GREMLIN Database
NIKR - Putative nickel-responsive regulator
UniProt: Q9UX49 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 133 (125)
Sequences: 683 (484)
Seq/√Len: 43.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_S92_I3.4161.00
56_I99_V3.1031.00
92_I120_L2.9531.00
62_H74_H2.8611.00
114_G122_A2.8111.00
74_H87_H2.8031.00
74_H93_C2.7231.00
102_E105_K2.6921.00
32_K39_R2.6871.00
85_H93_C2.6781.00
10_L38_L2.5411.00
27_I36_I2.3601.00
32_K35_Q2.3151.00
54_G99_V2.2401.00
62_H87_H2.1331.00
57_N125_L2.0870.99
87_H93_C2.0500.99
17_E46_R2.0110.99
18_L33_I1.8590.99
52_I106_L1.8120.98
27_I32_K1.7950.98
56_I113_L1.7590.98
75_E90_E1.7510.98
56_I124_L1.7220.98
62_H93_C1.5990.96
15_Y19_E1.5160.95
81_I100_K1.5140.95
58_L113_L1.4490.94
34_F96_A1.4010.93
53_Y88_V1.3680.92
3_A12_K1.3610.91
69_L113_L1.3420.91
63_E90_E1.3280.90
84_L98_A1.3130.90
32_K36_I1.3070.90
3_A7_S1.2890.89
37_A41_Y1.2790.89
35_Q39_R1.2420.87
4_E12_K1.2410.87
75_E112_K1.2290.87
70_T87_H1.1610.83
62_H85_H1.1570.83
18_L38_L1.1560.83
74_H85_H1.1540.83
60_Y87_H1.1390.82
70_T74_H1.1280.81
108_E112_K1.1220.81
77_N109_L1.0910.79
65_A90_E1.0770.78
55_I98_A1.0750.78
22_I33_I1.0670.78
65_A116_I1.0090.74
6_I9_S1.0080.73
121_K127_S1.0080.73
66_S70_T0.9940.72
34_F75_E0.9860.72
110_N124_L0.9840.72
10_L23_I0.9750.71
24_R49_N0.9710.71
86_L94_I0.9700.71
110_N122_A0.9680.70
18_L22_I0.9650.70
6_I34_F0.9610.70
3_A6_I0.9570.70
36_I119_I0.9530.69
19_E50_E0.9460.69
16_R25_K0.9420.68
5_K19_E0.9420.68
40_N123_R0.9390.68
58_L122_A0.9310.67
78_D105_K0.9290.67
9_S18_L0.9230.67
21_F42_L0.9200.66
34_F64_E0.9130.66
114_G123_R0.9080.65
7_S77_N0.9030.65
15_Y18_L0.9010.65
12_K16_R0.8960.64
8_I15_Y0.8910.64
114_G121_K0.8860.63
73_Q97_I0.8820.63
6_I63_E0.8550.61
92_I106_L0.8330.59
49_N91_K0.8290.58
80_I109_L0.8260.58
43_D47_D0.8120.57
42_L123_R0.8060.56
17_E26_G0.8050.56
46_R82_S0.7990.56
14_L39_R0.7960.55
18_L63_E0.7840.54
13_E105_K0.7820.54
26_G97_I0.7800.54
85_H95_E0.7760.53
47_D106_L0.7750.53
4_E7_S0.7730.53
9_S14_L0.7720.53
102_E106_L0.7710.53
58_L65_A0.7610.52
52_I127_S0.7530.51
83_T99_V0.7520.51
22_I27_I0.7500.51
76_Y122_A0.7470.51
84_L96_A0.7410.50
59_V111_N0.7300.49
76_Y108_E0.7270.49
34_F46_R0.7270.49
106_L110_N0.7250.48
63_E84_L0.7150.48
41_Y45_N0.7130.47
29_D122_A0.7090.47
105_K108_E0.6990.46
20_D49_N0.6960.46
18_L97_I0.6910.45
50_E79_S0.6890.45
58_L70_T0.6860.45
5_K95_E0.6790.44
9_S27_I0.6760.44
76_Y102_E0.6720.43
22_I89_S0.6710.43
33_I41_Y0.6650.43
5_K36_I0.6630.43
49_N76_Y0.6630.43
19_E111_N0.6600.42
89_S106_L0.6560.42
28_P126_I0.6560.42
19_E35_Q0.6530.42
70_T93_C0.6510.41
34_F49_N0.6470.41
5_K35_Q0.6470.41
7_S117_R0.6400.40
3_A50_E0.6350.40
47_D126_I0.6310.40
7_S66_S0.6290.39
83_T109_L0.6290.39
75_E105_K0.6250.39
50_E104_R0.6230.39
29_D121_K0.6200.39
26_G34_F0.6190.39
28_P116_I0.6140.38
30_R95_E0.6140.38
60_Y83_T0.6070.37
29_D37_A0.6060.37
20_D24_R0.6020.37
8_I39_R0.6010.37
11_P54_G0.5980.37
95_E101_G0.5940.36
19_E30_R0.5910.36
71_E103_K0.5910.36
37_A52_I0.5830.35
63_E85_H0.5760.35
107_V111_N0.5730.34
72_I112_K0.5700.34
64_E71_E0.5690.34
79_S105_K0.5680.34
3_A52_I0.5630.34
117_R127_S0.5620.34
86_L89_S0.5600.33
60_Y85_H0.5540.33
5_K33_I0.5500.33
76_Y110_N0.5480.32
43_D92_I0.5480.32
37_A122_A0.5450.32
64_E68_A0.5440.32
29_D119_I0.5420.32
58_L97_I0.5410.32
5_K29_D0.5410.32
29_D116_I0.5400.32
53_Y75_E0.5390.32
35_Q93_C0.5370.31
67_E71_E0.5330.31
47_D72_I0.5290.31
65_A118_G0.5180.30
18_L37_A0.5170.30
36_I39_R0.5160.30
54_G57_N0.5150.30
9_S57_N0.5140.30
24_R45_N0.5100.29
73_Q87_H0.5100.29
48_G68_A0.5090.29
78_D102_E0.5090.29
71_E80_I0.5070.29
43_D127_S0.5070.29
73_Q80_I0.5060.29
44_E48_G0.5060.29
91_K120_L0.5030.29
87_H90_E0.5030.29
36_I65_A0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wvfA 2 0.985 100 0.195 Contact Map
2bj7A 3 0.9925 100 0.227 Contact Map
2hzaA 3 0.9549 100 0.229 Contact Map
1q5yA 4 0.6165 99.9 0.53 Contact Map
2nzcA 3 0.594 99.8 0.583 Contact Map
4me7E 2 0.5865 98.8 0.763 Contact Map
3kxeC 2 0.5038 98.8 0.769 Contact Map
2k5jA 2 0.5489 98.7 0.776 Contact Map
2cpgA 2 0.3383 98.4 0.796 Contact Map
2mdvA 2 0.2857 98 0.815 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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