GREMLIN Database
ASSY - Argininosuccinate synthase
UniProt: Q9UX31 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 391 (385)
Sequences: 2264 (863)
Seq/√Len: 44.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
214_E222_A5.3101.00
241_F272_G5.2551.00
323_E326_K4.9281.00
104_K133_Y4.7621.00
209_E244_H4.2091.00
55_K106_E3.9631.00
329_S350_Y3.5201.00
209_E243_S3.5011.00
75_K322_D3.3581.00
226_E236_F3.3101.00
73_A90_L3.2951.00
209_E224_N3.2331.00
212_S331_E3.1651.00
210_I344_V2.9421.00
98_K101_E2.8791.00
34_D62_V2.8181.00
190_S347_E2.8151.00
331_E347_E2.8031.00
63_R67_N2.7731.00
214_E331_E2.7561.00
4_V108_A2.7211.00
192_E210_I2.6661.00
236_F239_L2.6481.00
46_E50_I2.6291.00
99_V129_V2.5541.00
223_V236_F2.5521.00
217_N326_K2.5451.00
202_K335_E2.4691.00
111_V129_V2.4311.00
33_V61_A2.4171.00
277_H325_N2.4061.00
104_K135_D2.3921.00
59_I98_K2.3321.00
314_R318_H2.2871.00
154_K158_E2.2421.00
22_E159_K2.2241.00
198_F264_V2.1991.00
63_R229_E2.1901.00
300_W318_H2.1631.00
291_R302_D2.1501.00
66_A234_V2.1100.99
57_Y105_K2.0960.99
18_R21_K2.0690.99
229_E232_K2.0630.99
256_V308_L2.0570.99
62_V235_D2.0560.99
40_D43_K1.9710.99
292_F296_I1.9640.99
81_E254_N1.9510.99
83_V279_D1.9270.99
29_I55_K1.9250.99
188_D355_E1.9110.99
195_E203_Q1.8410.99
99_V111_V1.8350.99
71_A230_L1.8190.98
214_E329_S1.8190.98
213_I220_P1.8000.98
204_I337_S1.7380.98
75_K219_V1.7240.98
210_I335_E1.7050.98
3_I26_A1.6930.98
237_L272_G1.6800.97
88_T91_A1.6750.97
69_Y310_F1.6560.97
67_N230_L1.6460.97
100_V136_V1.6440.97
30_T56_H1.6380.97
192_E335_E1.6160.97
201_T248_R1.5950.96
333_K345_G1.5890.96
27_E54_S1.5870.96
176_L234_V1.5780.96
42_K45_E1.5580.96
127_L379_G1.5570.96
216_S221_T1.5460.96
228_M236_F1.5240.95
277_H324_M1.5110.95
220_P233_L1.5040.95
316_T324_M1.4910.95
57_Y106_E1.4900.95
22_E155_Y1.4880.95
183_G360_Y1.4760.95
45_E49_Y1.4690.94
40_D174_E1.4570.94
87_S178_G1.4550.94
216_S227_K1.4370.94
61_A98_K1.4320.94
63_R231_N1.4230.93
357_I384_I1.4150.93
192_E344_V1.4140.93
296_I317_L1.4000.93
111_V136_V1.3980.93
239_L243_S1.3850.92
292_F313_L1.3840.92
316_T320_V1.3810.92
280_L332_A1.3790.92
57_Y102_V1.3590.92
212_S333_K1.3480.91
190_S333_K1.3430.91
26_A109_E1.3360.91
206_N338_N1.3300.91
64_Q97_E1.3270.91
69_Y94_L1.3220.91
316_T323_E1.3170.90
42_K46_E1.3170.90
299_L302_D1.3130.90
202_K208_K1.3080.90
213_I273_L1.2810.89
365_Y368_D1.2770.89
130_K376_E1.2750.89
357_I365_Y1.2750.89
334_V341_F1.2700.89
185_I194_P1.2650.88
229_E233_L1.2560.88
150_E361_N1.2420.88
96_A128_A1.2410.88
29_I106_E1.2390.87
172_I179_R1.2350.87
133_Y136_V1.2230.87
369_E372_R1.2220.87
3_I139_I1.2160.86
147_M152_E1.2140.86
100_V132_L1.2130.86
335_E344_V1.2020.86
359_S365_Y1.2010.86
366_P371_A1.1950.85
284_I328_I1.1920.85
130_K383_L1.1910.85
228_M233_L1.1910.85
64_Q68_N1.1820.85
40_D44_I1.1790.85
267_V270_A1.1750.84
26_A110_A1.1700.84
130_K379_G1.1670.84
221_T227_K1.1590.84
34_D38_K1.1580.84
232_K235_D1.1570.84
69_Y97_E1.1500.83
216_S329_S1.1450.83
98_K102_V1.1440.83
38_K174_E1.1390.83
315_E323_E1.1380.83
172_I181_I1.1360.82
234_V269_A1.1280.82
188_D191_L1.1240.82
77_N297_D1.1210.82
64_Q98_K1.1170.81
76_L321_A1.1150.81
195_E248_R1.1070.81
296_I321_A1.1070.81
292_F295_H1.1040.81
211_V237_L1.1010.80
29_I54_S1.1010.80
177_W270_A1.0990.80
285_Y324_M1.0980.80
236_F240_K1.0960.80
3_I28_I1.0890.80
166_E184_D1.0870.79
213_I233_L1.0840.79
248_R346_R1.0800.79
205_Y338_N1.0800.79
320_V324_M1.0760.79
204_I338_N1.0690.78
83_V275_Y1.0690.78
246_F271_L1.0650.78
208_K244_H1.0600.78
371_A375_I1.0550.77
77_N274_I1.0540.77
378_W381_H1.0530.77
237_L269_A1.0530.77
240_K243_S1.0480.77
222_A227_K1.0470.77
174_E200_W1.0450.77
100_V129_V1.0440.77
370_M376_E1.0380.76
226_E232_K1.0330.76
71_A219_V1.0260.75
333_K347_E1.0240.75
212_S225_G1.0240.75
67_N219_V1.0230.75
169_K184_D1.0140.75
181_I197_A1.0040.74
65_F70_I1.0040.74
77_N277_H0.9990.73
66_A70_I0.9950.73
319_K323_E0.9930.73
321_A324_M0.9850.72
59_I105_K0.9840.72
295_H299_L0.9810.72
367_S372_R0.9770.72
74_I273_L0.9760.72
32_T56_H0.9730.71
66_A230_L0.9670.71
294_R298_Q0.9660.71
254_N291_R0.9630.71
17_I30_T0.9630.71
153_I165_V0.9610.70
176_L231_N0.9580.70
85_P263_E0.9550.70
244_H338_N0.9510.70
210_I333_K0.9480.69
33_V95_I0.9430.69
169_K185_I0.9410.69
198_F248_R0.9410.69
289_E324_M0.9410.69
186_I189_P0.9410.69
71_A74_I0.9330.68
193_V345_G0.9330.68
224_N236_F0.9320.68
223_V237_L0.9240.67
170_Y196_D0.9220.67
214_E227_K0.9190.67
102_V106_E0.9180.67
88_T180_S0.9150.67
357_I363_G0.9150.67
285_Y293_K0.9100.66
214_E221_T0.9100.66
325_N328_I0.9090.66
321_A325_N0.9080.66
15_V156_A0.9050.66
222_A331_E0.9040.66
220_P273_L0.9020.66
279_D343_I0.9010.65
223_V228_M0.8970.65
211_V223_V0.8940.65
46_E49_Y0.8880.64
300_W314_R0.8820.64
244_H337_S0.8740.63
31_V61_A0.8730.63
302_D306_Q0.8670.62
313_L320_V0.8630.62
2_K27_E0.8580.62
123_V257_V0.8510.61
154_K157_K0.8500.61
279_D282_K0.8500.61
47_R161_I0.8450.60
156_A163_I0.8430.60
293_K297_D0.8400.60
280_L329_S0.8400.60
67_N71_A0.8360.60
7_Y17_I0.8300.59
203_Q245_G0.8300.59
66_A71_A0.8300.59
194_P197_A0.8290.59
68_N97_E0.8290.59
27_E109_E0.8260.59
45_E55_K0.8210.58
366_P370_M0.8210.58
174_E199_E0.8210.58
272_G334_V0.8200.58
44_I56_H0.8180.58
275_Y341_F0.8160.58
207_K244_H0.8110.57
281_E293_K0.8070.57
277_H328_I0.8070.57
130_K138_I0.8060.57
82_G294_R0.8060.57
279_D346_R0.8040.57
189_P332_A0.8020.56
165_V184_D0.8010.56
287_P306_Q0.8010.56
327_W350_Y0.7960.56
100_V133_Y0.7950.56
79_L85_P0.7930.56
96_A111_V0.7930.56
49_Y226_E0.7880.55
318_H322_D0.7870.55
259_F366_P0.7870.55
179_R263_E0.7850.55
311_E382_S0.7850.55
32_T44_I0.7840.55
337_S340_S0.7820.55
82_G278_I0.7810.54
16_S19_W0.7800.54
276_A334_V0.7720.54
31_V59_I0.7700.53
267_V271_L0.7690.53
87_S91_A0.7670.53
167_S199_E0.7640.53
214_E223_V0.7630.53
269_A272_G0.7620.53
33_V59_I0.7570.52
172_I199_E0.7570.52
70_I234_V0.7570.52
202_K337_S0.7520.52
17_I160_G0.7490.51
185_I196_D0.7490.51
213_I223_V0.7480.51
21_K54_S0.7470.51
43_K46_E0.7470.51
153_I169_K0.7460.51
85_P178_G0.7430.51
213_I275_Y0.7420.51
274_I278_I0.7420.51
254_N290_L0.7390.50
130_K136_V0.7370.50
178_G360_Y0.7330.50
359_S363_G0.7320.50
22_E158_E0.7310.50
55_K102_V0.7310.50
142_A263_E0.7300.50
206_N244_H0.7240.49
212_S347_E0.7240.49
343_I346_R0.7230.49
241_F246_F0.7230.49
75_K318_H0.7230.49
71_A233_L0.7190.48
18_R22_E0.7170.48
18_R51_A0.7170.48
168_D184_D0.7160.48
140_A143_R0.7160.48
50_I162_P0.7140.48
30_T53_A0.7140.48
211_V240_K0.7120.48
246_F336_V0.7120.48
181_I263_E0.7110.48
31_V99_V0.7080.47
200_W242_G0.7080.47
100_V111_V0.7070.47
150_E154_K0.7050.47
49_Y53_A0.7050.47
74_I230_L0.7050.47
376_E383_L0.7040.47
224_N243_S0.7020.47
18_R161_I0.7020.47
49_Y56_H0.7020.47
243_S272_G0.7010.47
289_E316_T0.7000.47
104_K138_I0.7000.47
238_N269_A0.6990.47
107_G160_G0.6990.47
359_S368_D0.6960.46
275_Y343_I0.6940.46
45_E56_H0.6940.46
173_D182_E0.6930.46
79_L274_I0.6900.46
177_W234_V0.6900.46
41_F58_T0.6890.46
257_V366_P0.6890.46
332_A348_S0.6860.45
73_A304_V0.6860.45
259_F357_I0.6850.45
215_F273_L0.6850.45
24_F144_I0.6840.45
303_L317_L0.6820.45
18_R23_T0.6820.45
360_Y368_D0.6820.45
83_V282_K0.6820.45
69_Y309_W0.6770.44
223_V233_L0.6770.44
72_Y318_H0.6730.44
17_I21_K0.6710.44
313_L381_H0.6700.44
313_L378_W0.6690.44
71_A75_K0.6680.44
48_A52_G0.6660.43
175_N182_E0.6640.43
56_H59_I0.6620.43
329_S351_S0.6620.43
209_E240_K0.6610.43
253_E265_Y0.6590.43
341_F344_V0.6590.43
148_T363_G0.6590.43
127_L256_V0.6580.43
97_E101_E0.6570.43
2_K107_G0.6560.42
85_P142_A0.6550.42
157_K160_G0.6530.42
6_A99_V0.6520.42
348_S351_S0.6520.42
256_V378_W0.6520.42
329_S349_E0.6510.42
147_M151_D0.6510.42
204_I244_H0.6490.42
291_R299_L0.6490.42
238_N268_P0.6450.41
153_I163_I0.6440.41
91_A267_V0.6430.41
281_E328_I0.6430.41
85_P271_L0.6420.41
47_R163_I0.6390.41
168_D197_A0.6370.41
182_E186_I0.6370.41
27_E40_D0.6360.41
286_T289_E0.6360.41
224_N377_I0.6360.41
24_F147_M0.6340.40
381_H384_I0.6340.40
126_D138_I0.6270.40
128_A310_F0.6260.40
73_A300_W0.6250.40
244_H340_S0.6250.40
142_A178_G0.6230.39
232_K239_L0.6220.39
41_F174_E0.6200.39
160_G165_V0.6200.39
212_S344_V0.6200.39
135_D196_D0.6190.39
308_L378_W0.6190.39
203_Q243_S0.6190.39
283_T351_S0.6150.39
16_S286_T0.6150.39
68_N230_L0.6140.39
256_V306_Q0.6130.38
104_K340_S0.6120.38
241_F336_V0.6120.38
105_K109_E0.6110.38
8_S11_L0.6100.38
78_G300_W0.6090.38
156_A159_K0.6090.38
67_N231_N0.6090.38
304_V309_W0.6080.38
14_T47_R0.6080.38
246_F334_V0.6070.38
177_W269_A0.6060.38
15_V152_E0.6060.38
232_K236_F0.6060.38
178_G263_E0.6050.38
163_I166_E0.6050.38
31_V98_K0.6040.38
42_K232_K0.6030.38
249_V269_A0.6020.38
91_A178_G0.6020.38
213_I237_L0.6020.38
156_A166_E0.6010.37
284_I327_W0.5940.37
197_A251_H0.5930.37
301_S336_V0.5920.37
257_V358_A0.5910.37
148_T361_N0.5910.37
94_L98_K0.5900.36
151_D362_K0.5890.36
265_Y305_Y0.5890.36
70_I177_W0.5890.36
148_T263_E0.5880.36
354_S387_R0.5880.36
293_K324_M0.5870.36
44_I58_T0.5850.36
263_E360_Y0.5850.36
181_I251_H0.5850.36
23_T146_N0.5850.36
100_V150_E0.5820.36
209_E239_L0.5810.36
79_L278_I0.5810.36
206_N337_S0.5790.35
133_Y386_R0.5780.35
126_D143_R0.5780.35
195_E198_F0.5770.35
172_I197_A0.5760.35
74_I177_W0.5760.35
211_V336_V0.5760.35
40_D45_E0.5750.35
215_F276_A0.5730.35
164_K169_K0.5720.35
165_V169_K0.5720.35
2_K54_S0.5690.35
275_Y278_I0.5690.35
24_F139_I0.5690.35
252_I283_T0.5670.34
4_V29_I0.5670.34
222_A228_M0.5660.34
277_H281_E0.5650.34
24_F145_W0.5640.34
213_I276_A0.5640.34
123_V374_F0.5640.34
101_E105_K0.5620.34
61_A111_V0.5580.34
148_T368_D0.5580.34
202_K206_N0.5580.34
85_P360_Y0.5560.33
153_I164_K0.5560.33
286_T354_S0.5550.33
86_L89_A0.5550.33
156_A162_P0.5540.33
203_Q209_E0.5540.33
8_S12_D0.5540.33
5_L13_T0.5540.33
303_L314_R0.5540.33
175_N187_S0.5530.33
320_V379_G0.5530.33
29_I57_Y0.5530.33
246_F272_G0.5520.33
327_W349_E0.5500.33
38_K43_K0.5470.33
166_E169_K0.5470.33
30_T49_Y0.5470.33
114_G121_D0.5450.33
202_K210_I0.5450.33
61_A94_L0.5430.32
77_N325_N0.5430.32
96_A129_V0.5410.32
355_E361_N0.5410.32
202_K338_N0.5410.32
91_A180_S0.5400.32
249_V261_S0.5400.32
20_L142_A0.5400.32
354_S357_I0.5400.32
289_E381_H0.5380.32
153_I264_V0.5380.32
9_G12_D0.5380.32
7_Y47_R0.5380.32
65_F90_L0.5360.32
35_V94_L0.5350.32
152_E177_W0.5340.32
215_F220_P0.5330.32
148_T360_Y0.5330.32
183_G370_M0.5330.32
173_D253_E0.5320.31
290_L302_D0.5320.31
271_L341_F0.5310.31
208_K335_E0.5310.31
174_E198_F0.5300.31
57_Y98_K0.5300.31
274_I297_D0.5300.31
179_R200_W0.5290.31
294_R297_D0.5290.31
278_I294_R0.5290.31
123_V375_I0.5290.31
327_W385_A0.5280.31
88_T263_E0.5270.31
372_R376_E0.5270.31
357_I368_D0.5260.31
24_F360_Y0.5260.31
308_L381_H0.5250.31
182_E187_S0.5240.31
142_A145_W0.5240.31
151_D303_L0.5230.31
308_L382_S0.5230.31
362_K365_Y0.5230.31
17_I22_E0.5230.31
383_L387_R0.5220.31
37_Q251_H0.5220.31
145_W360_Y0.5210.31
364_W368_D0.5180.30
144_I359_S0.5180.30
272_G341_F0.5180.30
121_D305_Y0.5170.30
288_M299_L0.5160.30
45_E58_T0.5160.30
32_T251_H0.5160.30
84_Y119_G0.5150.30
78_G304_V0.5150.30
288_M308_L0.5140.30
186_I353_Y0.5140.30
201_T241_F0.5140.30
261_S353_Y0.5130.30
179_R379_G0.5120.30
255_R265_Y0.5110.30
87_S126_D0.5110.30
168_D243_S0.5110.30
285_Y290_L0.5110.30
292_F308_L0.5100.30
119_G122_Q0.5090.30
182_E253_E0.5090.30
169_K172_I0.5080.29
311_E381_H0.5080.29
197_A345_G0.5080.29
87_S271_L0.5080.29
198_F201_T0.5080.29
6_A9_G0.5080.29
114_G262_R0.5070.29
6_A10_G0.5070.29
289_E320_V0.5060.29
142_A360_Y0.5060.29
292_F317_L0.5050.29
256_V381_H0.5050.29
20_L56_H0.5050.29
223_V322_D0.5040.29
153_I157_K0.5040.29
31_V111_V0.5040.29
110_A137_K0.5040.29
126_D251_H0.5030.29
3_I16_S0.5020.29
146_N364_W0.5020.29
164_K199_E0.5020.29
227_K236_F0.5020.29
121_D143_R0.5010.29
31_V102_V0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vl2A 4 0.977 100 0.218 Contact Map
2nz2A 4 0.9898 100 0.243 Contact Map
4xfjA 4 1 100 0.261 Contact Map
1k92A 4 0.9949 100 0.269 Contact Map
1korA 4 0.977 100 0.275 Contact Map
4nzpA 4 0.9591 100 0.286 Contact Map
2hmaA 2 0.8363 100 0.826 Contact Map
2derA 1 0.8107 99.8 0.869 Contact Map
3rjzA 2 0.5115 99.8 0.872 Contact Map
3k32A 2 0.4834 99.8 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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