GREMLIN Database
RL18 - 50S ribosomal protein L18
UniProt: Q9UX88 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 199 (192)
Sequences: 458 (230)
Seq/√Len: 16.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_T48_I6.5071.00
94_G130_A4.8751.00
49_V123_V4.4181.00
52_A61_M3.4380.99
15_R19_E3.3490.99
4_L8_P3.1670.99
76_W190_I3.1540.99
39_I52_A3.0000.98
46_Y68_A2.9030.98
172_R175_Q2.7970.98
144_D149_E2.3650.94
25_Y28_Y2.3220.93
47_V86_A2.2790.92
38_F127_A2.0580.88
49_V93_A2.0520.87
179_N182_N2.0360.87
189_E193_K2.0310.87
114_P121_F1.9810.85
38_F93_A1.9700.85
104_E133_K1.9610.85
46_Y66_H1.9480.84
186_H190_I1.9000.83
107_A124_I1.8870.83
185_S189_E1.8870.83
163_S167_S1.8810.82
122_Y142_E1.8770.82
78_G186_H1.8440.81
132_L173_Y1.7770.78
23_N26_K1.7650.78
62_I101_G1.7530.77
124_I136_I1.7150.76
17_R27_R1.6300.72
89_T92_L1.6230.72
4_L7_G1.5980.70
65_A69_E1.5960.70
67_S89_T1.5660.69
165_L169_L1.5620.69
51_I132_L1.5270.67
127_A132_L1.5260.67
69_E92_L1.5220.67
185_S196_S1.5120.66
46_Y67_S1.5010.65
84_P151_I1.4930.65
40_V123_V1.4890.65
63_A97_A1.4330.62
84_P105_C1.4250.61
38_F123_V1.3940.60
27_R41_R1.3630.58
28_Y32_I1.3550.57
145_R149_E1.3500.57
16_R22_T1.3490.57
191_L195_K1.3430.57
79_D82_N1.3380.56
40_V49_V1.3280.56
65_A96_R1.3260.56
14_P124_I1.3110.55
55_D60_I1.3050.54
25_Y29_V1.2390.50
76_W88_L1.2370.50
124_I128_I1.2360.50
158_L168_K1.2120.49
151_I165_L1.2030.48
156_E181_E1.1790.47
74_F132_L1.1750.47
69_E96_R1.1680.46
6_N11_K1.1650.46
60_I144_D1.1540.45
141_I144_D1.1510.45
68_A81_N1.1160.43
166_Y180_P1.1120.43
109_I114_P1.1100.43
47_V113_V1.1050.43
46_Y81_N1.0960.42
159_K181_E1.0930.42
115_S118_N1.0900.42
50_Q65_A1.0730.41
159_K166_Y1.0600.40
176_R183_L1.0530.40
180_P196_S1.0460.39
149_E153_K1.0390.39
34_K83_T1.0380.39
166_Y174_L1.0340.39
178_L186_H1.0230.38
74_F190_I1.0210.38
79_D96_R1.0160.38
141_I145_R1.0100.37
111_L121_F1.0020.37
178_L183_L0.9980.37
168_K171_S0.9940.36
91_Y95_L0.9900.36
42_I112_H0.9870.36
139_I193_K0.9820.36
35_Q104_E0.9800.36
173_Y183_L0.9780.35
158_L169_L0.9730.35
188_E192_N0.9680.35
143_N174_L0.9680.35
106_V190_I0.9630.35
5_A99_K0.9510.34
26_K40_V0.9460.34
120_V123_V0.9420.34
119_R164_D0.9370.33
84_P148_G0.9360.33
44_N54_I0.9310.33
162_N165_L0.9310.33
22_T27_R0.9190.32
78_G83_T0.9180.32
141_I156_E0.9130.32
76_W114_P0.8900.31
189_E196_S0.8850.31
64_S100_R0.8840.31
151_I161_E0.8770.30
47_V120_V0.8760.30
17_R41_R0.8750.30
153_K156_E0.8620.29
31_V104_E0.8590.29
20_G40_V0.8570.29
172_R196_S0.8570.29
168_K180_P0.8560.29
80_E94_G0.8560.29
166_Y179_N0.8540.29
24_Y108_D0.8510.29
178_L181_E0.8510.29
78_G88_L0.8490.29
119_R122_Y0.8320.28
85_A89_T0.8250.28
83_T97_A0.8170.27
87_Y90_G0.8170.27
92_L96_R0.8140.27
46_Y61_M0.8120.27
38_F49_V0.8110.27
91_Y94_G0.8000.27
104_E119_R0.7990.26
93_A123_V0.7940.26
106_V150_H0.7900.26
93_A105_C0.7860.26
79_D98_I0.7840.26
94_G98_I0.7810.26
42_I172_R0.7790.26
41_R108_D0.7790.26
85_A96_R0.7790.26
181_E188_E0.7790.26
143_N147_K0.7750.25
187_F190_I0.7730.25
76_W124_I0.7640.25
107_A126_G0.7640.25
30_Y79_D0.7630.25
83_T132_L0.7570.25
36_T53_K0.7570.25
152_A156_E0.7540.24
184_P187_F0.7510.24
140_S144_D0.7500.24
76_W186_H0.7480.24
157_K161_E0.7480.24
61_M164_D0.7460.24
57_K60_I0.7450.24
25_Y175_Q0.7400.24
145_R189_E0.7380.24
16_R27_R0.7350.24
107_A136_I0.7290.23
9_N30_Y0.7280.23
15_R52_A0.7210.23
49_V134_I0.7200.23
143_N146_I0.7200.23
41_R70_L0.7170.23
101_G145_R0.7150.23
65_A92_L0.7130.23
175_Q179_N0.7110.23
33_S36_T0.7070.22
184_P191_L0.7050.22
65_A89_T0.7030.22
77_K177_G0.7010.22
8_P112_H0.6940.22
38_F94_G0.6940.22
105_C132_L0.6930.22
15_R168_K0.6920.22
39_I57_K0.6890.22
121_F137_G0.6890.22
41_R59_D0.6890.22
68_A71_A0.6890.22
193_K196_S0.6880.22
171_S196_S0.6870.22
10_Y15_R0.6820.21
28_Y31_V0.6770.21
55_D106_V0.6770.21
53_K62_I0.6740.21
106_V169_L0.6680.21
43_T63_A0.6680.21
42_I47_V0.6610.21
59_D131_G0.6540.20
93_A128_I0.6470.20
89_T123_V0.6450.20
156_E185_S0.6430.20
82_N92_L0.6330.20
102_V105_C0.6320.20
23_N27_R0.6290.19
51_I93_A0.6250.19
157_K182_N0.6240.19
189_E192_N0.6210.19
128_I133_K0.6190.19
65_A155_A0.6170.19
59_D90_G0.6160.19
118_N124_I0.6150.19
66_H81_N0.6140.19
160_S181_E0.6130.19
166_Y176_R0.6120.19
47_V67_S0.6100.19
88_L106_V0.6100.19
154_Y170_F0.6090.19
81_N91_Y0.6080.19
41_R131_G0.6080.19
14_P188_E0.6070.19
7_G13_K0.6060.19
163_S166_Y0.6060.19
105_C134_I0.6060.19
78_G97_A0.6040.19
179_N190_I0.6030.18
31_V43_T0.6020.18
76_W102_V0.6020.18
128_I190_I0.6020.18
145_R177_G0.6020.18
127_A134_I0.6010.18
50_Q160_S0.6000.18
97_A168_K0.5990.18
80_E98_I0.5940.18
30_Y34_K0.5910.18
83_T88_L0.5850.18
156_E175_Q0.5800.18
6_N23_N0.5790.18
165_L188_E0.5770.18
86_A123_V0.5720.17
47_V105_C0.5690.17
45_K57_K0.5690.17
42_I153_K0.5680.17
57_K128_I0.5660.17
182_N185_S0.5640.17
76_W106_V0.5630.17
55_D168_K0.5620.17
51_I118_N0.5600.17
7_G28_Y0.5600.17
82_N87_Y0.5580.17
43_T81_N0.5580.17
25_Y31_V0.5570.17
163_S179_N0.5560.17
39_I62_I0.5560.17
13_K36_T0.5530.17
97_A101_G0.5520.17
35_Q107_A0.5510.17
16_R108_D0.5500.17
42_I60_I0.5460.17
97_A105_C0.5450.16
31_V192_N0.5450.16
69_E125_K0.5430.16
86_A91_Y0.5410.16
30_Y77_K0.5390.16
23_N30_Y0.5390.16
115_S162_N0.5370.16
71_A116_K0.5360.16
21_K69_E0.5340.16
185_S192_N0.5340.16
172_R178_L0.5330.16
125_K143_N0.5290.16
13_K26_K0.5290.16
34_K151_I0.5280.16
12_V15_R0.5270.16
128_I162_N0.5260.16
91_Y195_K0.5260.16
111_L118_N0.5260.16
128_I169_L0.5240.16
60_I175_Q0.5240.16
60_I145_R0.5200.16
22_T41_R0.5190.16
141_I188_E0.5170.16
31_V54_I0.5170.16
4_L143_N0.5160.16
9_N54_I0.5160.16
185_S188_E0.5080.15
79_D91_Y0.5060.15
90_G131_G0.5060.15
98_I113_V0.5060.15
64_S68_A0.5060.15
117_G121_F0.5040.15
89_T95_L0.5020.15
42_I149_E0.5020.15
99_K171_S0.5020.15
161_E181_E0.5010.15
31_V173_Y0.5000.15
151_I154_Y0.5000.15
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ujqG 1 0.995 100 0.191 Contact Map
3zf7u 1 0.995 100 0.195 Contact Map
3j61D 1 0.9799 100 0.197 Contact Map
4a17M 1 0.995 100 0.204 Contact Map
3j39D 1 0.9899 100 0.205 Contact Map
4w20D 1 0.995 100 0.211 Contact Map
1vx7R 1 0.9899 100 0.215 Contact Map
3j21O 1 0.9849 100 0.252 Contact Map
1vq8N 1 0.9196 100 0.326 Contact Map
1ovyA 1 0.4724 100 0.677 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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