GREMLIN Database
PURQ - Phosphoribosylformylglycinamidine synthase subunit PurQ
UniProt: Q9UX21 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 224 (208)
Sequences: 3208 (1561)
Seq/√Len: 108.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_V83_I3.5941.00
131_K215_I3.2621.00
104_L143_R3.1321.00
185_N189_N3.1061.00
146_V150_D2.9821.00
147_D150_D2.8821.00
118_I159_Q2.7571.00
42_G79_I2.6751.00
16_V44_I2.4951.00
91_V100_L2.3981.00
71_K75_E2.3691.00
80_V190_V2.3611.00
116_K132_I2.3191.00
20_L44_I2.2951.00
21_I26_P2.2391.00
5_I45_L2.1811.00
72_Q76_D2.1661.00
157_V184_A2.1251.00
19_A201_S2.1071.00
214_L218_R2.0461.00
28_V40_Y2.0381.00
12_C199_R2.0241.00
73_M78_K2.0201.00
35_F66_T2.0151.00
114_Y132_I1.9551.00
79_I123_I1.8771.00
115_L133_I1.8581.00
3_A30_V1.8481.00
69_K72_Q1.8181.00
32_Y64_T1.7941.00
144_Y183_I1.7701.00
59_S92_E1.7671.00
6_K29_I1.7081.00
122_T157_V1.6791.00
112_W134_R1.6751.00
158_L182_S1.6671.00
17_Y29_I1.6541.00
117_V158_L1.6491.00
128_L133_I1.6401.00
127_G219_R1.6351.00
20_L42_G1.6221.00
109_I137_I1.6161.00
137_I173_P1.5411.00
116_K161_C1.5271.00
10_T46_P1.5111.00
101_L145_Y1.4801.00
156_M180_I1.4751.00
12_C138_A1.4601.00
17_Y21_I1.4471.00
146_V151_Y1.4311.00
138_A199_R1.4311.00
160_Y181_A1.4271.00
155_H184_A1.4261.00
215_I218_R1.4161.00
114_Y161_C1.4091.00
87_F192_G1.3971.00
153_K186_E1.3901.00
44_I81_I1.3721.00
25_V221_G1.3691.00
182_S193_M1.3651.00
38_D72_Q1.3551.00
173_P179_N1.3541.00
20_L25_V1.3521.00
172_N179_N1.3401.00
122_T184_A1.3320.99
108_F138_A1.3300.99
132_I161_C1.3220.99
136_P200_A1.3200.99
184_A188_G1.3070.99
155_H186_E1.2730.99
162_D171_V1.2640.99
105_K109_I1.2640.99
116_K159_Q1.2560.99
119_R129_D1.2530.99
21_I27_T1.2430.99
157_V191_I1.2420.99
119_R154_T1.2360.99
114_Y134_R1.2340.99
5_I70_V1.2290.99
74_A95_L1.2150.99
185_N190_V1.2130.99
18_K22_E1.1920.99
37_P43_V1.1690.99
57_A141_E1.1610.99
49_F84_C1.1550.99
156_M159_Q1.1430.98
91_V96_L1.1400.98
72_Q75_E1.1270.98
148_D178_L1.1250.98
101_L143_R1.1040.98
125_T158_L1.1030.98
59_S63_S1.1030.98
171_V179_N1.1000.98
203_K211_V1.1000.98
102_P106_L1.0970.98
12_C135_M1.0960.98
159_Q178_L1.0960.98
119_R188_G1.0910.98
87_F96_L1.0880.98
92_E99_A1.0720.98
148_D177_L1.0570.97
41_N77_G1.0560.97
113_V137_I1.0540.97
13_E29_I1.0440.97
43_V80_V1.0410.97
128_L215_I1.0350.97
38_D69_K1.0340.97
127_G218_R1.0300.97
119_R122_T1.0210.97
151_Y177_L1.0200.97
184_A191_I1.0100.97
4_I20_L1.0060.97
158_L191_I1.0010.96
113_V173_P0.9900.96
22_E201_S0.9830.96
43_V78_K0.9680.96
145_Y177_L0.9620.95
23_A214_L0.9600.95
18_K201_S0.9500.95
43_V73_M0.9480.95
10_T13_E0.9380.95
67_M93_S0.9330.95
115_L197_P0.9310.95
11_T84_C0.9310.95
156_M178_L0.9300.95
57_A100_L0.9300.95
28_V36_D0.9250.94
58_G62_A0.9200.94
149_I152_A0.9180.94
96_L190_V0.9150.94
33_K64_T0.9070.94
138_A198_E0.9020.94
22_E202_F0.8950.93
96_L192_G0.8940.93
146_V183_I0.8900.93
127_G215_I0.8900.93
111_K137_I0.8850.93
125_T157_V0.8640.92
57_A102_P0.8600.92
90_L190_V0.8570.92
151_Y178_L0.8560.92
67_M70_V0.8540.92
102_P140_A0.8530.92
6_K17_Y0.8320.91
117_V128_L0.8310.91
87_F100_L0.8260.90
58_G89_I0.8250.90
36_D69_K0.8230.90
180_I183_I0.8220.90
4_I46_P0.8160.90
28_V39_R0.8130.90
80_V90_L0.8100.89
84_C174_N0.8090.89
204_L209_G0.8040.89
122_T125_T0.8000.89
39_R69_K0.7920.88
151_Y156_M0.7900.88
128_L131_K0.7830.88
161_C179_N0.7790.88
154_T188_G0.7790.88
183_I192_G0.7690.87
17_Y27_T0.7620.86
100_L144_Y0.7600.86
73_M79_I0.7570.86
182_S192_G0.7570.86
7_F61_A0.7520.86
4_I17_Y0.7460.85
49_F174_N0.7440.85
68_K71_K0.7430.85
102_P107_R0.7420.85
70_V74_A0.7350.84
11_T138_A0.7350.84
75_E187_E0.7330.84
59_S99_A0.7310.84
108_F198_E0.7290.84
121_D154_T0.7240.83
122_T188_G0.7200.83
139_H174_N0.7190.83
30_V36_D0.7150.83
155_H185_N0.7130.83
35_F69_K0.7120.82
44_I83_I0.7120.82
46_P110_S0.7110.82
42_G124_L0.7080.82
146_V178_L0.7050.82
100_L192_G0.7000.81
157_V188_G0.6920.81
162_D173_P0.6920.81
74_A80_V0.6890.80
128_L216_L0.6870.80
7_F32_Y0.6820.80
67_M71_K0.6810.80
77_G189_N0.6780.79
203_K209_G0.6760.79
120_A184_A0.6740.79
84_C141_E0.6710.79
85_N88_Q0.6690.78
49_F139_H0.6690.78
56_R92_E0.6670.78
66_T69_K0.6670.78
36_D39_R0.6650.78
49_F196_H0.6630.78
120_A123_I0.6620.78
146_V177_L0.6610.78
53_D84_C0.6560.77
37_P66_T0.6540.77
172_N176_S0.6530.77
7_F10_T0.6510.76
11_T139_H0.6500.76
37_P69_K0.6440.76
6_K34_D0.6430.76
68_K72_Q0.6410.75
117_V133_I0.6330.74
51_F64_T0.6320.74
115_L181_A0.6320.74
120_A129_D0.6300.74
110_S138_A0.6250.73
84_C139_H0.6220.73
14_T29_I0.6220.73
28_V34_D0.6220.73
42_G220_L0.6200.73
11_T199_R0.6190.73
79_I189_N0.6180.73
19_A24_G0.6170.73
113_V162_D0.6140.72
135_M199_R0.6130.72
20_L27_T0.6120.72
73_M76_D0.6090.72
90_L192_G0.6080.71
152_A156_M0.6060.71
194_M198_E0.6060.71
120_A130_K0.6040.71
84_C88_Q0.6040.71
127_G130_K0.6020.71
42_G81_I0.6010.71
50_S174_N0.5990.70
3_A40_Y0.5990.70
18_K23_A0.5980.70
128_L219_R0.5980.70
158_L193_M0.5960.70
126_K219_R0.5950.70
36_D66_T0.5920.69
58_G190_V0.5910.69
11_T49_F0.5890.69
123_I126_K0.5880.69
92_E95_L0.5870.69
81_I191_I0.5860.69
84_C196_H0.5830.68
119_R184_A0.5760.67
133_I136_P0.5750.67
7_F64_T0.5750.67
20_L23_A0.5740.67
62_A71_K0.5740.67
124_L191_I0.5720.67
57_A140_A0.5700.67
49_F53_D0.5670.66
116_K130_K0.5670.66
36_D40_Y0.5630.66
162_D179_N0.5630.66
13_E110_S0.5620.65
4_I27_T0.5580.65
113_V134_R0.5570.65
139_H196_H0.5520.64
23_A221_G0.5500.64
7_F67_M0.5500.64
114_Y179_N0.5480.64
133_I214_L0.5480.64
61_A89_I0.5470.63
13_E158_L0.5460.63
95_L190_V0.5460.63
47_G88_Q0.5440.63
112_W135_M0.5430.63
114_Y171_V0.5420.63
40_Y73_M0.5400.62
127_G131_K0.5360.62
79_I220_L0.5360.62
49_F194_M0.5350.62
55_L59_S0.5340.62
139_H194_M0.5340.62
156_M183_I0.5330.61
174_N196_H0.5330.61
45_L70_V0.5320.61
12_C16_V0.5300.61
125_T191_I0.5280.61
81_I157_V0.5280.61
47_G196_H0.5280.61
22_E218_R0.5260.60
108_F214_L0.5250.60
66_T70_V0.5240.60
25_V42_G0.5240.60
84_C194_M0.5230.60
18_K33_K0.5230.60
25_V79_I0.5220.60
174_N194_M0.5210.60
197_P213_G0.5210.60
117_V131_K0.5200.60
22_E216_L0.5190.59
5_I14_T0.5170.59
23_A107_R0.5150.59
85_N194_M0.5150.59
45_L90_L0.5130.59
56_R61_A0.5120.58
72_Q148_D0.5120.58
30_V40_Y0.5110.58
188_G191_I0.5100.58
32_Y51_F0.5090.58
139_H198_E0.5080.58
45_L89_I0.5080.58
152_A178_L0.5060.57
35_F38_D0.5060.57
144_Y177_L0.5000.57
200_A210_T0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lgyA 1 1 100 0.421 Contact Map
3d54D 1 0.9241 100 0.639 Contact Map
1l9xA 1 0.9375 99.9 0.746 Contact Map
3fijA 4 0.8393 99.9 0.76 Contact Map
2w7tA 1 0.8661 99.8 0.77 Contact Map
1wl8A 1 0.8036 99.8 0.77 Contact Map
2vxoA 2 0.7902 99.8 0.772 Contact Map
2ywbA 4 0.7902 99.8 0.772 Contact Map
4l8fC 3 0.9107 99.8 0.775 Contact Map
2vpiA 1 0.7634 99.8 0.777 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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