GREMLIN Database
KCY - Cytidylate kinase
UniProt: Q9UX81 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 189 (165)
Sequences: 8862 (5523)
Seq/√Len: 430.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_Y133_K3.8651.00
23_E168_L3.0291.00
102_L132_Y2.6561.00
19_K164_V2.5861.00
99_W152_V2.4791.00
50_N54_E2.3761.00
121_V125_I2.2821.00
52_V60_D2.2781.00
104_I107_N2.2121.00
116_S119_E2.0671.00
157_N166_L1.9981.00
64_D68_H1.9311.00
126_R129_Y1.9091.00
159_D162_N1.8771.00
111_I114_K1.8521.00
97_Y152_V1.8351.00
98_L155_T1.8291.00
107_N111_I1.8061.00
110_A114_K1.7741.00
24_L168_L1.7681.00
37_D41_S1.7661.00
104_I156_S1.7061.00
145_D152_V1.6841.00
51_R55_S1.6771.00
126_R130_M1.6611.00
23_E164_V1.6561.00
101_P156_S1.6541.00
111_I115_I1.6431.00
66_K69_E1.6361.00
151_L170_Y1.6191.00
48_N51_R1.6111.00
146_L152_V1.6101.00
40_Q44_L1.5611.00
16_V167_I1.5571.00
39_A53_A1.5431.00
102_L125_I1.5341.00
19_K22_N1.5261.00
109_I124_I1.5251.00
117_Y120_A1.5161.00
130_M134_R1.5071.00
166_L169_D1.5041.00
38_I65_K1.4851.00
65_K68_H1.4721.00
157_N162_N1.4651.00
19_K161_N1.4421.00
94_V151_L1.4361.00
5_I17_A1.4171.00
165_K169_D1.4011.00
24_L172_S1.3941.00
106_A125_I1.3921.00
132_Y136_N1.3851.00
122_S126_R1.3741.00
60_D63_V1.3641.00
42_M47_I1.3451.00
168_L172_S1.3441.00
65_K69_E1.3421.00
16_V164_V1.3331.00
96_I167_I1.3281.00
64_D67_I1.2831.00
47_I50_N1.2831.00
44_L47_I1.2681.00
164_V168_L1.2481.00
97_Y139_Y1.2021.00
117_Y121_V1.2001.00
66_K72_L1.1811.00
11_S100_A1.1781.00
15_S160_I1.1641.00
2_I89_R1.1601.00
26_Y76_N1.1561.00
120_A123_Q1.1491.00
95_A150_D1.1481.00
39_A50_N1.1401.00
94_V170_Y1.1301.00
32_G36_R1.1241.00
86_W147_S1.1191.00
44_L48_N1.1191.00
41_S45_D1.1031.00
18_I22_N1.0861.00
19_K23_E1.0821.00
6_S139_Y1.0781.00
155_T163_I1.0711.00
57_F126_R1.0581.00
122_S125_I1.0511.00
29_I79_V1.0471.00
165_K168_L1.0361.00
166_L170_Y1.0341.00
2_I93_D1.0331.00
162_N165_K1.0281.00
38_I43_G1.0231.00
96_I170_Y1.0161.00
128_E132_Y1.0151.00
43_G49_L1.0041.00
97_Y132_Y1.0021.00
119_E123_Q1.0021.00
98_L167_I1.0021.00
100_A155_T0.9851.00
51_R54_E0.9811.00
39_A49_L0.9651.00
106_A121_V0.9651.00
103_K107_N0.9601.00
20_L167_I0.9451.00
30_S33_K0.9411.00
153_I163_I0.9381.00
66_K70_Y0.9371.00
62_M66_K0.9341.00
125_I129_Y0.9291.00
102_L129_Y0.9281.00
153_I170_Y0.9251.00
70_Y74_E0.9221.00
162_N166_L0.9141.00
20_L164_V0.9131.00
103_K121_V0.9101.00
110_A121_V0.8991.00
38_I41_S0.8971.00
4_I92_T0.8941.00
47_I51_R0.8851.00
52_V57_F0.8821.00
49_L52_V0.8651.00
160_I164_V0.8591.00
110_A120_A0.8541.00
18_I28_F0.8521.00
131_H135_F0.8441.00
123_Q126_R0.8441.00
34_I38_I0.8431.00
49_L53_A0.8421.00
23_E172_S0.8401.00
67_I70_Y0.8331.00
92_T149_F0.8301.00
144_N147_S0.8241.00
94_V171_L0.8231.00
48_N52_V0.8221.00
8_P131_H0.8201.00
154_N157_N0.8191.00
10_G109_I0.8091.00
18_I21_A0.8041.00
87_I137_K0.8031.00
6_S95_A0.8011.00
110_A113_D0.7841.00
157_N163_I0.7711.00
27_K73_R0.7681.00
97_Y150_D0.7601.00
104_I157_N0.7551.00
51_R60_D0.7531.00
2_I77_L0.7501.00
79_V84_A0.7471.00
14_T80_E0.7411.00
8_P105_R0.7401.00
3_I171_L0.7371.00
145_D148_V0.7161.00
16_V163_I0.7161.00
103_K125_I0.7141.00
16_V160_I0.7141.00
21_A28_F0.7071.00
35_F39_A0.7011.00
4_I84_A0.6981.00
39_A43_G0.6971.00
43_G46_I0.6951.00
3_I94_V0.6941.00
56_N60_D0.6931.00
72_L89_R0.6901.00
17_A28_F0.6891.00
99_W139_Y0.6891.00
29_I77_L0.6891.00
12_G15_S0.6841.00
144_N148_V0.6831.00
26_Y77_L0.6821.00
154_N166_L0.6751.00
12_G108_R0.6731.00
106_A110_A0.6721.00
61_K87_I0.6701.00
161_N165_K0.6681.00
101_P104_I0.6651.00
61_K85_G0.6641.00
53_A56_N0.6601.00
86_W145_D0.6540.99
84_A88_F0.6480.99
42_M50_N0.6420.99
57_F61_K0.6410.99
7_G10_G0.6360.99
58_D61_K0.6310.99
147_S150_D0.6300.99
61_K88_F0.6280.99
76_N93_D0.6270.99
77_L92_T0.6260.99
102_L128_E0.6240.99
48_N62_M0.6110.99
119_E122_S0.6110.99
103_K106_A0.6090.99
5_I20_L0.6090.99
27_K66_K0.6060.99
54_E60_D0.6050.99
8_P11_S0.6050.99
57_F136_N0.6030.99
102_L121_V0.6020.99
35_F53_A0.6000.99
9_P123_Q0.5990.99
57_F60_D0.5980.99
27_K75_R0.5930.99
5_I78_I0.5870.99
83_I88_F0.5850.99
155_T167_I0.5830.99
70_Y73_R0.5820.99
20_L168_L0.5790.99
64_D70_Y0.5760.99
110_A117_Y0.5730.99
36_R127_R0.5690.99
52_V55_S0.5690.99
52_V56_N0.5650.98
10_G124_I0.5640.98
126_R133_K0.5640.98
139_Y150_D0.5630.98
86_W138_F0.5520.98
28_F33_K0.5520.98
135_F138_F0.5510.98
5_I98_L0.5510.98
64_D137_K0.5500.98
129_Y132_Y0.5500.98
100_A105_R0.5500.98
138_F150_D0.5480.98
153_I166_L0.5480.98
20_L78_I0.5450.98
27_K72_L0.5400.98
85_G88_F0.5400.98
93_D171_L0.5370.98
118_V121_V0.5360.98
52_V63_V0.5340.98
39_A42_M0.5340.98
82_H100_A0.5330.98
31_A34_I0.5300.98
99_W154_N0.5290.98
32_G84_A0.5280.98
35_F38_I0.5270.98
5_I96_I0.5230.97
79_V89_R0.5230.97
27_K77_L0.5200.97
7_G11_S0.5180.97
2_I92_T0.5170.97
23_E165_K0.5170.97
50_N60_D0.5160.97
116_S120_A0.5120.97
51_R57_F0.5120.97
134_R138_F0.5110.97
27_K76_N0.5110.97
105_R128_E0.5100.97
39_A46_I0.5090.97
106_A124_I0.5050.97
37_D69_E0.5010.97
62_M65_K0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qbgB 1 0.9153 100 0.388 Contact Map
2xb4A 4 0.8942 99.9 0.403 Contact Map
3be4A 1 0.8783 99.9 0.41 Contact Map
3tlxA 1 0.8995 99.9 0.411 Contact Map
4jzkA 1 0.8942 99.9 0.413 Contact Map
1akyA 1 0.9048 99.9 0.414 Contact Map
3gmtA 1 0.8042 99.9 0.419 Contact Map
1zd8A 1 0.9153 99.9 0.422 Contact Map
4pzlA 2 0.9048 99.9 0.422 Contact Map
1ak2A 1 0.9153 99.9 0.422 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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