.00
45_D167_N2.6811.00
64_L147_L2.5891.00
159_L265_L2.5131.00
162_V196_P2.5111.00
203_A213_P2.4671.00
227_F258_A2.4641.00
63_V146_V2.3861.00
43_T57_K2.3811.00
73_K76_E2.3061.00
196_P270_K2.2121.00
260_S264_K2.1451.00
248_L259_R2.1161.00
248_L252_D2.1021.00
72_D75_Y1.9991.00
82_G115_D1.9761.00
42_I56_V1.9511.00
72_D76_E1.8671.00
47_A66_G1.8201.00
267_E271_K1.7931.00
198_V262_A1.7931.00
40_L265_L1.7491.00
196_P266_L1.7141.00
247_S250_D1.6921.00
42_I163_A1.6881.00
81_Q127_T1.6491.00
231_P270_K1.6351.00
204_K250_D1.6321.00
34_L208_Y1.6181.00
67_T142_L1.6121.00
37_Y211_V1.5821.00
29_Q216_D1.5801.00
117_S237_G1.5461.00
29_Q214_D1.5301.00
104_D108_I1.4291.00
118_L161_S1.4271.00
264_K268_E1.4081.00
256_N260_S1.4061.00
35_T257_T1.4051.00
55_L62_M1.3991.00
166_Y193_L1.3981.00
259_R263_V1.3721.00
42_I272_H1.3681.00
42_I268_E1.3611.00
262_A266_L1.3571.00
71_I136_S1.3411.00
209_L257_T1.3361.00
252_D256_N1.3301.00
40_L268_E1.3231.00
248_L256_N1.3061.00
124_L165_L1.2931.00
89_E103_P1.2871.00
231_P267_E1.2831.00
67_T168_T1.2761.00
47_A50_A1.2591.00
195_Y230_T1.2581.00
229_Y262_A1.2571.00
230_T234_K1.2571.00
162_V270_K1.2251.00
227_F255_E1.2171.00
266_L270_K1.2111.00
162_V166_Y1.2061.00
230_T236_V1.1951.00
81_Q126_L1.1881.00
264_K267_E1.1831.00
229_Y259_R1.1641.00
104_D107_A1.1431.00
142_L161_S1.1171.00
203_A221_M1.1111.00
144_V157_C1.1071.00
103_P108_I1.0831.00
211_V257_T1.0771.00
65_A144_V1.0731.00
70_E141_W1.0661.00
256_N259_R1.0621.00
123_A197_V1.0551.00
115_D119_R1.0390.99
200_I211_V1.0380.99
159_L269_L1.0300.99
37_Y264_K1.0260.99
50_A66_G1.0210.99
123_A195_Y1.0190.99
129_L169_K1.0140.99
30_D205_V1.0100.99
40_L58_L1.0060.99
65_A142_L1.0040.99
206_D220_I0.9950.99
199_T228_S0.9860.99
68_K141_W0.9790.99
263_V267_E0.9780.99
58_L156_A0.9750.99
205_V220_I0.9730.99
202_V225_I0.9710.99
45_D52_G0.9630.99
167_N171_Y0.9620.99
69_L140_V0.9620.99
89_E99_E0.9610.99
209_L253_Q0.9600.99
209_L254_A0.9560.99
249_Q253_Q0.9540.99
123_A230_T0.9530.99
28_R217_E0.9510.99
123_A162_V0.9490.99
38_R212_D0.9450.99
56_V156_A0.9290.99
140_V169_K0.9260.99
167_N170_V0.9210.99
268_E272_H0.9180.99
252_D259_R0.9140.99
205_V210_V0.9140.99
63_V157_C0.9080.99
169_K193_L0.9040.98
204_K209_L0.9000.98
89_E101_G0.8950.98
47_A54_A0.8950.98
202_V209_L0.8870.98
162_V193_L0.8800.98
267_E270_K0.8710.98
58_L155_D0.8700.98
44_L272_H0.8700.98
202_V258_A0.8690.98
43_T55_L0.8560.98
58_L200_I0.8550.98
52_G168_T0.8480.98
78_T81_Q0.8450.98
166_Y170_V0.8440.98
144_V161_S0.8370.97
142_L165_L0.8370.97
163_A269_L0.8360.97
209_L250_D0.8290.97
60_T150_G0.8220.97
123_A194_N0.8190.97
208_Y253_Q0.8160.97
228_S237_G0.8150.97
43_T46_Y0.8150.97
155_D199_T0.8080.97
36_D39_P0.8050.97
69_L168_T0.8040.97
202_V227_F0.7980.97
253_Q256_N0.7960.97
99_E103_P0.7930.96
207_K222_D0.7920.96
70_E136_S0.7890.96
126_L135_K0.7870.96
90_L149_Y0.7860.96
41_S55_L0.7820.96
218_E224_K0.7780.96
84_L124_L0.7750.96
27_I33_K0.7690.96
124_L140_V0.7670.96
86_V161_S0.7640.96
261_T264_K0.7620.96
198_V265_L0.7610.96
214_D220_I0.7610.96
253_Q257_T0.7590.96
63_V160_A0.7580.95
114_V144_V0.7570.95
75_Y81_Q0.7550.95
75_Y78_T0.7550.95
196_P231_P0.7530.95
89_E143_D0.7480.95
223_A242_G0.7370.95
80_N135_K0.7330.95
242_G245_S0.7300.94
140_V165_L0.7290.94
42_I159_L0.7270.94
251_I255_E0.7270.94
144_V160_A0.7270.94
129_L171_Y0.7260.94
155_D158_T0.7200.94
66_G145_Y0.7170.94
26_G208_Y0.7150.94
56_V159_L0.7110.94
162_V273_L0.7100.94
69_L170_V0.7090.94
136_S171_Y0.7080.94
60_T148_D0.7070.93
65_A86_V0.7040.93
30_D210_V0.7020.93
250_D253_Q0.7020.93
94_A153_V0.7000.93
216_D220_I0.7000.93
210_V214_D0.6970.93
235_I255_E0.6940.93
65_A161_S0.6930.93
100_P103_P0.6920.93
206_D243_K0.6910.93
112_R119_R0.6890.93
82_G112_R0.6770.92
67_T140_V0.6690.91
249_Q259_R0.6690.91
54_A163_A0.6570.91
67_T160_A0.6570.91
119_R122_K0.6550.91
166_Y169_K0.6540.91
87_N143_D0.6530.90
37_Y200_I0.6530.90
260_S263_V0.6520.90
84_L142_L0.6480.90
26_G34_L0.6470.90
112_R115_D0.6470.90
125_D128_K0.6460.90
158_T199_T0.6420.90
82_G126_L0.6410.90
166_Y270_K0.6390.90
166_Y196_P0.6370.89
200_I261_T0.6360.89
63_V156_A0.6350.89
88_V218_E0.6340.89
79_P124_L0.6320.89
249_Q252_D0.6320.89
193_L196_P0.6320.89
88_V153_V0.6310.89
69_L136_S0.6300.89
74_P82_G0.6280.89
99_E104_D0.6280.89
225_I240_K0.6270.89
109_E116_R0.6230.88
52_G167_N0.6160.88
231_P266_L0.6150.88
117_S228_S0.6130.88
98_F101_G0.6130.88
61_T151_G0.6120.87
95_Y149_Y0.6100.87
149_Y215_L0.6090.87
98_F149_Y0.6090.87
44_L171_Y0.6080.87
89_E94_A0.6070.87
194_N230_T0.6070.87
28_R31_G0.6070.87
166_Y273_L0.6030.87
113_V239_Q0.6020.87
244_G247_S0.6010.86
32_R217_E0.6010.86
201_S226_S0.6000.86
258_A261_T0.5970.86
113_V154_L0.5960.86
144_V153_V0.5960.86
44_L163_A0.5950.86
248_L255_E0.5950.86
110_L153_V0.5930.86
114_V158_T0.5910.86
77_D232_D0.5900.85
29_Q210_V0.5900.85
206_D222_D0.5880.85
253_Q267_E0.5880.85
84_L161_S0.5870.85
46_Y62_M0.5840.85
41_S268_E0.5840.85
153_V218_E0.5830.85
233_L263_V0.5820.85
154_L224_K0.5820.85
49_K96_E0.5800.85
76_E79_P0.5780.84
63_V144_V0.5770.84
200_I262_A0.5750.84
224_K241_S0.5700.83
222_D243_K0.5690.83
122_K236_V0.5660.83
155_D201_S0.5650.83
229_Y235_I0.5640.83
149_Y152_N0.5640.83
157_C161_S0.5620.83
110_L154_L0.5610.83
68_K143_D0.5600.82
76_E81_Q0.5550.82
65_A162_V0.5550.82
205_V222_D0.5540.82
230_T266_L0.5540.82
86_V157_C0.5540.82
255_E259_R0.5530.82
112_R116_R0.5470.81
46_Y66_G0.5470.81
117_S122_K0.5450.81
66_G142_L0.5430.80
50_A53_S0.5400.80
256_N263_V0.5390.80
72_D81_Q0.5390.80
70_E74_P0.5390.80
28_R32_R0.5370.80
240_K243_K0.5370.80
146_V157_C0.5360.80
37_Y40_L0.5350.79
37_Y58_L0.5350.79
58_L159_L0.5350.79
160_A206_D0.5330.79
154_L218_E0.5330.79
235_I238_I0.5320.79
257_T261_T0.5280.79
61_T156_A0.5280.79
128_K171_Y0.5270.78
238_I259_R0.5240.78
212_D217_E0.5220.78
154_L226_S0.5210.78
34_L210_V0.5210.78
45_D171_Y0.5200.78
36_D264_K0.5190.77
215_L219_S0.5190.77
83_N86_V0.5190.77
88_V157_C0.5190.77
195_Y270_K0.5170.77
112_R228_S0.5160.77
28_R38_R0.5140.77
72_D139_T0.5120.76
85_I141_W0.5110.76
153_V224_K0.5100.76
149_Y154_L0.5070.76
225_I235_I0.5070.76
209_L216_D0.5060.76
46_Y55_L0.5050.76
83_N119_R0.5050.76
199_T226_S0.5030.75
49_K60_T0.5030.75
99_E141_W0.5020.75
81_Q128_K0.5020.75
79_P82_G0.5010.75
106_N154_L0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2po1B 1 0.96 100 0.126 Contact Map
2je6A 3 0.9891 100 0.126 Contact Map
2wnrA 1 0.9491 100 0.14 Contact Map
4ifdA 1 0.9709 100 0.161 Contact Map
2nn6C 1 0.96 100 0.164 Contact Map
2nn6E 1 0.9564 100 0.165 Contact Map
3m7nG 1 0.9236 100 0.167 Contact Map
2nn6A 1 0.9673 100 0.193 Contact Map
4ifdC 1 0.9491 100 0.232 Contact Map
4ifdE 1 0.9127 100 0.258 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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