GREMLIN Database
PUR7 - Phosphoribosylaminoimidazole-succinocarboxamide synthase
UniProt: Q9UX20 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (213)
Sequences: 3308 (1652)
Seq/√Len: 113.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_V119_F4.0081.00
145_E180_R3.8911.00
165_K201_G3.2721.00
84_M188_G2.8401.00
181_L184_K2.6851.00
21_H69_V2.6451.00
65_E184_K2.5611.00
91_L153_M2.5301.00
58_L159_V2.5021.00
132_Y150_E2.4881.00
82_L188_G2.4381.00
143_R147_Q2.4011.00
73_D76_T2.2871.00
34_D126_H2.2851.00
80_K181_L2.2791.00
60_E66_T2.1481.00
136_E143_R2.1021.00
18_D21_H2.0921.00
85_I185_L2.0821.00
148_H151_D2.0491.00
168_G202_N2.0381.00
53_A71_M2.0321.00
58_L163_F2.0191.00
16_D81_K1.9891.00
57_R60_E1.8271.00
106_K109_E1.8201.00
94_I172_Y1.8091.00
162_N166_S1.7321.00
82_L181_L1.6841.00
148_H184_K1.6551.00
55_F164_I1.6071.00
13_I25_E1.6061.00
151_D155_K1.5891.00
94_I110_V1.5271.00
148_H152_I1.5211.00
116_V135_M1.5061.00
5_K13_I1.4691.00
37_K211_Y1.4661.00
181_L186_V1.4631.00
22_V79_V1.4621.00
36_Q126_H1.4551.00
33_G36_Q1.4541.00
94_I170_I1.4531.00
17_F78_I1.4401.00
53_A68_Y1.4301.00
33_G216_D1.4281.00
43_G46_V1.4251.00
180_R185_L1.4181.00
29_D40_I1.4001.00
39_D211_Y1.3981.00
95_A109_E1.3891.00
171_L198_I1.3311.00
96_T107_E1.3091.00
8_E13_I1.3091.00
46_V74_E1.3061.00
110_V165_K1.2990.99
89_V149_I1.2880.99
110_V161_F1.2810.99
53_A77_M1.2800.99
93_N157_N1.2800.99
20_D81_K1.2700.99
164_I198_I1.2640.99
145_E185_L1.2640.99
89_V153_M1.2600.99
156_V176_L1.2500.99
26_F49_A1.2410.99
118_F135_M1.2380.99
52_S56_F1.2370.99
209_D213_K1.2280.99
161_F165_K1.2250.99
155_K159_V1.2230.99
46_V50_Q1.2190.99
87_V135_M1.2180.99
14_V24_L1.2150.99
147_Q151_D1.2090.99
158_D162_N1.2040.99
99_I111_F1.2010.99
85_I145_E1.2010.99
169_F198_I1.1970.99
152_I155_K1.1880.99
119_F129_L1.1800.99
163_F167_K1.1790.99
91_L154_M1.1780.99
134_H139_K1.1770.99
30_I211_Y1.1770.99
99_I103_L1.1630.99
105_I109_E1.1600.99
61_R159_V1.1540.99
85_I149_I1.1410.99
132_Y146_A1.1330.99
112_E139_K1.1320.99
142_N145_E1.1260.99
25_E75_R1.1210.98
54_F58_L1.1120.98
83_K180_R1.1030.98
219_T222_S1.0990.98
17_F21_H1.0960.98
46_V75_R1.0950.98
158_D161_F1.0940.98
133_Y150_E1.0910.98
101_K216_D1.0880.98
5_K8_E1.0820.98
87_V130_L1.0820.98
113_S158_D1.0810.98
65_E152_I1.0790.98
99_I105_I1.0750.98
47_L51_T1.0740.98
54_F163_F1.0650.98
21_H78_I1.0540.98
50_Q74_E1.0300.97
95_A100_V1.0280.97
49_A77_M1.0240.97
187_I191_I1.0160.97
136_E146_A1.0150.97
25_E76_T1.0110.97
152_I156_V1.0080.97
13_I27_K1.0030.97
8_E27_K1.0030.97
89_V116_V1.0020.97
96_T108_G0.9960.97
170_I201_G0.9870.97
148_H185_L0.9780.96
57_R68_Y0.9780.96
50_Q71_M0.9700.96
68_Y71_M0.9690.96
95_A111_F0.9680.96
163_F166_S0.9660.96
59_L63_G0.9650.96
107_E203_S0.9620.96
50_Q53_A0.9610.96
69_V80_K0.9540.96
85_I180_R0.9530.96
22_V81_K0.9410.96
53_A57_R0.9350.95
100_V105_I0.9330.95
23_L72_K0.9290.95
112_E161_F0.9270.95
72_K76_T0.9260.95
80_K186_V0.9220.95
28_D42_E0.9210.95
130_L140_L0.9170.95
132_Y147_Q0.9090.95
155_K158_D0.9070.95
70_G78_I0.9040.94
191_I195_S0.8990.94
65_E186_V0.8970.94
135_M146_A0.8880.94
150_E154_M0.8860.94
14_V22_V0.8850.94
68_Y77_M0.8700.93
24_L79_V0.8680.93
205_I213_K0.8630.93
89_V178_F0.8560.93
57_R70_G0.8560.93
51_T193_L0.8530.93
152_I185_L0.8530.93
82_L186_V0.8450.92
136_E139_K0.8430.92
131_N134_H0.8380.92
25_E73_D0.8380.92
55_F198_I0.8350.92
118_F146_A0.8280.91
133_Y136_E0.8270.91
200_D204_R0.8230.91
115_I131_N0.8230.91
102_R134_H0.8220.91
134_H140_L0.8200.91
145_E148_H0.8190.91
141_M149_I0.8160.91
98_S129_L0.8140.91
16_D22_V0.8140.91
5_K15_Y0.8130.91
105_I111_F0.8090.90
156_V191_I0.8060.90
122_D126_H0.8030.90
147_Q150_E0.7910.89
57_R61_R0.7910.89
116_V153_M0.7850.89
103_L134_H0.7820.89
33_G126_H0.7680.88
122_D128_P0.7650.88
95_A105_I0.7590.87
176_L195_S0.7590.87
64_I152_I0.7570.87
30_I41_L0.7570.87
41_L221_K0.7560.87
56_F77_M0.7550.87
100_V213_K0.7480.87
210_L220_V0.7440.86
72_K78_I0.7420.86
162_N165_K0.7380.86
28_D40_I0.7370.86
56_F67_H0.7360.86
39_D221_K0.7360.86
99_I102_R0.7340.86
87_V140_L0.7330.86
100_V109_E0.7310.85
18_D81_K0.7310.85
130_L134_H0.7260.85
132_Y143_R0.7250.85
7_S14_V0.7190.84
83_K183_D0.7170.84
118_F150_E0.7160.84
108_G199_R0.7160.84
107_E205_I0.7150.84
58_L61_R0.7140.84
83_K181_L0.7130.84
116_V154_M0.7130.84
141_M145_E0.7040.83
69_V78_I0.7030.83
65_E80_K0.7010.83
200_D206_Y0.6980.83
111_F114_P0.6980.83
108_G203_S0.6940.82
92_R173_D0.6900.82
95_A99_I0.6880.82
141_M146_A0.6850.81
103_L130_L0.6850.81
37_K216_D0.6810.81
146_A150_E0.6800.81
17_F23_L0.6770.81
116_V149_I0.6670.80
83_K145_E0.6660.80
86_P188_G0.6650.79
88_E127_D0.6650.79
86_P123_D0.6650.79
133_Y154_M0.6560.79
33_G37_K0.6550.78
132_Y135_M0.6520.78
6_I22_V0.6500.78
169_F206_Y0.6490.78
28_D75_R0.6470.78
216_D219_T0.6470.78
57_R71_M0.6460.78
91_L116_V0.6460.78
96_T100_V0.6440.77
63_G155_K0.6430.77
116_V150_E0.6390.77
90_V149_I0.6380.77
101_K209_D0.6370.77
5_K16_D0.6360.76
118_F149_I0.6320.76
149_I185_L0.6290.76
115_I133_Y0.6270.75
168_G201_G0.6270.75
118_F136_E0.6220.75
157_N161_F0.6210.75
49_A53_A0.6160.74
178_F185_L0.6140.74
66_T186_V0.6130.74
100_V106_K0.6120.74
156_V187_I0.6120.74
107_E213_K0.6100.73
130_L135_M0.6010.72
71_M77_M0.5990.72
190_E193_L0.5970.72
96_T216_D0.5970.72
52_S190_E0.5940.71
144_K147_Q0.5930.71
132_Y136_E0.5920.71
55_F160_L0.5920.71
59_L66_T0.5910.71
159_V163_F0.5840.70
114_P154_M0.5790.70
59_L159_V0.5780.69
102_R117_E0.5780.69
216_D222_S0.5770.69
165_K170_I0.5760.69
59_L156_V0.5680.68
166_S184_K0.5670.68
55_F199_R0.5660.68
174_F196_M0.5650.68
167_K198_I0.5650.68
176_L191_I0.5630.67
11_T195_S0.5560.66
49_A76_T0.5560.66
39_D220_V0.5550.66
128_P134_H0.5530.66
69_V182_G0.5500.66
20_D80_K0.5460.65
59_L191_I0.5460.65
148_H155_K0.5460.65
210_L217_L0.5450.65
120_L203_S0.5430.65
94_I196_M0.5420.64
205_I210_L0.5400.64
67_H79_V0.5400.64
172_Y199_R0.5390.64
192_S196_M0.5390.64
101_K213_K0.5370.64
139_K162_N0.5370.64
210_L222_S0.5360.64
5_K14_V0.5350.63
11_T48_N0.5290.63
115_I129_L0.5290.63
24_L77_M0.5270.62
103_L129_L0.5260.62
44_K194_D0.5220.62
159_V162_N0.5200.61
63_G66_T0.5190.61
102_R129_L0.5190.61
23_L76_T0.5180.61
35_G38_R0.5170.61
60_E65_E0.5160.61
96_T213_K0.5150.61
110_V170_I0.5140.60
136_E147_Q0.5140.60
50_Q54_F0.5130.60
119_F134_H0.5130.60
110_V148_H0.5070.59
117_E134_H0.5070.59
16_D21_H0.5050.59
204_R213_K0.5050.59
199_R207_D0.5040.59
54_F57_R0.5030.59
192_S195_S0.5020.59
43_G47_L0.5020.59
96_T102_R0.5010.58
51_T77_M0.5010.58
200_D210_L0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kreA 2 0.9785 100 0.056 Contact Map
2z02A 2 0.9914 100 0.059 Contact Map
3nuaA 2 0.9914 100 0.06 Contact Map
2gqrA 2 0.9914 100 0.061 Contact Map
4fe2A 2 0.9871 100 0.062 Contact Map
2ywvA 2 0.9914 100 0.066 Contact Map
1kutA 2 0.9399 100 0.073 Contact Map
4ja0A 6 0.9657 100 0.075 Contact Map
3u55A 2 0.9442 100 0.075 Contact Map
2h31A 6 0.8755 100 0.081 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0084 seconds.