GREMLIN Database
RL4 - 50S ribosomal protein L4
UniProt: Q9UXA6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (252)
Sequences: 443 (269)
Seq/√Len: 17.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_D252_S5.0991.00
206_I247_T4.2301.00
45_E111_A3.7061.00
127_T247_T3.3610.99
124_L249_Y3.3280.99
166_F170_I3.2030.99
21_K251_E3.0610.99
173_Y176_V3.0320.99
251_E255_K2.9080.98
14_D18_N2.8730.98
77_V89_A2.6140.97
86_A92_T2.6050.96
50_L53_K2.5490.96
179_V221_L2.5290.96
150_V170_I2.5270.96
183_I199_E2.5180.96
40_R44_A2.4510.95
68_F72_L2.4370.95
172_V246_L2.3780.94
56_D62_R2.2210.92
38_I243_P2.2090.91
182_R200_P2.1900.91
185_I197_Y2.1510.90
50_L107_L2.1340.90
163_V218_A2.1110.89
170_I248_I2.0680.88
106_K109_E1.9080.84
39_R43_I1.9050.84
70_I76_R1.8900.83
172_V175_D1.7910.80
41_V111_A1.7890.80
189_K192_M1.7670.79
39_R241_A1.7610.79
143_S171_G1.7500.78
33_V243_P1.7130.77
42_F46_F1.6960.76
230_K256_I1.6910.76
86_A94_G1.6870.75
154_I166_F1.6850.75
211_N214_I1.6820.75
54_G101_P1.6820.75
53_K101_P1.6650.74
209_D212_S1.6610.74
164_E173_Y1.6480.74
133_V146_F1.6430.73
155_V208_H1.6420.73
40_R115_E1.6160.72
65_A87_A1.6040.72
25_L29_F1.5920.71
226_V261_L1.5440.69
188_G195_R1.5380.68
92_T253_S1.5090.67
64_S87_A1.5020.66
64_S107_L1.5000.66
221_L224_V1.4580.64
154_I250_T1.4530.64
172_V248_I1.4510.64
151_T251_E1.4430.63
31_F121_I1.4300.62
53_K107_L1.4230.62
143_S146_F1.4170.62
208_H252_S1.4120.61
87_A94_G1.3900.60
117_R229_A1.3640.59
42_F241_A1.3640.59
142_D174_D1.3590.58
134_R141_K1.3500.58
124_L146_F1.3440.57
80_V83_S1.3420.57
123_A238_A1.3350.57
185_I216_K1.3300.57
198_K225_D1.3180.56
182_R199_E1.3110.56
157_L166_F1.2930.54
9_K22_E1.2860.54
89_A92_T1.2830.54
70_I84_G1.2590.52
140_F205_I1.2590.52
190_G196_K1.2560.52
124_L128_A1.2480.52
168_K173_Y1.2250.50
176_V221_L1.2230.50
79_R111_A1.2200.50
152_D162_E1.2150.50
47_T50_L1.2120.50
203_P248_I1.1940.49
44_A48_H1.1930.49
127_T249_Y1.1840.48
90_P97_L1.1660.47
63_T86_A1.1630.47
101_P178_R1.1570.46
14_D151_T1.1350.45
13_L150_V1.1350.45
161_S250_T1.1300.45
190_G193_R1.1290.45
188_G193_R1.1230.44
131_A134_R1.1180.44
23_V208_H1.1120.44
209_D213_P1.1100.44
94_G145_R1.1050.43
63_T94_G1.1010.43
155_V209_D1.0980.43
93_V105_K1.0930.43
42_F235_I1.0900.42
61_K96_R1.0880.42
204_L225_D1.0880.42
18_N189_K1.0850.42
181_E221_L1.0790.42
54_G146_F1.0760.42
63_T67_S1.0720.41
165_E169_K1.0630.41
158_K213_P1.0510.40
173_Y180_K1.0410.40
65_A70_I1.0370.39
154_I169_K1.0280.39
29_F124_L1.0250.39
67_S87_A1.0190.38
153_D156_N1.0150.38
40_R109_E1.0100.38
120_V260_R1.0010.37
63_T88_L1.0000.37
176_V224_V0.9970.37
233_S236_H0.9940.37
136_R243_P0.9820.36
17_G155_V0.9810.36
152_D251_E0.9800.36
252_S259_E0.9760.36
249_Y254_I0.9710.36
46_F236_H0.9680.36
229_A249_Y0.9650.35
165_E187_A0.9650.35
31_F196_K0.9600.35
67_S149_V0.9590.35
140_F202_G0.9560.35
166_F205_I0.9560.35
150_V154_I0.9450.34
48_H53_K0.9420.34
169_K252_S0.9410.34
183_I187_A0.9410.34
93_V157_L0.9390.34
160_T221_L0.9390.34
238_A245_R0.9320.34
70_I85_E0.9220.33
47_T53_K0.9160.33
117_R203_P0.9160.33
33_V129_D0.8970.32
57_P255_K0.8960.32
235_I241_A0.8940.32
159_T162_E0.8940.32
68_F220_N0.8930.32
179_V199_E0.8870.31
57_P61_K0.8850.31
66_E88_L0.8820.31
27_I118_L0.8790.31
67_S137_G0.8710.30
17_G166_F0.8690.30
45_E116_K0.8690.30
38_I122_S0.8690.30
123_A206_I0.8680.30
202_G221_L0.8670.30
37_L198_K0.8660.30
87_A116_K0.8650.30
197_Y201_I0.8630.30
80_V87_A0.8600.30
175_D202_G0.8580.30
75_A81_K0.8530.29
64_S68_F0.8480.29
110_E225_D0.8470.29
144_V148_I0.8430.29
149_V167_L0.8350.29
67_S70_I0.8340.29
61_K88_L0.8300.28
85_E148_I0.8300.28
37_L115_E0.8280.28
174_D177_E0.8260.28
15_K154_I0.8260.28
65_A72_L0.8250.28
33_V241_A0.8240.28
90_P96_R0.8230.28
41_V114_K0.8210.28
31_F99_F0.8160.28
188_G240_G0.8140.28
48_H107_L0.8120.28
155_V217_A0.8120.28
124_L224_V0.8110.27
55_R107_L0.8090.27
25_L33_V0.8070.27
122_S175_D0.8050.27
18_N152_D0.7970.27
33_V127_T0.7900.26
65_A100_P0.7850.26
56_D61_K0.7840.26
136_R225_D0.7830.26
76_R93_V0.7750.26
11_D19_R0.7720.26
61_K203_P0.7690.26
86_A114_K0.7670.25
89_A175_D0.7660.25
17_G22_E0.7650.25
86_A142_D0.7640.25
9_K183_I0.7640.25
186_R193_R0.7590.25
68_F74_M0.7580.25
179_V202_G0.7580.25
192_M241_A0.7540.25
55_R103_V0.7470.25
141_K156_N0.7470.25
37_L205_I0.7450.24
134_R150_V0.7450.24
22_E155_V0.7420.24
26_P34_R0.7370.24
12_I145_R0.7350.24
150_V252_S0.7330.24
158_K162_E0.7280.24
151_T217_A0.7250.24
70_I97_L0.7240.24
77_V91_N0.7220.23
65_A84_G0.7220.23
21_K227_V0.7210.23
76_R82_N0.7150.23
103_V192_M0.7150.23
50_L56_D0.7130.23
218_A235_I0.7120.23
90_P93_V0.7110.23
11_D166_F0.7110.23
188_G206_I0.7090.23
102_S229_A0.7080.23
53_K110_E0.7080.23
20_I151_T0.7070.23
172_V176_V0.7050.23
120_V124_L0.7030.23
162_E165_E0.6960.22
238_A250_T0.6960.22
17_G169_K0.6930.22
65_A89_A0.6910.22
71_N88_L0.6880.22
78_P89_A0.6860.22
158_K214_I0.6820.22
25_L51_Q0.6820.22
120_V234_V0.6820.22
205_I218_A0.6810.22
226_V231_D0.6800.22
141_K162_E0.6800.22
23_V230_K0.6770.22
48_H116_K0.6710.21
82_N93_V0.6710.21
190_G195_R0.6700.21
171_G178_R0.6690.21
184_R198_K0.6670.21
198_K201_I0.6660.21
69_G220_N0.6630.21
76_R79_R0.6620.21
130_I156_N0.6590.21
102_S112_N0.6570.21
205_I224_V0.6560.21
175_D222_A0.6560.21
9_K81_K0.6520.21
80_V85_E0.6520.21
224_V257_L0.6510.21
50_L117_R0.6490.20
73_G101_P0.6460.20
75_A156_N0.6440.20
83_S257_L0.6430.20
170_I209_D0.6400.20
68_F232_V0.6380.20
45_E121_I0.6370.20
52_P189_K0.6370.20
106_K129_D0.6360.20
181_E185_I0.6310.20
149_V207_V0.6310.20
74_M91_N0.6280.20
37_L209_D0.6270.20
17_G59_A0.6260.20
141_K174_D0.6250.20
239_P253_S0.6250.20
190_G244_G0.6250.20
177_E252_S0.6250.20
206_I231_D0.6220.19
69_G137_G0.6210.19
35_K252_S0.6190.19
234_V241_A0.6180.19
44_A47_T0.6180.19
166_F169_K0.6170.19
50_L63_T0.6170.19
46_F225_D0.6160.19
157_L208_H0.6130.19
52_P196_K0.6120.19
153_D183_I0.6120.19
46_F235_I0.6090.19
64_S257_L0.6080.19
127_T194_G0.6080.19
25_L155_V0.6040.19
50_L64_S0.6010.19
179_V252_S0.5990.19
189_K260_R0.5980.19
103_V146_F0.5980.19
49_S71_N0.5980.19
124_L241_A0.5960.18
22_E25_L0.5950.18
156_N161_S0.5940.18
144_V171_G0.5930.18
161_S253_S0.5910.18
39_R115_E0.5910.18
70_I90_P0.5910.18
81_K251_E0.5880.18
156_N169_K0.5800.18
15_K250_T0.5790.18
75_A224_V0.5780.18
161_S209_D0.5770.18
22_E142_D0.5760.18
39_R44_A0.5760.18
70_I88_L0.5750.18
187_A201_I0.5730.18
49_S58_N0.5730.18
127_T206_I0.5700.18
77_V175_D0.5700.18
171_G227_V0.5690.18
208_H256_I0.5680.17
62_R77_V0.5670.17
76_R84_G0.5670.17
29_F34_R0.5650.17
114_K194_G0.5640.17
55_R86_A0.5630.17
23_V114_K0.5620.17
23_V254_I0.5620.17
132_F135_A0.5610.17
49_S235_I0.5590.17
30_S103_V0.5550.17
68_F93_V0.5540.17
201_I204_L0.5530.17
39_R184_R0.5490.17
38_I234_V0.5490.17
152_D248_I0.5470.17
18_N178_R0.5470.17
161_S174_D0.5450.17
50_L80_V0.5450.17
52_P191_K0.5410.17
68_F71_N0.5400.17
39_R196_K0.5390.17
81_K171_G0.5390.17
195_R240_G0.5380.16
120_V227_V0.5360.16
70_I82_N0.5350.16
50_L76_R0.5340.16
40_R153_D0.5300.16
178_R246_L0.5290.16
124_L151_T0.5280.16
68_F110_E0.5270.16
11_D38_I0.5260.16
200_P246_L0.5260.16
29_F161_S0.5260.16
35_K243_P0.5240.16
168_K175_D0.5230.16
181_E212_S0.5220.16
17_G158_K0.5220.16
186_R191_K0.5220.16
230_K249_Y0.5210.16
52_P224_V0.5210.16
211_N215_I0.5200.16
87_A97_L0.5190.16
28_I126_A0.5180.16
133_V178_R0.5170.16
35_K125_S0.5170.16
150_V166_F0.5160.16
146_F249_Y0.5140.16
159_T228_N0.5140.16
44_A109_E0.5130.16
156_N165_E0.5070.15
250_T261_L0.5070.15
52_P255_K0.5060.15
179_V228_N0.5060.15
205_I258_D0.5040.15
81_K227_V0.5030.15
57_P134_R0.5030.15
36_D193_R0.5030.15
88_L91_N0.5030.15
234_V243_P0.5020.15
208_H212_S0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j21D 1 0.9513 100 0.308 Contact Map
1vx7F 1 0.97 100 0.31 Contact Map
4ujqF 1 0.9775 100 0.311 Contact Map
3j39C 1 0.9925 100 0.312 Contact Map
4a17C 1 0.985 100 0.315 Contact Map
3j61C 1 0.9738 100 0.317 Contact Map
3j3bC 1 0.9775 100 0.32 Contact Map
3zf7r 1 0.9738 100 0.321 Contact Map
4w20C 1 0.985 100 0.322 Contact Map
1vq8C 1 0.9213 100 0.339 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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