GREMLIN Database
RL19E - 50S ribosomal protein L19e
UniProt: Q9UX89 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 151 (142)
Sequences: 391 (237)
Seq/√Len: 19.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_V32_V5.8111.00
100_V128_T5.1591.00
60_G64_K4.0791.00
87_G92_S3.6211.00
8_K19_I3.0320.99
124_L142_V2.9160.99
28_Y49_K2.4530.97
14_I45_I2.3990.96
60_G63_L2.3470.96
94_Q97_V2.3310.96
69_K76_G2.2550.95
39_D42_R2.2010.94
4_L38_R2.1400.93
117_D120_T2.0470.92
59_S62_R2.0010.91
69_K75_E1.9850.90
89_R104_R1.8940.88
15_A52_V1.8680.87
6_A10_L1.8320.86
106_Y140_R1.8250.86
74_S133_Y1.7170.82
32_V44_L1.6470.80
38_R104_R1.6200.78
134_K138_D1.5140.73
127_K132_N1.5120.73
23_K51_I1.5080.73
22_I98_K1.4820.72
61_G65_E1.4100.68
65_E69_K1.4060.68
103_I139_V1.3900.67
100_V122_R1.3710.66
8_K79_S1.3660.65
47_D51_I1.3520.65
9_R13_S1.3340.64
35_S112_D1.3240.63
42_R62_R1.3220.63
127_K135_G1.2970.61
7_Q111_R1.2910.61
109_W115_V1.2910.61
22_I45_I1.2570.59
15_A45_I1.2340.57
21_R55_K1.2190.56
30_E37_T1.2090.56
10_L14_I1.2080.56
7_Q32_V1.2020.55
3_N6_A1.2000.55
50_I107_L1.1890.54
86_K114_K1.1790.54
56_V123_E1.1080.49
15_A78_K1.1040.49
111_R128_T1.0910.48
34_S142_V1.0570.46
80_G84_G1.0530.46
110_L143_L1.0450.45
78_K104_R1.0390.45
17_V124_L1.0320.44
89_R130_G1.0160.43
3_N16_G1.0130.43
90_A95_M1.0090.43
95_M99_R1.0090.43
103_I143_L0.9990.42
57_G114_K0.9980.42
82_R111_R0.9950.42
117_D124_L0.9780.41
123_E127_K0.9750.41
31_D83_K0.9680.40
81_S92_S0.9580.40
38_R111_R0.9480.39
39_D110_L0.9450.39
8_K38_R0.9110.37
42_R48_G0.9040.36
10_L117_D0.9020.36
15_A66_R0.9010.36
67_R108_K0.8940.36
84_G104_R0.8940.36
9_R18_G0.8930.36
14_I32_V0.8910.36
77_K87_G0.8900.36
17_V98_K0.8900.36
136_V144_I0.8890.36
34_S40_E0.8840.35
103_I136_V0.8830.35
137_S140_R0.8750.35
7_Q35_S0.8610.34
36_L75_E0.8610.34
46_K93_K0.8550.34
25_V69_K0.8510.33
22_I52_V0.8460.33
60_G89_R0.8450.33
100_V140_R0.8450.33
11_A18_G0.8440.33
115_V143_L0.8440.33
27_D124_L0.8390.33
96_W111_R0.8370.32
23_K78_K0.8290.32
13_S119_H0.8270.32
26_E124_L0.8260.32
106_Y109_W0.8220.32
81_S138_D0.8150.31
58_I70_R0.8150.31
85_K116_I0.8100.31
16_G114_K0.8080.31
10_L106_Y0.8080.31
93_K135_G0.8060.31
102_K109_W0.7980.30
37_T116_I0.7900.30
57_G77_K0.7850.30
4_L16_G0.7840.30
19_I123_E0.7840.30
75_E111_R0.7800.29
43_N47_D0.7780.29
91_N98_K0.7710.29
39_D123_E0.7650.29
109_W140_R0.7640.28
17_V52_V0.7600.28
124_L133_Y0.7580.28
11_A82_R0.7540.28
136_V140_R0.7520.28
95_M124_L0.7510.28
44_L49_K0.7510.28
138_D144_I0.7500.28
21_R145_Q0.7380.27
28_Y47_D0.7380.27
115_V134_K0.7360.27
47_D139_V0.7230.26
12_A56_V0.7200.26
38_R61_G0.7200.26
7_Q121_Y0.7120.26
28_Y31_D0.7100.26
37_T110_L0.7090.26
46_K55_K0.7050.25
129_K134_K0.7050.25
111_R125_Y0.7000.25
38_R62_R0.6990.25
23_K130_G0.6950.25
42_R104_R0.6920.25
59_S101_R0.6910.25
114_K118_R0.6900.25
103_I115_V0.6870.25
23_K26_E0.6850.25
91_N97_V0.6830.24
17_V34_S0.6780.24
43_N113_H0.6750.24
31_D46_K0.6750.24
69_K73_K0.6750.24
26_E133_Y0.6710.24
4_L99_R0.6690.24
102_K136_V0.6690.24
7_Q41_I0.6630.23
41_I144_I0.6570.23
17_V22_I0.6570.23
77_K100_V0.6510.23
60_G104_R0.6480.23
96_W129_K0.6440.23
20_N91_N0.6420.23
25_V28_Y0.6420.23
73_K129_K0.6390.22
10_L99_R0.6330.22
75_E139_V0.6290.22
10_L52_V0.6290.22
140_R145_Q0.6250.22
4_L33_Q0.6230.22
53_L115_V0.6180.21
24_V100_V0.6180.21
50_I135_G0.6160.21
51_I69_K0.6140.21
39_D56_V0.6130.21
106_Y136_V0.6120.21
20_N63_L0.6070.21
8_K92_S0.6010.21
31_D48_G0.5980.21
3_N103_I0.5920.20
105_A136_V0.5910.20
15_A74_S0.5900.20
88_A93_K0.5900.20
80_G89_R0.5890.20
56_V86_K0.5850.20
43_N58_I0.5790.20
4_L7_Q0.5770.20
126_L138_D0.5740.20
26_E48_G0.5740.20
24_V43_N0.5700.19
21_R51_I0.5700.19
71_S120_T0.5660.19
34_S37_T0.5630.19
10_L97_V0.5620.19
71_S94_Q0.5610.19
57_G65_E0.5580.19
124_L132_N0.5570.19
49_K86_K0.5550.19
22_I81_S0.5550.19
20_N66_R0.5540.19
25_V75_E0.5540.19
3_N86_K0.5500.19
97_V111_R0.5420.18
42_R134_K0.5400.18
65_E90_A0.5400.18
44_L105_A0.5370.18
70_R75_E0.5340.18
78_K89_R0.5330.18
60_G107_L0.5300.18
63_L67_R0.5290.18
23_K28_Y0.5240.18
60_G90_A0.5190.17
47_D53_L0.5120.17
50_I67_R0.5120.17
24_V29_I0.5110.17
73_K126_L0.5100.17
70_R73_K0.5080.17
33_Q55_K0.5050.17
14_I144_I0.5040.17
59_S84_G0.5030.17
45_I118_R0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zf7T 1 0.9868 100 -0.003 Contact Map
3j61R 1 0.9934 100 -0.001 Contact Map
4a17O 1 0.9669 100 0.002 Contact Map
4w20R 1 0.9868 100 0.002 Contact Map
4a1aO 1 0.9868 100 0.004 Contact Map
1vx7T 1 0.9801 100 0.016 Contact Map
4ujrE 1 0.9868 100 0.017 Contact Map
3j21Q 1 0.9934 100 0.02 Contact Map
1vq8P 1 0.947 100 0.025 Contact Map
3jywP 1 0.9868 100 0.113 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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