GREMLIN Database
ARCH - Protein archease
UniProt: Q9UX79 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 139 (136)
Sequences: 539 (424)
Seq/√Len: 36.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
5_E16_K4.0521.00
67_E117_M3.0241.00
52_Y95_E3.0181.00
101_E108_H2.9271.00
16_K134_T2.7821.00
7_F14_G2.6511.00
25_A133_I2.3721.00
55_G64_K2.3701.00
18_Y28_N2.3160.99
20_R24_E2.2460.99
63_Y122_L2.2300.99
14_G136_V2.1540.99
16_K132_V2.0100.98
69_L98_A2.0030.98
54_N93_T1.9890.98
104_N107_I1.9550.98
44_R107_I1.9430.98
30_A65_W1.8910.98
127_T130_G1.8590.97
84_D97_K1.8540.97
104_N108_H1.8510.97
66_I117_M1.7990.97
67_E122_L1.7730.97
80_F83_F1.7630.97
68_E72_Y1.6850.95
49_R76_E1.6430.95
43_V101_E1.6090.94
35_E40_T1.5700.93
30_A98_A1.5650.93
19_G24_E1.5610.93
6_F35_E1.5530.93
71_Y75_S1.5380.93
33_V114_V1.4540.90
19_G28_N1.4520.90
52_Y86_M1.4280.90
82_K99_W1.3810.88
117_M135_F1.3720.88
68_E71_Y1.3660.87
74_D113_V1.3510.87
30_A69_L1.3430.86
86_M95_E1.3150.85
127_T132_V1.2870.84
26_F62_L1.2790.84
116_A120_H1.2580.83
30_A83_F1.2450.82
65_W96_G1.2380.82
38_T110_R1.2280.81
126_K131_Y1.2270.81
19_G25_A1.2210.81
101_E107_I1.2160.80
52_Y93_T1.2090.80
63_Y67_E1.1890.79
34_F73_Y1.1610.77
48_Y97_K1.1470.76
38_T103_F1.1430.76
48_Y99_W1.1430.76
123_S134_T1.1190.74
9_H73_Y1.1100.74
110_R114_V1.0950.73
50_E95_E1.0920.73
34_F69_L1.0800.72
17_S25_A1.0660.71
57_D124_I1.0510.70
4_F35_E1.0480.69
23_E85_L1.0260.68
10_T116_A1.0220.67
120_H136_V1.0100.67
24_E52_Y1.0090.66
7_F137_V1.0080.66
69_L96_G1.0050.66
119_Y122_L0.9970.66
3_Q18_Y0.9930.65
33_V70_L0.9850.65
113_V117_M0.9730.64
55_G60_N0.9720.64
116_A135_F0.9630.63
65_W117_M0.9580.62
33_V66_I0.9500.62
61_L68_E0.9350.60
63_Y123_S0.9210.59
15_I137_V0.9080.58
66_I113_V0.9070.58
124_I135_F0.9030.58
45_P81_S0.9010.58
48_Y127_T0.8830.56
17_S114_V0.8830.56
61_L94_L0.8780.56
29_A62_L0.8700.55
32_G94_L0.8680.55
3_Q28_N0.8550.54
51_I96_G0.8540.54
47_E102_R0.8410.52
27_S84_D0.8180.50
32_G47_E0.8150.50
72_Y78_M0.8120.50
9_H121_Q0.8020.49
22_L26_F0.8020.49
5_E11_A0.8000.49
65_W134_T0.7980.49
50_E97_K0.7880.48
32_G116_A0.7870.48
45_P82_K0.7840.47
25_A137_V0.7770.47
51_I78_M0.7760.47
9_H12_D0.7730.46
122_L135_F0.7730.46
33_V37_I0.7710.46
87_I94_L0.7680.46
123_S132_V0.7650.46
43_V100_G0.7590.45
15_I32_G0.7550.45
27_S85_L0.7530.45
72_Y76_E0.7460.44
43_V108_H0.7440.44
60_N119_Y0.7430.44
14_G134_T0.7390.44
44_R93_T0.7390.44
114_V137_V0.7370.43
56_Y60_N0.7350.43
117_M137_V0.7250.42
121_Q134_T0.7200.42
117_M122_L0.7180.42
6_F137_V0.7050.41
15_I135_F0.7040.41
37_I109_E0.7020.40
53_L94_L0.7000.40
13_V43_V0.6900.39
17_S133_I0.6880.39
28_N31_L0.6870.39
18_Y121_Q0.6860.39
57_D60_N0.6860.39
8_E95_E0.6850.39
20_R27_S0.6810.39
56_Y63_Y0.6750.38
21_S24_E0.6690.38
23_E87_I0.6610.37
3_Q24_E0.6540.36
54_N91_S0.6510.36
67_E75_S0.6500.36
6_F16_K0.6490.36
36_V63_Y0.6460.36
3_Q20_R0.6440.36
70_L73_Y0.6390.35
79_I102_R0.6380.35
80_F98_A0.6340.35
25_A135_F0.6290.34
41_S136_V0.6230.34
88_D92_I0.6170.33
73_Y103_F0.6160.33
84_D104_N0.6130.33
115_K118_T0.6120.33
131_Y136_V0.6050.33
44_R88_D0.5990.32
120_H135_F0.5980.32
101_E114_V0.5980.32
66_I83_F0.5960.32
49_R120_H0.5950.32
53_L122_L0.5940.32
34_F83_F0.5860.31
6_F37_I0.5820.31
53_L68_E0.5780.31
112_T119_Y0.5770.30
4_F110_R0.5640.29
41_S65_W0.5620.29
65_W69_L0.5620.29
67_E70_L0.5590.29
6_F111_R0.5570.29
26_F30_A0.5550.29
68_E135_F0.5540.29
25_A124_I0.5530.29
85_L93_T0.5520.29
9_H113_V0.5510.29
38_T112_T0.5440.28
78_M83_F0.5400.28
38_T111_R0.5390.28
34_F79_I0.5380.28
84_D123_S0.5360.27
49_R72_Y0.5350.27
33_V135_F0.5340.27
85_L90_D0.5300.27
15_I71_Y0.5300.27
61_L108_H0.5280.27
24_E95_E0.5240.27
13_V64_K0.5230.27
43_V78_M0.5220.27
87_I119_Y0.5200.26
10_T70_L0.5180.26
20_R29_A0.5180.26
111_R120_H0.5160.26
72_Y99_W0.5160.26
18_Y134_T0.5160.26
44_R123_S0.5150.26
59_E124_I0.5140.26
47_E128_E0.5140.26
86_M139_I0.5130.26
54_N104_N0.5130.26
15_I38_T0.5120.26
32_G59_E0.5070.26
94_L107_I0.5030.25
5_E34_F0.5020.25
22_L106_K0.5020.25
71_Y94_L0.5020.25
30_A96_G0.5010.25
53_L61_L0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jw3A 1 0.9928 100 0.073 Contact Map
4n2pA 2 1 100 0.078 Contact Map
1j5uA 1 0.8633 100 0.277 Contact Map
1wv8A 2 0.4245 71.5 0.913 Contact Map
3gkuA 2 0.8777 50.6 0.924 Contact Map
2yztA 2 0.3957 29.9 0.933 Contact Map
2dsyA 3 0.4101 18.1 0.94 Contact Map
3kwrA 2 0.518 15.3 0.942 Contact Map
2lmcA 1 0.3597 11 0.945 Contact Map
1r7lA 2 0.2806 9.6 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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