GREMLIN Database
SECY - Protein translocase subunit SecY
UniProt: Q9UX84 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 469 (392)
Sequences: 3181 (1671)
Seq/√Len: 84.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_M75_A5.4101.00
396_P401_G5.1671.00
357_I419_G5.1491.00
36_A166_L5.0931.00
89_M111_F4.2771.00
379_A400_E4.0851.00
31_V35_V3.8461.00
365_I412_F3.7431.00
135_A149_A3.5151.00
32_W36_A3.4651.00
146_L150_G3.4471.00
404_A408_Y3.3741.00
97_L111_F3.2851.00
100_I114_A2.9421.00
105_P108_R2.8951.00
64_Q70_T2.8701.00
325_V329_P2.8351.00
326_F329_P2.7921.00
321_T325_V2.7801.00
39_I162_L2.7141.00
322_V325_V2.6991.00
162_L166_L2.6861.00
361_I419_G2.6821.00
120_F161_Y2.6401.00
127_S157_I2.6291.00
89_M118_L2.5631.00
267_V279_I2.5611.00
96_K99_S2.5601.00
124_L157_I2.5181.00
380_Q384_E2.5031.00
269_S387_I2.5011.00
324_G328_F2.4761.00
357_I361_I2.4361.00
281_L407_I2.3511.00
24_P28_Q2.3391.00
46_T74_L2.3111.00
89_M97_L2.2661.00
377_T381_Q2.2311.00
291_V422_A2.2271.00
147_F151_I2.1711.00
37_V182_L2.1631.00
261_M283_F2.1261.00
37_V186_A2.1251.00
161_Y164_L2.1201.00
33_S182_L2.0541.00
48_L152_V2.0181.00
110_K113_E1.9981.00
98_I102_L1.9931.00
30_L34_L1.9891.00
40_Y187_G1.9821.00
254_I420_L1.9631.00
364_G418_V1.9261.00
265_I389_I1.9191.00
39_I166_L1.8871.00
358_V362_L1.8431.00
380_Q383_V1.8331.00
405_R409_P1.8311.00
116_K168_E1.8231.00
351_E354_V1.7821.00
124_L153_I1.7591.00
265_I406_Y1.7051.00
416_I420_L1.6781.00
297_L359_L1.6721.00
242_L246_V1.6681.00
364_G415_S1.6671.00
376_A400_E1.6641.00
259_T282_N1.6401.00
350_L354_V1.6371.00
124_L127_S1.6331.00
198_G201_S1.6191.00
259_T417_I1.6151.00
395_N399_I1.5751.00
29_K454_E1.5641.00
96_K100_I1.5611.00
203_S241_D1.5481.00
121_I125_V1.5471.00
285_Y407_I1.5381.00
146_L149_A1.5371.00
373_L378_Q1.5291.00
260_T445_I1.5120.99
247_T251_L1.5070.99
93_A101_D1.4980.99
324_G327_F1.4710.99
323_S326_F1.4690.99
328_F351_E1.4630.99
99_S103_N1.4430.99
365_I408_Y1.4400.99
122_F463_L1.4320.99
302_Q305_A1.4290.99
35_V38_I1.4240.99
36_A162_L1.4110.99
323_S327_F1.4080.99
139_T142_N1.4040.99
25_S28_Q1.4010.99
57_F61_I1.4010.99
123_I157_I1.3940.99
375_P404_A1.3900.99
164_L180_V1.3590.99
123_I160_T1.3580.99
140_T143_A1.3370.99
103_N106_D1.3310.99
38_I42_I1.3290.99
89_M114_A1.3260.99
119_A164_L1.3250.99
322_V326_F1.3250.99
196_M200_A1.3230.99
417_I438_L1.3190.99
160_T163_I1.3180.99
116_K164_L1.3050.98
176_L451_L1.2860.98
33_S175_G1.2810.98
308_A311_V1.2790.98
322_V329_P1.2670.98
300_D304_F1.2650.98
148_I152_V1.2590.98
119_A160_T1.2580.98
361_I416_I1.2580.98
93_A111_F1.2510.98
378_Q403_L1.2500.98
79_I180_V1.2490.98
32_W174_W1.2330.98
403_L407_I1.2320.98
353_A423_V1.2250.98
149_A153_I1.2220.98
40_Y44_A1.2210.98
131_G152_V1.2200.98
128_A153_I1.2170.98
373_L403_L1.2150.98
141_I144_S1.2130.98
144_S148_I1.2090.98
257_Y261_M1.2020.97
303_L307_L1.1960.97
361_I415_S1.1900.97
350_L353_A1.1880.97
48_L131_G1.1790.97
288_S433_T1.1760.97
265_I403_L1.1730.97
302_Q306_S1.1700.97
279_I459_M1.1640.97
258_L261_M1.1560.97
18_T22_E1.1550.97
251_L255_T1.1530.97
80_G84_T1.1500.97
374_D377_T1.1480.97
436_G440_A1.1440.97
75_A163_I1.1350.96
185_L444_A1.1290.96
324_G330_P1.1290.96
447_Y451_L1.1290.96
369_D404_A1.1240.96
191_I194_W1.1220.96
264_E278_T1.1090.96
29_K283_F1.1060.96
254_I258_L1.1040.96
40_Y166_L1.1040.96
181_S443_I1.1000.96
20_P30_L1.0920.95
351_E355_V1.0910.95
127_S153_I1.0870.95
260_T449_S1.0730.95
394_N399_I1.0710.95
289_I370_V1.0700.95
85_A118_L1.0640.95
201_S221_S1.0630.95
19_K459_M1.0600.95
28_Q31_V1.0550.95
64_Q191_I1.0550.95
145_I148_I1.0510.94
148_I151_I1.0420.94
258_L417_I1.0380.94
354_V358_V1.0230.94
305_A308_A1.0180.93
16_A95_S1.0130.93
27_G31_V1.0100.93
124_L150_G0.9970.93
29_K40_Y0.9940.93
291_V434_G0.9940.93
256_I417_I0.9830.92
331_P350_L0.9800.92
446_Q450_L0.9750.92
104_D107_D0.9740.92
132_Y135_A0.9710.92
295_A356_F0.9630.91
141_I421_I0.9630.91
321_T324_G0.9630.91
17_V21_K0.9610.91
176_L447_Y0.9580.91
163_I183_F0.9540.91
427_L431_Y0.9540.91
64_Q67_F0.9520.91
322_V331_P0.9500.91
80_G368_V0.9430.90
288_S435_I0.9390.90
118_L180_V0.9390.90
48_L72_G0.9390.90
452_A458_E0.9340.90
143_A146_L0.9190.89
251_L424_F0.9170.89
238_F242_L0.9160.89
258_L279_I0.9160.89
308_A312_S0.9120.89
150_G154_A0.9120.89
298_G423_V0.9090.89
195_D199_I0.9050.89
245_L249_I0.8980.88
192_M437_I0.8960.88
194_W198_G0.8950.88
272_L275_I0.8930.88
188_V288_S0.8890.88
396_P400_E0.8810.87
183_F303_L0.8780.87
113_E117_G0.8770.87
97_L114_A0.8720.87
168_E271_K0.8710.87
77_L160_T0.8690.86
419_G423_V0.8670.86
77_L84_T0.8650.86
192_M196_M0.8650.86
309_S312_S0.8620.86
19_K23_K0.8610.86
96_K163_I0.8590.86
239_Q431_Y0.8570.86
291_V418_V0.8560.86
72_G156_L0.8550.86
105_P109_V0.8530.85
356_F423_V0.8520.85
132_Y149_A0.8500.85
376_A396_P0.8480.85
352_Y369_D0.8480.85
23_K455_R0.8460.85
40_Y73_T0.8430.85
281_L410_L0.8420.85
239_Q243_V0.8410.85
305_A325_V0.8360.84
415_S419_G0.8350.84
299_S303_L0.8350.84
24_P458_E0.8340.84
397_K401_G0.8330.84
114_A118_L0.8320.84
196_M199_I0.8290.84
183_F324_G0.8240.83
446_Q449_S0.8220.83
135_A146_L0.8210.83
382_L387_I0.8190.83
97_L100_I0.8170.83
50_G148_I0.8160.83
383_V386_G0.8160.83
186_A250_A0.8160.83
263_I301_I0.8130.83
186_A189_M0.8130.83
131_G149_A0.8110.82
279_I403_L0.8090.82
324_G329_P0.8090.82
153_I157_I0.8080.82
249_I253_I0.8060.82
94_G370_V0.8060.82
40_Y183_F0.8050.82
268_T453_Y0.8030.82
83_I439_L0.8010.82
352_Y357_I0.7980.81
388_E394_N0.7960.81
447_Y450_L0.7940.81
273_R387_I0.7920.81
246_V250_A0.7900.81
327_F330_P0.7880.81
137_T140_T0.7870.81
375_P379_A0.7850.80
122_F296_V0.7840.80
167_D180_V0.7810.80
184_I292_I0.7810.80
187_G190_K0.7810.80
44_A73_T0.7810.80
357_I423_V0.7790.80
112_T168_E0.7780.80
244_G432_G0.7770.80
128_A156_L0.7770.80
86_G435_I0.7740.79
32_W169_L0.7740.79
258_L413_F0.7710.79
355_V362_L0.7700.79
322_V330_P0.7700.79
45_S64_Q0.7690.79
392_V402_I0.7680.79
79_I161_Y0.7610.78
136_R144_S0.7600.78
240_P244_G0.7600.78
297_L362_L0.7590.78
381_Q385_A0.7580.78
186_A370_V0.7580.78
355_V359_L0.7570.78
40_Y186_A0.7570.78
61_I64_Q0.7540.78
288_S292_I0.7490.77
157_I407_I0.7480.77
197_F201_S0.7470.77
288_S434_G0.7460.77
357_I416_I0.7450.77
286_V368_V0.7400.76
25_S454_E0.7390.76
79_I262_T0.7360.76
137_T141_I0.7320.76
40_Y99_S0.7280.75
33_S36_A0.7270.75
182_L447_Y0.7240.75
442_T446_Q0.7240.75
79_I163_I0.7220.75
58_K64_Q0.7220.75
265_I390_P0.7200.74
29_K306_S0.7200.74
139_T143_A0.7200.74
298_G302_Q0.7190.74
94_G267_V0.7170.74
74_L432_G0.7170.74
88_I122_F0.7170.74
137_T142_N0.7150.74
77_L378_Q0.7150.74
378_Q417_I0.7150.74
20_P23_K0.7120.74
16_A20_P0.7110.73
78_G118_L0.7110.73
244_G248_T0.7110.73
185_L189_M0.7100.73
111_F297_L0.7070.73
455_R458_E0.7050.73
98_I101_D0.7040.73
145_I249_I0.7030.73
353_A426_T0.7020.72
263_I406_Y0.7010.72
452_A462_L0.6970.72
202_V221_S0.6970.72
267_V382_L0.6970.72
271_K278_T0.6950.72
356_F433_T0.6940.72
258_L421_I0.6940.72
86_G292_I0.6920.71
109_V271_K0.6910.71
356_F422_A0.6900.71
258_L283_F0.6880.71
311_V380_Q0.6870.71
20_P26_L0.6860.71
26_L128_A0.6840.71
428_L432_G0.6810.70
26_L176_L0.6810.70
16_A19_K0.6800.70
92_L95_S0.6780.70
298_G355_V0.6780.70
417_I444_A0.6780.70
408_Y412_F0.6770.70
412_F427_L0.6750.70
76_Q111_F0.6750.70
101_D259_T0.6730.69
371_A461_P0.6730.69
20_P451_L0.6720.69
250_A253_I0.6700.69
101_D377_T0.6700.69
84_T291_V0.6680.69
51_I54_A0.6670.69
294_V356_F0.6660.68
305_A464_K0.6660.68
130_F133_V0.6630.68
48_L78_G0.6600.68
360_S416_I0.6590.68
263_I390_P0.6580.68
452_A463_L0.6580.68
176_L182_L0.6560.67
72_G289_I0.6560.67
38_I325_V0.6540.67
388_E453_Y0.6530.67
116_K288_S0.6520.67
63_E403_L0.6520.67
138_S141_I0.6490.66
403_L410_L0.6490.66
51_I134_L0.6480.66
23_K452_A0.6470.66
33_S176_L0.6460.66
291_V295_A0.6460.66
101_D108_R0.6440.66
246_V252_I0.6440.66
114_A286_V0.6430.66
265_I392_V0.6430.66
375_P403_L0.6410.66
28_Q35_V0.6410.66
192_M195_D0.6400.65
267_V387_I0.6370.65
189_M192_M0.6360.65
243_V246_V0.6340.65
141_I148_I0.6340.65
326_F330_P0.6330.65
241_D245_L0.6300.64
32_W282_N0.6300.64
307_L351_E0.6300.64
312_S324_G0.6300.64
47_P192_M0.6290.64
239_Q309_S0.6280.64
357_I427_L0.6280.64
73_T367_W0.6280.64
376_A380_Q0.6260.64
199_I202_V0.6240.63
375_P407_I0.6240.63
23_K457_L0.6230.63
95_S114_A0.6220.63
84_T404_A0.6220.63
73_T191_I0.6200.63
56_F249_I0.6200.63
161_Y454_E0.6190.63
35_V39_I0.6190.63
197_F200_A0.6190.63
41_L190_K0.6180.63
383_V406_Y0.6180.63
182_L186_A0.6160.62
285_Y411_A0.6150.62
182_L421_I0.6140.62
296_V299_S0.6140.62
410_L415_S0.6140.62
85_A260_T0.6120.62
288_S293_F0.6100.62
112_T429_G0.6090.62
183_F234_T0.6080.61
23_K27_G0.6080.61
93_A97_L0.6070.61
243_V247_T0.6070.61
36_A170_I0.6070.61
74_L162_L0.6060.61
253_I257_Y0.6040.61
32_W284_L0.6030.61
181_S439_L0.6030.61
74_L368_V0.6030.61
358_V431_Y0.6020.61
40_Y46_T0.6020.61
459_M464_K0.6020.61
44_A456_S0.6010.61
96_K265_I0.5980.60
90_Q183_F0.5960.60
293_F363_F0.5960.60
46_T420_L0.5950.60
366_L370_V0.5950.60
99_S196_M0.5940.60
259_T291_V0.5940.60
268_T388_E0.5920.59
79_I164_L0.5920.59
50_G156_L0.5910.59
65_I253_I0.5900.59
329_P355_V0.5900.59
89_M289_I0.5900.59
133_V137_T0.5890.59
311_V324_G0.5890.59
439_L443_I0.5890.59
16_A21_K0.5880.59
292_I446_Q0.5880.59
135_A145_I0.5870.59
191_I424_F0.5860.59
157_I161_Y0.5850.59
265_I279_I0.5840.58
123_I351_E0.5830.58
19_K458_E0.5820.58
18_T378_Q0.5820.58
40_Y78_G0.5810.58
84_T88_I0.5800.58
34_L379_A0.5800.58
185_L367_W0.5790.58
95_S98_I0.5770.57
92_L97_L0.5750.57
83_I288_S0.5740.57
420_L424_F0.5740.57
286_V464_K0.5730.57
279_I359_L0.5720.57
65_I84_T0.5720.57
124_L128_A0.5720.57
196_M327_F0.5710.57
23_K26_L0.5710.57
118_L289_I0.5700.57
321_T329_P0.5700.57
95_S352_Y0.5690.56
44_A71_T0.5680.56
42_I46_T0.5680.56
74_L105_P0.5670.56
64_Q73_T0.5670.56
287_S438_L0.5660.56
283_F286_V0.5650.56
454_E457_L0.5640.56
248_T252_I0.5640.56
191_I300_D0.5630.56
119_A251_L0.5620.56
163_I286_V0.5620.56
64_Q69_S0.5620.56
370_V387_I0.5610.55
79_I86_G0.5600.55
86_G163_I0.5600.55
266_P270_Q0.5600.55
282_N287_S0.5570.55
348_G426_T0.5570.55
24_P154_A0.5570.55
44_A374_D0.5570.55
311_V321_T0.5560.55
331_P348_G0.5560.55
74_L424_F0.5550.55
308_A322_V0.5540.54
282_N371_A0.5530.54
76_Q383_V0.5520.54
150_G153_I0.5510.54
53_S142_N0.5510.54
168_E436_G0.5510.54
121_I308_A0.5500.54
402_I406_Y0.5500.54
378_Q460_Y0.5490.54
126_E409_P0.5490.54
255_T265_I0.5450.53
371_A403_L0.5440.53
259_T262_T0.5440.53
36_A163_I0.5440.53
270_Q273_R0.5440.53
359_L362_L0.5430.53
71_T267_V0.5430.53
285_Y373_L0.5420.53
76_Q241_D0.5420.53
267_V275_I0.5410.53
248_T428_L0.5410.53
426_T429_G0.5410.53
24_P27_G0.5400.53
234_T304_F0.5400.53
295_A298_G0.5380.52
250_A361_I0.5380.52
151_I361_I0.5350.52
191_I195_D0.5340.52
303_L378_Q0.5340.52
123_I161_Y0.5340.52
438_L441_V0.5340.52
328_F355_V0.5340.52
54_A324_G0.5340.52
445_I449_S0.5330.52
75_A162_L0.5310.51
240_P432_G0.5290.51
73_T352_Y0.5280.51
380_Q429_G0.5280.51
83_I292_I0.5280.51
96_K114_A0.5270.51
22_E275_I0.5260.51
136_R355_V0.5260.51
110_K389_I0.5250.51
422_A442_T0.5240.50
151_I154_A0.5240.50
74_L243_V0.5240.50
248_T251_L0.5230.50
120_F421_I0.5210.50
170_I292_I0.5210.50
45_S73_T0.5210.50
74_L142_N0.5190.50
44_A264_E0.5180.50
56_F127_S0.5180.50
348_G353_A0.5170.50
132_Y415_S0.5170.50
85_A103_N0.5170.50
141_I152_V0.5160.49
55_S201_S0.5160.49
255_T436_G0.5160.49
61_I160_T0.5160.49
98_I374_D0.5150.49
112_T405_R0.5140.49
306_S328_F0.5140.49
307_L382_L0.5130.49
142_N419_G0.5130.49
48_L99_S0.5130.49
122_F137_T0.5120.49
60_L415_S0.5110.49
52_T59_N0.5110.49
191_I272_L0.5110.49
82_I293_F0.5100.49
292_I434_G0.5100.49
169_L385_A0.5100.49
200_A354_V0.5090.48
348_G352_Y0.5080.48
367_W387_I0.5070.48
184_I187_G0.5070.48
166_L183_F0.5060.48
246_V249_I0.5060.48
70_T389_I0.5060.48
34_L194_W0.5060.48
73_T120_F0.5050.48
116_K119_A0.5050.48
56_F197_F0.5040.48
27_G43_M0.5040.48
100_I104_D0.5040.48
73_T360_S0.5030.48
194_W420_L0.5030.48
55_S62_L0.5020.48
79_I98_I0.5010.47
242_L376_A0.5010.47
118_L121_I0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3mp7A 1 0.791 100 0.11 Contact Map
2ww9A 1 0.9744 100 0.121 Contact Map
1rh5A 1 0.8614 100 0.129 Contact Map
4w251 1 0.8316 100 0.183 Contact Map
3dinC 1 0.8017 100 0.202 Contact Map
2zjsY 2 0.8316 100 0.205 Contact Map
3dl8G 1 0.8166 100 0.207 Contact Map
3j01A 1 0.8571 100 0.212 Contact Map
4j72A 2 0.2026 15.6 0.977 Contact Map
2m5zA 1 0.0618 6.8 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0116 seconds.