GREMLIN Database
RL3 - 50S ribosomal protein L3
UniProt: Q9UXA8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 351 (330)
Sequences: 397 (238)
Seq/√Len: 13.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
187_E190_S6.8811.00
277_E280_K5.7671.00
47_G78_L4.6521.00
227_A231_K4.6171.00
151_L157_F4.4981.00
227_A270_L4.3871.00
78_L315_I4.3591.00
230_I235_V4.2761.00
293_N303_I4.2471.00
311_L315_I4.0731.00
219_G316_L3.7860.99
77_V310_L3.7190.99
194_Y198_I3.6980.99
231_K270_L3.6980.99
159_L195_A3.6550.99
59_D66_T3.4780.99
160_L178_L3.2840.98
219_G323_I2.9530.96
83_I161_V2.9450.96
25_L272_F2.7900.95
247_G250_K2.6800.94
14_A264_T2.6730.94
206_R287_D2.6530.93
17_R233_Y2.4330.90
161_V181_I2.4090.89
226_F267_P2.3770.89
47_G80_V2.3310.88
293_N299_V2.1880.84
289_P293_N2.1850.84
14_A17_R2.1780.84
145_D149_S2.1540.83
24_E30_R2.1480.83
226_F246_K1.9880.78
315_I323_I1.9800.77
182_Q191_Q1.9700.77
116_I160_L1.9110.75
159_L203_I1.8870.74
231_K237_E1.8120.71
236_V246_K1.7460.68
151_L199_L1.7180.66
237_E248_S1.6980.65
348_S351_G1.6850.65
233_Y267_P1.6800.64
24_E28_T1.6470.63
243_K246_K1.6460.63
9_P13_S1.6170.61
9_P12_G1.5980.60
43_L182_Q1.5960.60
84_I202_E1.5890.60
42_L159_L1.5620.59
254_R266_Q1.5520.58
88_L199_L1.5490.58
50_V293_N1.5480.58
30_R218_V1.5040.56
22_S220_V1.4930.55
115_D166_R1.4820.55
217_V315_I1.4370.52
293_N298_F1.4220.51
231_K234_S1.4210.51
169_P305_R1.4200.51
156_Y191_Q1.4120.51
308_Y318_S1.4080.51
88_L159_L1.4050.50
115_D293_N1.4030.50
84_I164_Q1.3820.49
213_Q260_T1.3720.49
217_V323_I1.3620.48
92_A102_I1.3590.48
88_L195_A1.3470.47
149_S153_R1.3440.47
35_I41_K1.3360.47
8_S11_R1.3280.46
102_I155_V1.3260.46
24_E183_I1.3180.46
237_E259_G1.3130.46
229_V247_G1.3040.45
78_L311_L1.2970.45
238_L244_H1.2900.44
288_E308_Y1.2890.44
189_K193_D1.2800.44
234_S270_L1.2780.44
214_L332_S1.2720.44
10_R13_S1.2680.43
207_D224_K1.2520.43
277_E300_R1.2460.42
13_S19_R1.2380.42
227_A234_S1.2380.42
293_N349_Q1.2340.42
226_F230_I1.2290.41
105_Y148_K1.2290.41
328_P331_P1.2270.41
79_E306_N1.2230.41
14_A263_Y1.2220.41
232_R275_R1.1990.40
183_I194_Y1.1980.40
144_L199_L1.1880.39
13_S22_S1.1860.39
148_K196_L1.1810.39
239_P245_R1.1780.39
244_H247_G1.1770.39
258_L307_T1.1710.38
239_P243_K1.1690.38
5_K10_R1.1620.38
94_D346_L1.1620.38
194_Y235_V1.1610.38
187_E286_G1.1530.38
286_G290_K1.1510.37
193_D272_F1.1500.37
108_S197_N1.1490.37
139_R142_T1.1450.37
220_V322_P1.1450.37
229_V235_V1.1360.37
212_G338_P1.1210.36
108_S145_D1.1200.36
48_Y51_G1.1160.36
316_L323_I1.1010.35
64_S106_W1.0940.35
26_L220_V1.0910.35
46_V322_P1.0870.34
171_L323_I1.0830.34
162_S257_S1.0810.34
179_V324_F1.0760.34
85_P145_D1.0700.34
239_P244_H1.0640.33
75_V79_E1.0620.33
286_G309_V1.0550.33
108_S309_V1.0410.32
157_F199_L1.0400.32
215_I282_I1.0390.32
213_Q327_E1.0350.32
224_K231_K1.0270.32
259_G273_H1.0260.32
239_P247_G1.0250.31
108_S215_I1.0220.31
29_P218_V1.0210.31
59_D339_P1.0180.31
62_P284_K1.0170.31
34_Q127_L1.0170.31
90_A154_I1.0130.31
167_K212_G1.0110.31
244_H250_K1.0100.31
55_V69_K1.0080.31
89_R104_E0.9930.30
56_F60_D0.9890.30
116_I122_S0.9870.30
165_P168_I0.9860.30
24_E44_G0.9840.30
155_V222_K0.9830.30
79_E301_Y0.9820.30
53_T75_V0.9700.29
88_L204_T0.9660.29
47_G51_G0.9620.29
42_L203_I0.9590.29
265_P306_N0.9580.29
65_P258_L0.9530.28
343_Y347_L0.9530.28
99_P102_I0.9510.28
238_L243_K0.9510.28
60_D95_G0.9500.28
94_D337_N0.9490.28
24_E27_P0.9430.28
34_Q282_I0.9420.28
83_I179_V0.9390.28
240_R245_R0.9380.28
15_G45_F0.9370.28
219_G320_K0.9350.28
243_K247_G0.9340.27
139_R168_I0.9320.27
182_Q186_G0.9310.27
19_R29_P0.9280.27
240_R243_K0.9250.27
183_I197_N0.9190.27
98_E295_A0.9150.27
141_N145_D0.9140.27
102_I224_K0.9120.27
56_F342_T0.9110.27
85_P205_I0.9080.26
293_N304_V0.9080.26
198_I207_D0.9070.26
18_P21_R0.9050.26
88_L189_K0.9000.26
117_T160_L0.9000.26
216_D255_G0.8980.26
80_V157_F0.8970.26
41_K327_E0.8950.26
254_R261_P0.8930.26
86_L162_S0.8890.26
179_V233_Y0.8880.26
237_E246_K0.8860.26
238_L250_K0.8850.25
16_L160_L0.8820.25
205_I285_I0.8760.25
54_H75_V0.8750.25
230_I246_K0.8740.25
93_I272_F0.8710.25
233_Y274_R0.8690.25
50_V289_P0.8680.25
209_F282_I0.8630.25
62_P293_N0.8590.24
97_G348_S0.8590.24
167_K202_E0.8570.24
97_G296_G0.8520.24
31_T329_V0.8510.24
215_I219_G0.8500.24
304_V323_I0.8400.24
48_Y163_T0.8370.24
88_L307_T0.8370.24
140_F230_I0.8330.23
244_H248_S0.8300.23
251_I254_R0.8280.23
178_L272_F0.8280.23
54_H79_E0.8190.23
101_V203_I0.8190.23
193_D196_L0.8160.23
87_A177_D0.8140.23
48_Y52_M0.8130.23
259_G334_V0.8130.23
272_F340_K0.8120.23
342_T345_N0.8120.23
197_N201_K0.8090.23
147_I199_L0.8070.23
15_G238_L0.8030.22
160_L311_L0.8030.22
102_I154_I0.8020.22
7_A246_K0.7990.22
50_V62_P0.7990.22
140_F147_I0.7990.22
240_R246_K0.7930.22
86_L160_L0.7900.22
30_R144_L0.7900.22
230_I282_I0.7870.22
83_I328_P0.7830.22
283_I341_I0.7830.22
22_S308_Y0.7790.21
140_F199_L0.7730.21
213_Q328_P0.7730.21
55_V126_F0.7730.21
46_V163_T0.7710.21
237_E254_R0.7660.21
161_V179_V0.7630.21
24_E218_V0.7600.21
298_F349_Q0.7570.21
217_V311_L0.7570.21
44_G324_F0.7560.21
25_L217_V0.7550.21
275_R321_R0.7540.21
8_S230_I0.7510.21
139_R171_L0.7490.20
22_S314_S0.7470.20
215_I325_L0.7470.20
14_A175_A0.7450.20
16_L186_G0.7410.20
161_V178_L0.7410.20
146_L149_S0.7410.20
237_E244_H0.7400.20
85_P215_I0.7390.20
5_K11_R0.7380.20
16_L80_V0.7370.20
183_I235_V0.7350.20
15_G219_G0.7330.20
116_I227_A0.7310.20
64_S67_N0.7300.20
165_P330_R0.7300.20
251_I266_Q0.7300.20
204_T307_T0.7290.20
191_Q274_R0.7260.20
19_R322_P0.7250.20
115_D118_R0.7210.20
25_L44_G0.7200.19
151_L272_F0.7200.19
82_P315_I0.7200.19
190_S286_G0.7140.19
108_S144_L0.7140.19
74_P266_Q0.7140.19
31_T203_I0.7140.19
35_I50_V0.7110.19
313_G317_G0.7100.19
5_K12_G0.7100.19
16_L260_T0.7080.19
85_P208_V0.7080.19
299_V309_V0.7070.19
111_L162_S0.7060.19
81_P268_G0.7040.19
59_D71_I0.7030.19
216_D326_R0.7030.19
295_A347_L0.7030.19
80_V233_Y0.7010.19
90_A157_F0.7000.19
77_V273_H0.7000.19
143_K215_I0.7000.19
249_R275_R0.6980.19
46_V179_V0.6970.19
48_Y206_R0.6940.19
273_H340_K0.6920.19
83_I178_L0.6900.19
334_V341_I0.6890.18
243_K250_K0.6840.18
291_E318_S0.6830.18
6_L45_F0.6810.18
292_I305_R0.6790.18
32_W43_L0.6750.18
182_Q345_N0.6730.18
8_S236_V0.6720.18
79_E343_Y0.6690.18
167_K227_A0.6690.18
80_V273_H0.6660.18
311_L338_P0.6640.18
64_S341_I0.6640.18
15_G278_Y0.6630.18
192_L310_L0.6620.18
9_P20_K0.6620.18
317_G321_R0.6610.18
172_G318_S0.6610.18
78_L208_V0.6600.18
116_I178_L0.6580.18
239_P246_K0.6560.17
257_S260_T0.6550.17
46_V83_I0.6550.17
103_T150_N0.6540.17
183_I193_D0.6540.17
60_D306_N0.6530.17
297_G302_G0.6530.17
330_R350_Q0.6510.17
235_V264_T0.6510.17
226_F336_E0.6500.17
62_P285_I0.6500.17
253_T346_L0.6490.17
14_A234_S0.6470.17
55_V219_G0.6470.17
83_I107_S0.6450.17
168_I272_F0.6450.17
62_P303_I0.6420.17
185_G232_R0.6410.17
25_L220_V0.6400.17
95_G102_I0.6390.17
141_N149_S0.6390.17
140_F151_L0.6380.17
298_F303_I0.6380.17
246_K263_Y0.6370.17
194_Y197_N0.6360.17
208_V285_I0.6350.17
110_S293_N0.6350.17
250_K258_L0.6310.17
33_P235_V0.6310.17
282_I309_V0.6310.17
23_S196_L0.6290.17
288_E300_R0.6290.17
151_L204_T0.6290.17
187_E305_R0.6270.17
13_S263_Y0.6250.17
230_I331_P0.6250.17
151_L336_E0.6240.17
186_G238_L0.6210.16
77_V341_I0.6200.16
226_F265_P0.6200.16
94_D97_G0.6180.16
153_R175_A0.6180.16
139_R224_K0.6180.16
230_I273_H0.6170.16
244_H312_E0.6170.16
234_S265_P0.6170.16
155_V168_I0.6170.16
48_Y165_P0.6160.16
56_F72_Y0.6130.16
108_S141_N0.6120.16
146_L282_I0.6110.16
246_K277_E0.6100.16
97_G294_P0.6090.16
227_A330_R0.6090.16
169_P306_N0.6070.16
106_W163_T0.6060.16
235_V304_V0.6060.16
107_S144_L0.6000.16
30_R61_W0.5990.16
165_P235_V0.5970.16
8_S163_T0.5930.16
149_S187_E0.5920.16
253_T266_Q0.5910.16
142_T311_L0.5910.16
14_A171_L0.5900.16
307_T344_V0.5890.16
230_I234_S0.5880.15
194_Y203_I0.5860.15
196_L236_V0.5850.15
24_E258_L0.5850.15
202_E262_S0.5820.15
80_V88_L0.5810.15
175_A213_Q0.5810.15
52_M70_E0.5800.15
60_D282_I0.5800.15
17_R263_Y0.5800.15
168_I171_L0.5790.15
244_H260_T0.5790.15
55_V196_L0.5770.15
239_P248_S0.5760.15
225_G275_R0.5750.15
280_K311_L0.5720.15
199_L330_R0.5720.15
55_V276_T0.5710.15
268_G313_G0.5710.15
270_L330_R0.5680.15
248_S282_I0.5670.15
166_R206_R0.5660.15
183_I198_I0.5650.15
93_I155_V0.5650.15
278_Y311_L0.5650.15
172_G322_P0.5640.15
139_R202_E0.5630.15
101_V167_K0.5630.15
12_G21_R0.5620.15
7_A199_L0.5620.15
240_R244_H0.5610.15
90_A155_V0.5600.15
104_E266_Q0.5600.15
253_T328_P0.5580.15
34_Q290_K0.5570.15
98_E156_Y0.5570.15
155_V264_T0.5560.15
47_G316_L0.5540.15
33_P40_P0.5530.15
197_N236_V0.5530.15
33_P326_R0.5530.15
337_N349_Q0.5520.15
33_P44_G0.5510.15
74_P77_V0.5490.14
105_Y217_V0.5490.14
235_V246_K0.5490.14
76_T118_R0.5490.14
167_K287_D0.5490.14
240_R247_G0.5490.14
160_L214_L0.5490.14
191_Q312_E0.5480.14
73_M124_S0.5480.14
57_M71_I0.5470.14
299_V319_K0.5440.14
77_V175_A0.5420.14
17_R252_G0.5420.14
143_K178_L0.5420.14
345_N349_Q0.5410.14
48_Y173_K0.5390.14
297_G326_R0.5380.14
61_W203_I0.5360.14
77_V210_K0.5360.14
252_G266_Q0.5330.14
231_K350_Q0.5330.14
236_V334_V0.5290.14
226_F239_P0.5290.14
297_G321_R0.5280.14
13_S24_E0.5270.14
22_S46_V0.5270.14
90_A94_D0.5270.14
280_K300_R0.5260.14
176_P252_G0.5250.14
94_D99_P0.5240.14
250_K345_N0.5220.14
192_L346_L0.5210.14
207_D309_V0.5200.14
142_T168_I0.5200.14
27_P274_R0.5190.14
67_N244_H0.5190.14
91_Y232_R0.5180.14
54_H299_V0.5180.14
17_R244_H0.5170.14
116_I140_F0.5170.14
143_K165_P0.5170.14
103_T151_L0.5160.14
22_S25_L0.5150.14
203_I282_I0.5150.14
192_L329_V0.5140.14
150_N234_S0.5140.14
208_V247_G0.5140.14
19_R265_P0.5130.14
124_S127_L0.5130.14
22_S318_S0.5130.14
143_K169_P0.5110.13
86_L199_L0.5090.13
179_V311_L0.5080.13
290_K344_V0.5070.13
220_V274_R0.5060.13
191_Q250_K0.5060.13
165_P211_E0.5060.13
194_Y230_I0.5050.13
54_H280_K0.5050.13
249_R321_R0.5040.13
230_I319_K0.5040.13
87_A213_Q0.5030.13
231_K308_Y0.5030.13
125_S323_I0.5030.13
6_L253_T0.5030.13
191_Q327_E0.5020.13
181_I239_P0.5010.13
119_R175_A0.5010.13
160_L277_E0.5010.13
99_P346_L0.5000.13
86_L115_D0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ujqE 1 0.9772 100 0.202 Contact Map
3zf7f 1 0.9801 100 0.207 Contact Map
3j61B 1 0.9829 100 0.208 Contact Map
1vx7E 1 0.9772 100 0.208 Contact Map
4a17B 1 0.9772 100 0.213 Contact Map
4w20B 1 0.9772 100 0.216 Contact Map
3j21C 1 0.9601 100 0.27 Contact Map
1vq8B 1 0.9487 100 0.297 Contact Map
1vw3C 1 0.6923 100 0.596 Contact Map
4tp9D 1 0.584 100 0.646 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0095 seconds.