GREMLIN Database
PYRF - Orotidine 5'-phosphate decarboxylase
UniProt: Q9UX10 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 222 (198)
Sequences: 4161 (2497)
Seq/√Len: 177.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_L80_N3.0141.00
86_S107_N2.9661.00
20_K52_D2.8911.00
42_D45_R2.8811.00
195_N198_T2.6441.00
70_K99_R2.5711.00
88_I93_S2.5501.00
186_I189_S2.3711.00
115_S170_G2.2061.00
90_V95_D2.1941.00
146_L171_G2.1891.00
18_V22_M2.1871.00
98_K102_D2.1431.00
90_V121_T2.1211.00
94_L136_P2.0181.00
116_H120_S1.9791.00
174_G178_C1.9261.00
12_K46_E1.9141.00
92_G170_G1.9061.00
92_G95_D1.8831.00
153_R182_D1.8641.00
16_Y46_E1.8561.00
33_L37_L1.8531.00
129_N155_D1.8531.00
193_A199_A1.7901.00
175_D178_C1.7881.00
90_V133_E1.7321.00
171_G179_A1.7281.00
198_T202_T1.7231.00
12_K16_Y1.7161.00
58_V76_L1.6951.00
7_I28_G1.6931.00
62_L76_L1.6841.00
125_D155_D1.6801.00
172_S175_D1.6691.00
202_T206_I1.6531.00
6_V186_I1.6471.00
12_K49_I1.6251.00
153_R161_I1.6191.00
92_G118_G1.6071.00
58_V79_A1.5631.00
95_D99_R1.5601.00
197_L201_R1.5371.00
174_G206_I1.4911.00
115_S118_G1.4881.00
25_E201_R1.4641.00
132_R156_F1.4481.00
8_L26_L1.4451.00
19_L29_I1.4411.00
29_I54_E1.4091.00
35_L43_K1.4041.00
60_F82_F1.4041.00
9_A187_G1.3501.00
37_L62_L1.3491.00
202_T205_K1.3441.00
71_S74_E1.3411.00
31_V47_L1.3251.00
35_L39_L1.3191.00
74_E103_A1.3161.00
125_D129_N1.3121.00
15_S36_V1.3061.00
69_M97_L1.2981.00
139_I161_I1.2961.00
12_K39_L1.2911.00
55_E80_N1.2881.00
150_T179_A1.2761.00
20_K53_V1.2621.00
181_A184_E1.2521.00
70_K100_Y1.2381.00
199_A202_T1.2351.00
167_G170_G1.2321.00
150_T154_R1.2291.00
125_D151_Q1.2261.00
73_V82_F1.2251.00
13_P17_Q1.2171.00
25_E204_N1.2131.00
7_I183_Y1.2061.00
139_I159_M1.2051.00
8_L190_I1.2011.00
17_Q21_E1.1991.00
56_I79_A1.1971.00
38_D75_R1.1921.00
8_L191_Y1.1911.00
22_M29_I1.1901.00
14_L17_Q1.1701.00
141_V161_I1.1671.00
33_L58_V1.1651.00
28_G55_E1.1621.00
152_Y161_I1.1601.00
84_A94_L1.1571.00
94_L134_I1.1411.00
175_D179_A1.1361.00
67_Y71_S1.1181.00
152_Y156_F1.1161.00
8_L18_V1.1081.00
90_V134_I1.1041.00
69_M93_S1.1011.00
198_T201_R1.0961.00
98_K137_K1.0851.00
71_S75_R1.0791.00
45_R49_I1.0751.00
83_I108_L1.0751.00
110_L114_M1.0711.00
6_V200_L1.0601.00
114_M118_G1.0561.00
100_Y104_N1.0531.00
92_G96_E1.0491.00
111_V114_M1.0381.00
96_E99_R1.0340.99
87_F127_I1.0300.99
21_E196_P1.0220.99
86_S127_I1.0210.99
5_R177_V0.9910.99
163_S181_A0.9870.99
129_N133_E0.9810.99
33_L76_L0.9780.99
151_Q154_R0.9740.99
84_A97_L0.9650.99
16_Y20_K0.9620.99
83_I94_L0.9510.99
46_E49_I0.9490.99
73_V101_L0.9480.99
87_F110_L0.9430.99
16_Y53_V0.9410.99
151_Q155_D0.9370.99
12_K43_K0.9360.99
28_G57_I0.9350.99
10_M15_S0.9340.99
201_R205_K0.9330.99
112_A139_I0.9310.99
122_L130_V0.9290.99
70_K74_E0.9210.99
117_E121_T0.9180.99
156_F159_M0.9110.99
203_I206_I0.9040.99
62_L72_I0.8980.99
82_F108_L0.8870.98
109_Y138_G0.8820.98
16_Y19_L0.8700.98
149_I181_A0.8640.98
161_I182_D0.8640.98
4_S27_Y0.8640.98
99_R103_A0.8520.98
18_V191_Y0.8430.98
87_F114_M0.8380.98
197_L200_L0.8340.98
28_G81_S0.8310.98
21_E195_N0.8270.98
103_A106_K0.8240.97
69_M88_I0.8230.97
171_G175_D0.8210.97
6_V207_I0.8190.97
34_P71_S0.8180.97
113_V119_W0.8170.97
141_V152_Y0.8110.97
147_D171_G0.8070.97
132_R158_K0.8010.97
43_K46_E0.8010.97
7_I162_V0.7940.97
67_Y70_K0.7910.97
177_V184_E0.7800.96
12_K42_D0.7780.96
146_L166_M0.7750.96
47_L54_E0.7670.96
166_M186_I0.7660.96
118_G122_L0.7620.96
27_Y54_E0.7610.96
167_G189_S0.7590.96
126_Y130_V0.7570.96
74_E100_Y0.7570.96
39_L43_K0.7550.96
139_I156_F0.7540.96
71_S192_N0.7510.96
34_P191_Y0.7470.96
102_D105_S0.7400.95
129_N132_R0.7390.95
4_S55_E0.7310.95
199_A203_I0.7290.95
82_F101_L0.7260.95
90_V130_V0.7220.95
62_L69_M0.7200.95
27_Y200_L0.7190.94
74_E78_F0.7160.94
33_L72_I0.7150.94
90_V94_L0.7110.94
167_G192_N0.7110.94
189_S203_I0.6970.94
21_E197_L0.6920.93
41_V45_R0.6900.93
149_I161_I0.6880.93
36_V41_V0.6800.93
73_V97_L0.6790.93
107_N136_P0.6770.93
196_P199_A0.6760.92
70_K96_E0.6740.92
31_V35_L0.6730.92
166_M184_E0.6720.92
48_L52_D0.6720.92
10_M29_I0.6660.92
28_G80_N0.6610.92
8_L22_M0.6580.91
160_T182_D0.6580.91
63_A114_M0.6570.91
107_N131_I0.6540.91
177_V207_I0.6510.91
37_L75_R0.6510.91
189_S192_N0.6510.91
44_T56_I0.6490.91
27_Y183_Y0.6490.91
131_I135_S0.6480.91
112_A128_K0.6470.91
10_M31_V0.6460.91
113_V148_H0.6420.90
36_V75_R0.6400.90
130_V133_E0.6370.90
49_I52_D0.6350.90
131_I139_I0.6340.90
13_P16_Y0.6310.90
96_E100_Y0.6300.90
72_I75_R0.6240.89
118_G121_T0.6230.89
33_L60_F0.6230.89
10_M19_L0.6160.89
22_M197_L0.6130.88
86_S131_I0.6130.88
6_V204_N0.6110.88
190_I200_L0.6100.88
186_I203_I0.6090.88
25_E197_L0.6080.88
41_V48_L0.6080.88
38_D74_E0.6040.88
23_E29_I0.6040.88
186_I190_I0.6000.87
173_Y184_E0.6000.87
203_I207_I0.5990.87
14_L21_E0.5970.87
128_K156_F0.5950.87
81_S140_V0.5940.87
153_R183_Y0.5930.87
26_L200_L0.5820.86
60_F76_L0.5810.86
62_L73_V0.5800.85
131_I136_P0.5770.85
22_M54_E0.5770.85
109_Y139_I0.5720.85
127_I135_S0.5680.84
36_V60_F0.5680.84
139_I152_Y0.5670.84
132_R157_E0.5670.84
126_Y129_N0.5670.84
29_I47_L0.5650.84
124_A131_I0.5650.84
44_T48_L0.5640.84
108_L137_K0.5630.84
77_S105_S0.5610.84
26_L29_I0.5610.84
41_V44_T0.5600.83
18_V29_I0.5580.83
118_G123_F0.5570.83
113_V146_L0.5550.83
77_S104_N0.5520.83
131_I134_I0.5510.82
76_L82_F0.5500.82
194_G198_T0.5490.82
166_M176_A0.5480.82
23_E54_E0.5470.82
108_L111_V0.5460.82
74_E104_N0.5450.82
124_A127_I0.5440.82
172_S206_I0.5430.82
95_D133_E0.5430.82
22_M200_L0.5390.81
172_S176_A0.5350.81
161_I183_Y0.5350.81
37_L76_L0.5320.80
83_I159_M0.5320.80
75_R78_F0.5310.80
200_L204_N0.5280.80
196_P203_I0.5280.80
81_S183_Y0.5270.80
85_H93_S0.5250.79
64_D68_I0.5220.79
33_L44_T0.5220.79
98_K108_L0.5210.79
157_E161_I0.5210.79
67_Y94_L0.5180.78
98_K101_L0.5180.78
115_S167_G0.5180.78
28_G183_Y0.5160.78
38_D78_F0.5160.78
176_A180_G0.5130.78
97_L100_Y0.5080.77
15_S43_K0.5040.77
128_K135_S0.5040.77
117_E120_S0.5040.77
17_Q20_K0.5020.76
73_V100_Y0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mjzA 2 0.9685 100 0.22 Contact Map
3qw4B 4 0.982 100 0.224 Contact Map
3n3mA 2 0.964 100 0.234 Contact Map
3qw3A 2 0.9324 100 0.24 Contact Map
2fdsA 2 0.9459 100 0.245 Contact Map
3r89A 2 0.9505 100 0.248 Contact Map
3v75A 2 0.9414 100 0.25 Contact Map
2ffcA 2 0.9505 100 0.267 Contact Map
3gdmA 2 0.9369 100 0.292 Contact Map
3g3dA 2 0.9324 100 0.384 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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