GREMLIN Database
RL15 - 50S ribosomal protein L15
UniProt: Q9UX85 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 144 (136)
Sequences: 474 (277)
Seq/√Len: 23.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_L106_L5.5221.00
123_A138_V5.1101.00
9_S12_M3.9021.00
120_V123_A3.4551.00
62_N66_K2.9771.00
62_N65_T2.6870.99
129_Q133_E2.6390.99
20_W26_H2.6130.99
126_K129_Q2.6040.99
12_M18_M2.4700.98
106_L123_A2.4050.98
106_L120_V2.3930.98
16_R25_Q1.8980.92
24_G28_D1.7530.89
128_I132_K1.7180.88
9_S18_M1.7160.88
120_V138_V1.6970.87
89_E92_G1.6620.86
46_W50_Y1.6610.86
80_L84_Y1.6540.86
38_G110_G1.6370.85
99_N104_N1.6320.85
112_I116_V1.6040.84
98_L123_A1.5440.81
37_I55_Y1.5060.80
107_L124_T1.4700.78
82_S85_I1.4700.78
61_R64_T1.4560.77
36_Q47_L1.4380.77
15_S20_W1.4260.76
97_D100_E1.3750.73
118_I131_V1.3580.72
119_K139_I1.3080.69
96_V116_V1.3070.69
88_K92_G1.2920.68
10_R22_I1.2600.66
90_M94_K1.2410.65
77_N80_L1.2370.65
98_L104_N1.2070.63
39_M55_Y1.1990.62
22_I26_H1.1980.62
125_N129_Q1.1930.62
13_R27_R1.1550.59
11_K21_G1.1460.59
97_D119_K1.1370.58
73_L76_L1.1310.58
10_R14_G1.1200.57
25_Q31_S1.0940.55
36_Q45_S1.0910.55
116_V125_N1.0900.55
20_W25_Q1.0890.55
14_G27_R1.0670.53
106_L138_V1.0590.53
82_S86_K1.0390.51
15_S18_M1.0370.51
123_A128_I1.0200.50
10_R26_H1.0130.50
41_K60_F1.0130.50
88_K91_D0.9900.48
34_G127_A0.9890.48
83_G87_I0.9840.47
105_K124_T0.9840.47
23_R28_D0.9730.47
34_G110_G0.9680.46
73_L130_K0.9670.46
77_N83_G0.9670.46
86_K119_K0.9650.46
10_R27_R0.9610.46
22_I28_D0.9600.46
13_R22_I0.9530.45
50_Y115_P0.9490.45
36_Q137_E0.9410.44
17_T20_W0.9390.44
67_L73_L0.9270.44
5_R18_M0.9250.43
14_G21_G0.9240.43
96_V134_M0.8980.42
84_Y94_K0.8900.41
26_H31_S0.8860.41
51_G54_W0.8820.40
72_S124_T0.8810.40
95_I133_E0.8750.40
25_Q39_M0.8750.40
6_E71_I0.8740.40
117_T129_Q0.8690.40
13_R34_G0.8680.39
38_G127_A0.8350.37
113_S134_M0.8340.37
66_K93_K0.8260.37
110_G130_K0.8210.36
22_I25_Q0.8190.36
79_L115_P0.8120.36
7_K11_K0.8090.36
98_L103_Y0.8080.35
114_I133_E0.8060.35
67_L91_D0.8050.35
7_K12_M0.8000.35
81_E84_Y0.7940.35
89_E111_S0.7910.34
38_G136_G0.7860.34
93_K137_E0.7840.34
66_K134_M0.7840.34
13_R19_G0.7780.34
21_G107_L0.7760.33
70_A124_T0.7750.33
45_S81_E0.7750.33
13_R21_G0.7750.33
18_M46_W0.7740.33
68_T114_I0.7720.33
14_G127_A0.7710.33
6_E18_M0.7670.33
104_N121_G0.7600.32
52_K55_Y0.7550.32
42_E74_R0.7510.32
106_L112_I0.7510.32
27_R135_G0.7460.32
54_W124_T0.7370.31
39_M120_V0.7360.31
88_K132_K0.7350.31
5_R87_I0.7340.31
82_S103_Y0.7320.31
44_W48_V0.7270.30
40_H43_K0.7250.30
21_G24_G0.7170.30
72_S109_G0.7140.30
116_V134_M0.7070.29
12_M17_T0.7010.29
41_K63_P0.7000.29
80_L96_V0.6950.29
4_R62_N0.6890.28
104_N141_S0.6840.28
23_R26_H0.6830.28
40_H55_Y0.6820.28
27_R136_G0.6790.28
98_L138_V0.6780.28
98_L112_I0.6770.28
17_T78_E0.6730.27
8_K12_M0.6670.27
13_R118_I0.6610.27
68_T71_I0.6590.27
16_R20_W0.6550.26
78_E101_L0.6530.26
47_L139_I0.6520.26
17_T112_I0.6500.26
85_I141_S0.6480.26
90_M93_K0.6460.26
84_Y116_V0.6420.26
72_S130_K0.6420.26
91_D126_K0.6380.25
101_L111_S0.6370.25
23_R106_L0.6350.25
35_R59_G0.6340.25
69_S109_G0.6310.25
89_E126_K0.6300.25
66_K97_D0.6270.25
11_K99_N0.6240.25
110_G127_A0.6220.25
14_G34_G0.6210.24
113_S121_G0.6210.24
4_R33_G0.6200.24
94_K98_L0.6120.24
81_E139_I0.6060.24
61_R89_E0.6060.24
71_I106_L0.6060.24
69_S132_K0.6040.24
76_L118_I0.5990.23
4_R7_K0.5980.23
111_S114_I0.5970.23
81_E114_I0.5950.23
91_D133_E0.5940.23
77_N112_I0.5860.23
103_Y119_K0.5860.23
122_K129_Q0.5850.23
43_K114_I0.5850.23
56_G118_I0.5800.22
21_G105_K0.5780.22
51_G61_R0.5760.22
19_G27_R0.5700.22
84_Y140_L0.5670.22
11_K27_R0.5650.22
48_V54_W0.5630.22
98_L120_V0.5620.22
14_G118_I0.5590.21
71_I95_I0.5570.21
76_L96_V0.5560.21
68_T138_V0.5500.21
10_R135_G0.5470.21
48_V58_H0.5440.21
12_M123_A0.5430.21
66_K122_K0.5380.20
90_M138_V0.5370.20
14_G26_H0.5370.20
119_K132_K0.5360.20
11_K33_G0.5360.20
32_Q87_I0.5330.20
93_K115_P0.5290.20
4_R92_G0.5230.20
39_M115_P0.5150.19
62_N67_L0.5080.19
63_P129_Q0.5040.19
45_S121_G0.5030.19
57_K131_V0.5030.19
21_G59_G0.5020.19
9_S46_W0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4w20a 1 0.9583 100 0.321 Contact Map
3zf7b 1 0.9583 100 0.325 Contact Map
3j21L 1 0.9653 100 0.326 Contact Map
4a17K 1 0.9722 100 0.332 Contact Map
3j61a 1 0.9514 100 0.338 Contact Map
1vx7O 1 0.9583 100 0.346 Contact Map
4ujrN 1 0.9583 100 0.369 Contact Map
1vq8L 1 0.8958 100 0.407 Contact Map
3bboN 1 0.9444 99.9 0.563 Contact Map
4tp9L 1 0.0139 99.9 0.631 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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