GREMLIN Database
PUR5 - Phosphoribosylformylglycinamidine cyclo-ligase
UniProt: Q9UX29 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (308)
Sequences: 3318 (1712)
Seq/√Len: 97.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_I144_F3.9501.00
177_I185_V3.8211.00
29_S123_K3.8061.00
163_I223_G3.3041.00
69_T200_K2.8971.00
120_Q124_E2.8671.00
165_P307_N2.8561.00
170_L299_V2.8001.00
125_A209_I2.7821.00
169_V278_V2.7681.00
120_Q123_K2.7231.00
46_K156_K2.7121.00
275_I302_L2.6201.00
169_V280_F2.5891.00
32_K93_K2.5491.00
224_A277_I2.5421.00
188_L262_V2.4721.00
290_K299_V2.4231.00
7_K12_D2.3781.00
171_G275_I2.2781.00
22_M112_N2.2711.00
71_I201_N2.2471.00
170_L290_K2.2201.00
67_L143_G2.2191.00
238_L280_F2.1591.00
245_L264_H2.1431.00
222_K282_S2.1271.00
18_N22_M2.1271.00
281_V289_V2.0981.00
87_L150_A2.0181.00
162_E222_K2.0061.00
43_G130_I1.9711.00
195_S198_E1.9611.00
167_D222_K1.9161.00
137_M141_I1.9121.00
232_F235_L1.8901.00
177_I182_Y1.8311.00
242_K308_G1.8301.00
223_G238_L1.8071.00
188_L257_I1.7851.00
73_K116_D1.7651.00
202_E205_K1.7501.00
17_R233_S1.7431.00
121_G209_I1.7391.00
268_Y273_M1.7261.00
258_E264_H1.7221.00
286_M301_E1.7141.00
282_S285_L1.7031.00
14_E269_K1.6911.00
103_L111_V1.6891.00
224_A279_L1.6801.00
77_I121_G1.6281.00
89_C224_A1.6281.00
245_L268_Y1.6231.00
63_T140_V1.6211.00
232_F278_V1.6181.00
19_Y23_I1.6141.00
55_H87_L1.5981.00
287_K291_T1.5981.00
26_I116_D1.5751.00
5_E8_K1.5721.00
15_K108_D1.5721.00
116_D120_Q1.5601.00
34_T45_I1.5601.00
101_I111_V1.5481.00
19_Y111_V1.5421.00
258_E267_M1.5381.00
64_F143_G1.5321.00
290_K301_E1.5181.00
77_I124_E1.4991.00
21_N24_S1.4971.00
249_D300_Y1.4661.00
22_M109_N1.4601.00
285_L288_E1.4581.00
220_M292_K1.4541.00
170_L301_E1.4491.00
286_M290_K1.4441.00
124_E209_I1.4431.00
173_E300_Y1.4341.00
217_V289_V1.4231.00
288_E291_T1.4221.00
70_R110_V1.4211.00
48_G51_N1.4010.99
54_M96_A1.3880.99
26_I112_N1.3780.99
175_S205_K1.3780.99
65_L69_T1.3760.99
249_D255_K1.3750.99
217_V293_L1.3460.99
283_E304_R1.3450.99
214_I279_L1.3410.99
75_V146_L1.3270.99
163_I305_V1.3140.99
44_V53_A1.3130.99
169_V243_I1.3110.99
289_V292_K1.3100.99
16_L20_H1.3070.99
154_V157_L1.2960.99
163_I238_L1.2950.99
168_Y286_M1.2920.99
250_P255_K1.2790.99
177_I253_I1.2700.99
308_G311_I1.2680.99
164_R282_S1.2650.99
82_M179_A1.2500.99
214_I277_I1.2430.99
68_Q190_E1.2300.99
213_P216_E1.2220.99
65_L196_L1.2180.99
64_F68_Q1.2090.98
235_L243_I1.2000.98
263_A266_E1.1940.98
111_V114_I1.1930.98
82_M207_T1.1930.98
160_G163_I1.1840.98
216_E296_Y1.1820.98
168_Y301_E1.1780.98
126_D212_K1.1760.98
113_E116_D1.1720.98
216_E219_N1.1610.98
216_E292_K1.1590.98
172_L277_I1.1570.98
126_D215_L1.1540.98
171_G249_D1.1500.98
267_M271_F1.1430.98
96_A151_I1.1400.98
32_K45_I1.1390.98
83_N150_A1.1260.98
294_E298_T1.1250.98
106_P111_V1.1240.98
93_K126_D1.1100.97
54_M151_I1.1090.97
42_S53_A1.1040.97
26_I119_V1.1030.97
101_I114_I1.1030.97
159_T162_E1.1010.97
179_A207_T1.0940.97
18_N21_N1.0830.97
279_L289_V1.0760.97
4_E8_K1.0740.97
189_I256_T1.0730.97
14_E17_R1.0680.97
121_G125_A1.0660.97
173_E299_V1.0650.97
262_V267_M1.0620.97
46_K50_L1.0610.97
5_E266_E1.0580.96
189_I194_L1.0570.96
88_I277_I1.0530.96
194_L198_E1.0520.96
50_L153_V1.0490.96
53_A92_A1.0450.96
255_K259_K1.0450.96
28_S31_Y1.0430.96
250_P273_M1.0390.96
261_G267_M1.0320.96
168_Y283_E1.0300.96
266_E270_V1.0300.96
169_V305_V1.0140.95
211_V215_L1.0120.95
173_E298_T1.0090.95
220_M288_E1.0040.95
124_E212_K1.0030.95
84_V150_A1.0030.95
292_K296_Y1.0010.95
97_L148_C0.9980.95
67_L140_V0.9940.95
31_Y35_I0.9900.95
93_K219_N0.9870.95
121_G124_E0.9840.95
213_P293_L0.9820.95
218_M224_A0.9810.95
254_F267_M0.9810.95
19_Y108_D0.9750.94
81_A209_I0.9560.94
249_D252_Q0.9500.94
233_S236_K0.9500.94
96_A130_I0.9490.94
114_I146_L0.9480.94
17_R269_K0.9460.93
214_I218_M0.9370.93
190_E196_L0.9320.93
291_T295_G0.9300.93
82_M209_I0.9250.93
249_D298_T0.9220.93
281_V286_M0.9220.93
172_L293_L0.9210.93
64_F140_V0.9160.92
275_I300_Y0.9160.92
273_M308_G0.9070.92
189_I196_L0.9070.92
64_F67_L0.9070.92
255_K258_E0.9060.92
88_I214_I0.9060.92
170_L281_V0.9050.92
214_I224_A0.9040.92
256_T260_A0.9000.92
44_V157_L0.8990.92
93_K215_L0.8980.92
56_T149_T0.8890.91
194_L199_Y0.8880.91
235_L278_V0.8840.91
194_L260_A0.8680.90
48_G156_K0.8660.90
31_Y37_G0.8520.89
167_D282_S0.8510.89
291_T294_E0.8390.89
77_I120_Q0.8370.88
231_A234_K0.8370.88
19_Y115_I0.8350.88
213_P296_Y0.8340.88
83_N97_L0.8340.88
287_K301_E0.8330.88
42_S90_V0.8330.88
301_E304_R0.8320.88
189_I192_G0.8270.88
13_L269_K0.8250.88
163_I222_K0.8250.88
12_D15_K0.8220.88
225_A232_F0.8170.87
23_I27_I0.8140.87
164_R222_K0.8140.87
81_A207_T0.8130.87
196_L199_Y0.8080.87
190_E194_L0.8080.87
248_P275_I0.8080.87
47_I51_N0.8060.86
225_A278_V0.8050.86
168_Y304_R0.8020.86
47_I153_V0.7950.86
163_I240_S0.7940.86
187_K191_E0.7940.86
81_A179_A0.7940.86
189_I257_I0.7930.86
101_I146_L0.7920.86
140_V143_G0.7920.86
79_C146_L0.7910.85
290_K294_E0.7860.85
179_A209_I0.7850.85
13_L17_R0.7830.85
119_V123_K0.7820.85
48_G155_D0.7810.85
34_T93_K0.7800.85
73_K113_E0.7710.84
108_D112_N0.7710.84
158_K163_I0.7700.84
216_E220_M0.7700.84
196_L200_K0.7690.84
88_I216_E0.7670.84
137_M140_V0.7640.83
75_V114_I0.7630.83
109_N113_E0.7630.83
170_L289_V0.7620.83
104_E142_R0.7600.83
13_L16_L0.7550.83
26_I29_S0.7490.82
15_K105_R0.7490.82
171_G300_Y0.7440.82
288_E292_K0.7400.81
15_K18_N0.7390.81
45_I96_A0.7390.81
19_Y114_I0.7370.81
121_G211_V0.7340.81
192_G260_A0.7340.81
36_I46_K0.7340.81
49_S153_V0.7330.81
283_E301_E0.7290.80
258_E262_V0.7270.80
107_M110_V0.7200.80
114_I118_I0.7190.80
266_E269_K0.7140.79
4_E188_L0.7120.79
221_I289_V0.7060.78
36_I157_L0.7050.78
13_L266_E0.7030.78
18_N109_N0.7030.78
250_P258_E0.7030.78
5_E269_K0.7000.78
53_A154_V0.6990.78
171_G302_L0.6980.78
54_M130_I0.6920.77
283_E286_M0.6920.77
215_L219_N0.6900.77
16_L136_I0.6900.77
250_P264_H0.6900.77
35_I128_E0.6870.76
199_Y203_L0.6850.76
185_V190_E0.6850.76
232_F268_Y0.6830.76
110_V114_I0.6820.76
13_L270_V0.6810.76
22_M108_D0.6800.76
278_V302_L0.6790.76
196_L203_L0.6780.75
66_A75_V0.6770.75
45_I153_V0.6750.75
19_Y27_I0.6750.75
19_Y101_I0.6750.75
4_E270_V0.6740.75
20_H136_I0.6740.75
4_E262_V0.6740.75
218_M221_I0.6710.75
19_Y79_C0.6690.75
65_L185_V0.6680.74
139_D183_S0.6660.74
50_L155_D0.6650.74
217_V292_K0.6650.74
87_L152_G0.6620.74
55_H88_I0.6600.74
169_V279_L0.6580.73
202_E253_I0.6540.73
244_V304_R0.6540.73
18_N108_D0.6480.72
158_K224_A0.6450.72
40_H90_V0.6400.71
47_I50_L0.6390.71
74_P117_G0.6340.71
98_V149_T0.6330.70
267_M273_M0.6320.70
172_L213_P0.6310.70
165_P304_R0.6310.70
29_S120_Q0.6300.70
212_K215_L0.6290.70
46_K155_D0.6280.70
97_L149_T0.6270.70
217_V221_I0.6260.70
257_I262_V0.6260.70
100_Y145_D0.6240.69
70_R113_E0.6210.69
79_C232_F0.6210.69
65_L200_K0.6210.69
5_E270_V0.6200.69
46_K49_S0.6190.69
169_V238_L0.6190.69
71_I200_K0.6160.68
193_K198_E0.6130.68
4_E266_E0.6130.68
69_T204_L0.6130.68
34_T128_E0.6130.68
34_T46_K0.6100.68
158_K223_G0.6090.67
150_A207_T0.6080.67
82_M150_A0.6080.67
122_A129_V0.6070.67
218_M289_V0.6030.67
286_M299_V0.6030.67
81_A121_G0.6010.66
68_Q196_L0.6010.66
294_E299_V0.6000.66
250_P268_Y0.5970.66
215_L218_M0.5950.66
185_V257_I0.5940.66
217_V279_L0.5930.65
46_K153_V0.5920.65
190_E256_T0.5910.65
214_I217_V0.5910.65
16_L38_A0.5900.65
6_Y10_G0.5890.65
118_I150_A0.5880.65
244_V301_E0.5870.65
81_A125_A0.5860.64
175_S202_E0.5860.64
246_N249_D0.5840.64
27_I119_V0.5840.64
75_V121_G0.5830.64
157_L160_G0.5800.64
235_L239_T0.5780.63
61_T137_M0.5760.63
239_T305_V0.5740.63
189_I203_L0.5740.63
281_V292_K0.5730.63
187_K190_E0.5730.63
180_N229_G0.5730.63
27_I38_A0.5710.63
75_V140_V0.5700.62
79_C106_P0.5700.62
88_I215_L0.5690.62
71_I74_P0.5680.62
110_V144_F0.5670.62
55_H83_N0.5660.62
5_E262_V0.5640.62
177_I203_L0.5640.62
46_K51_N0.5630.61
110_V113_E0.5620.61
221_I292_K0.5610.61
254_F261_G0.5610.61
252_Q255_K0.5600.61
193_K196_L0.5600.61
49_S155_D0.5570.61
34_T51_N0.5540.60
134_T137_M0.5530.60
54_M149_T0.5530.60
27_I31_Y0.5520.60
48_G153_V0.5520.60
244_V247_M0.5510.60
63_T141_I0.5510.60
69_T196_L0.5510.60
292_K295_G0.5510.60
168_Y171_G0.5510.60
84_V125_A0.5500.60
217_V296_Y0.5500.60
19_Y273_M0.5480.59
189_I199_Y0.5480.59
81_A206_P0.5470.59
257_I267_M0.5470.59
177_I202_E0.5470.59
83_N233_S0.5450.59
158_K277_I0.5440.59
23_I26_I0.5430.59
51_N153_V0.5400.58
42_S87_L0.5400.58
189_I260_A0.5380.58
77_I81_A0.5370.58
287_K290_K0.5360.58
13_L111_V0.5340.57
106_P146_L0.5340.57
171_G248_P0.5340.57
208_K298_T0.5330.57
165_P306_Y0.5320.57
115_I118_I0.5290.57
185_V188_L0.5280.57
67_L144_F0.5280.57
200_K204_L0.5270.56
89_C248_P0.5270.56
177_I251_P0.5260.56
247_M302_L0.5260.56
242_K305_V0.5250.56
103_L110_V0.5240.56
164_R220_M0.5230.56
88_I218_M0.5230.56
30_T119_V0.5220.56
106_P136_I0.5220.56
57_D61_T0.5220.56
101_I143_G0.5210.56
65_L177_I0.5210.56
57_D180_N0.5210.56
171_G278_V0.5200.55
32_K127_V0.5190.55
54_M98_V0.5190.55
150_A179_A0.5160.55
23_I106_P0.5130.54
199_Y253_I0.5130.54
81_A211_V0.5130.54
306_Y309_N0.5120.54
47_I155_D0.5110.54
82_M206_P0.5110.54
250_P267_M0.5090.54
256_T273_M0.5090.54
25_Q112_N0.5080.54
125_A177_I0.5070.54
25_Q28_S0.5070.54
106_P139_D0.5070.54
228_T237_R0.5070.54
177_I254_F0.5070.54
246_N250_P0.5060.53
108_D111_V0.5050.53
222_K280_F0.5040.53
41_Y234_K0.5030.53
19_Y106_P0.5020.53
177_I257_I0.5010.53
213_P297_G0.5000.53
238_L278_V0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kizA 2 0.9226 100 0.439 Contact Map
3mdoA 2 0.9164 100 0.446 Contact Map
2btuA 2 0.9319 100 0.478 Contact Map
2z01A 2 0.8854 100 0.49 Contact Map
3m84A 2 0.9721 100 0.504 Contact Map
3p4eA 2 0.9257 100 0.506 Contact Map
2v9yA 2 0.8638 100 0.57 Contact Map
3wjpA 2 0.9412 100 0.659 Contact Map
4lgyA 1 0.9164 100 0.675 Contact Map
2zodA 2 0.8762 100 0.675 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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