GREMLIN Database
RL2 - 50S ribosomal protein L2
UniProt: Q9UXA5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 238 (226)
Sequences: 2512 (967)
Seq/√Len: 64.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_G57_V3.3551.00
113_D116_K3.2551.00
35_G152_R3.1981.00
42_I58_K3.0661.00
135_V149_N2.8721.00
127_V135_V2.7811.00
19_N187_I2.6431.00
106_N115_G2.5821.00
191_V208_V2.5291.00
104_V137_I2.5061.00
104_V127_V2.4831.00
102_T155_V2.4351.00
118_A125_A2.4341.00
71_Q161_G2.3801.00
96_G150_K2.3601.00
229_A232_T2.3031.00
184_K187_I2.2991.00
24_R176_W2.2641.00
137_I147_V2.2431.00
107_V125_A2.2271.00
208_V211_P2.0841.00
51_N163_V2.0641.00
157_I161_G1.9881.00
57_V79_I1.9461.00
34_F61_N1.9361.00
10_A16_T1.9311.00
168_L174_N1.8831.00
136_L144_I1.8711.00
92_V152_R1.8681.00
73_L79_I1.7821.00
20_P184_K1.7771.00
74_V77_Q1.7751.00
41_V73_L1.7641.00
220_P224_V1.7451.00
58_K64_K1.7431.00
191_V207_S1.7110.99
33_I65_F1.6950.99
211_P214_V1.6910.99
208_V222_R1.6820.99
68_Q115_G1.6700.99
98_A155_V1.6130.99
94_E97_D1.6030.99
77_Q88_A1.5990.99
34_F63_T1.5970.99
71_Q157_I1.5700.99
70_I73_L1.5630.99
38_I78_K1.5580.99
208_V212_S1.5560.99
215_S219_P1.5540.99
53_P159_A1.5480.99
55_A69_A1.5190.99
108_E114_G1.5170.99
129_G136_L1.5150.99
52_A158_V1.5080.99
36_H84_G1.4920.98
82_G85_S1.4860.98
117_Y147_V1.4780.98
40_K58_K1.4700.98
17_F187_I1.4570.98
107_V137_I1.4530.98
134_R148_S1.4510.98
228_A234_R1.4440.98
219_P224_V1.4410.98
221_G224_V1.4220.98
174_N177_K1.4150.98
130_K149_N1.4060.98
38_I60_E1.3940.98
200_H214_V1.3920.98
35_G82_G1.3780.97
168_L177_K1.3730.97
35_G81_F1.3700.97
229_A234_R1.3510.97
6_L20_P1.3490.97
36_H82_G1.3440.97
41_V57_V1.3360.97
85_S93_I1.3340.97
40_K78_K1.3260.97
200_H208_V1.3260.97
96_G149_N1.3230.97
93_I98_A1.3110.96
42_I64_K1.3080.96
133_D148_S1.3010.96
109_E117_Y1.2850.96
71_Q159_A1.2740.96
111_F148_S1.2250.95
223_K226_H1.2180.95
207_S211_P1.2170.95
231_R234_R1.2110.94
103_I124_Y1.1990.94
136_L146_A1.1880.94
55_A73_L1.1880.94
20_P187_I1.1870.94
194_N197_D1.1670.93
70_I105_C1.1590.93
162_G165_E1.1470.93
229_A233_G1.1460.93
34_F37_F1.1450.93
188_V192_A1.1420.93
230_R233_G1.1400.92
117_Y139_L1.1280.92
230_R234_R1.1070.91
207_S210_R1.1010.91
173_A177_K1.0930.91
210_R214_V1.0930.91
191_V210_R1.0830.90
19_N184_K1.0720.90
110_N113_D1.0700.90
109_E147_V1.0670.90
92_V154_T1.0520.89
98_A153_A1.0470.89
4_N7_Q1.0450.89
84_G97_D1.0410.89
200_H221_G1.0260.88
40_K60_E1.0120.87
215_S222_R1.0110.87
43_D75_V1.0070.87
187_I200_H1.0040.87
98_A127_V1.0030.87
212_S222_R0.9980.86
43_D55_A0.9930.86
133_D149_N0.9850.86
17_F20_P0.9810.85
130_K135_V0.9700.85
56_L66_L0.9670.85
18_R193_M0.9670.85
228_A231_R0.9630.84
211_P221_G0.9630.84
219_P222_R0.9440.83
68_Q158_V0.9400.83
166_K173_A0.9350.83
195_V204_L0.9330.82
19_N188_V0.9230.82
47_N50_M0.9210.82
56_L64_K0.9200.82
210_R222_R0.9140.81
191_V212_S0.9090.81
174_N184_K0.9090.81
204_L208_V0.9060.81
28_V54_V0.9050.80
211_P222_R0.9040.80
37_F60_E0.8990.80
43_D56_L0.8870.79
37_F63_T0.8860.79
68_Q106_N0.8860.79
44_I53_P0.8800.79
168_L173_A0.8640.77
51_N69_A0.8620.77
26_G29_R0.8590.77
105_C154_T0.8480.76
80_E86_P0.8420.75
190_G200_H0.8360.75
43_D64_K0.8320.75
215_S221_G0.8320.75
126_V138_R0.8300.74
15_P19_N0.8230.74
42_I57_V0.8230.74
43_D159_A0.8210.74
189_R192_A0.8110.73
81_F92_V0.8110.73
203_G206_Q0.8110.73
118_A137_I0.8060.72
107_V118_A0.8040.72
19_N193_M0.8040.72
127_V149_N0.7970.71
215_S220_P0.7920.71
7_Q20_P0.7920.71
84_G93_I0.7890.71
216_R228_A0.7880.70
214_V220_P0.7850.70
82_G152_R0.7830.70
223_K227_I0.7820.70
73_L105_C0.7790.70
34_F59_L0.7780.69
45_V66_L0.7750.69
200_H222_R0.7740.69
57_V65_F0.7730.69
44_I54_V0.7730.69
20_P23_L0.7700.69
196_V222_R0.7680.69
19_N185_W0.7630.68
39_G65_F0.7620.68
193_M197_D0.7580.67
72_G142_D0.7490.67
95_I137_I0.7450.66
39_G59_L0.7440.66
38_I80_E0.7390.66
67_M70_I0.7350.65
83_K97_D0.7230.64
73_L89_N0.7230.64
28_V43_D0.7220.64
53_P140_P0.7210.64
108_E112_G0.7210.64
10_A14_S0.7200.64
118_A140_P0.7190.63
39_G79_I0.7170.63
67_M105_C0.7140.63
105_C158_V0.7140.63
62_G114_G0.7130.63
208_V215_S0.7070.62
44_I55_A0.7070.62
200_H215_S0.7060.62
118_A123_S0.6990.61
191_V211_P0.6940.61
15_P188_V0.6920.60
43_D53_P0.6900.60
207_S214_V0.6900.60
71_Q165_E0.6870.60
124_Y157_I0.6850.60
87_I93_I0.6840.60
48_P119_R0.6830.59
227_I233_G0.6780.59
104_V107_V0.6700.58
75_V128_V0.6680.58
86_P152_R0.6670.58
195_V214_V0.6660.58
6_L17_F0.6650.57
161_G164_I0.6640.57
7_Q23_L0.6610.57
83_K96_G0.6600.57
36_H80_E0.6570.56
17_F188_V0.6570.56
106_N154_T0.6540.56
86_P164_I0.6530.56
104_V125_A0.6530.56
196_V210_R0.6490.56
196_V212_S0.6480.55
196_V208_V0.6460.55
210_R221_G0.6460.55
81_F152_R0.6450.55
228_A232_T0.6400.55
45_V54_V0.6380.54
192_A214_V0.6370.54
5_L20_P0.6360.54
103_I157_I0.6350.54
214_V221_G0.6340.54
87_I155_V0.6320.54
191_V214_V0.6320.54
53_P71_Q0.6270.53
57_V159_A0.6240.53
83_K94_E0.6240.53
125_A137_I0.6220.52
120_S123_S0.6210.52
224_V229_A0.6190.52
187_I216_R0.6110.51
82_G93_I0.6100.51
9_R13_G0.6100.51
121_A163_V0.6070.51
37_F59_L0.6050.50
169_L173_A0.6040.50
167_P206_Q0.6000.50
69_A159_A0.5920.49
109_E137_I0.5890.49
138_R225_G0.5880.48
53_P162_G0.5870.48
203_G208_V0.5850.48
94_E150_K0.5820.48
100_E129_G0.5820.48
168_L192_A0.5810.48
15_P187_I0.5810.48
129_G140_P0.5810.48
85_S97_D0.5810.48
51_N159_A0.5800.48
159_A164_I0.5800.48
95_I127_V0.5780.47
19_N216_R0.5770.47
33_I63_T0.5770.47
34_F62_G0.5760.47
191_V203_G0.5760.47
7_Q17_F0.5760.47
16_T111_F0.5750.47
218_A222_R0.5750.47
53_P166_K0.5730.47
11_G14_S0.5730.47
17_F53_P0.5730.47
26_G47_N0.5720.47
44_I64_K0.5690.46
224_V232_T0.5680.46
127_V130_K0.5660.46
36_H83_K0.5640.46
43_D140_P0.5640.46
96_G135_V0.5590.45
83_K93_I0.5590.45
100_E225_G0.5580.45
109_E151_A0.5560.45
200_H213_T0.5550.45
212_S221_G0.5530.44
60_E65_F0.5530.44
29_R32_N0.5530.44
195_V209_S0.5520.44
140_P165_E0.5520.44
131_S144_I0.5510.44
212_S224_V0.5490.44
106_N129_G0.5490.44
26_G30_Y0.5480.44
211_P220_P0.5470.44
43_D58_K0.5460.44
167_P224_V0.5460.44
32_N105_C0.5460.44
60_E78_K0.5460.44
135_V147_V0.5440.43
130_K138_R0.5440.43
124_Y161_G0.5440.43
208_V221_G0.5420.43
192_A203_G0.5420.43
121_A169_L0.5410.43
216_R221_G0.5410.43
11_G17_F0.5410.43
198_H201_G0.5390.43
108_E151_A0.5370.43
95_I103_I0.5340.42
217_N221_G0.5330.42
191_V222_R0.5310.42
196_V214_V0.5300.42
37_F80_E0.5290.42
128_V142_D0.5280.42
115_G154_T0.5260.41
100_E130_K0.5240.41
104_V135_V0.5240.41
107_V147_V0.5230.41
32_N92_V0.5220.41
75_V84_G0.5210.41
59_L62_G0.5190.41
129_G132_G0.5170.40
26_G48_P0.5170.40
45_V48_P0.5160.40
51_N166_K0.5150.40
44_I69_A0.5140.40
134_R146_A0.5140.40
129_G213_T0.5130.40
68_Q105_C0.5130.40
43_D54_V0.5110.40
19_N217_N0.5110.40
80_E85_S0.5110.40
83_K152_R0.5100.40
18_R215_S0.5090.39
131_S140_P0.5030.39
103_I126_V0.5030.39
129_G144_I0.5030.39
74_V79_I0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rb6D 1 0.979 100 0.062 Contact Map
4tp9C 1 0.0084 100 0.062 Contact Map
1vw3B 1 0.9706 100 0.068 Contact Map
1vq8A 1 0.9664 100 0.069 Contact Map
3j3wC 1 0.979 100 0.074 Contact Map
3bboE 1 0.9706 100 0.074 Contact Map
3j21B 1 0.9748 100 0.078 Contact Map
3zf7e 1 0.7395 100 0.084 Contact Map
3j61A 1 1 100 0.084 Contact Map
4a17A 2 0.9958 100 0.085 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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