GREMLIN Database
PYRB - Aspartate carbamoyltransferase
UniProt: Q9UX08 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (291)
Sequences: 7070 (3725)
Seq/√Len: 218.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
244_L269_R4.0601.00
151_T178_K3.9161.00
151_T180_F3.4051.00
34_N37_S3.3791.00
153_A214_I3.1561.00
256_I266_I3.1071.00
208_Y249_M2.9931.00
28_Y142_K2.7831.00
140_V216_V2.7701.00
23_L294_Y2.7081.00
92_N116_D2.6291.00
215_D251_K2.5931.00
93_N280_Y2.5921.00
143_A277_K2.5351.00
255_I277_K2.5101.00
206_N209_D2.5101.00
25_D141_Y2.4621.00
42_S95_S2.3091.00
22_E141_Y2.2781.00
8_S128_E2.2621.00
85_A110_F2.2361.00
60_A65_A2.1601.00
257_L277_K2.1471.00
41_V60_A2.0981.00
25_D138_Y2.0961.00
18_F141_Y2.0851.00
97_C293_F2.0681.00
191_R195_D2.0431.00
133_A170_A2.0051.00
185_S205_E1.9371.00
137_L170_A1.9051.00
182_I210_V1.9041.00
144_F253_D1.8981.00
188_K205_E1.8931.00
211_I217_L1.8771.00
62_K290_M1.8391.00
14_R18_F1.8311.00
244_L248_N1.8131.00
61_I66_D1.7961.00
143_A280_Y1.7941.00
93_N283_S1.7841.00
247_V254_G1.7831.00
171_L179_V1.7801.00
99_V122_A1.7521.00
178_K202_I1.7181.00
13_T16_D1.7091.00
19_R295_E1.6491.00
54_Q91_L1.6381.00
180_F204_T1.6381.00
104_F107_A1.6271.00
250_M254_G1.6221.00
204_T209_D1.6061.00
71_A75_S1.5961.00
27_F294_Y1.5961.00
131_T292_L1.5621.00
144_F150_R1.5381.00
41_V97_C1.5371.00
254_G275_N1.5321.00
245_K248_N1.5221.00
20_I295_E1.5101.00
187_L236_V1.5061.00
178_K200_P1.5031.00
185_S188_K1.4961.00
14_R173_R1.4811.00
167_L218_Y1.4701.00
23_L295_E1.4681.00
46_F107_A1.4671.00
128_E169_R1.4511.00
216_V255_I1.4431.00
153_A182_I1.4421.00
14_R148_D1.4181.00
232_E236_V1.4151.00
6_V134_V1.4081.00
35_Y294_Y1.4011.00
208_Y246_L1.3941.00
97_C297_L1.3861.00
24_A138_Y1.3731.00
131_T289_R1.3561.00
218_Y281_Q1.3431.00
153_A180_F1.3351.00
4_R16_D1.3341.00
183_S188_K1.3321.00
89_R272_K1.3271.00
21_F138_Y1.3241.00
207_P246_L1.3231.00
213_E251_K1.3171.00
88_I111_A1.3141.00
10_L196_E1.3131.00
217_L242_V1.2901.00
155_L211_I1.2851.00
243_D267_D1.2791.00
21_F141_Y1.2571.00
212_Q249_M1.2521.00
26_K30_V1.2481.00
50_T87_T1.2431.00
23_L26_K1.2411.00
9_S170_A1.2331.00
89_R279_F1.2331.00
10_L169_R1.2281.00
219_V242_V1.2281.00
241_V267_D1.2271.00
41_V99_V1.2131.00
138_Y288_V1.2091.00
287_P290_M1.1991.00
247_V256_I1.1981.00
18_F174_F1.1941.00
6_V292_L1.1931.00
109_L113_E1.1921.00
146_E150_R1.1911.00
53_A57_H1.1771.00
263_V268_R1.1761.00
50_T81_G1.1691.00
85_A114_I1.1631.00
5_H112_S1.1571.00
204_T210_V1.1511.00
194_L203_E1.1481.00
98_I117_I1.1241.00
180_F202_I1.1211.00
247_V275_N1.1211.00
98_I111_A1.1121.00
61_I67_V1.1091.00
50_T77_S1.1051.00
211_I246_L1.0901.00
134_V292_L1.0751.00
171_L176_P1.0681.00
106_G110_F1.0681.00
242_V256_I1.0671.00
150_R216_V1.0621.00
60_A67_V1.0611.00
59_A293_F1.0591.00
144_F215_D1.0571.00
21_F25_D1.0551.00
262_R272_K1.0541.00
283_S287_P1.0531.00
6_V12_L1.0511.00
8_S11_D1.0511.00
18_F22_E1.0421.00
25_D142_K1.0401.00
28_Y284_L1.0391.00
90_M282_A1.0361.00
48_P79_A1.0281.00
168_L181_L1.0131.00
273_T276_A1.0121.00
152_F171_L1.0101.00
144_F255_I1.0031.00
133_A167_L0.9981.00
271_D278_Y0.9941.00
89_R114_I0.9821.00
182_I204_T0.9821.00
152_F167_L0.9811.00
294_Y298_G0.9741.00
62_K286_V0.9711.00
77_S80_K0.9691.00
120_I292_L0.9681.00
57_H69_G0.9641.00
137_L174_F0.9581.00
133_A163_T0.9541.00
17_Y174_F0.9501.00
158_L183_S0.9451.00
41_V65_A0.9421.00
17_Y173_R0.9391.00
54_Q70_F0.9361.00
142_K284_L0.9341.00
108_A124_D0.9300.99
8_S169_R0.9280.99
92_N117_I0.9240.99
21_F288_V0.9180.99
209_D212_Q0.9170.99
165_N193_I0.9160.99
102_H124_D0.9110.99
205_E240_Y0.9090.99
77_S81_G0.9080.99
140_V150_R0.9050.99
85_A89_R0.9030.99
245_K249_M0.9030.99
146_E149_G0.9020.99
97_C120_I0.9010.99
236_V239_S0.9000.99
28_Y138_Y0.9000.99
85_A272_K0.8980.99
208_Y212_Q0.8910.99
5_H92_N0.8890.99
30_V33_L0.8890.99
40_V66_D0.8860.99
144_F277_K0.8810.99
151_T213_E0.8760.99
34_N64_G0.8760.99
232_E235_K0.8750.99
57_H67_V0.8730.99
128_E166_S0.8710.99
3_L295_E0.8700.99
180_F214_I0.8690.99
105_D109_L0.8690.99
77_S87_T0.8660.99
100_M111_A0.8650.99
40_V62_K0.8620.99
244_L273_T0.8610.99
5_H115_S0.8600.99
57_H61_I0.8600.99
147_I174_F0.8600.99
9_S133_A0.8540.99
22_E26_K0.8510.99
134_V288_V0.8480.99
280_Y283_S0.8480.99
189_V203_E0.8460.99
182_I214_I0.8450.99
138_Y142_K0.8450.99
262_R271_D0.8430.99
60_A293_F0.8420.99
158_L164_V0.8370.99
180_F213_E0.8360.99
234_E264_T0.8340.99
168_L197_L0.8230.99
56_F131_T0.8190.99
25_D29_D0.8150.99
3_L296_V0.8090.99
182_I207_P0.8080.99
26_K29_D0.8080.99
127_H190_R0.8070.99
247_V270_V0.8030.99
88_I115_S0.8010.98
268_R272_K0.7990.98
19_R23_L0.7990.98
202_I209_D0.7970.98
100_M107_A0.7970.98
46_F78_I0.7950.98
109_L112_S0.7910.98
140_V147_I0.7870.98
155_L217_L0.7860.98
208_Y245_K0.7840.98
139_T277_K0.7820.98
72_S75_S0.7810.98
39_K96_N0.7810.98
247_V250_M0.7760.98
270_V273_T0.7750.98
168_L179_V0.7680.98
7_V112_S0.7630.98
155_L246_L0.7630.98
85_A268_R0.7580.98
76_T81_G0.7580.98
110_F114_I0.7570.98
20_I288_V0.7560.98
140_V144_F0.7560.98
151_T214_I0.7530.98
210_V214_I0.7530.98
17_Y170_A0.7510.98
55_S94_Y0.7500.98
40_V58_T0.7440.98
24_A291_A0.7420.98
268_R271_D0.7370.97
243_D246_L0.7370.97
164_V181_L0.7370.97
89_R92_N0.7330.97
168_L189_V0.7320.97
9_S17_Y0.7310.97
231_V234_E0.7310.97
76_T80_K0.7300.97
194_L201_V0.7290.97
12_L20_I0.7220.97
144_F216_V0.7180.97
217_L254_G0.7170.97
36_L97_C0.7160.97
291_A295_E0.7160.97
277_K280_Y0.7150.97
110_F113_E0.7150.97
139_T284_L0.7130.97
242_V266_I0.7100.97
92_N115_S0.7070.97
262_R268_R0.7060.97
140_V171_L0.7060.97
167_L171_L0.7040.97
23_L27_F0.7000.96
102_H107_A0.6960.96
20_I291_A0.6930.96
59_A289_R0.6920.96
42_S98_I0.6910.96
55_S289_R0.6900.96
145_G149_G0.6900.96
15_D18_F0.6880.96
6_V296_V0.6870.96
50_T80_K0.6850.96
244_L267_D0.6850.96
81_G87_T0.6840.96
34_N38_G0.6840.96
235_K238_E0.6820.96
4_R295_E0.6810.96
247_V266_I0.6810.96
143_A255_I0.6800.96
95_S117_I0.6780.96
106_G109_L0.6740.96
176_P179_V0.6730.96
188_K191_R0.6710.96
211_I249_M0.6700.95
140_V255_I0.6700.95
193_I197_L0.6700.95
84_L107_A0.6700.95
221_R225_E0.6690.95
43_L60_A0.6690.95
152_F218_Y0.6670.95
238_E241_V0.6670.95
9_S12_L0.6670.95
189_V194_L0.6660.95
36_L65_A0.6640.95
223_Q231_V0.6620.95
24_A288_V0.6610.95
41_V293_F0.6590.95
246_L249_M0.6580.95
48_P77_S0.6570.95
153_A210_V0.6570.95
27_F35_Y0.6530.95
273_T278_Y0.6510.95
155_L207_P0.6470.95
207_P211_I0.6470.95
105_D126_K0.6430.94
137_L141_Y0.6420.94
256_I270_V0.6400.94
62_K96_N0.6380.94
48_P81_G0.6370.94
43_L67_V0.6350.94
140_V152_F0.6350.94
228_V231_V0.6340.94
17_Y134_V0.6320.94
27_F30_V0.6320.94
104_F126_K0.6320.94
97_C296_V0.6310.94
43_L69_G0.6300.94
120_I296_V0.6260.94
154_L159_K0.6250.93
188_K203_E0.6240.93
218_Y221_R0.6210.93
56_F289_R0.6180.93
218_Y257_L0.6180.93
248_N275_N0.6170.93
230_E233_Y0.6160.93
40_V61_I0.6110.93
47_E226_R0.6100.93
55_S131_T0.6100.93
244_L275_N0.6100.93
83_N272_K0.6080.93
20_I292_L0.6060.92
58_T68_I0.6060.92
50_T76_T0.6010.92
48_P75_S0.6000.92
217_L247_V0.6000.92
263_V269_R0.5980.92
133_A281_Q0.5970.92
155_L219_V0.5970.92
183_S189_V0.5960.92
148_D175_K0.5930.92
170_A174_F0.5920.92
120_I293_F0.5910.91
172_T199_Y0.5890.91
7_V109_L0.5870.91
124_D127_H0.5850.91
45_F49_S0.5840.91
237_K267_D0.5840.91
49_S52_T0.5820.91
9_S128_E0.5810.91
231_V264_T0.5770.90
271_D276_A0.5770.90
46_F102_H0.5760.90
153_A204_T0.5740.90
88_I98_I0.5730.90
106_G127_H0.5730.90
56_F99_V0.5700.90
141_Y146_E0.5700.90
58_T286_V0.5690.90
163_T218_Y0.5690.90
56_F122_A0.5680.90
271_D279_F0.5660.90
87_T91_L0.5650.90
90_M93_N0.5650.90
137_L147_I0.5650.90
153_A217_L0.5650.90
58_T62_K0.5640.89
11_D173_R0.5630.89
55_S90_M0.5620.89
70_F76_T0.5610.89
45_F52_T0.5590.89
229_D232_E0.5590.89
152_F176_P0.5580.89
15_D19_R0.5580.89
175_K200_P0.5570.89
133_A137_L0.5570.89
169_R196_E0.5570.89
142_K280_Y0.5550.89
84_L100_M0.5540.89
22_E25_D0.5530.89
106_G124_D0.5520.88
6_V17_Y0.5500.88
147_I176_P0.5490.88
216_V257_L0.5480.88
175_K178_K0.5450.88
90_M279_F0.5430.88
159_K187_L0.5400.87
145_G255_I0.5380.87
16_D19_R0.5380.87
33_L37_S0.5360.87
172_T179_V0.5360.87
182_I211_I0.5360.87
49_S53_A0.5340.87
123_G225_E0.5330.87
186_Q236_V0.5320.87
163_T167_L0.5320.87
21_F24_A0.5300.86
19_R22_E0.5290.86
47_E225_E0.5290.86
82_E86_D0.5290.86
293_F297_L0.5280.86
242_V247_V0.5270.86
256_I276_A0.5270.86
36_L293_F0.5240.86
150_R215_D0.5210.85
28_Y287_P0.5190.85
10_L128_E0.5190.85
178_K199_Y0.5190.85
273_T277_K0.5190.85
23_L291_A0.5170.85
8_S109_L0.5160.85
17_Y21_F0.5160.85
234_E238_E0.5120.84
90_M94_Y0.5120.84
75_S79_A0.5110.84
186_Q235_K0.5110.84
33_L64_G0.5110.84
227_F230_E0.5090.84
260_L279_F0.5090.84
154_L218_Y0.5070.84
233_Y237_K0.5070.84
255_I275_N0.5060.84
205_E209_D0.5050.84
48_P69_G0.5030.83
98_I115_S0.5020.83
242_V246_L0.5010.83
285_A289_R0.5010.83
211_I250_M0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ml4A 3 0.9868 100 0.017 Contact Map
1pg5A 4 0.9538 100 0.024 Contact Map
3csuA 3 0.9934 100 0.026 Contact Map
4iv5A 4 0.934 100 0.028 Contact Map
4nf2A 3 0.9703 100 0.032 Contact Map
3gd5A 4 0.901 100 0.041 Contact Map
4oh7A 3 0.967 100 0.043 Contact Map
2i6uA 3 0.9736 100 0.045 Contact Map
4eknB 5 0.9736 100 0.045 Contact Map
1pvvA 6 0.9769 100 0.047 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0091 seconds.