GREMLIN Database
COXX - Protoheme IX farnesyltransferase
UniProt: Q9UX46 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 285 (272)
Sequences: 9597 (6875)
Seq/√Len: 416.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_G87_R4.1981.00
66_I87_R4.0921.00
9_A84_Y3.6261.00
63_G91_I3.4341.00
86_S89_E3.4081.00
56_G98_A3.1471.00
12_K84_Y2.9791.00
206_T210_R2.9021.00
73_S76_S2.7341.00
30_A43_I2.5241.00
88_K92_V2.4991.00
247_F251_R2.4701.00
53_A101_G2.3921.00
10_Y89_E2.3061.00
188_R192_I2.1921.00
8_K12_K2.1241.00
109_N112_T2.0911.00
19_V51_T2.0861.00
189_E192_I2.0821.00
162_T165_A2.0691.00
104_L108_D2.0591.00
68_R196_Y2.0251.00
262_M265_F2.0071.00
262_M266_I2.0071.00
112_T155_T2.0061.00
110_A114_F2.0051.00
105_G108_D1.9521.00
241_L244_L1.9441.00
45_P107_I1.8611.00
39_S42_P1.7931.00
59_I97_L1.7931.00
207_T210_R1.7831.00
70_K81_V1.7761.00
14_G59_I1.7751.00
244_L248_L1.7561.00
154_Y158_T1.7531.00
80_T90_V1.7391.00
66_I80_T1.7181.00
27_I47_L1.7091.00
240_V244_L1.6961.00
66_I70_K1.6891.00
64_I129_I1.6801.00
92_V96_L1.6791.00
91_I95_S1.6511.00
203_V207_T1.6361.00
210_R214_T1.6341.00
268_S272_L1.6241.00
257_T260_E1.6221.00
180_F184_A1.6071.00
265_F269_N1.5831.00
10_Y93_V1.5801.00
106_F113_A1.5721.00
21_L179_H1.5711.00
13_L59_I1.5691.00
192_I201_A1.5491.00
244_L247_F1.5391.00
95_S99_V1.5261.00
114_F118_L1.4961.00
122_I145_A1.4771.00
200_P208_S1.4201.00
263_K266_I1.4131.00
232_L236_I1.3971.00
53_A116_I1.3771.00
52_L101_G1.3741.00
150_A153_G1.3721.00
11_L16_L1.3681.00
98_A120_V1.3531.00
251_R254_L1.3511.00
59_I94_G1.3411.00
52_L100_L1.3391.00
161_L165_A1.3381.00
217_A221_P1.3291.00
90_V94_G1.3261.00
205_I209_A1.3251.00
14_G93_V1.3201.00
181_W184_A1.3001.00
13_L85_V1.2751.00
85_V90_V1.2601.00
91_I94_G1.2601.00
269_N273_M1.2591.00
248_L252_L1.2561.00
245_L248_L1.2481.00
174_M215_S1.2471.00
261_A265_F1.2431.00
188_R201_A1.2421.00
126_V141_I1.2421.00
199_L203_V1.2391.00
59_I93_V1.2341.00
121_I125_F1.2321.00
156_S159_N1.2251.00
263_K267_F1.2201.00
14_G55_M1.2201.00
188_R205_I1.2201.00
180_F183_L1.2141.00
111_L115_F1.2101.00
14_G97_L1.2061.00
207_T211_A1.1981.00
219_M223_V1.1961.00
171_L222_I1.1891.00
63_G94_G1.1841.00
63_G90_V1.1781.00
269_N272_L1.1551.00
44_I48_I1.1441.00
243_A247_F1.1441.00
94_G98_A1.1431.00
183_L187_Y1.1391.00
131_L134_R1.1321.00
210_R213_A1.1301.00
267_F271_Y1.1251.00
104_L107_I1.1241.00
90_V97_L1.1201.00
55_M97_L1.1161.00
11_L14_G1.1141.00
90_V93_V1.1141.00
65_E133_P1.1101.00
131_L141_I1.1041.00
26_A50_G1.1011.00
144_F169_G1.0991.00
233_I237_V1.0961.00
187_Y191_Y1.0861.00
87_R91_I1.0841.00
7_I11_L1.0831.00
52_L97_L1.0651.00
57_A124_V1.0631.00
147_S173_F1.0611.00
179_H183_L1.0581.00
166_F170_F1.0551.00
260_E264_S1.0501.00
60_I94_G1.0471.00
184_A187_Y1.0451.00
138_N198_M1.0351.00
132_K135_T1.0341.00
249_S253_I1.0321.00
199_L202_V1.0301.00
197_P202_V1.0291.00
224_L227_G1.0291.00
250_Y253_I1.0281.00
59_I85_V1.0261.00
266_I270_I1.0241.00
231_S234_A1.0221.00
102_T105_G1.0201.00
111_L114_F1.0181.00
224_L228_Y1.0071.00
112_T152_A1.0071.00
235_L238_F1.0041.00
154_Y157_L0.9911.00
33_A154_Y0.9891.00
105_G110_A0.9881.00
247_F250_Y0.9861.00
117_A121_I0.9831.00
142_G146_G0.9821.00
243_A246_L0.9751.00
103_A107_I0.9721.00
119_G148_A0.9641.00
40_L44_I0.9641.00
246_L249_S0.9631.00
41_L44_I0.9631.00
55_M93_V0.9621.00
270_I274_L0.9611.00
227_G235_L0.9561.00
81_V90_V0.9491.00
131_L135_T0.9461.00
206_T209_A0.9441.00
148_A152_A0.9391.00
242_S245_L0.9371.00
255_N258_K0.9361.00
268_S271_Y0.9341.00
269_N276_L0.9301.00
93_V97_L0.9241.00
38_I43_I0.9221.00
161_L166_F0.9201.00
170_F174_M0.9201.00
213_A217_A0.9191.00
237_V241_L0.9171.00
63_G80_T0.9101.00
185_L207_T0.9101.00
231_S236_I0.9091.00
189_E193_N0.9031.00
262_M269_N0.9011.00
77_N84_Y0.8981.00
183_L186_K0.8951.00
237_V278_S0.8951.00
184_A200_P0.8931.00
261_A264_S0.8881.00
97_L101_G0.8831.00
259_E263_K0.8801.00
265_F268_S0.8781.00
136_W202_V0.8701.00
220_I242_S0.8681.00
111_L155_T0.8671.00
41_L45_P0.8671.00
138_N142_G0.8601.00
32_L154_Y0.8591.00
241_L245_L0.8551.00
79_P83_G0.8521.00
26_A46_M0.8511.00
223_V226_M0.8511.00
178_G215_S0.8471.00
54_S58_M0.8471.00
68_R133_P0.8411.00
265_F278_S0.8351.00
48_I52_L0.8351.00
147_S176_T0.8331.00
223_V227_G0.8311.00
268_S273_M0.8201.00
29_G33_A0.8171.00
46_M156_S0.8131.00
49_G104_L0.8121.00
245_L249_S0.8121.00
265_F272_L0.8111.00
134_R138_N0.8011.00
89_E92_V0.8011.00
162_T166_F0.7971.00
72_M190_D0.7951.00
229_Y233_I0.7931.00
239_S243_A0.7911.00
65_E68_R0.7881.00
220_I223_V0.7851.00
122_I144_F0.7851.00
196_Y202_V0.7831.00
272_L276_L0.7821.00
267_F270_I0.7771.00
211_A215_S0.7761.00
273_M276_L0.7741.00
209_A213_A0.7711.00
267_F273_M0.7691.00
267_F272_L0.7691.00
21_L25_A0.7691.00
266_I269_N0.7681.00
272_L275_I0.7661.00
229_Y232_L0.7651.00
67_N70_K0.7581.00
270_I273_M0.7561.00
23_D27_I0.7561.00
200_P203_V0.7551.00
236_I239_S0.7531.00
105_G116_I0.7491.00
209_A212_I0.7461.00
67_N71_V0.7411.00
261_A268_S0.7401.00
276_L279_I0.7331.00
232_L235_L0.7301.00
13_L90_V0.7281.00
188_R200_P0.7271.00
269_N275_I0.7271.00
196_Y199_L0.7271.00
45_P104_L0.7241.00
163_L166_F0.7231.00
222_I225_L0.7231.00
30_A38_I0.7221.00
10_Y14_G0.7211.00
98_A101_G0.7201.00
103_A106_F0.7191.00
218_L222_I0.7171.00
240_V243_A0.7171.00
80_T85_V0.7131.00
72_M75_T0.7111.00
261_A266_I0.7111.00
254_L257_T0.7091.00
253_I256_P0.7081.00
264_S268_S0.7081.00
179_H184_A0.7051.00
234_A238_F0.6991.00
147_S150_A0.6981.00
219_M222_I0.6981.00
37_G41_L0.6941.00
34_Y38_I0.6881.00
266_I272_L0.6871.00
273_M277_L0.6861.00
248_L267_F0.6851.00
153_G157_L0.6821.00
160_S164_E0.6821.00
264_S272_L0.6791.00
222_I226_M0.6771.00
92_V95_S0.6771.00
139_I177_P0.6751.00
62_S65_E0.6751.00
230_I236_I0.6741.00
55_M59_I0.6731.00
139_I181_W0.6731.00
79_P84_Y0.6721.00
88_K91_I0.6721.00
10_Y85_V0.6650.99
131_L138_N0.6640.99
53_A120_V0.6620.99
22_L54_S0.6610.99
63_G66_I0.6610.99
99_V103_A0.6610.99
250_Y254_L0.6610.99
45_P108_D0.6610.99
215_S218_L0.6600.99
22_L25_A0.6590.99
236_I240_V0.6580.99
181_W211_A0.6570.99
142_G180_F0.6570.99
260_E263_K0.6560.99
255_N260_E0.6520.99
216_N219_M0.6510.99
139_I180_F0.6490.99
81_V84_Y0.6460.99
275_I278_S0.6450.99
137_L140_V0.6420.99
268_S275_I0.6410.99
242_S271_Y0.6350.99
23_D47_L0.6340.99
154_Y159_N0.6320.99
230_I279_I0.6300.99
39_S157_L0.6260.99
165_A169_G0.6260.99
249_S252_L0.6240.99
221_P225_L0.6210.99
234_A237_V0.6200.99
185_L209_A0.6190.99
102_T113_A0.6190.99
251_R255_N0.6170.99
85_V89_E0.6160.99
241_L248_L0.6150.99
233_I238_F0.6140.99
204_G208_S0.6130.99
242_S246_L0.6110.99
94_G97_L0.6090.99
271_Y275_I0.6070.99
144_F173_F0.6070.99
30_A157_L0.6050.99
177_P215_S0.6040.99
30_A34_Y0.6030.99
12_K79_P0.6030.99
191_Y198_M0.6010.99
85_V93_V0.5920.99
177_P180_F0.5910.99
30_A46_M0.5880.99
248_L253_I0.5880.99
261_A267_F0.5880.99
118_L121_I0.5870.99
172_I176_T0.5870.99
19_V47_L0.5850.99
246_L250_Y0.5850.99
147_S153_G0.5850.99
28_A172_I0.5830.99
108_D112_T0.5830.99
185_L208_S0.5810.99
126_V131_L0.5810.99
185_L205_I0.5800.99
90_V95_S0.5790.99
275_I279_I0.5760.98
68_R194_A0.5750.98
220_I224_L0.5740.98
119_G145_A0.5730.98
222_I227_G0.5700.98
9_A85_V0.5700.98
42_P108_D0.5690.98
93_V101_G0.5680.98
28_A168_L0.5630.98
46_M50_G0.5610.98
78_R83_G0.5610.98
137_L146_G0.5610.98
10_Y13_L0.5600.98
226_M234_A0.5600.98
65_E196_Y0.5600.98
177_P181_W0.5560.98
122_I141_I0.5550.98
178_G216_N0.5530.98
110_A113_A0.5530.98
237_V274_L0.5510.98
71_V194_A0.5500.98
41_L107_I0.5450.98
262_M272_L0.5430.98
60_I125_F0.5420.98
265_F271_Y0.5410.98
121_I126_V0.5410.98
128_T133_P0.5400.98
185_L188_R0.5390.98
239_S247_F0.5390.98
218_L221_P0.5380.98
147_S172_I0.5360.98
215_S219_M0.5360.98
100_L103_A0.5360.98
143_G148_A0.5360.98
60_I64_I0.5350.98
139_I142_G0.5350.98
143_G176_T0.5320.97
235_L239_S0.5320.97
98_A102_T0.5320.97
146_G150_A0.5300.97
159_N162_T0.5300.97
78_R142_G0.5290.97
171_L175_W0.5280.97
149_A153_G0.5280.97
16_L55_M0.5260.97
100_L104_L0.5240.97
31_F34_Y0.5240.97
230_I234_A0.5200.97
238_F242_S0.5200.97
135_T202_V0.5190.97
196_Y201_A0.5190.97
67_N87_R0.5180.97
232_L238_F0.5140.97
135_T141_I0.5130.97
186_K262_M0.5120.97
90_V108_D0.5100.97
34_Y157_L0.5100.97
151_W169_G0.5100.97
264_S269_N0.5080.97
272_L278_S0.5060.97
197_P201_A0.5060.97
183_L191_Y0.5030.96
198_M202_V0.5030.96
102_T106_F0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4od4A 1 0.9263 100 0.202 Contact Map
4tq3A 1 0.9544 100 0.277 Contact Map
2xq2A 2 0.814 35.8 0.937 Contact Map
3ze3A 4 0.3684 14.2 0.948 Contact Map
4xnjA 1 0.593 4.1 0.96 Contact Map
3ne5A 3 0.4561 3.6 0.96 Contact Map
2cfqA 1 0.8877 3.6 0.961 Contact Map
3o7qA 1 0.8491 3 0.962 Contact Map
1qleC 1 0.5474 2.6 0.963 Contact Map
1pw4A 1 0.8772 2.5 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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