GREMLIN Database
AMZA - Archaemetzincin
UniProt: Q9UX78 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 183 (169)
Sequences: 334 (256)
Seq/√Len: 19.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_G103_F4.0671.00
57_A94_L3.7981.00
76_I129_V3.6991.00
104_L125_V3.0740.99
84_Y90_F2.8710.99
131_H141_H2.7680.99
89_N152_S2.7110.98
131_H135_H2.6920.98
79_A103_F2.4780.97
128_E161_K2.3600.96
107_L158_V2.3230.96
132_E141_H2.2920.95
79_A83_G2.1930.94
132_E135_H2.1870.94
93_G141_H2.1790.94
89_N151_F2.1590.93
135_H149_M2.1360.93
166_C169_C2.1180.93
92_F161_K2.0360.91
139_L169_C1.9870.90
102_I129_V1.9780.90
135_H141_H1.9760.90
124_R159_D1.9560.89
17_S78_L1.9430.89
33_V83_G1.9150.88
69_D72_Y1.8790.87
93_G132_E1.8420.86
74_S136_T1.8260.86
91_V152_S1.7840.85
151_F157_D1.7760.84
89_N153_N1.7700.84
64_L77_F1.7340.83
131_H149_M1.6670.80
92_F153_N1.6470.79
150_N158_V1.6270.78
54_Q84_Y1.6260.78
93_G135_H1.5560.75
159_D169_C1.5510.75
132_E149_M1.5410.74
102_I125_V1.5160.73
9_V77_F1.5130.73
84_Y89_N1.4610.70
55_Y170_A1.4560.70
112_Y117_D1.4380.69
102_I107_L1.3000.61
35_I65_K1.2800.60
85_I88_Y1.2780.60
93_G131_H1.2700.59
110_E113_N1.2500.58
54_Q151_F1.2440.58
7_L71_N1.2250.56
144_T150_N1.1970.55
135_H142_C1.1840.54
64_L75_I1.1660.53
88_Y153_N1.1660.53
82_D106_R1.1660.53
66_S75_I1.1570.52
78_L129_V1.1510.52
167_K170_A1.1400.51
25_N29_Y1.1380.51
27_S34_D1.1270.50
74_S97_D1.1240.50
130_T165_F1.0810.47
148_V158_V1.0760.47
54_Q82_D1.0680.46
97_D136_T1.0610.46
90_F165_F1.0540.45
54_Q95_T1.0350.44
134_G159_D1.0320.44
122_M126_V1.0300.44
133_V163_A1.0270.44
142_C149_M1.0240.44
54_Q157_D1.0230.43
88_Y92_F1.0200.43
135_H166_C1.0190.43
81_S103_F1.0140.43
130_T137_L1.0120.43
95_T141_H1.0020.42
9_V12_T0.9970.42
49_N86_D0.9940.42
26_L170_A0.9870.41
139_L155_V0.9820.41
88_Y94_L0.9810.41
11_L78_L0.9750.40
52_R134_G0.9730.40
22_I102_I0.9600.40
52_R107_L0.9370.38
91_V159_D0.9310.38
92_F159_D0.9280.38
56_D94_L0.9270.38
119_D123_K0.9270.38
88_Y165_F0.9250.37
29_Y172_K0.9240.37
78_L113_N0.9050.36
38_D70_F0.8990.36
147_C166_C0.8920.35
91_V94_L0.8890.35
64_L165_F0.8850.35
120_L124_R0.8840.35
110_E116_P0.8830.35
146_G162_Q0.8780.35
57_A92_F0.8770.35
76_I102_I0.8720.34
124_R134_G0.8680.34
109_E114_R0.8530.33
33_V41_K0.8510.33
60_V78_L0.8390.32
89_N158_V0.8380.32
80_D133_V0.8370.32
147_C169_C0.8360.32
43_L46_S0.8350.32
57_A97_D0.8350.32
76_I105_H0.8320.32
23_V62_S0.8310.32
148_V155_V0.8310.32
128_E136_T0.8230.32
64_L68_H0.8200.31
6_I25_N0.8090.31
149_M166_C0.8030.30
98_N163_A0.8000.30
45_I48_F0.7920.30
145_T150_N0.7910.30
170_A174_E0.7830.29
51_E137_L0.7810.29
79_A101_I0.7670.28
61_L96_I0.7520.28
14_I78_L0.7520.28
100_A136_T0.7510.28
11_L32_E0.7470.27
104_L163_A0.7470.27
98_N136_T0.7460.27
32_E80_D0.7400.27
24_N39_S0.7390.27
88_Y100_A0.7320.27
22_I163_A0.7320.27
85_I100_A0.7310.27
78_L154_S0.7300.27
107_L128_E0.7290.27
20_D148_V0.7290.27
120_L140_S0.7270.26
150_N172_K0.7230.26
89_N154_S0.7180.26
82_D141_H0.7180.26
20_D99_F0.7180.26
26_L73_D0.7170.26
9_V38_D0.7170.26
10_T41_K0.7160.26
11_L65_K0.7160.26
48_F159_D0.7150.26
83_G155_V0.7140.26
111_F115_K0.7110.26
32_E35_I0.7110.26
54_Q90_F0.7110.26
48_F161_K0.7100.26
43_L60_V0.7100.26
33_V73_D0.7090.26
126_V139_L0.7080.25
47_A129_V0.7030.25
20_D76_I0.7010.25
158_V161_K0.6930.25
84_Y153_N0.6900.25
104_L107_L0.6890.25
74_S137_L0.6880.25
142_C166_C0.6860.24
120_L123_K0.6830.24
84_Y95_T0.6810.24
25_N72_Y0.6780.24
29_Y53_L0.6740.24
18_I122_M0.6700.24
90_F128_E0.6700.24
57_A107_L0.6670.24
43_L76_I0.6650.23
129_V174_E0.6640.23
131_H142_C0.6640.23
91_V100_A0.6620.23
138_G142_C0.6610.23
83_G101_I0.6600.23
54_Q83_G0.6570.23
7_L72_Y0.6560.23
38_D162_Q0.6550.23
102_I158_V0.6530.23
60_V116_P0.6500.23
58_E94_L0.6450.23
49_N52_R0.6430.22
12_T77_F0.6390.22
6_I31_L0.6380.22
92_F158_V0.6380.22
85_I97_D0.6370.22
90_F112_Y0.6340.22
128_E163_A0.6330.22
74_S130_T0.6310.22
90_F153_N0.6280.22
87_G154_S0.6270.22
95_T113_N0.6270.22
18_I104_L0.6250.22
14_I130_T0.6220.22
7_L99_F0.6220.22
52_R159_D0.6180.21
137_L158_V0.6170.21
61_L92_F0.6140.21
32_E130_T0.6090.21
26_L129_V0.6070.21
91_V95_T0.6050.21
139_L142_C0.6040.21
111_F161_K0.6040.21
120_L127_K0.6030.21
55_Y172_K0.6020.21
18_I21_E0.6000.21
126_V169_C0.6000.21
76_I79_A0.5970.20
47_A55_Y0.5960.20
82_D90_F0.5940.20
92_F105_H0.5930.20
107_L161_K0.5900.20
134_G148_V0.5850.20
8_I171_H0.5850.20
92_F107_L0.5830.20
89_N148_V0.5830.20
132_E142_C0.5780.20
146_G167_K0.5760.20
20_D101_I0.5750.20
57_A114_R0.5740.19
96_I157_D0.5730.19
150_N162_Q0.5730.19
89_N94_L0.5690.19
86_D89_N0.5660.19
95_T152_S0.5600.19
137_L160_K0.5600.19
17_S50_W0.5600.19
85_I122_M0.5570.19
37_L47_A0.5560.19
88_Y128_E0.5460.18
52_R113_N0.5430.18
11_L77_F0.5400.18
16_K34_D0.5390.18
22_I174_E0.5380.18
44_P101_I0.5330.18
67_I114_R0.5300.18
79_A119_D0.5290.18
51_E79_A0.5290.18
85_I104_L0.5240.18
68_H98_N0.5220.17
31_L165_F0.5210.17
85_I94_L0.5180.17
8_I51_E0.5150.17
40_R79_A0.5150.17
76_I148_V0.5090.17
78_L96_I0.5090.17
44_P116_P0.5060.17
52_R128_E0.5060.17
90_F105_H0.5050.17
26_L130_T0.5040.17
50_W117_D0.5010.17
113_N159_D0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lmcA 1 0.9235 100 0.436 Contact Map
3zvsA 1 0.8634 100 0.445 Contact Map
2x7mA 1 0.929 100 0.503 Contact Map
1kufA 1 0.8962 98.2 0.852 Contact Map
1atlA 2 0.8962 98.2 0.853 Contact Map
1r55A 1 0.8962 98.2 0.854 Contact Map
1budA 1 0.8962 98.2 0.854 Contact Map
3k7lA 1 0.7978 98.1 0.855 Contact Map
3k7nA 1 0.8907 98.1 0.855 Contact Map
4j4mA 1 0.8962 98.1 0.856 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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