PURL - SULSO - GREMLIN Contacts

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PURL - Phosphoribosylformylglycinamidine synthase subunit PurL

UniProt:	Q9UX24	Sequences: MGINLLPIEMDEIRKRLGREPNETEWRVIDAVWSEHCSYKSSKIFLKSFSIDSPNVIMGIKDWQDAGAVDIGDGWAVVIKVESHNHPSAIDPFNGAATGVGGIIRDIISKGAKPIALMDMIRVGNLKIKKNVWLLKNIIAGIAAYGNSIGVPVVGGELSFDDTYNDNPLVDVAAIGIVRKDKIKPSIVDKAGLKLVLAGLTGVDGLGGASFASRKLSGEDEIGAVQIADPFAGKIILDVTLEIADKVEAIKDLGGGGLAVAVTEITNGLGATVDIEKIPLRVKNMNPSDVIISETQERMLYAVEEKNVKEVCEAFEEYEYPCSVIGEITNEPVIKFRYIGKDLVSLPTNVLLNPPRFLWPIKNTKKNVEEKIVDLPLESAIYTVLTHPDLVSKGWAYSQFDYEVNTSTVVKPGDADSAVVSLPNGKLLAIKADANPDMCAEDGYECGKGIVAEAYRNLATVGARGMVAVDHLQFGDPKKAEVYYTFVEAIRGIGEATRFFNIPIVGGKVSFYNENNQGRPIKPTPLIVMAGLVQDKLLKNRVEDNLYVVSVGYTRKELGGSLLSKIFKIPSQAPKVRLQEDLLSSEVVIDSINEGKITFAKDVSRGGLAASLFSILVHGYGVEISTKSILSDTDNVIENLFSESSGRFIVLTNEPEWIVEKSKSKGIVASIIGRVNKKTNILTIDNIDYNLKNIVDNYFNFLEEVMGNG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	709 (691)
Sequences:	3232 (1608)
Seq/√Len:	61.2

ECOLI - PUR4
BACSU - PURL
HALSA - PURL
SULSO - PURL

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
333_V	345_S	5.008	1.00
612_L	624_I	4.990	1.00
272_T	327_E	4.740	1.00
93_F	144_A	4.668	1.00
620_Y	675_V	4.169	1.00
541_R	548_V	4.055	1.00
458_L	463_A	4.042	1.00
342_D	345_S	3.694	1.00
274_D	277_K	3.673	1.00
272_T	337_R	3.497	1.00
312_C	316_E	3.377	1.00
262_V	325_I	3.365	1.00
603_V	649_I	3.303	1.00
200_L	321_P	3.271	1.00
309_K	313_E	3.074	1.00
309_K	312_C	3.023	1.00
591_S	658_I	2.988	1.00
382_Y	697_N	2.928	1.00
337_R	342_D	2.871	1.00
387_H	562_L	2.861	1.00
384_V	390_L	2.855	1.00
445_E	448_K	2.835	1.00
158_L	396_A	2.772	1.00
209_A	255_G	2.745	1.00
549_V	671_I	2.704	1.00
623_E	682_L	2.686	1.00
376_P	379_S	2.684	1.00
548_V	622_V	2.647	1.00
587_V	662_S	2.585	1.00
449_G	645_S	2.579	1.00
623_E	674_R	2.568	1.00
307_N	310_E	2.554	1.00
444_Y	495_E	2.539	1.00
486_F	511_F	2.521	1.00
680_N	688_D	2.513	1.00
599_F	615_I	2.488	1.00
310_E	313_E	2.461	1.00
154_V	418_A	2.452	1.00
381_I	609_A	2.451	1.00
276_E	339_I	2.436	1.00
394_G	699_F	2.375	1.00
279_P	323_S	2.363	1.00
379_S	383_T	2.340	1.00
149_I	237_L	2.262	1.00
416_D	601_K	2.246	1.00
546_L	598_T	2.243	1.00
493_I	527_I	2.232	1.00
382_Y	693_N	2.221	1.00
70_D	180_K	2.221	1.00
454_A	527_I	2.207	1.00
171_D	526_L	2.179	1.00
195_L	303_V	2.165	1.00
439_C	489_A	2.160	1.00
536_K	539_K	2.144	1.00
117_L	174_A	2.130	1.00
539_K	542_V	2.117	1.00
280_L	290_V	2.105	1.00
378_E	693_N	2.080	1.00
622_V	681_I	2.078	1.00
312_C	322_C	2.062	1.00
75_W	179_R	2.003	1.00
662_S	669_A	2.002	1.00
563_L	637_I	1.998	1.00
287_P	338_Y	1.995	1.00
77_V	428_L	1.988	1.00
13_I	29_I	1.987	1.00
378_E	382_Y	1.987	1.00
549_V	658_I	1.983	1.00
272_T	335_K	1.976	1.00
612_L	622_V	1.972	1.00
9_E	40_K	1.972	1.00
546_L	675_V	1.968	1.00
438_M	449_G	1.956	1.00
599_F	651_L	1.953	1.00
659_V	669_A	1.951	1.00
113_K	238_D	1.947	1.00
613_F	681_I	1.946	1.00
590_D	594_E	1.942	1.00
335_K	342_D	1.935	1.00
362_K	481_E	1.926	1.00
115_I	420_V	1.919	1.00
308_V	324_V	1.916	1.00
611_S	648_F	1.915	1.00
652_T	655_P	1.897	1.00
459_A	589_I	1.888	1.00
44_I	358_L	1.887	1.00
488_E	491_R	1.886	1.00
104_I	149_I	1.882	1.00
616_L	622_V	1.878	1.00
546_L	651_L	1.872	1.00
361_I	487_V	1.868	1.00
48_S	491_R	1.860	1.00
549_V	659_V	1.858	1.00
689_Y	694_I	1.857	1.00
611_S	649_I	1.857	1.00
588_V	597_I	1.857	1.00
50_S	60_I	1.842	1.00
207_G	210_S	1.827	1.00
700_N	704_E	1.827	1.00
682_L	688_D	1.791	1.00
613_F	617_V	1.779	0.99
661_K	665_K	1.770	0.99
547_Y	671_I	1.768	0.99
274_D	337_R	1.763	0.99
544_D	677_K	1.755	0.99
696_D	700_N	1.752	0.99
541_R	622_V	1.743	0.99
161_D	569_I	1.742	0.99
447_G	486_F	1.741	0.99
598_T	651_L	1.730	0.99
104_I	174_A	1.730	0.99
601_K	614_S	1.715	0.99
381_I	613_F	1.714	0.99
690_N	693_N	1.688	0.99
592_I	597_I	1.686	0.99
615_I	651_L	1.666	0.99
417_S	461_V	1.659	0.99
125_N	162_D	1.659	0.99
452_A	645_S	1.652	0.99
623_E	676_N	1.650	0.99
29_I	350_V	1.649	0.99
163_T	522_K	1.647	0.99
68_A	78_V	1.636	0.99
119_D	142_I	1.621	0.99
617_V	698_Y	1.611	0.99
695_V	699_F	1.594	0.99
267_N	352_L	1.593	0.99
548_V	651_L	1.588	0.99
425_G	535_D	1.579	0.99
382_Y	689_Y	1.564	0.99
382_Y	694_I	1.562	0.99
157_E	393_K	1.550	0.99
635_N	638_E	1.548	0.99
389_D	562_L	1.547	0.99
211_F	216_L	1.542	0.99
332_P	349_N	1.541	0.99
468_A	503_P	1.539	0.98
48_S	52_D	1.533	0.98
55_N	464_R	1.524	0.98
494_G	498_R	1.521	0.98
386_T	697_N	1.521	0.98
381_I	610_A	1.518	0.98
442_D	572_Q	1.515	0.98
442_D	573_A	1.512	0.98
386_T	700_N	1.510	0.98
244_A	310_E	1.508	0.98
543_E	546_L	1.506	0.98
441_E	573_A	1.501	0.98
482_V	520_P	1.494	0.98
387_H	566_I	1.488	0.98
17_L	347_P	1.483	0.98
418_A	421_S	1.481	0.98
324_V	327_E	1.480	0.98
397_Y	413_G	1.478	0.98
390_L	610_A	1.475	0.98
392_S	699_F	1.475	0.98
474_F	489_A	1.470	0.98
597_I	600_A	1.470	0.98
466_M	469_V	1.469	0.98
54_P	501_N	1.468	0.98
444_Y	488_E	1.456	0.98
331_E	335_K	1.441	0.98
418_A	423_P	1.429	0.98
416_D	604_S	1.428	0.98
118_M	430_I	1.428	0.98
394_G	398_S	1.423	0.97
669_A	672_I	1.422	0.97
6_L	357_F	1.421	0.97
171_D	432_A	1.417	0.97
276_E	338_Y	1.408	0.97
420_V	423_P	1.403	0.97
70_D	74_G	1.398	0.97
69_V	467_V	1.397	0.97
89_A	216_L	1.387	0.97
253_L	261_A	1.386	0.97
313_E	316_E	1.381	0.97
533_V	537_L	1.380	0.97
598_T	653_N	1.379	0.97
551_V	650_V	1.378	0.97
27_R	288_S	1.372	0.97
335_K	345_S	1.372	0.97
73_D	426_K	1.371	0.97
549_V	669_A	1.371	0.97
609_A	683_T	1.369	0.97
689_Y	693_N	1.360	0.97
588_V	650_V	1.358	0.97
410_V	538_L	1.352	0.97
495_E	499_F	1.343	0.96
76_A	180_K	1.341	0.96
557_E	644_S	1.336	0.96
290_V	338_Y	1.333	0.96
603_V	611_S	1.332	0.96
453_E	604_S	1.331	0.96
650_V	658_I	1.329	0.96
438_M	645_S	1.327	0.96
15_K	18_G	1.327	0.96
416_D	420_V	1.323	0.96
652_T	658_I	1.316	0.96
303_V	308_V	1.313	0.96
464_R	593_N	1.309	0.96
554_T	644_S	1.304	0.96
287_P	343_L	1.301	0.96
460_T	600_A	1.299	0.96
602_D	614_S	1.293	0.96
591_S	597_I	1.291	0.96
385_L	613_F	1.282	0.95
616_L	681_I	1.282	0.95
410_V	539_K	1.280	0.95
55_N	466_M	1.272	0.95
46_L	49_F	1.268	0.95
203_V	289_D	1.266	0.95
537_L	592_I	1.263	0.95
74_G	180_K	1.260	0.95
585_S	648_F	1.259	0.95
541_R	615_I	1.254	0.95
591_S	661_K	1.252	0.95
457_N	602_D	1.249	0.95
582_L	586_E	1.245	0.95
191_A	198_A	1.244	0.95
53_S	69_V	1.242	0.94
193_L	303_V	1.241	0.94
248_E	304_E	1.240	0.94
128_I	165_N	1.237	0.94
429_A	458_L	1.236	0.94
658_I	662_S	1.235	0.94
587_V	665_K	1.230	0.94
161_D	440_A	1.228	0.94
243_I	311_V	1.218	0.94
610_A	614_S	1.218	0.94
609_A	613_F	1.211	0.94
600_A	648_F	1.211	0.94
587_V	661_K	1.209	0.94
612_L	672_I	1.209	0.94
553_Y	581_D	1.206	0.94
268_G	332_P	1.201	0.93
378_E	689_Y	1.201	0.93
460_T	648_F	1.200	0.93
304_E	307_N	1.199	0.93
123_V	135_L	1.198	0.93
551_V	584_S	1.194	0.93
484_Y	488_E	1.194	0.93
71_I	422_L	1.193	0.93
246_K	307_N	1.192	0.93
476_D	485_T	1.190	0.93
363_N	485_T	1.190	0.93
657_W	660_E	1.189	0.93
556_K	642_S	1.189	0.93
374_D	637_I	1.182	0.93
541_R	675_V	1.180	0.93
501_N	582_L	1.177	0.93
543_E	653_N	1.174	0.93
612_L	649_I	1.169	0.92
596_K	657_W	1.169	0.92
81_V	526_L	1.168	0.92
374_D	635_N	1.168	0.92
189_D	304_E	1.166	0.92
329_T	332_P	1.164	0.92
616_L	691_L	1.156	0.92
442_D	445_E	1.153	0.92
7_P	11_D	1.151	0.92
676_N	679_T	1.145	0.92
375_L	380_A	1.144	0.92
605_R	614_S	1.143	0.92
385_L	694_I	1.141	0.92
588_V	648_F	1.141	0.92
453_E	602_D	1.141	0.92
336_F	344_V	1.139	0.91
81_V	432_A	1.130	0.91
534_Q	593_N	1.129	0.91
395_W	399_Q	1.129	0.91
625_S	684_I	1.126	0.91
554_T	557_E	1.124	0.91
118_M	173_A	1.122	0.91
272_T	331_E	1.121	0.91
617_V	695_V	1.120	0.91
88_S	138_I	1.118	0.91
388_P	391_V	1.117	0.91
383_T	567_F	1.115	0.91
56_V	59_G	1.114	0.91
464_R	534_Q	1.112	0.90
56_V	60_I	1.112	0.90
193_L	324_V	1.111	0.90
179_R	182_K	1.107	0.90
458_L	469_V	1.107	0.90
554_T	647_R	1.105	0.90
435_N	453_E	1.101	0.90
161_D	437_D	1.101	0.90
89_A	211_F	1.099	0.90
417_S	431_K	1.099	0.90
441_E	571_S	1.096	0.90
464_R	589_I	1.095	0.90
439_C	450_I	1.094	0.90
171_D	470_D	1.091	0.90
137_N	140_A	1.090	0.90
265_I	302_A	1.088	0.89
164_Y	434_A	1.086	0.89
348_T	352_L	1.086	0.89
418_A	422_L	1.085	0.89
452_A	581_D	1.085	0.89
431_K	454_A	1.083	0.89
76_A	178_V	1.083	0.89
282_V	285_M	1.081	0.89
550_S	603_V	1.078	0.89
337_R	340_G	1.078	0.89
136_K	140_A	1.075	0.89
48_S	494_G	1.075	0.89
429_A	463_A	1.070	0.89
603_V	608_L	1.067	0.89
692_K	695_V	1.066	0.88
548_V	603_V	1.066	0.88
28_V	346_L	1.065	0.88
193_L	327_E	1.064	0.88
359_W	478_K	1.063	0.88
469_V	528_V	1.061	0.88
117_L	149_I	1.058	0.88
455_Y	502_I	1.058	0.88
656_E	659_V	1.055	0.88
248_E	307_N	1.053	0.88
549_V	667_I	1.053	0.88
495_E	498_R	1.052	0.88
548_V	624_I	1.051	0.88
416_D	421_S	1.051	0.88
11_D	14_R	1.049	0.88
543_E	598_T	1.048	0.88
623_E	684_I	1.046	0.88
492_G	496_A	1.042	0.87
291_I	336_F	1.042	0.87
45_F	49_F	1.041	0.87
78_V	112_A	1.035	0.87
403_E	411_K	1.035	0.87
604_S	614_S	1.033	0.87
454_A	530_A	1.032	0.87
580_E	583_L	1.031	0.87
11_D	15_K	1.031	0.87
193_L	305_E	1.030	0.87
427_L	535_D	1.030	0.87
431_K	458_L	1.029	0.87
620_Y	677_K	1.026	0.86
617_V	691_L	1.023	0.86
416_D	422_L	1.022	0.86
547_Y	674_R	1.022	0.86
349_N	353_N	1.021	0.86
363_N	488_E	1.019	0.86
597_I	650_V	1.018	0.86
173_A	528_V	1.015	0.86
455_Y	585_S	1.012	0.86
451_V	493_I	1.011	0.86
314_A	317_E	1.010	0.86
385_L	390_L	1.010	0.86
125_N	165_N	1.006	0.85
454_A	529_M	1.006	0.85
65_D	109_S	1.005	0.85
278_I	290_V	1.005	0.85
679_T	688_D	1.003	0.85
594_E	657_W	1.002	0.85
378_E	687_I	1.000	0.85
693_N	697_N	0.998	0.85
240_T	314_A	0.998	0.85
536_K	593_N	0.996	0.85
193_L	308_V	0.996	0.85
657_W	661_K	0.994	0.85
24_T	344_V	0.994	0.85
262_V	334_I	0.992	0.85
211_F	224_A	0.991	0.85
626_T	639_N	0.990	0.84
591_S	596_K	0.990	0.84
563_L	635_N	0.988	0.84
140_A	144_A	0.988	0.84
303_V	311_V	0.986	0.84
89_A	168_P	0.986	0.84
384_V	610_A	0.983	0.84
462_G	534_Q	0.983	0.84
280_L	285_M	0.982	0.84
155_G	431_K	0.982	0.84
549_V	650_V	0.981	0.84
246_K	310_E	0.981	0.84
362_K	480_A	0.974	0.83
471_H	493_I	0.973	0.83
422_L	426_K	0.971	0.83
371_K	374_D	0.971	0.83
45_F	483_Y	0.969	0.83
276_E	340_G	0.969	0.83
542_V	651_L	0.968	0.83
194_K	262_V	0.967	0.83
557_E	575_K	0.966	0.83
549_V	652_T	0.965	0.83
135_L	396_A	0.962	0.83
136_K	705_V	0.960	0.83
104_I	151_V	0.958	0.82
671_I	674_R	0.958	0.82
444_Y	491_R	0.957	0.82
541_R	620_Y	0.954	0.82
456_R	581_D	0.951	0.82
57_I	76_A	0.950	0.82
267_N	349_N	0.946	0.82
143_A	172_V	0.945	0.82
316_E	322_C	0.944	0.82
459_A	592_I	0.943	0.81
203_V	282_V	0.942	0.81
12_E	15_K	0.939	0.81
59_G	63_W	0.939	0.81
346_L	352_L	0.935	0.81
313_E	317_E	0.933	0.81
243_I	314_A	0.932	0.81
190_K	193_L	0.928	0.80
301_Y	311_V	0.928	0.80
453_E	614_S	0.927	0.80
104_I	117_L	0.925	0.80
65_D	251_K	0.921	0.80
118_M	155_G	0.921	0.80
499_F	579_Q	0.918	0.80
188_V	192_G	0.916	0.80
546_L	550_S	0.913	0.79
134_L	168_P	0.912	0.79
439_C	446_C	0.912	0.79
557_E	574_P	0.911	0.79
76_A	183_I	0.910	0.79
407_S	423_P	0.910	0.79
382_Y	386_T	0.906	0.79
589_I	593_N	0.904	0.79
373_V	376_P	0.903	0.79
56_V	468_A	0.900	0.78
112_A	175_I	0.898	0.78
5_L	13_I	0.897	0.78
288_S	292_I	0.897	0.78
124_G	165_N	0.896	0.78
588_V	592_I	0.896	0.78
608_L	649_I	0.892	0.78
77_V	532_L	0.891	0.78
93_F	228_A	0.891	0.78
622_V	673_G	0.890	0.78
457_N	614_S	0.890	0.78
442_D	488_E	0.887	0.77
697_N	700_N	0.887	0.77
490_I	528_V	0.881	0.77
58_M	183_I	0.880	0.77
551_V	587_V	0.879	0.77
60_I	63_W	0.878	0.77
538_L	592_I	0.877	0.76
429_A	533_V	0.875	0.76
616_L	651_L	0.873	0.76
693_N	696_D	0.873	0.76
656_E	660_E	0.873	0.76
193_L	328_I	0.871	0.76
443_G	482_V	0.869	0.76
416_D	602_D	0.868	0.76
453_E	457_N	0.867	0.76
541_R	651_L	0.866	0.76
548_V	672_I	0.864	0.75
197_L	253_L	0.863	0.75
125_N	565_K	0.862	0.75
427_L	533_V	0.862	0.75
470_D	526_L	0.859	0.75
391_V	702_L	0.857	0.75
267_N	332_P	0.857	0.75
636_V	685_D	0.855	0.75
115_I	428_L	0.855	0.75
596_K	661_K	0.851	0.74
3_I	26_W	0.851	0.74
73_D	179_R	0.850	0.74
275_I	338_Y	0.850	0.74
459_A	585_S	0.850	0.74
41_S	483_Y	0.847	0.74
192_G	248_E	0.846	0.74
415_A	461_V	0.846	0.74
473_Q	477_P	0.844	0.74
211_F	483_Y	0.843	0.74
198_A	315_F	0.843	0.74
75_W	177_I	0.840	0.73
562_L	565_K	0.840	0.73
544_D	620_Y	0.839	0.73
457_N	601_K	0.839	0.73
457_N	604_S	0.839	0.73
153_V	418_A	0.838	0.73
384_V	609_A	0.838	0.73
240_T	317_E	0.837	0.73
63_W	184_K	0.837	0.73
548_V	612_L	0.836	0.73
402_Y	412_P	0.834	0.73
131_N	165_N	0.833	0.73
243_I	301_Y	0.831	0.73
10_M	14_R	0.830	0.72
57_I	468_A	0.829	0.72
587_V	591_S	0.829	0.72
120_M	157_E	0.827	0.72
242_E	317_E	0.826	0.72
659_V	671_I	0.824	0.72
310_E	314_A	0.822	0.72
126_L	135_L	0.821	0.72
274_D	339_I	0.821	0.72
679_T	692_K	0.819	0.71
679_T	691_L	0.819	0.71
559_G	573_A	0.815	0.71
268_G	349_N	0.815	0.71
194_K	273_V	0.814	0.71
580_E	594_E	0.814	0.71
610_A	613_F	0.814	0.71
594_E	661_K	0.814	0.71
453_E	601_K	0.812	0.71
546_L	599_F	0.812	0.71
601_K	604_S	0.812	0.71
483_Y	487_V	0.810	0.71
458_L	530_A	0.807	0.70
190_K	330_N	0.807	0.70
381_I	687_I	0.807	0.70
305_E	327_E	0.807	0.70
198_A	262_V	0.803	0.70
402_Y	411_K	0.803	0.70
545_N	671_I	0.802	0.70
149_I	174_A	0.801	0.70
260_V	506_G	0.801	0.70
452_A	456_R	0.795	0.69
364_T	481_E	0.793	0.69
377_L	381_I	0.792	0.69
26_W	65_D	0.791	0.69
620_Y	676_N	0.788	0.68
545_N	653_N	0.785	0.68
587_V	590_D	0.784	0.68
468_A	504_I	0.784	0.68
133_W	137_N	0.784	0.68
577_R	580_E	0.783	0.68
431_K	461_V	0.781	0.68
334_I	346_L	0.780	0.68
586_E	590_D	0.780	0.68
473_Q	476_D	0.780	0.68
333_V	347_P	0.779	0.68
374_D	563_L	0.779	0.68
243_I	310_E	0.777	0.67
50_S	57_I	0.776	0.67
214_R	221_E	0.773	0.67
163_T	440_A	0.773	0.67
561_S	574_P	0.772	0.67
590_D	661_K	0.772	0.67
616_L	619_G	0.772	0.67
221_E	224_A	0.770	0.67
278_I	325_I	0.769	0.67
602_D	605_R	0.767	0.66
71_I	77_V	0.765	0.66
555_R	644_S	0.765	0.66
370_E	571_S	0.765	0.66
392_S	702_L	0.763	0.66
419_V	429_A	0.761	0.66
416_D	423_P	0.760	0.66
563_L	567_F	0.760	0.66
588_V	662_S	0.758	0.65
71_I	428_L	0.758	0.65
330_N	382_Y	0.757	0.65
175_I	430_I	0.757	0.65
48_S	498_R	0.757	0.65
374_D	377_L	0.757	0.65
41_S	359_W	0.757	0.65
581_D	585_S	0.754	0.65
431_K	529_M	0.753	0.65
349_N	352_L	0.752	0.65
93_F	143_A	0.750	0.65
545_N	675_V	0.748	0.64
427_L	537_L	0.748	0.64
482_V	485_T	0.747	0.64
479_K	482_V	0.747	0.64
579_Q	590_D	0.745	0.64
173_A	430_I	0.744	0.64
444_Y	447_G	0.743	0.64
486_F	492_G	0.741	0.64
144_A	148_S	0.741	0.64
90_I	211_F	0.741	0.64
467_V	502_I	0.740	0.64
228_A	281_R	0.739	0.63
589_I	592_I	0.738	0.63
445_E	575_K	0.736	0.63
360_P	480_A	0.736	0.63
659_V	662_S	0.736	0.63
547_Y	675_V	0.734	0.63
80_K	172_V	0.734	0.63
548_V	675_V	0.734	0.63
377_L	641_F	0.733	0.63
482_V	486_F	0.732	0.63
474_F	477_P	0.732	0.63
451_V	496_A	0.732	0.63
434_A	439_C	0.729	0.62
613_F	622_V	0.727	0.62
45_F	486_F	0.727	0.62
394_G	702_L	0.725	0.62
101_G	145_Y	0.725	0.62
255_G	258_L	0.723	0.62
448_K	575_K	0.721	0.62
115_I	422_L	0.719	0.61
498_R	550_S	0.719	0.61
397_Y	698_Y	0.719	0.61
65_D	80_K	0.718	0.61
381_I	689_Y	0.718	0.61
43_K	356_R	0.718	0.61
541_R	545_N	0.716	0.61
542_V	545_N	0.716	0.61
380_A	384_V	0.715	0.61
125_N	131_N	0.715	0.61
88_S	137_N	0.714	0.61
86_H	212_A	0.713	0.61
688_D	693_N	0.713	0.61
263_T	334_I	0.712	0.61
192_G	198_A	0.712	0.61
91_D	94_N	0.712	0.61
194_K	308_V	0.710	0.60
240_T	243_I	0.710	0.60
380_A	567_F	0.709	0.60
113_K	405_N	0.708	0.60
302_A	328_I	0.708	0.60
416_D	419_V	0.707	0.60
315_F	322_C	0.707	0.60
410_V	419_V	0.705	0.60
698_Y	701_F	0.704	0.60
132_V	567_F	0.701	0.59
115_I	177_I	0.698	0.59
46_L	50_S	0.698	0.59
273_V	325_I	0.698	0.59
546_L	615_I	0.698	0.59
93_F	230_P	0.697	0.59
554_T	603_V	0.695	0.59
676_N	682_L	0.695	0.59
546_L	654_E	0.694	0.59
122_R	157_E	0.693	0.59
253_L	300_L	0.693	0.59
77_V	175_I	0.692	0.58
159_S	389_D	0.692	0.58
658_I	661_K	0.691	0.58
245_D	304_E	0.691	0.58
701_F	705_V	0.688	0.58
50_S	501_N	0.688	0.58
45_F	48_S	0.687	0.58
658_I	669_A	0.687	0.58
222_I	282_V	0.686	0.58
625_S	628_S	0.686	0.58
552_G	556_K	0.686	0.58
402_Y	408_T	0.685	0.58
554_T	642_S	0.684	0.58
175_I	530_A	0.683	0.57
178_V	183_I	0.682	0.57
433_D	457_N	0.680	0.57
502_I	529_M	0.680	0.57
564_S	568_K	0.679	0.57
39_Y	42_S	0.678	0.57
47_K	660_E	0.676	0.57
274_D	338_Y	0.676	0.57
262_V	273_V	0.675	0.57
266_T	328_I	0.675	0.57
626_T	672_I	0.675	0.57
542_V	620_Y	0.675	0.57
623_E	700_N	0.675	0.57
122_R	436_P	0.675	0.57
281_R	295_T	0.674	0.56
308_V	312_C	0.672	0.56
691_L	695_V	0.672	0.56
616_L	683_T	0.670	0.56
407_S	421_S	0.669	0.56
276_E	287_P	0.669	0.56
471_H	527_I	0.669	0.56
4_N	214_R	0.669	0.56
538_L	600_A	0.668	0.56
583_L	597_I	0.667	0.56
578_L	582_L	0.667	0.56
514_E	520_P	0.666	0.56
553_Y	668_V	0.665	0.55
542_V	546_L	0.665	0.55
39_Y	83_S	0.665	0.55
329_T	335_K	0.664	0.55
486_F	490_I	0.663	0.55
538_L	542_V	0.663	0.55
536_K	595_G	0.661	0.55
564_S	569_I	0.661	0.55
584_S	667_I	0.661	0.55
8_I	358_L	0.661	0.55
68_A	178_V	0.661	0.55
69_V	77_V	0.660	0.55
31_A	210_S	0.660	0.55
280_L	338_Y	0.660	0.55
591_S	594_E	0.659	0.55
77_V	467_V	0.659	0.55
249_A	269_L	0.659	0.55
579_Q	582_L	0.658	0.55
484_Y	487_V	0.658	0.55
447_G	489_A	0.657	0.55
313_E	623_E	0.657	0.55
305_E	308_V	0.656	0.54
639_N	670_S	0.656	0.54
140_A	399_Q	0.656	0.54
126_L	388_P	0.655	0.54
601_K	605_R	0.655	0.54
175_I	528_V	0.655	0.54
406_T	423_P	0.655	0.54
315_F	320_Y	0.654	0.54
542_V	675_V	0.654	0.54
246_K	314_A	0.653	0.54
201_T	280_L	0.652	0.54
622_V	675_V	0.652	0.54
93_F	148_S	0.651	0.54
591_S	595_G	0.650	0.54
202_G	281_R	0.650	0.54
233_G	295_T	0.648	0.54
601_K	611_S	0.647	0.53
448_K	495_E	0.647	0.53
604_S	643_E	0.647	0.53
458_L	461_V	0.645	0.53
215_K	514_E	0.645	0.53
699_F	703_E	0.645	0.53
564_S	570_P	0.645	0.53
93_F	140_A	0.645	0.53
494_G	497_T	0.643	0.53
622_V	694_I	0.643	0.53
555_R	577_R	0.642	0.53
459_A	646_G	0.642	0.53
275_I	336_F	0.642	0.53
155_G	432_A	0.641	0.53
376_P	380_A	0.641	0.53
187_I	249_A	0.641	0.53
437_D	440_A	0.641	0.53
553_Y	580_E	0.641	0.53
438_M	559_G	0.641	0.53
657_W	690_N	0.640	0.53
581_D	646_G	0.640	0.53
81_V	470_D	0.639	0.52
435_N	605_R	0.639	0.52
124_G	161_D	0.639	0.52
24_T	291_I	0.638	0.52
628_S	636_V	0.637	0.52
159_S	562_L	0.636	0.52
291_I	334_I	0.636	0.52
372_I	375_L	0.635	0.52
549_V	662_S	0.635	0.52
280_L	283_K	0.634	0.52
12_E	355_P	0.634	0.52
16_R	349_N	0.633	0.52
451_V	527_I	0.633	0.52
68_A	183_I	0.632	0.52
609_A	641_F	0.632	0.52
201_T	295_T	0.632	0.52
164_Y	524_T	0.631	0.52
121_I	142_I	0.630	0.51
194_K	324_V	0.629	0.51
215_K	478_K	0.629	0.51
123_V	138_I	0.628	0.51
454_A	502_I	0.627	0.51
189_D	248_E	0.627	0.51
179_R	332_P	0.626	0.51
266_T	271_A	0.626	0.51
173_A	432_A	0.625	0.51
550_S	608_L	0.624	0.51
378_E	690_N	0.624	0.51
649_I	658_I	0.624	0.51
454_A	471_H	0.624	0.51
330_N	333_V	0.623	0.51
38_S	41_S	0.623	0.51
374_D	380_A	0.623	0.51
687_I	694_I	0.622	0.51
394_G	695_V	0.621	0.50
540_N	618_H	0.621	0.50
48_S	492_G	0.620	0.50
195_L	271_A	0.619	0.50
543_E	696_D	0.619	0.50
31_A	207_G	0.619	0.50
441_E	559_G	0.618	0.50
585_S	647_R	0.618	0.50
557_E	645_S	0.618	0.50
461_V	592_I	0.618	0.50
658_I	671_I	0.617	0.50
455_Y	467_V	0.617	0.50
487_V	491_R	0.617	0.50
546_L	620_Y	0.616	0.50
55_N	69_V	0.615	0.50
435_N	602_D	0.615	0.50
410_V	415_A	0.615	0.50
249_A	271_A	0.614	0.50
483_Y	486_F	0.614	0.50
178_V	182_K	0.614	0.50
429_A	461_V	0.613	0.50
416_D	457_N	0.613	0.50
171_D	508_K	0.613	0.50
43_K	47_K	0.613	0.50
333_V	346_L	0.612	0.49
390_L	453_E	0.612	0.49
551_V	591_S	0.612	0.49
196_V	312_C	0.611	0.49
469_V	504_I	0.611	0.49
203_V	288_S	0.610	0.49
593_N	596_K	0.609	0.49
89_A	515_N	0.609	0.49
685_D	693_N	0.608	0.49
241_L	245_D	0.608	0.49
412_P	619_G	0.607	0.49
434_A	526_L	0.607	0.49
313_E	594_E	0.605	0.49
31_A	34_S	0.604	0.49
465_G	468_A	0.603	0.48
493_I	497_T	0.603	0.48
69_V	79_I	0.603	0.48
376_P	686_N	0.603	0.48
590_D	656_E	0.602	0.48
409_V	427_L	0.602	0.48
385_L	610_A	0.601	0.48
120_M	155_G	0.600	0.48
623_E	686_N	0.600	0.48
410_V	537_L	0.600	0.48
580_E	584_S	0.598	0.48
547_Y	550_S	0.598	0.48
692_K	696_D	0.597	0.48
656_E	684_I	0.597	0.48
659_V	672_I	0.596	0.48
653_N	659_V	0.596	0.48
544_D	675_V	0.595	0.48
590_D	665_K	0.595	0.48
139_I	399_Q	0.594	0.47
682_L	685_D	0.594	0.47
606_G	643_E	0.594	0.47
679_T	690_N	0.593	0.47
267_N	353_N	0.591	0.47
538_L	597_I	0.591	0.47
327_E	337_R	0.591	0.47
197_L	236_I	0.588	0.47
479_K	514_E	0.588	0.47
177_I	422_L	0.586	0.46
383_T	566_I	0.586	0.46
444_Y	486_F	0.586	0.46
390_L	606_G	0.586	0.46
625_S	686_N	0.583	0.46
376_P	637_I	0.582	0.46
154_V	420_V	0.581	0.46
455_Y	529_M	0.581	0.46
195_L	322_C	0.581	0.46
551_V	648_F	0.581	0.46
435_N	438_M	0.581	0.46
662_S	665_K	0.580	0.46
583_L	657_W	0.580	0.46
496_A	578_L	0.580	0.46
277_K	323_S	0.578	0.46
612_L	616_L	0.578	0.46
491_R	495_E	0.578	0.46
10_M	188_V	0.576	0.45
426_K	534_Q	0.576	0.45
456_R	616_L	0.575	0.45
41_S	45_F	0.575	0.45
218_G	516_N	0.575	0.45
338_Y	343_L	0.575	0.45
551_V	669_A	0.575	0.45
700_N	703_E	0.574	0.45
233_G	261_A	0.574	0.45
151_V	405_N	0.573	0.45
622_V	672_I	0.572	0.45
609_A	640_L	0.571	0.45
540_N	544_D	0.571	0.45
202_G	299_M	0.570	0.45
419_V	537_L	0.570	0.45
230_P	552_G	0.570	0.45
49_F	447_G	0.569	0.45
682_L	690_N	0.569	0.45
57_I	503_P	0.567	0.44
184_K	250_I	0.567	0.44
564_S	637_I	0.566	0.44
377_L	640_L	0.566	0.44
583_L	681_I	0.566	0.44
680_N	690_N	0.566	0.44
469_V	502_I	0.565	0.44
110_K	186_S	0.565	0.44
416_D	614_S	0.564	0.44
547_Y	654_E	0.563	0.44
279_P	322_C	0.562	0.44
9_E	207_G	0.562	0.44
678_K	690_N	0.561	0.44
390_L	562_L	0.561	0.44
126_L	702_L	0.560	0.44
188_V	248_E	0.560	0.44
545_N	674_R	0.560	0.44
217_S	220_D	0.559	0.43
259_A	311_V	0.559	0.43
52_D	498_R	0.559	0.43
51_I	60_I	0.559	0.43
69_V	422_L	0.559	0.43
88_S	170_V	0.559	0.43
660_E	666_G	0.557	0.43
540_N	619_G	0.557	0.43
666_G	681_I	0.557	0.43
364_T	484_Y	0.557	0.43
465_G	586_E	0.557	0.43
74_G	181_D	0.556	0.43
195_L	385_L	0.556	0.43
186_S	249_A	0.556	0.43
209_A	258_L	0.556	0.43
238_D	400_F	0.556	0.43
373_V	672_I	0.555	0.43
448_K	576_V	0.555	0.43
75_W	534_Q	0.554	0.43
242_E	318_Y	0.554	0.43
146_G	153_V	0.553	0.43
559_G	574_P	0.553	0.43
24_T	288_S	0.553	0.43
596_K	655_P	0.551	0.43
161_D	522_K	0.550	0.42
547_Y	655_P	0.550	0.42
272_T	342_D	0.550	0.42
206_L	221_E	0.549	0.42
191_A	194_K	0.549	0.42
674_R	678_K	0.548	0.42
587_V	669_A	0.547	0.42
409_V	421_S	0.547	0.42
194_K	198_A	0.547	0.42
16_R	350_V	0.545	0.42
482_V	492_G	0.544	0.42
375_L	378_E	0.544	0.42
59_G	196_V	0.544	0.42
295_T	325_I	0.544	0.42
568_K	637_I	0.543	0.42
197_L	261_A	0.543	0.42
267_N	348_T	0.542	0.42
597_I	667_I	0.541	0.41
148_S	400_F	0.541	0.41
558_L	642_S	0.540	0.41
389_D	565_K	0.540	0.41
555_R	572_Q	0.540	0.41
378_E	381_I	0.540	0.41
445_E	576_V	0.539	0.41
41_S	360_P	0.539	0.41
255_G	511_F	0.539	0.41
616_L	620_Y	0.539	0.41
476_D	509_V	0.538	0.41
274_D	287_P	0.538	0.41
23_E	26_W	0.537	0.41
403_E	412_P	0.537	0.41
598_T	675_V	0.537	0.41
100_V	145_Y	0.537	0.41
159_S	387_H	0.536	0.41
312_C	323_S	0.536	0.41
42_S	83_S	0.536	0.41
598_T	615_I	0.536	0.41
491_R	498_R	0.536	0.41
245_D	310_E	0.535	0.41
90_I	104_I	0.535	0.41
77_V	422_L	0.534	0.41
455_Y	500_F	0.534	0.41
677_K	680_N	0.533	0.41
583_L	661_K	0.533	0.41
135_L	158_L	0.533	0.41
72_G	534_Q	0.533	0.41
72_G	690_N	0.533	0.41
483_Y	497_T	0.532	0.40
89_A	118_M	0.532	0.40
601_K	615_I	0.532	0.40
378_E	688_D	0.532	0.40
260_V	505_V	0.532	0.40
160_F	492_G	0.532	0.40
28_V	351_L	0.532	0.40
50_S	56_V	0.531	0.40
420_V	428_L	0.531	0.40
568_K	571_S	0.531	0.40
583_L	672_I	0.530	0.40
14_R	20_E	0.530	0.40
203_V	292_I	0.530	0.40
41_S	89_A	0.530	0.40
157_E	432_A	0.530	0.40
448_K	499_F	0.530	0.40
660_E	674_R	0.528	0.40
440_A	522_K	0.528	0.40
600_A	650_V	0.527	0.40
550_S	649_I	0.526	0.40
79_I	469_V	0.525	0.40
43_K	511_F	0.525	0.40
516_N	519_R	0.525	0.40
639_N	697_N	0.525	0.40
49_F	490_I	0.525	0.40
116_A	430_I	0.524	0.40
191_A	269_L	0.523	0.39
108_I	265_I	0.523	0.39
305_E	555_R	0.522	0.39
627_K	685_D	0.522	0.39
668_V	671_I	0.522	0.39
485_T	497_T	0.521	0.39
258_L	278_I	0.521	0.39
556_K	638_E	0.521	0.39
196_V	324_V	0.521	0.39
171_D	509_V	0.521	0.39
195_L	308_V	0.521	0.39
78_V	178_V	0.520	0.39
615_I	619_G	0.519	0.39
40_K	80_K	0.518	0.39
499_F	502_I	0.517	0.39
210_S	214_R	0.517	0.39
28_V	353_N	0.517	0.39
143_A	148_S	0.517	0.39
543_E	623_E	0.517	0.39
207_G	288_S	0.516	0.39
192_G	328_I	0.516	0.39
221_E	391_V	0.515	0.39
30_D	38_S	0.515	0.39
665_K	674_R	0.515	0.39
89_A	483_Y	0.515	0.39
459_A	597_I	0.515	0.39
171_D	473_Q	0.514	0.39
417_S	536_K	0.514	0.39
386_T	590_D	0.514	0.39
104_I	237_L	0.514	0.39
403_E	406_T	0.514	0.39
90_I	513_N	0.514	0.39
369_E	572_Q	0.514	0.39
194_K	306_K	0.513	0.38
560_G	574_P	0.513	0.38
593_N	654_E	0.513	0.38
363_N	484_Y	0.512	0.38
541_R	544_D	0.512	0.38
592_I	600_A	0.512	0.38
376_P	610_A	0.511	0.38
70_D	468_A	0.511	0.38
674_R	684_I	0.511	0.38
481_E	484_Y	0.511	0.38
49_F	53_S	0.511	0.38
499_F	582_L	0.511	0.38
587_V	597_I	0.511	0.38
196_V	262_V	0.510	0.38
550_S	647_R	0.510	0.38
584_S	646_G	0.510	0.38
113_K	241_L	0.509	0.38
259_A	334_I	0.508	0.38
463_A	589_I	0.508	0.38
230_P	447_G	0.507	0.38
462_G	592_I	0.506	0.38
134_L	617_V	0.506	0.38
417_S	460_T	0.505	0.38
564_S	635_N	0.505	0.38
188_V	249_A	0.504	0.37
585_S	646_G	0.504	0.37
48_S	54_P	0.503	0.37
23_E	286_N	0.503	0.37
375_L	563_L	0.503	0.37
584_S	648_F	0.502	0.37
149_I	172_V	0.502	0.37
623_E	685_D	0.501	0.37
262_V	266_T	0.501	0.37
286_N	441_E	0.501	0.37
596_K	658_I	0.501	0.37
159_S	605_R	0.500	0.37
479_K	484_Y	0.500	0.37

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3viuA	1	0.9577	100	0.356	Contact Map
4lgyA	1	0.9732	100	0.362	Contact Map
1vk3A	1	0.8166	100	0.455	Contact Map
2zodA	2	0.4034	100	0.849	Contact Map
3u0oA	2	0.4161	100	0.856	Contact Map
2rb9A	2	0.4175	100	0.86	Contact Map
3vtiC	2	0.4048	100	0.865	Contact Map
3fd5A	2	0.4443	100	0.865	Contact Map
3wjpA	2	0.4386	100	0.868	Contact Map
2yxzA	2	0.4048	100	0.868	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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