GREMLIN Database
PFDB - Prefoldin subunit beta
UniProt: Q9UXB8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 126 (113)
Sequences: 178 (132)
Seq/√Len: 12.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_D71_S3.4400.98
48_S77_N2.7100.93
23_L97_L2.4300.88
103_D107_K2.3410.86
52_A69_K2.2430.84
11_A32_T2.1660.82
57_Y87_S1.9850.75
85_L99_K1.9640.74
41_N80_K1.9300.73
26_L73_E1.9210.73
15_K95_S1.8520.70
6_P100_Q1.7830.67
24_D94_E1.7680.66
67_S72_V1.7680.66
13_L81_E1.7160.64
4_K25_R1.6330.60
17_Q86_R1.6310.60
16_F101_L1.5710.57
46_E89_T1.5310.55
97_L114_K1.5200.54
5_L18_Q1.5010.53
106_A110_D1.4970.53
70_T75_E1.4950.53
44_L73_E1.4510.51
46_E49_V1.4480.50
4_K18_Q1.4240.49
70_T74_K1.3730.47
42_K45_E1.3590.46
88_R92_K1.3440.45
54_A110_D1.3430.45
10_Q78_D1.3360.45
56_I80_K1.3300.44
68_D72_V1.3220.44
11_A100_Q1.3180.44
21_D24_D1.3150.44
16_F43_V1.3130.44
13_L77_N1.3100.43
5_L70_T1.3090.43
17_Q105_Q1.3040.43
75_E89_T1.3020.43
44_L76_L1.2900.42
8_E107_K1.2640.41
13_L37_L1.2550.41
107_K111_M1.2390.40
5_L74_K1.2220.39
48_S73_E1.1890.38
37_L64_L1.1820.37
29_E86_R1.1810.37
15_K66_K1.1630.36
28_L85_L1.1550.36
26_L90_Y1.1540.36
24_D29_E1.1450.35
26_L75_E1.1430.35
73_E98_R1.1370.35
71_S109_N1.1260.35
16_F111_M1.1220.34
55_T66_K1.1170.34
58_K103_D1.1050.34
91_Q95_S1.0830.33
10_Q17_Q1.0810.33
9_V99_K1.0690.32
58_K75_E1.0680.32
20_K23_L1.0680.32
81_E99_K1.0430.31
20_K24_D1.0400.31
34_E57_Y1.0380.31
43_V96_I1.0200.30
12_Q39_E1.0200.30
92_K104_L0.9930.29
27_L75_E0.9860.28
30_K94_E0.9770.28
11_A101_L0.9770.28
65_V82_L0.9590.27
23_L96_I0.9580.27
84_E88_R0.9570.27
12_Q22_Q0.9540.27
48_S99_K0.9430.27
26_L114_K0.9140.26
86_R105_Q0.9140.26
51_N63_L0.9040.25
29_E100_Q0.9000.25
12_Q107_K0.8980.25
12_Q18_Q0.8940.25
39_E93_Q0.8880.25
29_E32_T0.8870.24
12_Q21_D0.8690.24
45_E79_R0.8670.24
66_K74_K0.8460.23
51_N77_N0.8430.23
34_E87_S0.8370.23
27_L98_R0.8230.22
7_P34_E0.8230.22
40_I110_D0.8170.22
46_E91_Q0.7900.21
16_F60_V0.7840.21
22_Q89_T0.7820.21
65_V72_V0.7800.21
59_I81_E0.7700.20
32_T38_R0.7590.20
36_E87_S0.7490.20
45_E77_N0.7460.20
15_K89_T0.7450.20
50_L53_D0.7450.20
40_I43_V0.7390.19
45_E82_L0.7370.19
16_F55_T0.7290.19
46_E58_K0.7280.19
20_K94_E0.7270.19
39_E106_A0.7260.19
56_I79_R0.7060.18
30_K92_K0.7040.18
85_L89_T0.6990.18
46_E66_K0.6990.18
44_L57_Y0.6990.18
28_L77_N0.6970.18
13_L99_K0.6970.18
17_Q20_K0.6930.18
36_E79_R0.6880.18
7_P104_L0.6760.17
52_A113_S0.6700.17
25_R92_K0.6680.17
49_V56_I0.6640.17
73_E116_Y0.6640.17
7_P16_F0.6600.17
23_L27_L0.6510.17
64_L75_E0.6500.17
22_Q38_R0.6490.17
7_P107_K0.6480.17
8_E21_D0.6430.16
31_S43_V0.6390.16
60_V108_I0.6290.16
47_L50_L0.6290.16
20_K86_R0.6290.16
103_D111_M0.6270.16
4_K29_E0.6260.16
24_D43_V0.6090.16
87_S111_M0.6090.16
33_I83_L0.6070.15
9_V108_I0.5920.15
12_Q26_L0.5830.15
84_E99_K0.5770.15
44_L47_L0.5720.15
16_F63_L0.5720.15
95_S100_Q0.5700.15
88_R99_K0.5670.14
16_F104_L0.5620.14
23_L98_R0.5600.14
9_V109_N0.5470.14
50_L106_A0.5450.14
30_K43_V0.5430.14
30_K78_D0.5430.14
38_R41_N0.5390.14
16_F79_R0.5370.14
4_K56_I0.5360.14
9_V28_L0.5310.14
9_V110_D0.5290.14
11_A96_I0.5260.13
97_L116_Y0.5250.13
9_V14_A0.5250.13
50_L55_T0.5200.13
15_K85_L0.5200.13
95_S99_K0.5180.13
15_K29_E0.5150.13
27_L104_L0.5130.13
13_L17_Q0.5120.13
42_K49_V0.5090.13
22_Q85_L0.5040.13
5_L67_S0.5010.13
75_E87_S0.5000.13
31_S94_E0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zqmA 5 0.9048 99.8 0.519 Contact Map
1fxkA 2 0.8492 99.8 0.542 Contact Map
3aeiA 3 0.746 99.7 0.569 Contact Map
2zdiC 2 0.9683 99.5 0.641 Contact Map
1fxkC 2 0.873 99.2 0.691 Contact Map
4cgkA 3 0.6429 85 0.886 Contact Map
4q4gX 1 0 84.2 0.888 Contact Map
1l8dA 2 0.8254 75.7 0.897 Contact Map
4rsiA 1 0.4921 74.2 0.898 Contact Map
1deqA 1 0.9127 72.2 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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