GREMLIN Database
RL14 - 50S ribosomal protein L14
UniProt: Q9UX97 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 138 (118)
Sequences: 1566 (564)
Seq/√Len: 51.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_V75_F4.8571.00
35_A101_V4.1381.00
37_I59_V3.7181.00
35_A61_V3.1681.00
23_V34_E3.0141.00
18_L37_I2.8291.00
36_M64_K2.6681.00
21_Y36_M2.6201.00
77_A101_V2.5121.00
34_E65_K2.2901.00
41_Y60_M2.1961.00
87_R93_W2.1391.00
18_L22_S2.0561.00
35_A63_I2.0311.00
60_M76_R1.9831.00
103_I111_K1.9631.00
53_A79_I1.8680.99
19_Q22_S1.8640.99
25_N98_D1.8370.99
123_A131_A1.8030.99
23_V36_M1.7420.99
26_V35_A1.7370.99
105_N109_T1.7050.99
76_R106_P1.6720.98
54_N86_Y1.6570.98
20_H39_G1.6060.98
25_N34_E1.5810.98
49_R52_F1.5510.98
94_I138_V1.5260.97
54_N85_P1.5060.97
36_M62_S1.4710.97
88_R122_E1.4380.96
111_K125_E1.4270.96
58_M127_W1.3020.93
80_V119_I1.2530.92
58_M104_I1.2380.91
124_A128_P1.1610.88
20_H36_M1.1450.88
119_I123_A1.1390.88
108_G127_W1.1310.87
23_V64_K1.1260.87
129_K132_S1.0920.85
26_V101_V1.0800.85
30_S111_K1.0740.84
100_A125_E1.0710.84
55_I86_Y1.0430.82
59_V79_I1.0270.81
38_I138_V1.0210.81
24_V35_A0.9990.80
81_R117_G0.9870.79
40_V53_A0.9720.78
27_A118_P0.9330.75
81_R98_D0.9270.74
30_S112_G0.9110.73
128_P131_A0.9110.73
119_I130_I0.8980.72
69_E73_Q0.8900.71
65_K118_P0.8870.71
55_I85_P0.8870.71
58_M108_G0.8820.71
77_A103_I0.8750.70
105_N111_K0.8640.69
81_R100_A0.8570.68
27_A80_V0.8570.68
35_A79_I0.8540.68
30_S39_G0.8530.68
23_V62_S0.8420.67
34_E64_K0.8280.66
70_V74_K0.8280.66
17_A114_E0.8210.65
65_K72_K0.8210.65
24_V101_V0.8180.65
39_G47_L0.8100.64
40_V49_R0.8070.64
88_R100_A0.8060.64
131_A138_V0.8040.63
88_R91_G0.8040.63
45_G49_R0.7980.63
105_N108_G0.7980.63
70_V73_Q0.7970.63
82_Q86_Y0.7940.62
61_V103_I0.7930.62
18_L24_V0.7900.62
78_V127_W0.7810.61
38_I73_Q0.7740.60
24_V59_V0.7670.60
123_A126_R0.7660.60
85_P93_W0.7630.59
61_V101_V0.7580.59
104_I108_G0.7480.58
39_G46_V0.7400.57
75_F103_I0.7310.56
85_P95_S0.7300.56
32_G70_V0.7280.56
120_A125_E0.7250.55
80_V102_V0.7250.55
75_F111_K0.7240.55
48_R79_I0.7220.55
33_K45_G0.7160.54
33_K38_I0.7110.54
71_R127_W0.7070.54
116_R136_L0.7060.53
38_I47_L0.6970.52
33_K67_T0.6940.52
30_S67_T0.6910.52
114_E133_L0.6870.51
41_Y76_R0.6770.50
91_G100_A0.6750.50
42_G121_R0.6730.50
32_G104_I0.6710.50
110_P133_L0.6710.50
131_A135_T0.6690.50
107_D111_K0.6600.49
67_T70_V0.6570.48
124_A137_V0.6560.48
81_R118_P0.6550.48
27_A110_P0.6450.47
98_D118_P0.6450.47
135_T138_V0.6450.47
52_F112_G0.6420.47
86_Y93_W0.6420.47
96_F118_P0.6320.46
78_V130_I0.6300.46
122_E130_I0.6290.45
61_V77_A0.6250.45
17_A82_Q0.6190.44
133_L136_L0.6170.44
18_L58_M0.6140.44
20_H62_S0.6130.44
76_R113_T0.6070.43
53_A90_D0.6040.43
104_I107_D0.5980.42
35_A75_F0.5970.42
78_V116_R0.5930.42
37_I41_Y0.5780.40
27_A81_R0.5780.40
114_E129_K0.5760.40
85_P90_D0.5750.40
62_S74_K0.5750.40
123_A133_L0.5740.40
130_I133_L0.5720.40
54_N82_Q0.5690.39
89_P125_E0.5680.39
26_V32_G0.5670.39
32_G127_W0.5640.39
24_V37_I0.5640.39
81_R88_R0.5640.39
119_I124_A0.5630.39
21_Y65_K0.5550.38
20_H83_R0.5530.38
45_G48_R0.5500.37
35_A103_I0.5490.37
105_N129_K0.5480.37
89_P92_T0.5480.37
55_I82_Q0.5480.37
76_R108_G0.5470.37
121_R127_W0.5370.36
62_S107_D0.5370.36
32_G35_A0.5350.36
71_R124_A0.5340.36
22_S84_M0.5330.36
48_R57_D0.5320.36
36_M138_V0.5280.35
75_F104_I0.5270.35
96_F120_A0.5240.35
42_G48_R0.5230.35
93_W120_A0.5190.34
21_Y60_M0.5170.34
19_Q138_V0.5120.34
26_V63_I0.5100.34
33_K93_W0.5090.33
100_A111_K0.5050.33
37_I101_V0.5040.33
121_R136_L0.5030.33
132_S136_L0.5010.33
25_N83_R0.5010.33
95_S134_A0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j21J 1 0.9493 100 0.084 Contact Map
1vq8K 1 0.9565 100 0.095 Contact Map
3zf7W 1 0.9928 100 0.103 Contact Map
1vx7M 1 0.9565 100 0.121 Contact Map
4ujrI 1 0.9855 100 0.121 Contact Map
3bboM 1 0.8551 100 0.154 Contact Map
1whiA 2 0.8551 100 0.159 Contact Map
4rb6O 1 0.8551 100 0.161 Contact Map
4tp9K 1 0.8478 100 0.174 Contact Map
1vw4I 1 0.8406 100 0.183 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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