GREMLIN Database
KADA - Adenylate kinase
UniProt: Q9UX83 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 195 (180)
Sequences: 128 (96)
Seq/√Len: 7.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
109_R113_E4.8890.99
124_E159_R3.3870.91
21_A190_I2.7740.79
8_G178_N2.4440.69
34_I185_I2.4250.68
37_Y68_L2.2840.63
182_D185_I2.2670.63
183_P190_I2.2300.62
134_Q158_A2.1740.59
93_T106_G2.0830.56
103_Y153_E2.0630.55
52_K56_E2.0500.55
42_L70_A2.0490.55
37_Y147_D1.9860.52
17_V126_D1.9590.51
18_L123_L1.9570.51
183_P187_A1.8910.49
111_V144_D1.8640.48
54_R106_G1.8430.47
54_R93_T1.8430.47
92_D137_D1.8170.46
100_P170_G1.8080.45
158_A165_S1.7970.45
55_D58_R1.7490.43
146_S154_V1.7070.42
154_V158_A1.6890.41
155_I165_S1.6870.41
134_Q165_S1.6690.40
155_I158_A1.6520.39
176_V180_E1.6340.39
134_Q154_V1.6260.39
121_F145_Y1.6250.39
69_Q93_T1.6240.38
69_Q106_G1.6240.38
111_V124_E1.6130.38
8_G12_V1.5750.37
7_T99_T1.5430.36
115_L166_A1.5340.35
39_D42_L1.5280.35
16_T104_L1.5230.35
124_E158_A1.4950.34
97_I105_P1.4930.34
96_V161_S1.4540.32
48_E71_L1.4500.32
12_V146_S1.4460.32
95_A120_I1.4390.32
49_G152_N1.3970.31
96_V158_A1.3940.30
128_K148_T1.3900.30
63_E151_I1.3550.29
54_R69_Q1.3550.29
141_A184_S1.3390.29
51_V171_A1.3340.29
65_Q144_D1.3290.28
36_N39_D1.3070.28
15_T147_D1.3000.27
152_N156_Q1.2810.27
89_G101_A1.2670.26
65_Q170_G1.2650.26
14_K92_D1.2620.26
12_V181_G1.2230.25
75_R141_A1.2120.25
45_A99_T1.2100.25
56_E62_I1.2050.25
75_R148_T1.2050.25
47_K192_N1.1850.24
56_E116_S1.1840.24
38_G94_H1.1770.24
132_E135_K1.1720.24
12_V68_L1.1700.24
6_V17_V1.1630.23
10_P117_P1.1620.23
125_A182_D1.1580.23
65_Q99_T1.1520.23
45_A65_Q1.1330.23
74_R176_V1.1190.22
7_T120_I1.1170.22
102_G117_P1.1140.22
103_Y150_V1.0910.21
21_A191_I1.0910.21
126_D131_L1.0790.21
14_K137_D1.0780.21
87_G188_S1.0780.21
5_I87_G1.0750.21
47_K86_E1.0720.21
67_E77_V1.0530.21
112_I120_I1.0490.20
37_Y97_I1.0470.20
77_V123_L1.0460.20
91_I112_I1.0410.20
159_R162_A1.0380.20
123_L152_N1.0330.20
176_V190_I1.0260.20
110_H172_S1.0260.20
12_V37_Y1.0190.20
69_Q97_I1.0150.20
75_R174_K0.9860.19
57_I162_A0.9820.19
42_L135_K0.9770.19
14_K62_I0.9690.18
55_D105_P0.9660.18
134_Q155_I0.9590.18
41_M102_G0.9490.18
122_L159_R0.9330.18
51_V180_E0.9230.17
47_K121_F0.9230.17
60_L130_I0.9190.17
91_I164_A0.9180.17
125_A178_N0.9160.17
40_Y134_Q0.9150.17
7_T165_S0.9150.17
146_S158_A0.9050.17
47_K78_E0.9010.17
39_D177_V0.9000.17
63_E97_I0.9000.17
37_Y123_L0.8990.17
122_L126_D0.8860.17
93_T105_P0.8850.17
170_G178_N0.8840.17
9_I37_Y0.8810.17
118_K121_F0.8780.16
54_R105_P0.8720.16
134_Q184_S0.8710.16
10_P15_T0.8690.16
58_R144_D0.8650.16
65_Q178_N0.8650.16
8_G125_A0.8470.16
97_I106_G0.8470.16
93_T97_I0.8470.16
136_R188_S0.8430.16
8_G65_Q0.8380.16
55_D93_T0.8370.16
55_D106_G0.8370.16
32_H110_H0.8320.15
74_R114_V0.8290.15
188_S192_N0.8260.15
6_V173_V0.8240.15
58_R93_T0.8230.15
58_R106_G0.8230.15
58_R137_D0.8180.15
134_Q146_S0.8180.15
16_T176_V0.8160.15
91_I157_F0.8150.15
77_V134_Q0.8150.15
103_Y160_Y0.8130.15
36_N177_V0.8110.15
5_I62_I0.8080.15
32_H48_E0.7940.15
17_V162_A0.7910.15
156_Q176_V0.7830.15
10_P58_R0.7820.15
36_N146_S0.7800.14
120_I162_A0.7790.14
40_Y44_T0.7720.14
57_I115_L0.7720.14
110_H180_E0.7670.14
14_K120_I0.7660.14
16_T105_P0.7640.14
53_S126_D0.7630.14
125_A129_I0.7600.14
41_M45_A0.7580.14
53_S113_E0.7570.14
21_A171_A0.7540.14
14_K95_A0.7530.14
69_Q105_P0.7440.14
5_I95_A0.7350.14
4_G146_S0.7340.14
21_A160_Y0.7320.14
162_A186_A0.7310.14
30_I157_F0.7310.14
89_G134_Q0.7290.14
49_G125_A0.7280.13
70_A184_S0.7280.13
173_V190_I0.7270.13
48_E150_V0.7260.13
76_I169_V0.7220.13
73_A117_P0.7170.13
33_K180_E0.7160.13
5_I93_T0.7090.13
5_I106_G0.7090.13
154_V165_S0.7090.13
119_V162_A0.7060.13
169_V180_E0.7040.13
67_E123_L0.7030.13
139_S144_D0.6920.13
64_K91_I0.6910.13
76_I97_I0.6880.13
32_H171_A0.6870.13
43_N116_S0.6860.13
99_T104_L0.6850.13
43_N46_L0.6810.13
120_I136_R0.6810.13
9_I174_K0.6800.13
6_V96_V0.6780.13
63_E66_R0.6720.13
12_V178_N0.6700.12
110_H155_I0.6570.12
20_F168_L0.6550.12
78_E86_E0.6550.12
55_D92_D0.6510.12
77_V162_A0.6510.12
127_P186_A0.6480.12
8_G129_I0.6420.12
130_I151_I0.6410.12
53_S177_V0.6410.12
58_R69_Q0.6340.12
51_V104_L0.6320.12
53_S90_L0.6310.12
110_H170_G0.6300.12
10_P175_V0.6290.12
111_V165_S0.6280.12
55_D144_D0.6280.12
38_G108_P0.6260.12
94_H108_P0.6260.12
55_D142_R0.6250.12
121_F160_Y0.6230.12
136_R180_E0.6160.12
70_A91_I0.6140.12
71_L166_A0.6090.11
66_R176_V0.6080.11
28_K101_A0.5990.11
14_K163_M0.5950.11
52_K156_Q0.5940.11
105_P140_R0.5900.11
42_L46_L0.5870.11
63_E89_G0.5860.11
15_T135_K0.5860.11
103_Y115_L0.5840.11
8_G49_G0.5840.11
37_Y135_K0.5840.11
36_N159_R0.5770.11
32_H169_V0.5750.11
98_R153_E0.5730.11
55_D137_D0.5710.11
8_G170_G0.5710.11
3_I177_V0.5620.11
45_A60_L0.5610.11
163_M171_A0.5610.11
43_N72_A0.5610.11
103_Y122_L0.5570.11
45_A68_L0.5540.11
12_V103_Y0.5530.11
121_F190_I0.5520.11
122_L162_A0.5510.11
90_L145_Y0.5460.11
70_A130_I0.5450.11
66_R78_E0.5440.11
5_I58_R0.5410.10
22_D190_I0.5390.10
58_R97_I0.5360.10
74_R136_R0.5360.10
32_H114_V0.5350.10
97_I164_A0.5330.10
117_P166_A0.5320.10
6_V68_L0.5310.10
96_V187_A0.5300.10
51_V162_A0.5290.10
157_F163_M0.5260.10
33_K177_V0.5240.10
43_N169_V0.5210.10
30_I185_I0.5200.10
18_L105_P0.5200.10
66_R118_K0.5190.10
116_S149_A0.5190.10
160_Y192_N0.5160.10
124_E144_D0.5080.10
58_R92_D0.5060.10
176_V183_P0.5030.10
77_V89_G0.5010.10
3_I6_V0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1nksA 5 0.9949 100 0.638 Contact Map
1khtA 5 0.9692 100 0.671 Contact Map
3ld9A 3 0.8205 99.5 0.812 Contact Map
3v9pA 2 0.9179 99.4 0.821 Contact Map
2pbrA 2 0.8718 99.4 0.822 Contact Map
3tmkA 2 0.9282 99.4 0.824 Contact Map
2iyvA 1 0.8513 99.4 0.824 Contact Map
4eaqA 2 0.9026 99.4 0.825 Contact Map
4hlcA 2 0.9026 99.4 0.825 Contact Map
3hjnA 2 0.8718 99.3 0.827 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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