GREMLIN Database
PYRE - Orotate phosphoribosyltransferase
UniProt: Q9UX09 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 195 (169)
Sequences: 3469 (1773)
Seq/√Len: 136.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_Q165_S4.0511.00
19_V25_V3.9341.00
17_S25_V3.8761.00
106_R133_K3.8651.00
127_I132_G3.7521.00
139_V160_S2.7791.00
125_L129_N2.2221.00
124_T156_V2.2161.00
62_G71_S2.1921.00
45_V49_I2.1121.00
71_S82_M1.9931.00
46_N77_N1.9551.00
148_S152_E1.9501.00
58_D105_K1.9131.00
14_L18_F1.9081.00
61_V83_G1.8511.00
106_R135_S1.8511.00
56_P106_R1.8331.00
88_E91_G1.8321.00
59_I105_K1.8181.00
136_D159_H1.8141.00
125_L154_L1.7911.00
120_I137_A1.7411.00
149_Q153_K1.7251.00
43_D77_N1.7251.00
73_F76_C1.7181.00
5_E9_E1.7071.00
125_L128_L1.6991.00
114_A158_L1.6911.00
47_Q50_K1.6371.00
128_L133_K1.6271.00
128_L156_V1.5941.00
52_A108_L1.5711.00
111_D114_A1.5591.00
144_Q163_K1.5481.00
102_V132_G1.5481.00
102_V105_K1.5341.00
20_L26_S1.5201.00
52_A138_L1.4531.00
51_K159_H1.4491.00
57_H108_L1.4461.00
30_L141_I1.4351.00
139_V158_L1.4251.00
43_D79_K1.4031.00
163_K166_E1.3961.00
151_L158_L1.3941.00
105_K132_G1.3881.00
136_D157_K1.3811.00
114_A147_A1.3531.00
64_A68_V1.3501.00
48_A52_A1.3271.00
58_D106_R1.3201.00
72_A82_M1.3171.00
109_L120_I1.3001.00
150_R153_K1.2711.00
134_V156_V1.2711.00
114_A139_V1.2621.00
49_I78_L1.2611.00
59_I83_G1.2611.00
97_T126_E1.2561.00
44_I49_I1.2351.00
121_E154_L1.2321.00
35_L44_I1.2311.00
48_A161_L1.2291.00
6_V41_F1.2141.00
46_N49_I1.2091.00
97_T129_N1.1540.99
137_A156_V1.1350.99
108_L136_D1.1310.99
45_V73_F1.1290.99
109_L124_T1.1050.99
81_P105_K1.1040.99
39_P79_K1.0940.99
6_V9_E1.0870.99
85_I126_E1.0830.99
48_A51_K1.0820.99
45_V48_A1.0800.99
34_P101_D1.0710.99
46_N50_K1.0630.99
58_D104_G1.0630.99
55_I136_D1.0570.99
49_I52_A1.0540.99
14_L94_T1.0480.99
74_I110_V1.0390.99
32_L113_V1.0330.99
17_S27_P1.0270.99
128_L154_L1.0150.98
44_I48_A1.0040.98
44_I51_K0.9840.98
45_V52_A0.9810.98
54_D159_H0.9780.98
66_G69_P0.9780.98
21_T91_G0.9760.98
60_I71_S0.9730.98
142_D146_G0.9690.98
109_L134_V0.9660.98
24_K145_E0.9490.98
45_V51_K0.9250.97
120_I151_L0.9100.97
65_T68_V0.9080.97
121_E150_R0.8990.97
15_I28_Y0.8980.97
160_S163_K0.8930.96
75_A81_P0.8900.96
68_V84_Y0.8890.96
22_S115_T0.8850.96
111_D120_I0.8800.96
121_E153_K0.8800.96
40_E79_K0.8690.96
118_V122_K0.8650.96
73_F77_N0.8630.96
124_T128_L0.8610.96
89_K97_T0.8600.96
3_F162_F0.8570.96
44_I47_Q0.8510.95
55_I58_D0.8470.95
14_L34_P0.8440.95
137_A151_L0.8380.95
128_L134_V0.8360.95
109_L127_I0.8350.95
141_I167_I0.8320.95
15_I27_P0.8310.95
75_A82_M0.8290.95
47_Q51_K0.8230.94
5_E170_E0.8220.94
57_H80_E0.8210.94
13_L30_L0.8210.94
67_G84_Y0.8170.94
119_S124_T0.8040.94
145_E149_Q0.8020.94
7_L30_L0.7980.94
21_T118_V0.7910.93
12_L35_L0.7910.93
45_V74_I0.7700.92
122_K125_L0.7690.92
4_A162_F0.7590.92
9_E41_F0.7550.92
20_L115_T0.7520.91
142_D163_K0.7510.91
140_I161_L0.7510.91
7_L35_L0.7390.91
101_D105_K0.7380.91
43_D46_N0.7290.90
14_L63_I0.7260.90
67_G83_G0.7230.90
123_A126_E0.7220.90
164_I168_L0.7200.90
146_G149_Q0.7190.89
63_I66_G0.7190.89
46_N52_A0.7170.89
21_T92_H0.7140.89
31_D96_R0.7140.89
152_E155_G0.7120.89
44_I50_K0.7110.89
111_D139_V0.7090.89
83_G132_G0.7080.89
166_E169_D0.7020.88
91_G129_N0.7000.88
11_K14_L0.6980.88
129_N133_K0.6970.88
70_L110_V0.6970.88
149_Q152_E0.6960.88
107_V127_I0.6940.88
128_L155_G0.6940.88
59_I132_G0.6910.88
152_E157_K0.6850.87
85_I127_I0.6850.87
65_T84_Y0.6840.87
37_N79_K0.6790.87
147_A158_L0.6760.86
36_P73_F0.6680.86
48_A138_L0.6570.85
104_G131_G0.6560.85
35_L140_I0.6530.84
4_A171_L0.6460.84
22_S26_S0.6440.84
28_Y164_I0.6430.84
83_G102_V0.6300.82
8_L15_I0.6300.82
7_L32_L0.6290.82
138_L159_H0.6260.82
20_L143_R0.6260.82
64_A67_G0.6260.82
63_I123_A0.6230.82
13_L28_Y0.6170.81
96_R99_E0.6100.80
21_T119_S0.6070.80
64_A87_I0.6050.80
102_V127_I0.6000.79
33_R65_T0.5980.79
131_G134_V0.5960.79
46_N51_K0.5940.78
121_E124_T0.5940.78
146_G150_R0.5880.78
58_D80_E0.5860.77
45_V70_L0.5810.77
108_L135_S0.5800.77
33_R99_E0.5800.77
6_V47_Q0.5790.77
49_I74_I0.5790.77
66_G85_I0.5750.76
31_D63_I0.5740.76
45_V50_K0.5730.76
103_K130_G0.5690.75
61_V85_I0.5690.75
35_L70_L0.5680.75
43_D167_I0.5670.75
8_L171_L0.5670.75
88_E96_R0.5670.75
6_V10_R0.5670.75
39_P42_Y0.5660.75
67_G71_S0.5650.75
37_N83_G0.5620.75
21_T63_I0.5600.74
137_A158_L0.5580.74
43_D76_C0.5570.74
29_Y94_T0.5560.74
92_H95_N0.5540.73
7_L12_L0.5540.73
111_D123_A0.5520.73
21_T120_I0.5500.73
44_I52_A0.5500.73
10_R41_F0.5480.73
57_H60_I0.5430.72
59_I102_V0.5430.72
135_S157_K0.5420.72
69_P86_R0.5420.72
74_I138_L0.5420.72
83_G98_L0.5400.72
104_G132_G0.5380.71
116_T119_S0.5370.71
83_G127_I0.5360.71
108_L138_L0.5360.71
37_N81_P0.5350.71
17_S171_L0.5340.71
61_V127_I0.5330.71
44_I161_L0.5310.70
39_P81_P0.5310.70
42_Y76_C0.5310.70
59_I107_V0.5280.70
29_Y33_R0.5270.70
124_T154_L0.5260.70
55_I108_L0.5180.68
45_V77_N0.5170.68
11_K101_D0.5170.68
104_G133_K0.5170.68
124_T134_V0.5160.68
91_G122_K0.5150.68
46_N129_N0.5130.68
61_V123_A0.5120.68
111_D161_L0.5100.67
53_K159_H0.5030.66
32_L140_I0.5000.66
21_T65_T0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qw4B 4 0.959 100 0.293 Contact Map
3n2lA 4 0.9436 100 0.317 Contact Map
3mjdA 2 0.9487 100 0.32 Contact Map
2wnsA 2 0.9949 100 0.335 Contact Map
1lh0A 2 0.9846 100 0.341 Contact Map
2ps1A 2 0.9897 100 0.351 Contact Map
3m3hA 2 0.9385 100 0.36 Contact Map
4ohcA 5 1 100 0.364 Contact Map
3dezA 2 0.959 100 0.374 Contact Map
2aeeA 4 0.9795 100 0.389 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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