GREMLIN Database
RL6 - 50S ribosomal protein L6
UniProt: Q9UX91 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 181 (171)
Sequences: 3819 (2157)
Seq/√Len: 165.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
80_T84_K3.1311.00
76_K80_T2.9941.00
124_I130_V2.6021.00
28_K33_E2.5771.00
131_T140_E2.4841.00
47_S56_E2.4351.00
87_R140_E2.3621.00
107_E123_Q2.2431.00
89_Y168_F2.1481.00
133_K136_D2.1091.00
107_E121_R2.1011.00
17_V28_K2.0701.00
114_I157_A2.0491.00
149_Q153_N2.0461.00
55_L75_I2.0461.00
166_R172_I2.0431.00
59_F64_K2.0301.00
26_K33_E1.8851.00
139_V147_V1.8851.00
93_I166_R1.8581.00
36_K145_E1.8321.00
122_A150_T1.7821.00
141_G147_V1.7591.00
103_V132_V1.7341.00
24_I35_V1.7321.00
129_K140_E1.7131.00
89_Y138_V1.6901.00
122_A157_A1.6901.00
143_N146_A1.6111.00
41_A64_K1.6001.00
24_I37_D1.5921.00
36_K78_M1.5871.00
89_Y136_D1.5701.00
57_T68_F1.5381.00
45_Q56_E1.5251.00
110_I114_I1.5201.00
20_L25_I1.5101.00
26_K35_V1.4991.00
103_V124_I1.4871.00
106_N126_E1.4831.00
109_Q121_R1.4771.00
104_V109_Q1.4561.00
91_K169_S1.4561.00
11_E52_K1.4541.00
104_V107_E1.4461.00
48_L53_I1.3931.00
114_I165_R1.3871.00
12_I18_V1.3651.00
127_G146_A1.3511.00
176_K179_V1.3441.00
120_R157_A1.3431.00
29_G32_G1.3221.00
45_Q58_T1.3161.00
136_D168_F1.3141.00
122_A153_N1.3081.00
25_I75_I1.3011.00
36_K74_H1.3001.00
70_S74_H1.2911.00
84_K87_R1.2591.00
12_I48_L1.2521.00
31_K142_P1.2481.00
130_V150_T1.2251.00
128_V150_T1.2121.00
106_N123_Q1.1951.00
20_L48_L1.1941.00
67_V71_I1.1931.00
57_T65_K1.1751.00
63_R66_A1.1731.00
116_E120_R1.1701.00
11_E51_N1.1641.00
92_I101_V1.1401.00
131_T138_V1.1401.00
27_I78_M1.1281.00
91_K168_F1.1231.00
38_F46_I1.1101.00
70_S73_S1.1091.00
110_I157_A1.1011.00
47_S54_V1.0941.00
156_S159_K1.0891.00
6_L68_F1.0861.00
155_E170_D1.0801.00
166_R174_I1.0720.99
61_N64_K1.0710.99
150_T154_I1.0660.99
31_K140_E1.0630.99
102_K109_Q1.0520.99
101_V110_I1.0510.99
145_E149_Q1.0420.99
130_V139_V1.0410.99
19_D26_K1.0350.99
58_T64_K1.0340.99
72_V76_K1.0290.99
23_S37_D1.0220.99
53_I75_I1.0190.99
109_Q119_T1.0160.99
108_V130_V1.0070.99
91_K136_D1.0020.99
22_G37_D0.9950.99
44_I58_T0.9940.99
21_K24_I0.9870.99
124_I150_T0.9840.99
17_V33_E0.9820.99
87_R138_V0.9720.99
102_K111_T0.9710.99
146_A150_T0.9510.99
116_E157_A0.9500.99
101_V137_I0.9470.99
44_I64_K0.9440.99
93_I172_I0.9400.99
108_V154_I0.9250.98
57_T60_A0.9230.98
122_A130_V0.9230.98
104_V121_R0.9170.98
18_V53_I0.9170.98
111_T119_T0.9080.98
139_V154_I0.9050.98
103_V130_V0.9000.98
107_E124_I0.8870.98
124_I139_V0.8870.98
34_V78_M0.8790.98
36_K71_I0.8760.98
41_A59_F0.8740.98
91_K166_R0.8740.98
66_A73_S0.8740.98
29_G82_V0.8700.98
32_G82_V0.8660.98
39_S67_V0.8630.98
14_K51_N0.8620.98
149_Q156_S0.8610.98
155_E167_I0.8560.97
31_K85_G0.8490.97
126_E146_A0.8480.97
128_V141_G0.8440.97
97_F158_S0.8300.97
106_N129_K0.8210.97
127_G141_G0.8180.97
41_A63_R0.8040.96
125_L146_A0.8020.96
27_I83_T0.8000.96
63_R67_V0.7900.96
49_D52_K0.7880.96
88_Y169_S0.7860.96
116_E158_S0.7830.96
31_K129_K0.7800.96
8_E72_V0.7770.96
3_I6_L0.7680.95
114_I118_N0.7660.95
65_K68_F0.7620.95
100_S134_G0.7600.95
151_A167_I0.7570.95
12_I53_I0.7490.95
66_A70_S0.7480.95
68_F179_V0.7420.94
16_V83_T0.7400.94
19_D28_K0.7370.94
90_L137_I0.7360.94
103_V131_T0.7330.94
39_S63_R0.7260.94
39_S71_I0.7240.94
49_D54_V0.7230.94
34_V142_P0.7220.93
150_T153_N0.7190.93
44_I67_V0.7070.93
41_A58_T0.7070.93
166_R169_S0.7020.93
13_P16_V0.6990.92
10_I79_I0.6920.92
32_G142_P0.6870.92
38_F75_I0.6870.92
160_I165_R0.6830.91
5_I73_S0.6790.91
100_S111_T0.6780.91
146_A153_N0.6770.91
21_K26_K0.6760.91
92_I114_I0.6750.91
82_V142_P0.6570.90
16_V82_V0.6560.90
128_V139_V0.6560.90
93_I169_S0.6550.90
18_V27_I0.6550.90
9_E52_K0.6530.90
62_R66_A0.6500.89
44_I55_L0.6500.89
55_L71_I0.6440.89
108_V137_I0.6430.89
23_S45_Q0.6420.89
12_I15_N0.6410.89
15_N30_P0.6400.89
174_I177_K0.6380.88
101_V132_V0.6370.88
39_S44_I0.6360.88
167_I170_D0.6310.88
9_E54_V0.6220.87
72_V79_I0.6220.87
160_I164_D0.6210.87
7_R56_E0.6210.87
17_V48_L0.6210.87
88_Y167_I0.6190.87
25_I48_L0.6140.86
73_S77_N0.6120.86
90_L151_A0.6070.86
94_Y164_D0.6060.86
10_I76_K0.6020.85
120_R165_R0.6020.85
9_E72_V0.6010.85
46_I55_L0.5990.85
153_N157_A0.5940.85
116_E159_K0.5920.84
90_L139_V0.5910.84
88_Y171_G0.5840.84
20_L53_I0.5820.83
67_V70_S0.5790.83
175_Y178_E0.5780.83
162_G174_I0.5780.83
150_T157_A0.5730.83
6_L177_K0.5710.82
7_R65_K0.5690.82
124_I128_V0.5690.82
5_I72_V0.5680.82
12_I79_I0.5570.81
166_R171_G0.5530.80
73_S76_K0.5530.80
87_R168_F0.5520.80
86_Y147_V0.5490.80
132_V137_I0.5480.80
147_V151_A0.5460.79
60_A63_R0.5440.79
94_Y160_I0.5440.79
93_I135_E0.5430.79
23_S58_T0.5400.79
76_K84_K0.5370.78
102_K137_I0.5340.78
10_I72_V0.5330.78
34_V143_N0.5320.78
96_H164_D0.5320.78
41_A67_V0.5270.77
27_I36_K0.5260.77
153_N156_S0.5240.77
168_F171_G0.5240.77
6_L65_K0.5220.76
93_I159_K0.5210.76
34_V82_V0.5190.76
158_S165_R0.5190.76
48_L51_N0.5170.76
128_V146_A0.5160.76
108_V132_V0.5160.76
37_D78_M0.5140.75
7_R57_T0.5130.75
25_I38_F0.5130.75
44_I57_T0.5120.75
60_A68_F0.5110.75
19_D48_L0.5100.75
124_I147_V0.5080.74
110_I137_I0.5050.74
20_L46_I0.5040.74
21_K37_D0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j21F 1 0.9945 100 0.122 Contact Map
1vx7H 1 0.9834 100 0.122 Contact Map
4w20H 1 0.9945 100 0.124 Contact Map
4ujqK 1 0.9945 100 0.124 Contact Map
4a17E 1 0.9945 100 0.127 Contact Map
3j39H 1 0.9834 100 0.13 Contact Map
3zf7y 1 0.989 100 0.132 Contact Map
4tp9G 1 0.9503 100 0.133 Contact Map
1nkwE 1 0.9392 100 0.135 Contact Map
1rl6A 1 0.884 100 0.136 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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