GREMLIN Database
RS4E - 30S ribosomal protein S4e
UniProt: Q9UX94 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 239 (226)
Sequences: 454 (300)
Seq/√Len: 19.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_R33_I5.9771.00
179_A211_L4.3451.00
68_D117_K3.9971.00
86_S93_Y3.8891.00
60_I65_V3.7981.00
42_V106_F3.7231.00
134_L167_I3.4081.00
66_L88_P3.1681.00
65_V87_I3.1530.99
119_V160_I2.9310.99
155_L223_I2.8780.99
116_Y159_K2.7530.99
96_V106_F2.7080.98
27_N74_D2.6770.98
63_G73_K2.6720.98
121_I152_F2.6100.98
92_L108_K2.5430.98
123_N135_N2.3390.96
91_D178_Y2.3210.96
64_K89_S2.2950.95
205_K216_G2.1640.94
54_R58_H2.0760.92
169_D231_R2.0110.91
179_A193_V2.0000.91
140_R165_Q1.9090.89
8_E25_R1.8280.86
57_K75_Y1.7080.82
161_E164_S1.6950.82
117_K140_R1.6580.80
177_S228_S1.6540.80
97_L107_S1.6470.80
49_L92_L1.5750.77
52_T60_I1.5650.76
171_F228_S1.5530.76
162_L208_V1.5400.75
28_A139_G1.5390.75
115_R163_P1.5360.75
4_I26_P1.5180.74
50_A59_I1.5160.74
189_I213_S1.4840.72
156_M170_S1.4640.71
30_P78_P1.4600.71
183_G227_M1.4300.69
4_I22_W1.4150.68
82_M140_R1.4070.68
22_W58_H1.3990.67
68_D140_R1.3620.65
68_D138_D1.3580.65
4_I13_L1.3490.65
43_I65_V1.3440.64
25_R28_A1.3330.64
44_R68_D1.3320.64
179_A203_S1.3310.63
68_D163_P1.3260.63
222_N225_N1.3180.63
95_R143_L1.3050.62
68_D82_M1.2780.60
22_W126_T1.2470.58
190_H229_I1.2460.58
56_A60_I1.2330.57
117_K138_D1.2220.57
58_H126_T1.2210.57
167_I170_S1.2180.56
130_G133_Q1.1690.53
52_T185_R1.1670.53
66_L71_V1.1660.53
85_V97_L1.1640.53
161_E168_L1.1530.52
82_M137_E1.1450.52
55_E80_G1.1440.52
179_A187_V1.1410.52
53_I128_K1.1400.51
79_V87_I1.1360.51
172_T176_R1.1350.51
4_I8_E1.1340.51
120_R190_H1.1320.51
198_L207_S1.1300.51
14_M46_Y1.1290.51
221_T225_N1.1250.50
4_I9_A1.1250.50
177_S193_V1.1190.50
161_E166_Q1.1170.50
7_F129_E1.1130.50
19_Q57_K1.1120.50
79_V96_V1.1060.49
125_T135_N1.1030.49
6_R29_G1.0960.49
112_D128_K1.0860.48
132_I181_F1.0850.48
184_G188_G1.0830.48
99_D102_R1.0740.47
60_I75_Y1.0700.47
54_R125_T1.0640.47
128_K192_I1.0520.46
41_V56_A1.0450.45
85_V123_N1.0400.45
135_N141_N1.0390.45
197_N210_T1.0360.45
132_I145_D1.0270.44
24_V40_A1.0240.44
125_T133_Q1.0170.44
93_Y114_A1.0080.43
85_V115_R0.9990.42
6_R95_R0.9920.42
133_Q139_G0.9910.42
49_L90_A0.9760.41
41_V209_I0.9760.41
7_F181_F0.9720.41
72_R78_P0.9600.40
29_G80_G0.9580.40
21_K28_A0.9550.40
81_L157_T0.9550.40
197_N208_V0.9460.39
57_K119_V0.9460.39
69_G162_L0.9450.39
109_I113_E0.9440.39
22_W120_R0.9390.39
31_H68_D0.9350.38
82_M117_K0.9330.38
94_F142_I0.9310.38
40_A53_I0.9280.38
14_M34_E0.9260.38
91_D198_L0.9240.38
10_P13_L0.9220.38
22_W231_R0.9200.37
39_L79_V0.9160.37
117_K163_P0.9150.37
177_S232_E0.9130.37
83_D95_R0.9120.37
177_S187_V0.9040.37
89_S115_R0.9010.36
102_R219_Y0.9010.36
31_H138_D0.8960.36
9_A158_L0.8940.36
49_L145_D0.8920.36
86_S162_L0.8890.36
126_T203_S0.8840.35
174_S211_L0.8780.35
71_V211_L0.8730.35
124_K133_Q0.8650.34
32_S35_K0.8630.34
22_W42_V0.8620.34
91_D111_A0.8600.34
121_I161_E0.8580.34
114_A181_F0.8570.34
58_H216_G0.8560.34
39_L78_P0.8550.34
49_L94_F0.8530.34
114_A159_K0.8500.33
43_I76_K0.8490.33
125_T128_K0.8480.33
133_Q152_F0.8480.33
58_H87_I0.8440.33
202_K206_Y0.8380.33
23_T78_P0.8340.32
189_I204_R0.8340.32
139_G179_A0.8320.32
22_W187_V0.8260.32
53_I76_K0.8250.32
159_K187_V0.8240.32
4_I15_I0.8210.32
187_V216_G0.8180.32
25_R181_F0.8160.31
121_I143_L0.8160.31
139_G160_I0.8150.31
57_K154_T0.8140.31
134_L158_L0.8120.31
15_I50_A0.8110.31
215_D226_V0.8100.31
22_W207_S0.8030.31
211_L226_V0.7940.30
63_G95_R0.7940.30
77_Y87_I0.7920.30
186_N207_S0.7870.30
168_L171_F0.7850.30
26_P36_S0.7840.30
167_I233_K0.7830.30
99_D219_Y0.7820.30
60_I129_E0.7810.29
92_L107_S0.7760.29
66_L226_V0.7750.29
52_T148_T0.7750.29
206_Y222_N0.7720.29
19_Q128_K0.7710.29
204_R207_S0.7690.29
5_T156_M0.7650.29
177_S210_T0.7630.29
28_A187_V0.7630.29
19_Q36_S0.7620.28
129_E233_K0.7560.28
209_I226_V0.7550.28
212_E220_Q0.7510.28
186_N204_R0.7500.28
126_T209_I0.7480.28
85_V92_L0.7470.28
67_V121_I0.7470.28
45_D68_D0.7460.28
12_F82_M0.7370.27
97_L106_F0.7370.27
17_K137_E0.7370.27
95_R140_R0.7360.27
119_V158_L0.7360.27
43_I60_I0.7350.27
128_K163_P0.7320.27
22_W193_V0.7300.27
168_L196_I0.7250.27
179_A192_I0.7250.27
3_H8_E0.7210.26
160_I165_Q0.7190.26
117_K176_R0.7190.26
14_M25_R0.7150.26
60_I133_Q0.7150.26
6_R13_L0.7120.26
80_G230_G0.7090.26
124_K163_P0.7090.26
48_K65_V0.7060.26
177_S231_R0.7020.25
29_G121_I0.7010.25
61_F163_P0.6990.25
20_Y23_T0.6890.25
61_F76_K0.6890.25
85_V179_A0.6860.25
29_G95_R0.6850.25
159_K225_N0.6840.25
37_I103_F0.6830.24
109_I186_N0.6830.24
115_R177_S0.6830.24
5_T13_L0.6820.24
11_W155_L0.6750.24
159_K182_V0.6750.24
123_N141_N0.6640.24
209_I221_T0.6620.24
162_L168_L0.6600.23
53_I175_E0.6590.23
10_P30_P0.6530.23
23_T81_L0.6530.23
5_T102_R0.6520.23
194_K212_E0.6520.23
194_K218_T0.6510.23
178_Y190_H0.6500.23
37_I51_G0.6500.23
16_S34_E0.6500.23
160_I192_I0.6470.23
120_R185_R0.6470.23
160_I175_E0.6460.23
202_K205_K0.6320.22
159_K168_L0.6320.22
84_I116_Y0.6300.22
118_Y157_T0.6280.22
36_S96_V0.6280.22
39_L152_F0.6270.22
69_G142_I0.6260.22
3_H7_F0.6260.22
108_K146_K0.6250.22
135_N154_T0.6230.22
93_Y171_F0.6200.22
28_A41_V0.6180.22
158_L162_L0.6170.21
42_V61_F0.6150.21
85_V216_G0.6140.21
119_V179_A0.6100.21
24_V76_K0.6090.21
103_F143_L0.6060.21
106_F187_V0.6050.21
38_P47_L0.6020.21
132_I152_F0.6010.21
132_I144_V0.6010.21
65_V89_S0.5980.21
80_G95_R0.5980.21
42_V174_S0.5970.21
28_A77_Y0.5970.21
191_G211_L0.5960.21
190_H226_V0.5960.21
17_K46_Y0.5940.20
85_V105_R0.5930.20
54_R68_D0.5900.20
59_I173_I0.5890.20
90_A128_K0.5840.20
67_V226_V0.5820.20
74_D163_P0.5770.20
157_T178_Y0.5760.20
99_D118_Y0.5730.20
122_I210_T0.5670.19
57_K125_T0.5630.19
77_Y169_D0.5620.19
72_R143_L0.5620.19
103_F118_Y0.5580.19
136_L144_V0.5570.19
5_T219_Y0.5560.19
60_I165_Q0.5560.19
19_Q41_V0.5550.19
178_Y182_V0.5530.19
129_E134_L0.5530.19
181_F219_Y0.5530.19
56_A140_R0.5520.19
5_T12_F0.5520.19
102_R207_S0.5520.19
97_L105_R0.5510.19
44_R82_M0.5500.19
102_R221_T0.5490.19
120_R229_I0.5470.19
57_K76_K0.5450.18
46_Y87_I0.5430.18
162_L209_I0.5420.18
74_D211_L0.5410.18
128_K185_R0.5410.18
15_I147_E0.5390.18
39_L221_T0.5390.18
22_W159_K0.5380.18
186_N189_I0.5330.18
30_P84_I0.5320.18
174_S231_R0.5310.18
65_V182_V0.5290.18
153_K156_M0.5290.18
84_I118_Y0.5260.18
193_V228_S0.5250.18
12_F173_I0.5240.18
131_R216_G0.5230.18
74_D221_T0.5230.18
186_N198_L0.5210.18
27_N223_I0.5210.18
8_E130_G0.5190.17
48_K121_I0.5170.17
50_A68_D0.5170.17
44_R221_T0.5170.17
85_V91_D0.5130.17
219_Y227_M0.5130.17
78_P191_G0.5130.17
35_K164_S0.5110.17
8_E12_F0.5090.17
34_E74_D0.5070.17
187_V194_K0.5070.17
197_N220_Q0.5070.17
67_V108_K0.5060.17
108_K158_L0.5020.17
176_R209_I0.5020.17
68_D72_R0.5010.17
3_H10_P0.5010.17
37_I41_V0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ujpF 1 0.9749 100 0.023 Contact Map
3j60E 1 0.8201 100 0.024 Contact Map
3j7aF 1 0.9749 100 0.025 Contact Map
3zey1 1 0.9498 100 0.026 Contact Map
4bpeW 1 0.9749 100 0.028 Contact Map
3j20E 1 0.9916 100 0.161 Contact Map
3kbgA 2 0.8033 100 0.365 Contact Map
1p9kA 1 0.3222 95.8 0.931 Contact Map
2cqjA 1 0.2887 95.8 0.932 Contact Map
4rb5D 1 0.5565 90.8 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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