GREMLIN Database
SYI - Isoleucine--tRNA ligase
UniProt: Q9UXB1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 986 (782)
Sequences: 4513 (2432)
Seq/√Len: 87.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_E212_K5.3311.00
181_D218_K4.9861.00
196_K216_T4.8441.00
10_Q15_K4.3211.00
183_A196_K3.8121.00
68_D71_T3.7201.00
367_E377_K3.7171.00
304_L312_A3.6151.00
104_K107_E3.5001.00
277_G282_F3.3961.00
301_Y316_D3.3411.00
181_D196_K3.3101.00
147_K190_E3.2301.00
604_E607_K3.2031.00
158_L248_V3.1901.00
223_I250_A3.1551.00
180_Y256_L3.0691.00
622_L735_D2.9031.00
13_L636_N2.8891.00
174_V262_L2.8541.00
533_R539_L2.8271.00
33_A36_K2.7731.00
58_K61_E2.7611.00
489_D519_T2.7061.00
365_E368_K2.6991.00
692_K696_I2.6711.00
181_D216_T2.6451.00
121_C339_C2.6291.00
253_I276_V2.6241.00
370_N520_S2.6021.00
198_R201_A2.5691.00
551_K574_W2.5571.00
223_I280_Y2.5391.00
8_R703_P2.5191.00
183_A199_V2.5061.00
611_D616_Y2.4691.00
530_E575_K2.4581.00
634_K650_Y2.4351.00
300_K316_D2.4311.00
191_I214_L2.4051.00
591_F709_I2.4031.00
253_I265_S2.3961.00
249_D276_V2.3921.00
158_L262_L2.3091.00
698_A706_S2.3011.00
67_A88_Y2.2891.00
361_K514_D2.2821.00
71_T84_E2.2641.00
446_C449_C2.2511.00
316_D320_K2.2441.00
430_V434_L2.2221.00
749_N753_L2.2111.00
174_V227_Y2.2011.00
82_D85_R2.1711.00
624_I690_I2.1691.00
197_D256_L2.1671.00
71_T75_K2.1411.00
360_D364_N2.1341.00
140_E330_V2.1291.00
274_F278_Q2.1291.00
51_G54_T2.1251.00
433_D437_P2.1151.00
718_K724_E2.0791.00
121_C124_C2.0701.00
57_N61_E2.0691.00
408_E454_K2.0651.00
547_V551_K2.0651.00
138_D330_V2.0571.00
420_E424_S2.0281.00
305_K308_D2.0271.00
272_E275_T2.0261.00
251_G276_V2.0131.00
490_L522_L2.0101.00
202_V206_A2.0081.00
148_F171_N1.9991.00
637_E641_D1.9941.00
312_A315_S1.9891.00
186_E191_I1.9861.00
626_S739_E1.9841.00
138_D332_R1.9811.00
631_M650_Y1.9691.00
184_D215_R1.9671.00
354_R357_K1.9551.00
46_I49_K1.9511.00
158_L174_V1.9471.00
289_N293_E1.9371.00
149_K322_T1.9261.00
407_C449_C1.9241.00
94_Y469_A1.9141.00
371_W521_V1.9091.00
100_S427_I1.9061.00
173_F249_D1.9011.00
364_N367_E1.8931.00
124_C339_C1.8871.00
407_C446_C1.8651.00
296_E302_K1.8651.00
37_L65_S1.8621.00
636_N726_S1.8601.00
361_K364_N1.8491.00
315_S319_S1.8411.00
184_D191_I1.8411.00
157_Y190_E1.8371.00
218_K221_E1.8141.00
200_E204_K1.8121.00
431_P434_L1.8041.00
407_C410_C1.8021.00
410_C446_C1.8011.00
151_K226_K1.7961.00
175_M265_S1.7941.00
149_K228_E1.7941.00
9_Y640_K1.7821.00
185_V199_V1.7811.00
364_N368_K1.7811.00
187_V190_E1.7791.00
530_E573_S1.7771.00
175_M276_V1.7741.00
9_Y13_L1.7661.00
749_N752_S1.7531.00
160_I174_V1.7471.00
628_F693_Q1.7471.00
37_L58_K1.7461.00
168_I231_L1.7431.00
490_L520_S1.7391.00
183_A216_T1.7371.00
226_K245_H1.7301.00
149_K157_Y1.7261.00
104_K108_K1.7241.00
627_R658_D1.7171.00
437_P441_N1.7131.00
624_I659_V1.7021.00
140_E328_K1.6991.00
315_S318_K1.6981.00
630_S739_E1.6891.00
5_C562_L1.6741.00
177_N180_Y1.6701.00
720_S723_M1.6691.00
430_V433_D1.6671.00
547_V550_E1.6661.00
410_C449_C1.6611.00
633_K637_E1.6581.00
215_R221_E1.6561.00
100_S423_E1.6561.00
752_S794_L1.6511.00
64_L90_L1.6491.00
25_T90_L1.6481.00
203_M211_Y1.6401.00
12_V699_S1.6351.00
88_Y91_D1.6271.00
183_A213_I1.6241.00
632_L693_Q1.6191.00
433_D436_R1.6171.00
475_G513_L1.6161.00
144_I168_I1.6111.00
365_E510_L1.6071.00
429_P433_D1.6001.00
186_E189_G1.5951.00
103_K107_E1.5871.00
597_Y600_L1.5871.00
423_E427_I1.5861.00
636_N640_K1.5851.00
784_G787_K1.5841.00
105_A511_I1.5841.00
371_W380_I1.5791.00
113_K406_I1.5691.00
233_E300_K1.5581.00
619_I741_A1.5541.00
738_L745_A1.5541.00
175_M251_G1.5531.00
768_A798_D1.5511.00
10_Q640_K1.5471.00
7_L17_V1.5391.00
695_I709_I1.5341.00
340_K538_S1.5231.00
750_E753_L1.5211.00
771_Y802_S1.5191.00
176_I248_V1.5131.00
205_E327_G1.5051.00
147_K157_Y1.5041.00
780_L784_G1.5041.00
484_E487_P1.5011.00
633_K731_E1.4981.00
150_I225_I1.4981.00
268_G287_F1.4981.00
742_F745_A1.4931.00
2_I492_L1.4921.00
424_S427_I1.4800.99
194_I202_V1.4760.99
155_N191_I1.4710.99
316_D319_S1.4660.99
19_D81_M1.4660.99
149_K155_N1.4630.99
159_L324_F1.4540.99
159_L192_L1.4510.99
176_I262_L1.4480.99
151_K228_E1.4450.99
78_G704_F1.4290.99
177_N252_N1.4260.99
231_L316_D1.4250.99
431_P435_H1.4230.99
184_D217_Y1.4180.99
547_V574_W1.4160.99
434_L438_W1.4090.99
426_A442_V1.4060.99
696_I724_E1.4050.99
426_A431_P1.4040.99
124_C336_C1.4040.99
674_E679_D1.3940.99
423_E429_P1.3890.99
408_E452_V1.3860.99
691_L713_F1.3820.99
304_L309_A1.3800.99
639_M647_M1.3790.99
611_D614_I1.3680.99
10_Q13_L1.3640.99
94_Y472_A1.3580.99
222_L225_I1.3570.99
432_N435_H1.3560.99
741_A785_R1.3540.99
178_K250_A1.3530.99
156_R184_D1.3510.99
796_A799_I1.3480.99
250_A280_Y1.3440.99
548_V577_L1.3320.99
45_E49_K1.3270.99
103_K417_G1.3160.99
54_T57_N1.3160.99
304_L308_D1.3050.99
311_K326_E1.3030.99
97_S100_S1.3030.99
470_F508_S1.3000.99
707_E720_S1.3000.99
251_G275_T1.3000.99
426_A430_V1.3000.99
429_P436_R1.2970.99
13_L640_K1.2960.99
123_R339_C1.2950.99
468_V508_S1.2920.99
426_A434_L1.2910.99
265_S277_G1.2850.98
367_E381_S1.2840.98
293_E308_D1.2830.98
429_P437_P1.2810.98
217_Y221_E1.2810.98
82_D483_K1.2810.98
506_L517_P1.2800.98
527_M570_A1.2790.98
486_G515_R1.2750.98
768_A800_E1.2730.98
781_A784_G1.2720.98
643_K646_E1.2690.98
172_V285_V1.2680.98
355_V358_I1.2640.98
287_F295_T1.2630.98
271_E275_T1.2620.98
156_R191_I1.2560.98
179_D220_S1.2550.98
738_L741_A1.2530.98
611_D615_K1.2520.98
175_M249_D1.2500.98
365_E516_A1.2480.98
372_I520_S1.2470.98
427_I434_L1.2460.98
745_A793_M1.2460.98
686_I690_I1.2450.98
366_I384_V1.2410.98
362_M507_R1.2400.98
151_K245_H1.2390.98
185_V213_I1.2390.98
105_A508_S1.2370.98
433_D438_W1.2300.98
742_F749_N1.2280.98
632_L697_L1.2200.98
699_S722_S1.2170.98
184_D193_V1.2160.98
76_N550_E1.2150.98
539_L542_Y1.2150.98
179_D218_K1.2150.98
426_A433_D1.2110.98
503_F507_R1.2110.98
629_N632_L1.2070.98
417_G420_E1.2060.98
119_H345_L1.2060.98
384_V503_F1.2020.98
745_A749_N1.1950.98
318_K326_E1.1940.98
423_E426_A1.1900.98
170_S294_F1.1890.97
203_M208_I1.1870.97
639_M701_I1.1860.97
168_I320_K1.1850.97
807_F810_F1.1830.97
515_R519_T1.1810.97
425_I433_D1.1800.97
486_G513_L1.1790.97
434_L440_D1.1750.97
99_W429_P1.1740.97
298_G302_K1.1720.97
462_V465_D1.1720.97
736_N740_R1.1700.97
142_P309_A1.1700.97
288_V306_V1.1680.97
636_N728_N1.1680.97
670_R683_M1.1670.97
620_E667_I1.1630.97
142_P326_E1.1620.97
125_E291_R1.1610.97
251_G265_S1.1600.97
116_A391_V1.1580.97
199_V203_M1.1580.97
520_S642_Y1.1570.97
175_M253_I1.1530.97
97_S476_K1.1530.97
546_S550_E1.1530.97
378_S382_N1.1490.97
121_C336_C1.1480.97
564_N570_A1.1470.97
370_N641_D1.1460.97
301_Y312_A1.1450.97
227_Y246_Q1.1430.97
617_A625_L1.1400.97
311_K315_S1.1390.97
425_I429_P1.1330.97
492_L524_H1.1300.97
107_E417_G1.1250.96
475_G478_W1.1250.96
412_N448_K1.1250.96
196_K213_I1.1230.96
780_L803_K1.1220.96
741_A745_A1.1210.96
176_I250_A1.1200.96
307_R310_S1.1190.96
54_T58_K1.1190.96
293_E305_K1.1170.96
745_A753_L1.1120.96
68_D72_Q1.1090.96
268_G284_V1.1090.96
213_I216_T1.1070.96
590_T664_I1.1050.96
145_Y205_E1.1020.96
173_F277_G1.0980.96
98_S460_A1.0980.96
427_I431_P1.0960.96
430_V435_H1.0950.96
101_V464_F1.0930.96
647_M701_I1.0930.96
187_V192_L1.0860.96
434_L437_P1.0850.96
790_L799_I1.0850.96
616_Y678_Q1.0850.96
435_H438_W1.0840.96
603_F685_Y1.0830.96
438_W441_N1.0750.95
509_G513_L1.0730.95
695_I706_S1.0710.95
105_A353_I1.0680.95
381_S385_K1.0660.95
417_G421_E1.0650.95
738_L742_F1.0620.95
617_A686_I1.0590.95
353_I392_I1.0590.95
101_V512_L1.0500.95
651_L698_A1.0470.95
787_K791_I1.0470.95
85_R91_D1.0440.95
776_N781_A1.0440.95
306_V344_I1.0430.95
431_P436_R1.0430.95
289_N295_T1.0420.95
13_L726_S1.0410.95
626_S734_I1.0400.95
434_L439_I1.0360.94
103_K422_L1.0350.94
110_M358_I1.0340.94
752_S770_V1.0320.94
181_D197_D1.0300.94
144_I323_L1.0290.94
299_G302_K1.0290.94
158_L193_V1.0260.94
380_I521_V1.0250.94
106_Y111_L1.0240.94
178_K220_S1.0180.94
312_A316_D1.0160.94
625_L689_Y1.0160.94
617_A685_Y1.0160.94
575_K579_L1.0130.94
102_I111_L1.0130.94
737_E741_A1.0130.94
170_S287_F1.0090.94
275_T278_Q1.0080.94
478_W483_K1.0070.94
186_E214_L1.0060.94
614_I617_A1.0030.93
133_V343_L1.0030.93
176_I222_L1.0010.93
150_I158_L1.0010.93
80_F722_S1.0010.93
692_K717_A1.0010.93
12_V722_S1.0010.93
6_I644_V0.9970.93
698_A702_I0.9950.93
144_I314_I0.9920.93
674_E677_T0.9910.93
217_Y222_L0.9900.93
147_K192_L0.9850.93
314_I326_E0.9850.93
64_L67_A0.9830.93
750_E754_N0.9820.93
220_S223_I0.9820.93
609_T685_Y0.9810.93
395_Q458_D0.9810.93
369_V516_A0.9770.93
172_V283_P0.9750.92
295_T298_G0.9750.92
142_P328_K0.9740.92
746_R749_N0.9740.92
269_H286_M0.9730.92
630_S736_N0.9700.92
336_C339_C0.9670.92
474_L488_V0.9670.92
121_C410_C0.9670.92
423_E434_L0.9650.92
695_I721_V0.9640.92
680_K684_Y0.9600.92
340_K539_L0.9590.92
113_K349_D0.9560.92
168_I313_I0.9540.92
408_E451_G0.9520.92
202_V324_F0.9500.91
224_G247_V0.9470.91
544_E547_V0.9440.91
265_S276_V0.9400.91
632_L727_I0.9370.91
448_K451_G0.9360.91
572_F577_L0.9320.91
407_C453_A0.9310.91
617_A682_A0.9300.91
738_L746_R0.9300.91
171_N246_Q0.9290.91
703_P722_S0.9290.91
445_K448_K0.9280.90
635_V697_L0.9280.90
72_Q75_K0.9280.90
35_E55_F0.9280.90
689_Y727_I0.9260.90
591_F712_S0.9250.90
178_K223_I0.9250.90
288_V344_I0.9230.90
195_A198_R0.9230.90
126_T339_C0.9220.90
363_L381_S0.9210.90
627_R743_E0.9180.90
69_K73_N0.9160.90
205_E325_F0.9150.90
446_C450_G0.9150.90
53_E57_N0.9140.90
193_V217_Y0.9110.90
627_R630_S0.9100.90
152_G226_K0.9100.90
429_P434_L0.9100.90
334_P345_L0.9080.89
150_I156_R0.9080.89
153_E156_R0.9060.89
424_S428_D0.9050.89
52_V436_R0.9050.89
160_I230_P0.9030.89
382_N385_K0.9000.89
761_I767_L0.9000.89
108_K361_K0.8990.89
710_Y724_E0.8990.89
407_C412_N0.8970.89
506_L516_A0.8940.89
693_Q697_L0.8920.89
530_E574_W0.8910.89
226_K247_V0.8880.88
610_L685_Y0.8880.88
638_S646_E0.8860.88
206_A324_F0.8860.88
121_C449_C0.8860.88
101_V471_F0.8850.88
767_L796_A0.8840.88
224_G280_Y0.8840.88
563_R648_T0.8830.88
427_I430_V0.8820.88
631_M654_F0.8810.88
174_V248_V0.8810.88
778_D781_A0.8790.88
409_R452_V0.8790.88
632_L729_Y0.8780.88
301_Y304_L0.8770.88
366_I371_W0.8760.88
362_M503_F0.8720.88
601_D680_K0.8710.87
438_W442_V0.8710.87
714_V717_A0.8700.87
601_D684_Y0.8700.87
543_V548_V0.8700.87
287_F294_F0.8690.87
762_K765_W0.8680.87
308_D311_K0.8670.87
121_C446_C0.8670.87
380_I384_V0.8660.87
738_L749_N0.8650.87
158_L227_Y0.8650.87
774_I783_V0.8640.87
65_S69_K0.8630.87
548_V557_L0.8630.87
135_E139_L0.8630.87
155_N190_E0.8620.87
772_I799_I0.8620.87
437_P440_D0.8600.87
148_F174_V0.8600.87
742_F753_L0.8590.87
8_R722_S0.8580.87
614_I622_L0.8580.87
406_I413_V0.8570.87
137_R340_K0.8570.87
610_L678_Q0.8570.87
624_I654_F0.8570.87
377_K381_S0.8560.87
628_F690_I0.8540.86
434_L442_V0.8540.86
737_E740_R0.8540.86
339_C410_C0.8520.86
255_T258_D0.8490.86
432_N436_R0.8480.86
64_L68_D0.8480.86
695_I713_F0.8480.86
430_V437_P0.8460.86
791_I799_I0.8440.86
294_F309_A0.8420.86
527_M542_Y0.8390.85
423_E430_V0.8390.85
610_L617_A0.8380.85
626_S630_S0.8360.85
749_N754_N0.8350.85
491_V505_L0.8350.85
360_D363_L0.8340.85
153_E225_I0.8330.85
486_G509_G0.8320.85
605_P688_Y0.8320.85
180_Y195_A0.8320.85
662_F746_R0.8300.85
148_F160_I0.8300.85
12_V696_I0.8300.85
710_Y718_K0.8300.85
142_P310_S0.8300.85
415_V418_S0.8290.85
634_K646_E0.8270.85
156_R193_V0.8260.85
62_F66_N0.8260.85
725_S728_N0.8220.84
173_F247_V0.8220.84
765_W797_K0.8210.84
234_F244_F0.8200.84
629_N633_K0.8190.84
195_A256_L0.8190.84
8_R80_F0.8170.84
121_C407_C0.8160.84
735_D738_L0.8160.84
199_V213_I0.8160.84
93_S427_I0.8160.84
73_N544_E0.8150.84
61_E65_S0.8150.84
414_M425_I0.8140.84
366_I380_I0.8120.84
756_R762_K0.8110.83
430_V438_W0.8100.83
185_V203_M0.8080.83
150_I227_Y0.8070.83
715_V718_K0.8040.83
387_L507_R0.8040.83
173_F282_F0.8030.83
201_A204_K0.8020.83
136_Y139_L0.8010.83
617_A689_Y0.8010.83
355_V387_L0.8000.83
249_D280_Y0.7990.83
638_S647_M0.7990.83
730_D733_F0.7980.82
693_Q696_I0.7970.82
123_R341_T0.7970.82
426_A429_P0.7960.82
740_R744_V0.7940.82
102_I460_A0.7940.82
40_I45_E0.7930.82
771_Y800_E0.7930.82
745_A752_S0.7930.82
788_D791_I0.7920.82
689_Y692_K0.7920.82
626_S733_F0.7910.82
682_A686_I0.7900.82
443_R452_V0.7900.82
228_E233_E0.7890.82
559_L648_T0.7870.82
60_K64_L0.7870.82
444_V447_N0.7870.82
276_V280_Y0.7860.81
744_V782_K0.7850.81
431_P437_P0.7850.81
227_Y248_V0.7850.81
794_L799_I0.7840.81
268_G286_M0.7840.81
172_V282_F0.7830.81
699_S706_S0.7800.81
339_C449_C0.7790.81
355_V388_R0.7790.81
790_L794_L0.7780.81
744_V749_N0.7770.81
609_T689_Y0.7760.81
170_S269_H0.7760.81
498_L523_V0.7760.81
339_C446_C0.7740.80
504_S518_Y0.7730.80
414_M453_A0.7720.80
157_Y192_L0.7710.80
495_H498_L0.7700.80
361_K365_E0.7680.80
435_H439_I0.7670.80
295_T302_K0.7670.80
73_N546_S0.7670.80
407_C452_V0.7660.80
363_L367_E0.7640.80
545_P548_V0.7640.80
427_I433_D0.7630.80
425_I430_V0.7620.79
629_N733_F0.7610.79
247_V280_Y0.7610.79
407_C411_N0.7600.79
719_E723_M0.7590.79
339_C407_C0.7580.79
127_T395_Q0.7580.79
180_Y197_D0.7570.79
412_N415_V0.7560.79
75_K84_E0.7560.79
152_G225_I0.7550.79
201_A257_T0.7540.79
742_F746_R0.7540.79
412_N449_C0.7540.79
2_I524_H0.7530.79
449_C453_A0.7510.78
286_M290_D0.7510.78
683_M686_I0.7510.78
223_I279_K0.7510.78
751_A754_N0.7500.78
184_D214_L0.7480.78
404_I413_V0.7480.78
350_Q391_V0.7460.78
806_G810_F0.7460.78
99_W403_P0.7460.78
9_Y636_N0.7460.78
154_K225_I0.7460.78
449_C452_V0.7460.78
431_P438_W0.7450.78
287_F297_E0.7450.78
740_R743_E0.7450.78
66_N69_K0.7450.78
442_V445_K0.7430.78
21_P83_W0.7430.78
122_P305_K0.7420.78
416_V425_I0.7420.78
619_I742_F0.7420.78
185_V194_I0.7410.78
779_T782_K0.7400.77
637_E640_K0.7390.77
185_V211_Y0.7390.77
380_I498_L0.7380.77
433_D439_I0.7360.77
11_R17_V0.7360.77
787_K801_I0.7360.77
433_D440_D0.7350.77
633_K729_Y0.7350.77
224_G250_A0.7340.77
356_T359_K0.7340.77
425_I431_P0.7330.77
252_N279_K0.7320.77
158_L176_I0.7320.77
296_E299_G0.7320.77
315_S326_E0.7310.77
12_V726_S0.7300.76
494_G524_H0.7290.76
649_N653_N0.7290.76
436_R439_I0.7290.76
249_D282_F0.7290.76
425_I428_D0.7280.76
160_I262_L0.7270.76
368_K515_R0.7260.76
363_L385_K0.7250.76
632_L636_N0.7250.76
99_W426_A0.7240.76
426_A435_H0.7240.76
806_G809_S0.7230.76
575_K578_E0.7230.76
426_A437_P0.7230.76
435_H440_D0.7230.76
630_S634_K0.7220.76
369_V517_P0.7190.75
71_T83_W0.7190.75
105_A111_L0.7190.75
314_I328_K0.7180.75
638_S650_Y0.7180.75
33_A66_N0.7180.75
100_S420_E0.7170.75
741_A746_R0.7170.75
699_S720_S0.7160.75
495_H526_F0.7140.75
591_F695_I0.7130.75
249_D277_G0.7120.75
773_F802_S0.7120.75
562_L701_I0.7120.75
371_W377_K0.7110.75
618_K683_M0.7110.75
635_V651_L0.7100.74
370_N377_K0.7090.74
108_K514_D0.7090.74
227_Y262_L0.7090.74
374_D377_K0.7070.74
294_F301_Y0.7070.74
426_A432_N0.7070.74
369_V506_L0.7050.74
376_G523_V0.7040.74
196_K199_V0.7040.74
74_F83_W0.7020.74
249_D253_I0.6990.73
176_I223_I0.6980.73
143_S327_G0.6970.73
253_I258_D0.6970.73
738_L744_V0.6950.73
142_P311_K0.6950.73
587_I698_A0.6950.73
471_F513_L0.6940.73
667_I683_M0.6940.73
143_S329_I0.6940.73
140_E329_I0.6940.73
384_V507_R0.6930.73
208_I211_Y0.6930.73
437_P442_V0.6930.73
430_V436_R0.6930.73
311_K314_I0.6920.73
756_R761_I0.6910.72
764_R795_N0.6910.72
251_G255_T0.6900.72
121_C341_T0.6900.72
594_A598_M0.6890.72
692_K695_I0.6890.72
526_F534_E0.6890.72
666_L792_S0.6870.72
23_Y71_T0.6850.72
662_F793_M0.6850.72
673_I677_T0.6850.72
439_I442_V0.6840.72
331_H334_P0.6840.72
418_S421_E0.6810.71
150_I248_V0.6800.71
48_D397_F0.6800.71
543_V570_A0.6780.71
412_N447_N0.6770.71
76_N554_R0.6770.71
294_F298_G0.6770.71
628_F632_L0.6750.71
618_K679_D0.6750.71
433_D442_V0.6740.71
444_V448_K0.6720.70
253_I272_E0.6720.70
420_E423_E0.6720.70
98_S101_V0.6720.70
736_N739_E0.6720.70
699_S721_V0.6720.70
183_A217_Y0.6690.70
600_L603_F0.6690.70
232_R300_K0.6680.70
671_A687_L0.6680.70
678_Q682_A0.6680.70
94_Y468_V0.6680.70
408_E450_G0.6680.70
621_D670_R0.6670.70
406_I456_I0.6650.70
358_I511_I0.6650.70
146_V160_I0.6650.70
431_P439_I0.6650.70
412_N446_C0.6640.69
145_Y159_L0.6630.69
751_A755_A0.6620.69
543_V574_W0.6620.69
228_E232_R0.6620.69
57_N60_K0.6600.69
135_E138_D0.6600.69
150_I193_V0.6590.69
68_D75_K0.6580.69
732_R735_D0.6580.69
429_P435_H0.6580.69
49_K54_T0.6560.69
48_D51_G0.6560.69
72_Q550_E0.6560.69
584_L702_I0.6550.68
738_L752_S0.6550.68
731_E734_I0.6550.68
124_C341_T0.6530.68
763_L766_P0.6520.68
50_I58_K0.6510.68
168_I316_D0.6510.68
494_G526_F0.6500.68
148_F246_Q0.6490.68
429_P438_W0.6480.68
446_C451_G0.6480.68
9_Y726_S0.6470.67
436_R440_D0.6450.67
206_A325_F0.6450.67
633_K734_I0.6430.67
301_Y319_S0.6430.67
416_V422_L0.6420.67
707_E711_K0.6420.67
79_V83_W0.6420.67
60_K90_L0.6410.67
535_M542_Y0.6400.67
172_V234_F0.6390.67
587_I655_L0.6390.67
542_Y548_V0.6390.67
783_V790_L0.6380.66
32_V55_F0.6370.66
232_R246_Q0.6370.66
639_M726_S0.6360.66
297_E302_K0.6360.66
369_V521_V0.6340.66
617_A622_L0.6330.66
619_I622_L0.6310.66
285_V297_E0.6300.65
681_I685_Y0.6300.65
530_E571_K0.6290.65
302_K306_V0.6280.65
471_F475_G0.6270.65
7_L11_R0.6260.65
423_E431_P0.6260.65
199_V211_Y0.6250.65
444_V449_C0.6240.65
289_N296_E0.6240.65
445_K449_C0.6240.65
298_G301_Y0.6240.65
67_A71_T0.6220.64
192_L324_F0.6220.64
194_I206_A0.6220.64
365_E515_R0.6220.64
157_Y322_T0.6210.64
293_E306_V0.6210.64
65_S68_D0.6200.64
742_F752_S0.6200.64
574_W578_E0.6200.64
446_C453_A0.6200.64
183_A194_I0.6200.64
92_P95_I0.6190.64
140_E326_E0.6190.64
410_C413_V0.6190.64
702_I705_I0.6160.64
628_F697_L0.6160.64
670_R679_D0.6160.64
141_D333_Y0.6150.64
180_Y255_T0.6130.63
741_A786_I0.6130.63
552_Y577_L0.6120.63
145_Y202_V0.6110.63
748_I752_S0.6100.63
647_M657_E0.6100.63
610_L616_Y0.6100.63
95_I387_L0.6090.63
410_C451_G0.6090.63
416_V420_E0.6080.63
74_F79_V0.6070.63
203_M207_S0.6060.62
172_V246_Q0.6060.62
224_G281_G0.6050.62
535_M541_N0.6050.62
691_L709_I0.6050.62
414_M444_V0.6040.62
144_I313_I0.6040.62
620_E666_L0.6040.62
625_L686_I0.6040.62
782_K785_R0.6020.62
430_V440_D0.6010.62
104_K512_L0.6010.62
301_Y313_I0.6000.62
421_E424_S0.6000.62
333_Y345_L0.6000.62
752_S755_A0.6000.62
634_K638_S0.5990.62
64_L88_Y0.5980.61
174_V230_P0.5980.61
176_I219_G0.5970.61
5_C639_M0.5970.61
593_F664_I0.5970.61
471_F512_L0.5960.61
57_N436_R0.5960.61
423_E433_D0.5960.61
614_I733_F0.5950.61
748_I753_L0.5950.61
267_T277_G0.5950.61
423_E437_P0.5950.61
21_P74_F0.5950.61
425_I434_L0.5950.61
629_N734_I0.5940.61
423_E440_D0.5940.61
387_L503_F0.5940.61
5_C701_I0.5930.61
419_K422_L0.5920.61
780_L801_I0.5920.61
175_M282_F0.5920.61
790_L797_K0.5920.61
542_Y545_P0.5910.61
309_A313_I0.5910.61
411_N416_V0.5900.60
33_A37_L0.5900.60
602_N684_Y0.5900.60
551_K578_E0.5900.60
669_K673_I0.5890.60
639_M644_V0.5880.60
689_Y693_Q0.5870.60
685_Y689_Y0.5870.60
405_W422_L0.5870.60
50_I54_T0.5870.60
323_L326_E0.5860.60
177_N250_A0.5860.60
634_K637_E0.5860.60
603_F688_Y0.5860.60
363_L366_I0.5850.60
15_K18_H0.5850.60
149_K152_G0.5840.60
362_M510_L0.5830.59
774_I779_T0.5830.59
288_V292_G0.5830.59
75_K83_W0.5820.59
93_S97_S0.5820.59
190_E321_N0.5820.59
410_C448_K0.5810.59
702_I706_S0.5800.59
747_E751_A0.5800.59
672_W684_Y0.5790.59
738_L753_L0.5790.59
303_G306_V0.5790.59
12_V724_E0.5780.59
300_K319_S0.5780.59
560_W576_A0.5780.59
756_R759_A0.5770.59
599_N687_L0.5770.59
614_I732_R0.5760.59
228_E245_H0.5760.59
426_A436_R0.5760.59
193_V248_V0.5750.58
362_M387_L0.5750.58
730_D742_F0.5740.58
629_N729_Y0.5740.58
372_I380_I0.5730.58
231_L320_K0.5730.58
50_I55_F0.5730.58
271_E345_L0.5720.58
192_L208_I0.5710.58
150_I154_K0.5710.58
366_I521_V0.5700.58
623_W627_R0.5700.58
744_V779_T0.5700.58
407_C414_M0.5690.58
618_K678_Q0.5680.58
118_L127_T0.5680.58
549_V555_D0.5670.57
119_H343_L0.5670.57
626_S735_D0.5650.57
776_N803_K0.5650.57
618_K667_I0.5650.57
528_L569_D0.5650.57
582_R585_Q0.5650.57
32_V36_K0.5640.57
524_H566_T0.5640.57
426_A440_D0.5640.57
127_T402_L0.5640.57
71_T86_P0.5640.57
509_G516_A0.5640.57
194_I330_V0.5630.57
425_I436_R0.5620.57
647_M698_A0.5620.57
624_I686_I0.5610.57
424_S434_L0.5610.57
430_V442_V0.5600.56
229_H232_R0.5590.56
2_I6_I0.5580.56
56_I435_H0.5580.56
418_S422_L0.5580.56
69_K72_Q0.5570.56
538_S542_Y0.5570.56
34_T62_F0.5570.56
159_L202_V0.5570.56
423_E436_R0.5570.56
146_V168_I0.5570.56
105_A512_L0.5570.56
610_L682_A0.5560.56
168_I229_H0.5560.56
665_R795_N0.5560.56
403_P415_V0.5550.56
490_L566_T0.5550.56
597_Y672_W0.5550.56
110_M357_K0.5540.56
407_C451_G0.5540.56
475_G486_G0.5540.56
381_S503_F0.5540.56
689_Y730_D0.5540.56
103_K421_E0.5530.56
375_W378_S0.5520.55
435_H442_V0.5520.55
492_L522_L0.5510.55
404_I456_I0.5510.55
111_L353_I0.5510.55
425_I440_D0.5500.55
230_P246_Q0.5500.55
127_T391_V0.5500.55
787_K799_I0.5490.55
711_K714_V0.5490.55
781_A785_R0.5490.55
519_T539_L0.5490.55
90_L98_S0.5480.55
562_L648_T0.5480.55
247_V250_A0.5480.55
141_D331_H0.5470.55
706_S709_I0.5470.55
355_V507_R0.5470.55
443_R454_K0.5470.55
53_E436_R0.5470.55
482_W487_P0.5460.55
670_R674_E0.5460.55
672_W680_K0.5450.54
562_L639_M0.5450.54
378_S381_S0.5450.54
407_C447_N0.5450.54
708_K712_S0.5440.54
444_V451_G0.5440.54
598_M601_D0.5440.54
627_R739_E0.5430.54
755_A759_A0.5430.54
172_V277_G0.5420.54
470_F486_G0.5420.54
631_M635_V0.5410.54
359_K385_K0.5410.54
420_E429_P0.5410.54
7_L12_V0.5400.54
477_D483_K0.5400.54
269_H287_F0.5400.54
768_A771_Y0.5400.54
198_R257_T0.5390.54
714_V718_K0.5390.54
10_Q636_N0.5390.54
296_E409_R0.5390.54
776_N779_T0.5380.53
425_I437_P0.5370.53
413_V416_V0.5370.53
21_P86_P0.5360.53
770_V796_A0.5360.53
15_K640_K0.5360.53
427_I436_R0.5360.53
32_V123_R0.5360.53
332_R335_V0.5350.53
580_T583_D0.5350.53
654_F690_I0.5350.53
603_F681_I0.5350.53
246_Q285_V0.5350.53
279_K282_F0.5330.53
737_E778_D0.5330.53
425_I438_W0.5330.53
638_S641_D0.5330.53
496_D526_F0.5320.53
101_V105_A0.5320.53
98_S400_T0.5320.53
744_V747_E0.5320.53
313_I316_D0.5310.53
202_V205_E0.5310.53
301_Y320_K0.5310.53
458_D462_V0.5310.53
529_D542_Y0.5310.53
545_P577_L0.5310.53
52_V435_H0.5310.53
542_Y547_V0.5300.52
655_L694_W0.5300.52
226_K244_F0.5290.52
745_A750_E0.5290.52
77_V557_L0.5290.52
527_M572_F0.5290.52
392_I460_A0.5280.52
274_F286_M0.5280.52
588_W708_K0.5270.52
415_V421_E0.5270.52
590_T659_V0.5270.52
52_V56_I0.5260.52
407_C450_G0.5260.52
20_Q478_W0.5250.52
286_M294_F0.5250.52
12_V725_S0.5250.52
142_P314_I0.5240.52
198_R258_D0.5240.52
445_K450_G0.5240.52
155_N189_G0.5240.52
605_P714_V0.5240.52
756_R765_W0.5230.51
667_I671_A0.5230.51
411_N415_V0.5230.51
268_G295_T0.5220.51
284_V287_F0.5220.51
336_C341_T0.5220.51
30_I63_A0.5220.51
260_T521_V0.5220.51
311_K328_K0.5220.51
400_T460_A0.5210.51
566_T644_V0.5210.51
365_E369_V0.5210.51
103_K423_E0.5200.51
309_A312_A0.5190.51
742_F750_E0.5190.51
582_R586_I0.5190.51
148_F282_F0.5190.51
530_E533_R0.5190.51
767_L770_V0.5190.51
204_K218_K0.5180.51
191_I218_K0.5170.51
542_Y572_F0.5170.51
102_I355_V0.5160.51
624_I682_A0.5150.50
348_I395_Q0.5150.50
667_I670_R0.5140.50
248_V262_L0.5140.50
741_A753_L0.5130.50
624_I667_I0.5130.50
255_T265_S0.5120.50
274_F347_A0.5120.50
170_S298_G0.5120.50
318_K328_K0.5120.50
108_K278_Q0.5120.50
530_E570_A0.5120.50
535_M543_V0.5120.50
20_Q86_P0.5110.50
372_I521_V0.5110.50
527_M580_T0.5110.50
223_I249_D0.5110.50
53_E441_N0.5100.50
628_F631_M0.5090.50
200_E216_T0.5090.50
688_Y692_K0.5090.50
427_I432_N0.5080.49
311_K318_K0.5070.49
197_D216_T0.5070.49
173_F265_S0.5070.49
106_Y415_V0.5060.49
651_L694_W0.5060.49
105_A518_Y0.5050.49
426_A438_W0.5050.49
621_D682_A0.5040.49
776_N780_L0.5040.49
445_K451_G0.5040.49
142_P330_V0.5040.49
287_F309_A0.5030.49
350_Q526_F0.5030.49
425_I442_V0.5030.49
495_H569_D0.5030.49
617_A620_E0.5030.49
423_E428_D0.5020.49
285_V298_G0.5020.49
429_P432_N0.5020.49
203_M324_F0.5020.49
469_A473_S0.5020.49
616_Y619_I0.5020.49
721_V724_E0.5020.49
293_E296_E0.5010.49
409_R451_G0.5010.49
428_D431_P0.5010.49
527_M530_E0.5010.49
360_D385_K0.5010.49
630_S734_I0.5010.49
2_I566_T0.5000.48
509_G515_R0.5000.48
423_E435_H0.5000.48
299_G316_D0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ffyA 1 0.8306 100 0.312 Contact Map
1gaxA 1 0.8022 100 0.39 Contact Map
1ileA 1 0.7535 100 0.39 Contact Map
1wz2A 1 0.8286 100 0.42 Contact Map
1wkbA 1 0.6694 100 0.5 Contact Map
2v0cA 1 0.6278 100 0.535 Contact Map
4arcA 1 0.6471 100 0.554 Contact Map
3ziuA 1 0.5294 100 0.654 Contact Map
1rqgA 2 0.5132 100 0.719 Contact Map
4qreA 1 0.4838 100 0.727 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0191 seconds.