GREMLIN Database
PYRI - Aspartate carbamoyltransferase regulatory chain
UniProt: Q9UX07 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 159 (140)
Sequences: 758 (470)
Seq/√Len: 39.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_R74_E3.8001.00
105_K135_I3.0581.00
49_V52_V2.9201.00
29_A61_D2.8671.00
17_N91_R2.8511.00
91_R96_T2.6541.00
28_R31_A2.6441.00
69_V91_R2.5261.00
32_V63_V2.4761.00
108_R129_R2.4391.00
131_I143_K2.3711.00
80_L107_I2.3671.00
33_L61_D2.2951.00
108_R127_E2.0990.99
35_I78_I2.0910.99
42_E59_R2.0030.99
27_G61_D1.9670.99
129_R143_K1.9260.99
36_L74_E1.8810.98
111_I140_L1.6820.96
133_I148_Y1.6800.96
37_G40_G1.6430.96
25_P82_A1.6350.96
39_R120_T1.6110.95
103_V139_K1.5700.95
134_S137_P1.5340.94
80_L149_I1.5060.94
19_T68_R1.5040.93
106_Q143_K1.4960.93
106_Q129_R1.4900.93
109_G127_E1.4750.93
15_I90_I1.4740.93
61_D86_T1.4560.92
32_V149_I1.4520.92
105_K108_R1.3620.90
17_N32_V1.3560.89
100_H135_I1.3450.89
132_T140_L1.3090.88
88_N109_G1.2980.87
122_N128_S1.2710.86
12_V53_E1.2340.84
52_V61_D1.2330.84
47_A62_I1.2070.83
121_N128_S1.1920.82
15_I20_V1.1770.81
32_V38_I1.1740.81
21_I87_I1.1690.81
32_V81_I1.1680.81
82_A85_A1.1680.81
47_A147_M1.1610.80
29_A38_I1.1400.79
20_V90_I1.1280.78
17_N149_I1.1140.78
133_I141_K1.0880.76
14_K52_V1.0640.74
35_I95_V1.0580.74
36_L81_I1.0560.74
37_G97_E1.0530.73
91_R97_E1.0520.73
59_R96_T1.0360.72
20_V46_V1.0340.72
61_D66_E1.0160.71
15_I33_L1.0140.71
89_I97_E1.0070.70
83_P138_L0.9950.69
33_L50_M0.9930.69
69_V81_I0.9920.69
134_S139_K0.9910.69
78_I85_A0.9880.68
78_I101_L0.9800.68
133_I146_E0.9720.67
105_K132_T0.9720.67
38_I123_D0.9710.67
16_R92_D0.9680.67
27_G104_P0.9640.67
53_E90_I0.9610.66
120_T133_I0.9570.66
33_L48_L0.9540.66
103_V138_L0.9450.65
57_I84_S0.9320.64
20_V24_I0.9290.64
72_E112_K0.9240.63
109_G129_R0.9240.63
12_V88_N0.9210.63
16_R99_R0.9080.62
15_I69_V0.9060.62
15_I45_R0.8980.61
17_N83_P0.8910.60
15_I50_M0.8900.60
12_V49_V0.8880.60
126_A148_Y0.8850.60
32_V75_A0.8640.58
90_I99_R0.8630.58
73_K92_D0.8510.57
47_A52_V0.8360.56
74_E93_Y0.8320.55
12_V47_A0.8310.55
83_P100_H0.8280.55
120_T128_S0.8280.55
33_L82_A0.8210.54
46_V131_I0.8190.54
33_L85_A0.8170.54
29_A33_L0.8090.53
112_K121_N0.8080.53
72_E75_A0.8050.53
69_V89_I0.8050.53
50_M61_D0.8020.52
64_K130_F0.7900.51
33_L93_Y0.7810.50
46_V63_V0.7800.50
51_N59_R0.7790.50
71_D114_P0.7750.50
27_G86_T0.7710.50
51_N88_N0.7690.49
88_N111_I0.7680.49
117_Q146_E0.7660.49
67_D146_E0.7640.49
34_R39_R0.7620.49
90_I95_V0.7570.48
51_N64_K0.7560.48
53_E83_P0.7520.48
10_L52_V0.7470.47
114_P149_I0.7420.47
44_Y87_I0.7400.47
92_D106_Q0.7330.46
105_K131_I0.7250.45
31_A95_V0.7220.45
21_I50_M0.7210.45
100_H105_K0.7200.45
11_I114_P0.7200.45
120_T150_T0.7110.44
95_V112_K0.7090.44
26_A90_I0.7090.44
84_S100_H0.7060.44
73_K77_L0.7030.43
48_L139_K0.7030.43
77_L147_M0.7010.43
10_L149_I0.7010.43
13_S82_A0.6980.43
96_T102_E0.6970.43
27_G81_I0.6900.42
35_I81_I0.6890.42
24_I116_P0.6890.42
55_K150_T0.6890.42
102_E135_I0.6860.42
44_Y67_D0.6850.42
14_K49_V0.6830.42
32_V135_I0.6760.41
35_I111_I0.6750.41
55_K65_I0.6680.40
67_D108_R0.6660.40
40_G127_E0.6650.40
26_A61_D0.6630.40
70_I89_I0.6630.40
13_S50_M0.6610.40
101_L143_K0.6580.39
110_L133_I0.6500.39
49_V93_Y0.6490.39
45_R66_E0.6450.38
14_K57_I0.6410.38
77_L110_L0.6360.38
57_I93_Y0.6350.37
44_Y59_R0.6330.37
63_V111_I0.6320.37
80_L109_G0.6290.37
59_R120_T0.6280.37
87_I101_L0.6240.36
65_I106_Q0.6120.35
33_L128_S0.6100.35
78_I121_N0.6080.35
72_E90_I0.6080.35
67_D91_R0.6060.35
29_A86_T0.6050.35
69_V87_I0.6050.35
100_H107_I0.5980.34
27_G93_Y0.5960.34
117_Q121_N0.5950.34
14_K95_V0.5910.34
37_G137_P0.5840.33
56_K137_P0.5800.33
103_V114_P0.5790.33
72_E111_I0.5750.32
16_R93_Y0.5700.32
14_K77_L0.5680.32
48_L61_D0.5670.32
65_I116_P0.5670.32
34_R150_T0.5650.32
41_S48_L0.5620.31
45_R52_V0.5590.31
99_R151_E0.5570.31
25_P123_D0.5550.31
10_L56_K0.5530.31
81_I101_L0.5510.31
131_I141_K0.5470.30
80_L129_R0.5420.30
17_N55_K0.5400.30
67_D95_V0.5320.29
40_G123_D0.5320.29
24_I103_V0.5250.29
46_V90_I0.5240.29
17_N109_G0.5240.29
48_L148_Y0.5190.28
26_A130_F0.5170.28
142_C145_C0.5130.28
25_P134_S0.5110.28
14_K94_V0.5100.27
90_I94_V0.5020.27
12_V111_I0.5010.27
37_G65_I0.5010.27
24_I90_I0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pg5B 2 0.9182 100 0.052 Contact Map
4fyyB 2 0.9245 100 0.082 Contact Map
2be7D 2 0.8365 100 0.086 Contact Map
2ywwA 2 0.8931 100 0.101 Contact Map
2jrrA 1 0.3585 66.4 0.934 Contact Map
2jvmA 1 0.4591 29.9 0.948 Contact Map
1dl6A 1 0.3145 22.5 0.951 Contact Map
1gh9A 1 0.2516 18 0.953 Contact Map
2drpA 1 0.3522 17.1 0.953 Contact Map
2eluA 1 0.1824 16.3 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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