GREMLIN Database
RL5 - 50S ribosomal protein L5
UniProt: Q9UX93 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 182 (151)
Sequences: 2530 (1059)
Seq/√Len: 86.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_V48_T3.5771.00
110_S136_A3.4541.00
9_L149_R3.4161.00
25_T138_T2.6111.00
3_K18_K2.6051.00
5_A8_T2.5821.00
12_S146_I2.5551.00
24_V87_L2.4921.00
113_I118_I2.4321.00
55_T75_K2.3001.00
45_Q51_K2.2981.00
21_L137_I2.2641.00
88_R92_E2.1971.00
28_I40_A2.1711.00
87_L137_I2.1051.00
105_D144_Y2.0981.00
123_R126_P2.0741.00
87_L91_L2.0051.00
90_V111_F1.9991.00
100_K148_R1.9621.00
57_S60_T1.8971.00
85_E89_K1.8901.00
7_S18_K1.8681.00
56_I71_E1.7961.00
12_S143_G1.7541.00
28_I44_L1.7301.00
17_R142_A1.6921.00
45_Q52_P1.6881.00
66_I72_I1.6561.00
41_Y54_Y1.6171.00
10_P149_R1.6051.00
30_L40_A1.5861.00
22_S140_E1.5601.00
44_L74_V1.5461.00
37_L74_V1.5321.00
143_G146_I1.5321.00
54_Y71_E1.5201.00
55_T73_G1.5111.00
104_D108_N1.5081.00
99_K102_S1.5011.00
145_R148_R1.4700.99
24_V91_L1.4590.99
34_G72_I1.4230.99
57_S69_G1.4100.99
95_G98_L1.4020.99
116_H131_F1.3790.99
9_L145_R1.3690.99
7_S15_P1.3390.99
60_T68_K1.3270.99
26_V133_M1.3000.99
75_K134_D1.2860.98
41_Y45_Q1.2770.98
102_S134_D1.2700.98
98_L111_F1.2360.98
117_V124_Y1.2240.98
4_M8_T1.2220.98
43_L131_F1.2180.98
39_K43_L1.2110.98
115_E130_I1.1820.97
128_I131_F1.1750.97
85_E88_R1.1580.97
32_E129_G1.1390.97
28_I131_F1.1130.96
42_Q45_Q1.1050.96
38_Q42_Q1.0830.96
4_M7_S1.0730.95
42_Q46_E1.0660.95
117_V130_I1.0630.95
30_L37_L1.0620.95
28_I74_V1.0560.95
90_V95_G1.0490.95
22_S25_T1.0410.94
148_R152_K1.0290.94
78_L86_F1.0240.94
27_N134_D1.0060.93
5_A9_L1.0060.93
39_K128_I1.0020.93
26_V44_L0.9940.93
34_G37_L0.9930.93
34_G66_I0.9930.93
8_T11_L0.9890.93
21_L87_L0.9820.93
41_Y74_V0.9770.92
53_V75_K0.9710.92
3_K15_P0.9460.91
124_Y131_F0.9330.90
10_P146_I0.9240.90
45_Q48_T0.9070.89
39_K124_Y0.9050.89
3_K7_S0.8940.89
141_R146_I0.8830.88
40_A74_V0.8820.88
12_S17_R0.8810.88
113_I134_D0.8760.87
149_R152_K0.8730.87
21_L24_V0.8670.87
32_E131_F0.8520.86
142_A146_I0.8480.86
106_Y144_Y0.8340.85
124_Y128_I0.8260.84
44_L76_V0.8140.83
94_I113_I0.8140.83
126_P129_G0.8020.82
94_I118_I0.7970.82
102_S111_F0.7940.82
139_L147_S0.7940.82
81_A85_E0.7930.82
50_A82_Q0.7860.81
86_F119_L0.7830.81
26_V90_V0.7750.80
66_I70_Q0.7630.79
32_E36_R0.7620.79
15_P18_K0.7580.79
99_K103_F0.7560.79
141_R147_S0.7510.78
102_S109_V0.7460.78
14_N113_I0.7440.77
30_L45_Q0.7380.77
27_N114_A0.7370.77
115_E125_D0.7240.76
24_V137_I0.7190.75
60_T69_G0.7170.75
131_F134_D0.7170.75
125_D134_D0.7140.75
19_V139_L0.7140.75
9_L12_S0.7110.74
17_R141_R0.7100.74
46_E126_P0.7060.74
107_G112_G0.7000.73
41_Y52_P0.7000.73
34_G70_Q0.7000.73
55_T61_I0.6920.72
21_L83_A0.6850.71
81_A84_E0.6820.71
145_R149_R0.6790.71
124_Y129_G0.6780.71
98_L109_V0.6770.71
61_I110_S0.6770.71
35_D63_E0.6750.70
112_G132_G0.6730.70
110_S134_D0.6720.70
33_S36_R0.6660.69
114_A124_Y0.6650.69
4_M113_I0.6630.69
80_G98_L0.6610.69
28_I134_D0.6610.69
22_S138_T0.6600.69
28_I43_L0.6560.68
44_L48_T0.6500.67
34_G110_S0.6490.67
43_L116_H0.6450.67
29_G73_G0.6450.67
23_K79_R0.6430.67
48_T52_P0.6370.66
105_D139_L0.6370.66
29_G64_F0.6280.65
2_I5_A0.6190.64
35_D113_I0.6120.63
16_M28_I0.6100.63
27_N52_P0.6070.62
30_L55_T0.6060.62
111_F120_P0.6050.62
43_L128_I0.6030.62
25_T75_K0.6000.61
20_K84_E0.6000.61
104_D107_G0.5960.61
40_A44_L0.5960.61
19_V94_I0.5960.61
23_K77_T0.5960.61
31_G67_R0.5940.61
106_Y145_R0.5930.60
101_S145_R0.5900.60
24_V83_A0.5870.60
46_E80_G0.5820.59
13_Q17_R0.5790.59
140_E148_R0.5770.58
4_M81_A0.5750.58
30_L81_A0.5740.58
116_H137_I0.5740.58
24_V86_F0.5740.58
7_S14_N0.5740.58
109_V116_H0.5730.58
82_Q85_E0.5690.57
6_E10_P0.5680.57
61_I66_I0.5680.57
17_R125_D0.5670.57
55_T125_D0.5650.57
5_A21_L0.5630.56
7_S10_P0.5630.56
57_S66_I0.5590.56
7_S11_L0.5560.56
27_N110_S0.5560.56
16_M117_V0.5560.56
3_K30_L0.5530.55
124_Y130_I0.5470.54
86_F104_D0.5470.54
140_E144_Y0.5470.54
19_V104_D0.5380.53
100_K145_R0.5380.53
29_G72_I0.5360.53
48_T116_H0.5310.52
110_S138_T0.5290.52
33_S40_A0.5280.52
32_E128_I0.5260.52
30_L33_S0.5230.51
9_L13_Q0.5220.51
40_A131_F0.5210.51
90_V113_I0.5180.50
19_V121_G0.5170.50
33_S37_L0.5170.50
103_F108_N0.5150.50
44_L52_P0.5140.50
6_E9_L0.5130.50
8_T58_K0.5120.50
2_I63_E0.5120.50
26_V78_L0.5080.49
7_S13_Q0.5080.49
7_S12_S0.5070.49
129_G149_R0.5060.49
53_V84_E0.5040.49
6_E12_S0.5040.49
21_L138_T0.5040.49
21_L84_E0.5040.49
5_A45_Q0.5030.48
39_K131_F0.5020.48
144_Y148_R0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j21E 1 0.9945 100 0.12 Contact Map
3zf7L 1 0.9286 100 0.132 Contact Map
1vq8D 1 0.7692 100 0.149 Contact Map
4ujqM 1 0.9286 100 0.151 Contact Map
1vx7G 1 0.6813 100 0.153 Contact Map
4a17D 1 0.9286 100 0.154 Contact Map
1iq4A 1 0.8791 100 0.183 Contact Map
4tp9F 1 0.8736 100 0.183 Contact Map
4rb6G 1 0.8791 100 0.184 Contact Map
3bboH 1 0.8681 100 0.19 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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