GREMLIN Database
RL24 - 50S ribosomal protein L24P
UniProt: Q9UX95 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 119 (114)
Sequences: 494 (286)
Seq/√Len: 26.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_L98_V6.9951.00
53_M99_M3.4021.00
39_I114_L2.8011.00
34_A40_K2.3380.98
24_L72_G2.2680.98
42_I100_I2.2390.98
3_S9_Q2.2230.98
113_K116_K2.2190.98
64_V74_L2.0600.96
28_K98_V1.9870.96
17_P20_Q1.8920.94
75_A92_W1.7960.93
79_I91_V1.7680.92
18_L22_K1.7210.91
6_P13_L1.6290.88
54_R59_G1.6160.88
28_K53_M1.6120.88
22_K69_T1.5800.87
29_V33_I1.5750.86
52_V79_I1.4850.83
65_V75_A1.4630.82
76_I79_I1.4330.81
6_P10_R1.4300.81
6_P14_Y1.4160.80
25_L43_R1.3900.79
20_Q59_G1.3700.78
36_Q39_I1.3700.78
34_A59_G1.3690.78
57_N60_K1.3670.77
15_T115_E1.3610.77
23_K70_K1.3300.75
83_K86_G1.3250.75
39_I42_I1.2820.73
42_I103_L1.2620.71
38_G114_L1.2470.71
48_D110_R1.2430.70
44_V74_L1.2290.69
40_K97_K1.2260.69
63_K77_E1.1840.66
85_D104_D1.1700.65
13_L24_L1.1700.65
80_T111_R1.1670.65
52_V76_I1.1640.65
21_R110_R1.1630.65
25_L69_T1.1590.65
23_K117_S1.1520.64
43_R72_G1.1260.62
10_R110_R1.1200.62
31_D44_V1.1140.62
57_N91_V1.1120.61
61_E101_T1.1100.61
42_I114_L1.1090.61
44_V72_G1.0700.58
105_L114_L1.0630.58
111_R117_S1.0630.58
71_T108_P1.0590.58
20_Q23_K1.0490.57
105_L109_R1.0200.55
80_T90_Y1.0030.53
56_G60_K0.9750.51
55_G62_G0.9670.51
3_S102_K0.9540.50
18_L69_T0.9500.50
100_I116_K0.9450.49
51_R99_M0.9190.47
36_Q108_P0.9190.47
55_G67_V0.9180.47
54_R107_D0.9110.47
73_R94_H0.9090.46
25_L72_G0.8980.46
31_D83_K0.8950.45
49_T101_T0.8750.44
68_N71_T0.8710.44
3_S64_V0.8700.44
26_V43_R0.8670.43
37_Y114_L0.8560.43
63_K108_P0.8520.42
27_A102_K0.8470.42
42_I113_K0.8390.41
34_A90_Y0.8290.41
26_V41_R0.8290.41
25_L74_L0.8110.39
47_G88_P0.8100.39
99_M107_D0.8020.39
52_V57_N0.8010.39
37_Y101_T0.7970.38
81_R91_V0.7940.38
48_D64_V0.7810.37
47_G68_N0.7810.37
105_L111_R0.7790.37
32_D113_K0.7790.37
6_P15_T0.7750.37
59_G113_K0.7620.36
17_P21_R0.7600.36
31_D57_N0.7570.35
52_V93_I0.7560.35
31_D36_Q0.7520.35
78_G112_E0.7470.35
37_Y77_E0.7450.35
31_D84_V0.7440.35
51_R59_G0.7420.34
43_R114_L0.7380.34
3_S77_E0.7350.34
43_R58_S0.7320.34
38_G46_K0.7310.34
39_I100_I0.7270.33
47_G66_E0.7190.33
43_R113_K0.7170.33
46_K74_L0.7150.33
28_K97_K0.7120.32
26_V40_K0.7010.32
31_D100_I0.7000.32
5_K69_T0.6990.32
71_T83_K0.6970.31
27_A98_V0.6950.31
65_V90_Y0.6800.30
39_I43_R0.6780.30
54_R110_R0.6780.30
9_Q19_H0.6730.30
49_T85_D0.6660.29
98_V104_D0.6660.29
28_K40_K0.6650.29
11_K15_T0.6640.29
61_E112_E0.6620.29
60_K105_L0.6610.29
51_R78_G0.6480.28
77_E82_K0.6460.28
84_V97_K0.6450.28
26_V97_K0.6450.28
54_R97_K0.6450.28
6_P9_Q0.6390.28
68_N92_W0.6370.28
103_L107_D0.6360.28
25_L29_V0.6290.27
56_G90_Y0.6280.27
45_R116_K0.6270.27
66_E97_K0.6250.27
30_S33_I0.6170.27
62_G76_I0.6160.26
25_L95_A0.6110.26
60_K79_I0.6080.26
16_L82_K0.5970.25
56_G91_V0.5910.25
70_K104_D0.5870.25
23_K67_V0.5870.25
30_S91_V0.5790.24
5_K92_W0.5790.24
43_R69_T0.5760.24
40_K114_L0.5710.24
50_V77_E0.5620.23
55_G110_R0.5570.23
27_A46_K0.5540.23
42_I91_V0.5530.23
36_Q93_I0.5500.23
104_D115_E0.5460.23
49_T69_T0.5430.22
16_L20_Q0.5430.22
52_V91_V0.5420.22
23_K57_N0.5410.22
52_V115_E0.5370.22
3_S46_K0.5280.22
10_R21_R0.5250.22
49_T102_K0.5220.21
54_R61_E0.5170.21
47_G56_G0.5160.21
85_D88_P0.5160.21
15_T19_H0.5130.21
46_K111_R0.5120.21
29_V32_D0.5080.21
112_E115_E0.5020.20
25_L67_V0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ujrL 1 0.9916 100 0.226 Contact Map
3j61Y 1 0.9916 100 0.226 Contact Map
3zf7Z 1 0.9916 100 0.23 Contact Map
4w20Y 1 0.9916 100 0.23 Contact Map
4a17S 1 0.9916 100 0.233 Contact Map
1vx7Z 1 0.9832 100 0.233 Contact Map
3j21U 1 1 100 0.243 Contact Map
1vq8T 1 0.9832 100 0.259 Contact Map
3j7yV 1 0.9076 99.9 0.486 Contact Map
3bboW 1 0.6387 99.9 0.509 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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