GREMLIN Database
ARLY - Argininosuccinate lyase
UniProt: Q9UX32 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 444 (390)
Sequences: 10986 (5715)
Seq/√Len: 289.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_Y52_A3.9491.00
51_T90_W3.4971.00
43_L199_K3.3491.00
35_K60_N3.3051.00
341_N344_E3.1951.00
114_I175_L3.1481.00
39_I56_L3.1031.00
39_I203_L2.9271.00
288_M317_V2.9231.00
29_E111_N2.8521.00
121_N168_W2.8271.00
79_F83_K2.8241.00
234_M285_S2.8031.00
124_R165_A2.7391.00
126_I329_S2.6431.00
126_I333_S2.6421.00
113_L226_T2.6301.00
117_L172_F2.6241.00
25_E319_N2.5781.00
281_K324_S2.5321.00
153_F337_V2.5221.00
177_Q225_S2.4631.00
119_D326_G2.4041.00
199_K202_E2.3991.00
117_L168_W2.3681.00
130_K133_E2.3331.00
231_T289_L2.3181.00
42_Y49_K2.3101.00
110_R179_N2.2851.00
122_S329_S2.2551.00
48_G51_T2.2451.00
179_N207_D2.1671.00
136_T339_K2.1621.00
372_K376_E2.1571.00
329_S333_S2.1001.00
121_N172_F2.0701.00
284_E313_Y2.0311.00
61_E83_K2.0191.00
129_D333_S1.9881.00
124_R168_W1.9631.00
341_N345_S1.9551.00
49_K53_R1.9441.00
256_P336_Q1.9221.00
129_D133_E1.9061.00
235_V286_I1.8971.00
199_K203_L1.8891.00
391_M394_V1.8761.00
241_A278_L1.8751.00
173_S177_Q1.8741.00
198_E202_E1.8701.00
119_D322_K1.8701.00
168_W172_F1.8651.00
170_I225_S1.8501.00
126_I332_F1.8311.00
32_L111_N1.8151.00
128_L165_A1.7911.00
120_I233_L1.7881.00
35_K56_L1.7341.00
173_S176_K1.7181.00
210_I216_A1.7111.00
134_H137_T1.7101.00
237_L278_L1.6971.00
365_S368_F1.6931.00
181_S201_A1.6861.00
124_R161_E1.6701.00
167_R236_V1.6631.00
339_K343_D1.6541.00
166_S215_S1.6491.00
53_R57_V1.6391.00
39_I199_K1.6121.00
180_K208_S1.6001.00
376_E380_K1.5751.00
224_L296_Y1.5521.00
52_A56_L1.5431.00
119_D329_S1.5411.00
54_K84_V1.5371.00
79_F82_K1.5321.00
81_I88_A1.5201.00
241_A328_L1.5181.00
226_T318_I1.5141.00
278_L328_L1.5111.00
231_T293_L1.4931.00
131_A161_E1.4901.00
361_V369_E1.4861.00
166_S221_A1.4771.00
109_L314_Y1.4721.00
284_E316_L1.4641.00
130_K134_H1.4551.00
40_S199_K1.4501.00
61_E79_F1.4401.00
35_K63_K1.4331.00
291_S309_E1.4241.00
384_K387_D1.4231.00
185_S216_A1.4021.00
112_K322_K1.4011.00
220_R307_L1.3961.00
176_K207_D1.3861.00
174_T229_E1.3801.00
275_M331_L1.3761.00
28_E32_L1.3631.00
60_N64_E1.3561.00
338_N341_N1.3431.00
124_R164_L1.3271.00
128_L132_K1.3231.00
246_F300_P1.3181.00
25_E112_K1.3081.00
240_I328_L1.3041.00
157_L160_I1.3011.00
35_K39_I1.3011.00
123_L329_S1.3011.00
365_S389_I1.2991.00
169_E177_Q1.2941.00
122_S333_S1.2851.00
340_I344_E1.2851.00
228_S232_V1.2851.00
30_V100_H1.2781.00
224_L232_V1.2761.00
117_L175_L1.2721.00
31_K62_F1.2531.00
115_E322_K1.2511.00
153_F157_L1.2451.00
383_L387_D1.2441.00
109_L226_T1.2391.00
227_I292_L1.2381.00
378_S386_E1.2341.00
160_I302_G1.2281.00
46_Y93_L1.2251.00
72_I76_L1.2181.00
287_G291_S1.2131.00
120_I164_L1.2121.00
38_V47_L1.1991.00
126_I129_D1.1981.00
94_G196_D1.1971.00
290_T294_S1.1971.00
137_T339_K1.1911.00
278_L324_S1.1891.00
399_N402_L1.1811.00
132_K135_I1.1781.00
81_I86_E1.1741.00
31_K63_K1.1701.00
31_K72_I1.1691.00
233_L325_I1.1651.00
227_I314_Y1.1641.00
61_E82_K1.1581.00
234_M321_T1.1561.00
372_K387_D1.1531.00
361_V366_T1.1481.00
20_V316_L1.1471.00
134_H339_K1.1441.00
344_E347_L1.1431.00
286_I294_S1.1371.00
254_K338_N1.1361.00
153_F342_I1.1341.00
128_L161_E1.1291.00
227_I317_V1.1281.00
147_L251_K1.1271.00
127_L240_I1.1241.00
110_R206_F1.1181.00
233_L321_T1.1181.00
119_D122_S1.1161.00
123_L164_L1.1151.00
292_L314_Y1.1131.00
201_A207_D1.1071.00
223_I314_Y1.1011.00
36_A203_L1.1001.00
244_L275_M1.0971.00
116_L321_T1.0911.00
139_F342_I1.0881.00
171_I233_L1.0861.00
160_I240_I1.0861.00
122_S326_G1.0831.00
117_L121_N1.0831.00
135_I154_A1.0831.00
123_L332_F1.0831.00
33_T100_H1.0821.00
285_S321_T1.0801.00
229_E233_L1.0761.00
105_L311_N1.0741.00
56_L60_N1.0731.00
282_A286_I1.0711.00
158_T212_N1.0691.00
147_L250_N1.0661.00
94_G195_I1.0651.00
29_E107_L1.0531.00
54_K57_V1.0481.00
284_E312_K1.0461.00
238_S279_R1.0451.00
112_K115_E1.0451.00
43_L203_L1.0441.00
28_E63_K1.0381.00
65_I68_G1.0371.00
400_F404_A1.0291.00
136_T154_A1.0251.00
130_K332_F1.0241.00
130_K157_L1.0231.00
387_D390_N1.0221.00
135_I152_T1.0211.00
121_N125_K1.0191.00
105_L223_I1.0191.00
385_I389_I1.0191.00
226_T314_Y1.0141.00
58_A61_E1.0091.00
49_K52_A1.0081.00
169_E176_K1.0061.00
256_P338_N1.0031.00
28_E111_N1.0021.00
113_L175_L1.0001.00
69_Y75_A0.9971.00
110_R175_L0.9941.00
60_N63_K0.9911.00
24_R28_E0.9901.00
291_S313_Y0.9891.00
162_E166_S0.9891.00
392_K396_G0.9881.00
254_K336_Q0.9861.00
259_H330_S0.9851.00
42_Y53_R0.9821.00
113_L171_I0.9801.00
137_T342_I0.9751.00
57_V83_K0.9731.00
105_L314_Y0.9711.00
228_S289_L0.9671.00
32_L203_L0.9661.00
284_E320_Y0.9601.00
110_R114_I0.9581.00
53_R56_L0.9561.00
46_Y196_D0.9551.00
69_Y78_D0.9501.00
173_S225_S0.9491.00
120_I168_W0.9471.00
359_K402_L0.9461.00
169_E173_S0.9451.00
197_R201_A0.9441.00
33_T103_T0.9391.00
385_I392_K0.9371.00
54_K58_A0.9371.00
235_V296_Y0.9341.00
144_H276_E0.9321.00
124_R128_L0.9301.00
142_Y251_K0.9281.00
50_E53_R0.9271.00
288_M316_L0.9221.00
151_T188_I0.9201.00
112_K318_I0.9191.00
373_K391_M0.9181.00
175_L179_N0.9171.00
237_L328_L0.9141.00
227_I289_L0.9121.00
30_V33_T0.9101.00
179_N206_F0.9101.00
142_Y147_L0.9101.00
237_L325_I0.9101.00
312_K316_L0.9101.00
244_L335_I0.9081.00
255_L335_I0.9081.00
141_S151_T0.9071.00
186_G265_L0.9061.00
127_L157_L0.9021.00
44_T196_D0.9001.00
48_G90_W0.8981.00
289_L293_L0.8981.00
43_L49_K0.8931.00
230_L321_T0.8931.00
372_K383_L0.8891.00
40_S44_T0.8871.00
127_L332_F0.8831.00
151_T214_L0.8801.00
30_V72_I0.8771.00
29_E108_R0.8771.00
18_S277_I0.8721.00
145_L246_F0.8721.00
25_E111_N0.8691.00
80_L91_I0.8671.00
137_T337_V0.8671.00
131_A158_T0.8671.00
162_E211_Y0.8641.00
155_H213_T0.8561.00
161_E165_A0.8461.00
59_L62_F0.8411.00
255_L334_Q0.8411.00
32_L200_E0.8311.00
127_L161_E0.8281.00
390_N404_A0.8281.00
277_I327_V0.8271.00
383_L386_E0.8241.00
384_K388_S0.8231.00
61_E64_E0.8151.00
125_K129_D0.8141.00
378_S383_L0.8131.00
133_E336_Q0.8111.00
50_E54_K0.8101.00
219_S236_V0.8101.00
37_H95_R0.8091.00
283_A291_S0.8091.00
218_S302_G0.8081.00
181_S200_E0.8081.00
103_T181_S0.8060.99
145_L249_S0.8050.99
238_S297_K0.8040.99
126_I130_K0.8030.99
17_T327_V0.8000.99
360_K398_P0.7990.99
13_V274_T0.7960.99
156_Y247_F0.7950.99
225_S228_S0.7920.99
47_L55_I0.7880.99
114_I206_F0.7860.99
235_V293_L0.7800.99
354_L359_K0.7770.99
384_K390_N0.7760.99
39_I43_L0.7710.99
52_A55_I0.7690.99
51_T87_D0.7690.99
134_H337_V0.7680.99
295_I309_E0.7650.99
197_R209_I0.7650.99
181_S209_I0.7630.99
180_K210_I0.7630.99
38_V52_A0.7570.99
176_K179_N0.7570.99
123_L325_I0.7540.99
139_F156_Y0.7520.99
85_G88_A0.7520.99
42_Y47_L0.7510.99
256_P334_Q0.7500.99
284_E288_M0.7460.99
164_L325_I0.7420.99
226_T230_L0.7400.99
221_A236_V0.7380.99
51_T55_I0.7360.99
385_I395_I0.7360.99
325_I329_S0.7350.99
17_T305_L0.7330.99
392_K395_I0.7300.99
286_I290_T0.7290.99
54_K87_D0.7280.99
47_L93_L0.7260.99
384_K389_I0.7260.99
142_Y250_N0.7260.99
376_E387_D0.7250.99
39_I52_A0.7250.99
376_E383_L0.7230.99
182_P216_A0.7220.99
113_L174_T0.7190.99
368_F372_K0.7170.99
215_S221_A0.7170.99
361_V394_V0.7170.99
253_I338_N0.7160.99
337_V342_I0.7120.99
349_T352_A0.7110.99
159_Y239_R0.7070.99
43_L196_D0.7060.99
120_I325_I0.7060.99
376_E379_Y0.7050.99
386_E389_I0.7040.99
372_K386_E0.7040.99
127_L164_L0.7040.99
78_D82_K0.7020.99
133_E339_K0.7010.99
36_A39_I0.7000.99
401_D404_A0.6990.99
208_S211_Y0.6970.99
286_I293_L0.6960.99
376_E391_M0.6960.99
209_I213_T0.6950.99
166_S180_K0.6940.98
70_E257_D0.6920.98
241_A275_M0.6920.98
35_K52_A0.6910.98
340_I343_D0.6910.98
13_V17_T0.6900.98
163_E219_S0.6900.98
58_A84_V0.6890.98
372_K375_R0.6890.98
169_E180_K0.6880.98
170_I221_A0.6880.98
214_L302_G0.6870.98
32_L63_K0.6870.98
163_E236_V0.6870.98
38_V55_I0.6830.98
361_V365_S0.6820.98
200_E203_L0.6820.98
116_L318_I0.6790.98
137_T152_T0.6790.98
164_L167_R0.6790.98
179_N201_A0.6760.98
290_T293_L0.6760.98
134_H153_F0.6750.98
26_I101_V0.6730.98
57_V61_E0.6720.98
331_L335_I0.6710.98
44_T199_K0.6700.98
223_I292_L0.6660.98
242_E279_R0.6660.98
106_R222_D0.6650.98
394_V398_P0.6650.98
62_F76_L0.6640.98
375_R379_Y0.6640.98
382_T390_N0.6630.98
224_L293_L0.6620.98
132_K136_T0.6600.98
115_E119_D0.6570.98
137_T343_D0.6570.98
122_S126_I0.6540.98
110_R207_D0.6540.98
170_I173_S0.6530.98
362_P365_S0.6510.98
64_E79_F0.6490.98
131_A135_I0.6470.98
374_V377_G0.6460.98
35_K203_L0.6460.98
247_F301_T0.6450.98
215_S236_V0.6450.98
224_L292_L0.6440.98
51_T54_K0.6430.98
125_K128_L0.6420.97
382_T386_E0.6400.97
170_I177_Q0.6400.97
46_Y94_G0.6390.97
354_L398_P0.6380.97
129_D132_K0.6380.97
167_R232_V0.6380.97
20_V312_K0.6370.97
381_S392_K0.6370.97
283_A294_S0.6370.97
283_A295_I0.6370.97
121_N124_R0.6360.97
69_Y74_E0.6360.97
108_R315_W0.6310.97
181_S185_S0.6300.97
108_R318_I0.6270.97
121_N165_A0.6270.97
114_I172_F0.6260.97
22_S312_K0.6250.97
21_D112_K0.6250.97
327_V330_S0.6220.97
130_K335_I0.6210.97
116_L230_L0.6180.97
281_K320_Y0.6130.97
59_L63_K0.6120.97
62_F79_F0.6120.97
240_I332_F0.6090.97
169_E172_F0.6070.97
380_K387_D0.6070.97
109_L318_I0.6060.96
87_D90_W0.6050.96
113_L117_L0.6020.96
28_E66_G0.6000.96
193_V353_E0.5970.96
17_T330_S0.5960.96
197_R200_E0.5950.96
38_V91_I0.5950.96
13_V18_S0.5940.96
35_K59_L0.5940.96
382_T387_D0.5940.96
139_F151_T0.5920.96
368_F375_R0.5920.96
119_D325_I0.5910.96
157_L342_I0.5910.96
371_A375_R0.5900.96
259_H334_Q0.5900.96
167_R170_I0.5900.96
16_Y278_L0.5900.96
160_I163_E0.5890.96
18_S21_D0.5880.96
42_Y56_L0.5870.96
285_S317_V0.5870.96
287_G290_T0.5860.96
59_L76_L0.5860.96
224_L228_S0.5850.96
381_S396_G0.5850.96
231_T235_V0.5850.96
244_L328_L0.5840.96
16_Y324_S0.5840.96
278_L331_L0.5810.96
373_K376_E0.5800.95
395_I400_F0.5790.95
11_D15_N0.5770.95
163_E218_S0.5770.95
48_G52_A0.5760.95
389_I396_G0.5760.95
31_K76_L0.5760.95
314_Y318_I0.5750.95
156_Y243_D0.5740.95
38_V56_L0.5720.95
157_L335_I0.5710.95
84_V88_A0.5690.95
201_A206_F0.5690.95
274_T331_L0.5680.95
171_I229_E0.5670.95
14_V17_T0.5670.95
221_A224_L0.5670.95
162_E165_A0.5650.95
179_N208_S0.5650.95
90_W93_L0.5630.95
241_A279_R0.5630.95
385_I400_F0.5620.95
174_T226_T0.5620.95
350_D354_L0.5610.95
238_S294_S0.5610.95
285_S320_Y0.5610.95
86_E89_G0.5600.95
279_R306_D0.5600.95
395_I399_N0.5600.95
183_L200_E0.5590.95
32_L36_A0.5570.94
380_K384_K0.5570.94
221_A225_S0.5570.94
162_E212_N0.5570.94
151_T155_H0.5560.94
313_Y316_L0.5560.94
367_Y371_A0.5550.94
33_T104_A0.5520.94
114_I179_N0.5510.94
225_S232_V0.5480.94
384_K391_M0.5480.94
144_H305_L0.5460.94
364_R368_F0.5450.94
387_D391_M0.5450.94
165_A169_E0.5450.94
140_P350_D0.5450.94
260_V273_V0.5450.94
156_Y302_G0.5440.94
113_L178_V0.5440.94
339_K342_I0.5430.94
72_I104_A0.5430.94
29_E32_L0.5400.93
139_F247_F0.5380.93
170_I232_V0.5380.93
54_K86_E0.5370.93
316_L320_Y0.5360.93
164_L233_L0.5360.93
123_L126_I0.5360.93
176_K180_K0.5350.93
164_L237_L0.5350.93
18_S327_V0.5350.93
294_S298_G0.5340.93
228_S231_T0.5340.93
140_P345_S0.5320.93
11_D14_V0.5320.93
84_V87_D0.5310.93
25_E115_E0.5310.93
118_T122_S0.5310.93
20_V25_E0.5300.93
55_I80_L0.5300.93
246_F249_S0.5290.93
174_T178_V0.5270.93
174_T225_S0.5250.92
147_L346_S0.5250.92
166_S225_S0.5240.92
58_A83_K0.5240.92
137_T154_A0.5230.92
128_L131_A0.5220.92
393_A396_G0.5220.92
31_K59_L0.5200.92
384_K392_K0.5180.92
283_A297_K0.5180.92
176_K208_S0.5170.92
15_N19_S0.5170.92
109_L178_V0.5170.92
224_L235_V0.5160.92
278_L282_A0.5160.92
32_L204_L0.5150.92
117_L229_E0.5150.92
37_H200_E0.5150.92
246_F301_T0.5130.92
180_K222_D0.5130.92
296_Y307_L0.5120.92
120_I171_I0.5080.91
182_P217_T0.5070.91
174_T177_Q0.5070.91
216_A220_R0.5070.91
97_R182_P0.5060.91
291_S295_I0.5060.91
230_L233_L0.5060.91
369_E383_L0.5060.91
111_N114_I0.5050.91
15_N323_S0.5040.91
117_L120_I0.5030.91
134_H154_A0.5030.91
24_R31_K0.5020.91
185_S188_I0.5010.91
232_V236_V0.5010.91
182_P188_I0.5000.91
47_L52_A0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k7wA 4 0.9662 100 0.168 Contact Map
2e9fA 4 0.9595 100 0.175 Contact Map
1tj7A 4 0.9707 100 0.183 Contact Map
1re5A 4 0.9459 100 0.211 Contact Map
3c8tA 4 0.9099 100 0.216 Contact Map
1q5nA 4 0.9167 100 0.218 Contact Map
1c3cA 4 0.9099 100 0.227 Contact Map
4eeiA 4 0.9054 100 0.239 Contact Map
2pfmA 4 0.9279 100 0.243 Contact Map
2j91A 4 0.964 100 0.264 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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