GREMLIN Database
RL22 - 50S ribosomal protein L22
UniProt: Q9UXA2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 157 (149)
Sequences: 493 (299)
Seq/√Len: 24.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_R58_E6.0111.00
101_A153_L5.8621.00
45_D58_E4.0841.00
23_D126_I3.5601.00
49_F60_L3.4521.00
47_K102_E3.0621.00
59_A72_K2.9481.00
59_A75_I2.9241.00
21_I24_V2.6530.99
54_L91_I2.6250.99
52_R57_K2.5850.99
35_C94_V2.3830.98
45_D52_R2.2750.97
30_D90_A1.9720.94
60_L91_I1.9400.94
72_K75_I1.8140.91
65_Y124_K1.8050.91
34_V90_A1.7990.91
47_K51_N1.7830.90
51_N95_L1.7730.90
59_A84_G1.7250.89
121_A150_E1.6660.87
31_L90_A1.6600.87
43_L151_V1.6450.86
30_D34_V1.5880.84
88_K92_R1.5780.84
62_F66_N1.5210.82
34_V91_I1.4840.80
115_L148_N1.4520.78
118_R154_E1.4500.78
69_A83_A1.4350.78
17_A153_L1.4260.77
34_V94_V1.3950.75
54_L60_L1.3930.75
49_F79_W1.3780.75
99_E102_E1.3490.73
74_N86_Y1.3470.73
45_D92_R1.2480.67
35_C151_V1.2380.66
67_K73_S1.2370.66
51_N55_E1.2330.66
117_I120_I1.2230.65
42_Y116_I1.2120.65
66_N69_A1.2000.64
75_I84_G1.1880.63
51_N88_K1.1820.63
32_Y64_R1.1630.61
27_S62_F1.1560.61
132_M142_K1.1450.60
35_C120_I1.1440.60
37_A60_L1.1410.60
21_I97_V1.1360.59
17_A101_A1.1050.57
30_D71_H1.0890.56
26_E118_R1.0740.55
33_N70_S1.0620.54
47_K99_E1.0580.54
16_I154_E1.0500.53
41_M45_D1.0420.53
43_L47_K1.0390.53
42_Y45_D1.0370.52
26_E31_L1.0270.52
37_A49_F1.0200.51
111_D155_E1.0120.51
38_I81_I1.0110.51
64_R138_R0.9850.49
73_S76_S0.9720.48
135_A150_E0.9550.47
133_P139_A0.9520.46
61_P98_L0.9520.46
56_E60_L0.9470.46
131_Y146_T0.9400.46
132_M140_T0.9390.45
28_I65_Y0.9320.45
80_K91_I0.9210.44
106_T155_E0.9130.44
31_L94_V0.9090.43
95_L102_E0.9070.43
109_G155_E0.9020.43
9_L13_E0.8970.42
63_W85_R0.8960.42
128_L144_R0.8950.42
25_P43_L0.8940.42
112_V115_L0.8910.42
59_A74_N0.8720.41
68_G75_I0.8690.41
144_R147_S0.8500.39
45_D57_K0.8420.39
19_A63_W0.8410.39
39_R67_K0.8370.38
51_N111_D0.8360.38
7_P119_H0.8330.38
31_L34_V0.8320.38
60_L81_I0.8230.37
70_S126_I0.8130.37
53_V61_P0.8110.37
67_K136_F0.8100.37
39_R119_H0.8050.36
7_P150_E0.8010.36
28_I123_H0.7990.36
61_P89_K0.7990.36
40_G80_K0.7960.36
130_R143_Y0.7820.35
106_T112_V0.7800.35
98_L115_L0.7780.34
18_K98_L0.7770.34
36_K128_L0.7750.34
10_D16_I0.7750.34
65_Y83_A0.7750.34
125_G146_T0.7750.34
64_R85_R0.7650.34
62_F69_A0.7650.34
62_F83_A0.7610.33
103_A114_K0.7600.33
27_S145_R0.7540.33
30_D69_A0.7520.33
66_N83_A0.7500.33
138_R141_A0.7480.32
40_G104_N0.7480.32
12_D15_K0.7420.32
7_P117_I0.7370.32
12_D94_V0.7370.32
72_K84_G0.7320.31
131_Y147_S0.7250.31
85_R134_R0.7230.31
125_G133_P0.7160.31
53_V137_G0.7140.30
4_W20_V0.7130.30
115_L153_L0.7120.30
69_A72_K0.7120.30
11_V18_K0.7110.30
20_V150_E0.7050.30
62_F85_R0.7040.30
23_D150_E0.7030.30
13_E16_I0.6920.29
43_L102_E0.6920.29
80_K84_G0.6900.29
48_D123_H0.6810.28
26_E143_Y0.6800.28
47_K95_L0.6710.28
92_R111_D0.6710.28
47_K54_L0.6690.28
118_R124_K0.6690.28
33_N141_A0.6690.28
93_Q99_E0.6680.28
133_P140_T0.6680.28
120_I153_L0.6670.28
23_D148_N0.6660.28
56_E59_A0.6620.27
34_V38_I0.6620.27
13_E18_K0.6610.27
142_K146_T0.6600.27
21_I57_K0.6590.27
102_E105_A0.6580.27
25_P130_R0.6570.27
16_I108_K0.6550.27
4_W19_A0.6510.27
27_S35_C0.6490.27
54_L59_A0.6440.26
109_G150_E0.6350.26
21_I101_A0.6290.25
25_P144_R0.6280.25
125_G131_Y0.6270.25
35_C122_A0.6260.25
28_I146_T0.6250.25
9_L16_I0.6230.25
7_P121_A0.6200.25
76_S133_P0.6180.25
44_N113_D0.6170.25
93_Q140_T0.6160.25
58_E79_W0.6150.25
120_I151_V0.6150.25
42_Y114_K0.6140.25
30_D70_S0.6080.24
122_A147_S0.6080.24
81_I84_G0.6040.24
10_D113_D0.6020.24
53_V62_F0.6000.24
64_R141_A0.5960.24
100_N132_M0.5920.24
72_K79_W0.5910.23
5_K120_I0.5890.23
36_K39_R0.5870.23
10_D18_K0.5870.23
139_A146_T0.5810.23
124_K127_T0.5800.23
131_Y139_A0.5800.23
19_A39_R0.5790.23
24_V39_R0.5740.23
53_V87_P0.5690.22
4_W7_P0.5690.22
136_F146_T0.5630.22
131_Y136_F0.5620.22
50_L53_V0.5580.22
48_D52_R0.5570.22
140_T143_Y0.5530.22
63_W81_I0.5520.22
62_F107_N0.5520.22
108_K127_T0.5490.21
107_N128_L0.5490.21
32_Y112_V0.5480.21
92_R117_I0.5430.21
12_D155_E0.5420.21
4_W9_L0.5410.21
30_D76_S0.5410.21
41_M114_K0.5350.21
5_K79_W0.5320.21
130_R142_K0.5260.20
63_W91_I0.5260.20
104_N149_I0.5230.20
19_A119_H0.5230.20
34_V92_R0.5220.20
79_W113_D0.5200.20
126_I148_N0.5170.20
49_F52_R0.5100.20
21_I123_H0.5070.19
85_R105_A0.5070.19
23_D92_R0.5060.19
75_I83_A0.5050.19
9_L14_L0.5040.19
132_M146_T0.5040.19
115_L121_A0.5010.19
101_A117_I0.5010.19
23_D30_D0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4a17Q 1 0.9873 100 0.162 Contact Map
1vx7W 1 0.9618 100 0.167 Contact Map
3j39P 1 0.9745 100 0.177 Contact Map
4ujrC 1 0.9745 100 0.18 Contact Map
3j61P 1 0.9873 100 0.184 Contact Map
1vq8R 1 0.9554 100 0.192 Contact Map
3zf7R 1 0.9745 100 0.2 Contact Map
3j21S 1 0.949 100 0.202 Contact Map
3j3bP 1 0.9682 100 0.221 Contact Map
4w20P 1 0.9745 100 0.227 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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