GREMLIN Database
BRIX - Probable Brix domain-containing ribosomal biogenesis protein
UniProt: Q9UXB9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 170 (153)
Sequences: 611 (325)
Seq/√Len: 26.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_Y123_F4.0311.00
141_N144_L3.8341.00
141_N155_M3.6881.00
30_V152_L3.6721.00
10_I27_L3.4661.00
8_I31_L3.0151.00
58_Y76_D2.9451.00
10_I34_S2.8701.00
27_L62_V2.6350.99
138_V154_F2.4030.99
48_F59_L2.2370.98
100_S103_Q2.1320.97
101_L104_I2.1200.97
8_I60_L1.9780.95
60_L74_V1.9350.95
145_I148_N1.9160.94
14_R17_S1.8830.94
65_K70_L1.8620.93
104_I107_H1.8540.93
113_K121_R1.8500.93
24_L62_V1.8080.92
71_R85_F1.7810.92
9_V56_A1.7600.91
20_T62_V1.7580.91
108_S129_M1.6910.90
62_V72_I1.6000.87
19_R22_N1.5790.86
20_T69_P1.5780.86
17_S40_G1.5300.84
114_L144_L1.5290.84
78_E82_I1.5290.84
26_V69_P1.5020.83
50_R53_N1.4820.82
124_L143_R1.4490.81
112_I141_N1.3900.78
146_H149_I1.3860.78
111_C129_M1.3440.75
43_S46_E1.3210.74
136_C139_V1.3140.74
9_V51_A1.3090.73
27_L160_N1.3000.73
114_L146_H1.2910.72
143_R150_C1.2810.72
32_P129_M1.2790.72
14_R40_G1.2750.71
26_V96_D1.2530.70
121_R125_V1.2480.70
93_L96_D1.2470.70
60_L72_I1.2400.69
69_P88_L1.2400.69
78_E81_S1.2250.68
35_V56_A1.2240.68
74_V127_M1.1710.65
51_A56_A1.1620.64
10_I60_L1.1580.64
74_V123_F1.1540.64
122_D126_D1.1440.63
113_K143_R1.1420.63
26_V93_L1.1100.61
49_E55_G1.1000.60
122_D125_V1.0790.58
31_L107_H1.0670.57
78_E86_F1.0640.57
7_R55_G1.0540.56
27_L108_S1.0470.56
7_R35_V1.0300.55
147_T151_E1.0120.53
8_I30_V0.9840.51
19_R68_N0.9840.51
17_S88_L0.9790.51
16_P20_T0.9790.51
122_D146_H0.9700.50
81_S109_N0.9610.50
141_N146_H0.9590.49
148_N153_L0.9580.49
61_F68_N0.9530.49
68_N91_L0.9500.49
15_D96_D0.9420.48
137_D155_M0.9400.48
88_L91_L0.9340.48
66_N69_P0.9320.47
37_I47_I0.9220.47
119_F122_D0.9180.46
16_P40_G0.9100.46
146_H151_E0.9070.46
137_D152_L0.9070.46
125_V131_N0.9060.46
20_T25_N0.9000.45
42_K97_Y0.8990.45
37_I56_A0.8950.45
12_S24_L0.8920.44
92_S96_D0.8910.44
48_F77_L0.8830.44
97_Y100_S0.8830.44
15_D18_I0.8710.43
132_L136_C0.8710.43
74_V86_F0.8700.43
81_S153_L0.8650.43
23_F40_G0.8590.42
32_P120_L0.8550.42
153_L157_T0.8550.42
63_L70_L0.8510.42
54_L135_N0.8490.41
54_L93_L0.8430.41
97_Y101_L0.8430.41
87_K101_L0.8360.40
43_S59_L0.8320.40
134_N151_E0.8320.40
34_S37_I0.8260.40
101_L158_T0.8230.40
95_S123_F0.8150.39
7_R30_V0.8140.39
144_L151_E0.8120.39
10_I107_H0.8050.38
47_I67_G0.8000.38
8_I68_N0.7920.37
120_L128_N0.7920.37
76_D82_I0.7910.37
18_I25_N0.7850.37
59_L127_M0.7850.37
141_N148_N0.7830.37
121_R144_L0.7820.37
81_S116_E0.7640.35
62_V118_D0.7630.35
33_D55_G0.7630.35
102_N140_V0.7570.35
147_T156_L0.7530.35
109_N116_E0.7500.34
18_I21_R0.7470.34
82_I153_L0.7450.34
22_N43_S0.7420.34
74_V93_L0.7410.34
108_S130_Y0.7400.34
110_V116_E0.7370.34
29_F154_F0.7340.33
73_I83_K0.7340.33
14_R41_K0.7330.33
27_L127_M0.7320.33
79_S140_V0.7240.33
135_N138_V0.7220.33
88_L117_C0.7220.33
137_D153_L0.7190.32
17_S20_T0.7180.32
49_E52_I0.7140.32
24_L27_L0.7130.32
65_K116_E0.7090.32
74_V124_L0.7030.31
38_T67_G0.6990.31
8_I33_D0.6930.31
79_S93_L0.6910.31
97_Y102_N0.6900.31
14_R38_T0.6860.30
148_N157_T0.6820.30
78_E83_K0.6750.30
52_I79_S0.6700.29
97_Y104_I0.6680.29
126_D133_T0.6590.29
89_S121_R0.6560.28
9_V43_S0.6490.28
42_K133_T0.6490.28
20_T64_A0.6480.28
100_S104_I0.6470.28
30_V140_V0.6440.28
10_I45_I0.6430.28
8_I94_P0.6420.28
151_E157_T0.6380.27
7_R56_A0.6370.27
52_I55_G0.6320.27
50_R54_L0.6280.27
24_L87_K0.6260.27
42_K50_R0.6250.27
48_F71_R0.6200.26
73_I154_F0.6170.26
107_H136_C0.6070.26
35_V72_I0.6070.26
32_P155_M0.6060.26
58_Y126_D0.6050.25
20_T95_S0.6050.25
10_I24_L0.6030.25
33_D152_L0.6020.25
150_C153_L0.6010.25
50_R101_L0.5990.25
46_E101_L0.5980.25
110_V159_K0.5910.25
93_L103_Q0.5910.25
149_I157_T0.5910.25
47_I59_L0.5900.25
51_A159_K0.5860.24
48_F52_I0.5820.24
25_N67_G0.5800.24
47_I156_L0.5800.24
61_F122_D0.5780.24
14_R19_R0.5780.24
58_Y127_M0.5760.24
31_L44_K0.5720.24
34_S40_G0.5700.24
13_S69_P0.5690.23
41_K50_R0.5680.23
70_L152_L0.5630.23
99_V103_Q0.5600.23
110_V134_N0.5600.23
77_L114_L0.5580.23
82_I109_N0.5560.23
101_L141_N0.5550.23
62_V69_P0.5550.23
52_I77_L0.5530.23
151_E156_L0.5520.23
110_V113_K0.5490.22
57_L131_N0.5420.22
33_D57_L0.5400.22
50_R87_K0.5380.22
33_D45_I0.5330.22
5_R131_N0.5320.22
42_K54_L0.5300.21
61_F95_S0.5280.21
117_C160_N0.5270.21
21_R38_T0.5230.21
52_I158_T0.5230.21
139_V157_T0.5230.21
42_K56_A0.5230.21
30_V139_V0.5210.21
7_R57_L0.5210.21
16_P25_N0.5210.21
85_F108_S0.5190.21
10_I35_V0.5100.20
77_L82_I0.5060.20
36_K88_L0.5060.20
14_R94_P0.5040.20
13_S37_I0.5010.20
5_R126_D0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w94A 1 0.8529 100 0.378 Contact Map
2cxhA 1 0.9471 100 0.379 Contact Map
5by8A 1 0.9706 100 0.5 Contact Map
4xd9A 1 0.9765 100 0.516 Contact Map
1h4vB 2 0.5706 33 0.945 Contact Map
1httA 2 0.5765 20.9 0.95 Contact Map
2lw7A 1 0.6176 20.3 0.95 Contact Map
3netA 2 0.5706 18.2 0.951 Contact Map
3iklA 2 0.6 17.3 0.952 Contact Map
4hwtA 2 0.6235 16.7 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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