GREMLIN Database
PYRC - Dihydroorotase
UniProt: Q9UX05 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 390 (349)
Sequences: 21496 (16682)
Seq/√Len: 892.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
365_I370_V4.9191.00
321_E326_N4.8861.00
22_N28_K4.8151.00
363_M370_V4.1951.00
44_T362_Y4.1531.00
6_I38_I4.0751.00
5_W41_P4.0431.00
299_S302_R3.8641.00
41_P332_I3.4811.00
323_K326_N3.4151.00
47_L333_I3.2161.00
8_G41_P3.1611.00
29_E324_E2.9101.00
319_Y327_Y2.9081.00
305_E309_T2.8981.00
49_G81_T2.7621.00
302_R305_E2.5851.00
327_Y367_Q2.5631.00
47_L331_T2.5401.00
4_L20_C2.4621.00
305_E310_N2.3941.00
25_R327_Y2.3801.00
19_V46_I2.2971.00
21_I330_F2.2361.00
7_M40_L2.1861.00
26_R327_Y2.1731.00
3_I365_I2.1431.00
31_K34_C2.1381.00
46_I332_I2.1181.00
310_N313_R2.1091.00
322_I330_F2.0471.00
18_D34_C2.0191.00
240_T244_L2.0181.00
20_C36_P2.0111.00
217_T220_H1.9781.00
10_A17_R1.9631.00
19_V322_I1.9511.00
8_G46_I1.9461.00
309_T313_R1.9241.00
309_T321_E1.9021.00
47_L50_A1.9001.00
185_Y210_L1.8781.00
20_C29_E1.8251.00
44_T334_Q1.8251.00
145_E149_E1.7861.00
6_I18_D1.7681.00
17_R32_S1.7551.00
46_I330_F1.7521.00
44_T332_I1.7361.00
206_L209_E1.7341.00
240_T243_R1.7211.00
150_V153_S1.7171.00
25_R367_Q1.7061.00
318_P326_N1.6581.00
144_K147_T1.6371.00
313_R321_E1.6161.00
3_I37_D1.6121.00
10_A19_V1.6081.00
30_I324_E1.6051.00
245_W249_A1.5671.00
100_T104_R1.5661.00
330_F365_I1.5631.00
53_L315_L1.5521.00
27_I322_I1.5341.00
20_C28_K1.5301.00
47_L304_V1.4801.00
142_L145_E1.4671.00
216_I220_H1.4531.00
206_L210_L1.4461.00
342_T353_D1.4401.00
5_W21_I1.4401.00
75_A83_I1.4361.00
253_V256_V1.4271.00
254_D257_V1.4261.00
19_V330_F1.4231.00
3_I21_I1.4171.00
334_Q362_Y1.4051.00
193_V196_T1.4031.00
18_D33_I1.3971.00
51_I82_L1.3701.00
245_W248_Q1.3661.00
286_V290_L1.3581.00
304_V308_S1.3551.00
53_L311_P1.3431.00
254_D259_D1.3411.00
14_K323_K1.3321.00
143_E146_E1.3271.00
4_L18_D1.3121.00
243_R247_L1.3091.00
239_D242_E1.2921.00
232_K235_P1.2871.00
146_E149_E1.2871.00
45_L335_F1.2861.00
136_K139_P1.2811.00
51_I319_Y1.2761.00
101_A104_R1.2631.00
51_I311_P1.2531.00
203_T206_L1.2521.00
18_D31_K1.2501.00
192_N195_I1.2411.00
202_R206_L1.2391.00
5_W330_F1.2351.00
215_D218_P1.2341.00
41_P46_I1.2291.00
247_L250_I1.2271.00
101_A105_E1.2211.00
7_M42_K1.2211.00
118_S121_T1.2091.00
205_R209_E1.2091.00
255_T314_I1.1991.00
278_G281_A1.1981.00
246_L249_A1.1891.00
144_K151_L1.1891.00
113_D367_Q1.1851.00
84_G315_L1.1791.00
275_C278_G1.1751.00
17_R31_K1.1701.00
138_F141_D1.1651.00
6_I40_L1.1481.00
178_W182_G1.1461.00
331_T361_I1.1441.00
82_L319_Y1.1401.00
243_R249_A1.1391.00
244_L248_Q1.1371.00
298_I306_L1.1371.00
243_R246_L1.1321.00
215_D219_H1.1251.00
31_K35_K1.1241.00
235_P238_R1.1191.00
294_S358_R1.1111.00
104_R108_Y1.1091.00
115_F118_S1.1071.00
182_G186_Y1.1041.00
191_Q194_H1.1021.00
158_I193_V1.1011.00
212_F215_D1.0981.00
144_K148_L1.0971.00
219_H222_L1.0961.00
29_E35_K1.0951.00
115_F119_G1.0931.00
9_K45_L1.0931.00
105_E108_Y1.0891.00
240_T245_W1.0891.00
27_I330_F1.0871.00
7_M43_G1.0841.00
119_G122_K1.0821.00
242_E245_W1.0801.00
17_R30_I1.0791.00
338_W360_S1.0781.00
276_P280_A1.0751.00
231_T234_N1.0701.00
12_L15_E1.0681.00
5_W365_I1.0541.00
69_V73_S1.0481.00
136_K141_D1.0481.00
202_R205_R1.0461.00
252_E259_D1.0461.00
241_N245_W1.0451.00
115_F120_V1.0441.00
39_A363_M1.0341.00
253_V313_R1.0331.00
241_N244_L1.0281.00
114_Y117_Y1.0181.00
113_D117_Y1.0021.00
142_L146_E1.0001.00
287_P290_L0.9991.00
148_L151_L0.9991.00
11_Y45_L0.9981.00
53_L255_T0.9971.00
182_G185_Y0.9901.00
190_Y193_V0.9891.00
18_D35_K0.9871.00
13_S309_T0.9851.00
8_G332_I0.9831.00
123_D126_K0.9761.00
306_L310_N0.9741.00
332_I363_M0.9731.00
234_N238_R0.9731.00
283_S286_V0.9711.00
21_I365_I0.9691.00
280_A283_S0.9681.00
76_S366_I0.9661.00
244_L247_L0.9511.00
117_Y120_V0.9501.00
99_I102_K0.9501.00
57_I83_I0.9431.00
254_D258_S0.9421.00
128_D131_P0.9401.00
252_E255_T0.9321.00
285_T289_I0.9321.00
39_A365_I0.9261.00
143_E147_T0.9231.00
224_D227_K0.9231.00
272_Y275_C0.9221.00
178_W203_T0.9151.00
191_Q213_T0.9141.00
14_K321_E0.9141.00
6_I33_I0.9131.00
88_N91_P0.9101.00
5_W39_A0.9091.00
228_E232_K0.9081.00
98_T101_A0.9081.00
283_S287_P0.9081.00
132_I136_K0.9061.00
28_K324_E0.9021.00
281_A285_T0.9001.00
341_S353_D0.8971.00
179_Y183_A0.8941.00
301_D305_E0.8921.00
181_I185_Y0.8911.00
293_V303_A0.8821.00
337_D358_R0.8801.00
239_D243_R0.8741.00
103_L107_E0.8721.00
214_V217_T0.8711.00
288_F291_T0.8701.00
96_M100_T0.8701.00
246_L250_I0.8681.00
255_T259_D0.8661.00
146_E150_V0.8621.00
117_Y122_K0.8611.00
143_E151_L0.8601.00
16_I301_D0.8581.00
17_R33_I0.8571.00
255_T258_S0.8551.00
319_Y329_N0.8531.00
3_I39_A0.8531.00
137_I140_E0.8531.00
147_T151_L0.8511.00
229_C234_N0.8501.00
284_F289_I0.8501.00
242_E246_L0.8501.00
117_Y121_T0.8501.00
256_V260_H0.8451.00
197_H200_N0.8431.00
165_L169_G0.8381.00
220_H224_D0.8341.00
76_S112_V0.8321.00
7_M41_P0.8311.00
128_D132_I0.8211.00
95_T98_T0.8201.00
262_P266_F0.8201.00
51_I312_A0.8191.00
245_W250_I0.8191.00
55_T75_A0.8161.00
332_I365_I0.8111.00
203_T207_A0.8111.00
115_F121_T0.8081.00
51_I315_L0.8071.00
20_C31_K0.8041.00
69_V72_T0.8041.00
253_V259_D0.7991.00
276_P281_A0.7921.00
110_S113_D0.7911.00
160_H164_P0.7891.00
220_H225_R0.7861.00
100_T103_L0.7861.00
259_D262_P0.7851.00
50_A80_I0.7831.00
4_L36_P0.7821.00
37_D370_V0.7821.00
103_L106_F0.7821.00
361_I364_T0.7791.00
274_I278_G0.7791.00
5_W46_I0.7751.00
242_E247_L0.7741.00
302_R306_L0.7681.00
278_G283_S0.7681.00
11_Y16_I0.7651.00
111_R115_F0.7631.00
219_H223_V0.7611.00
97_E101_A0.7591.00
282_L285_T0.7571.00
218_P221_L0.7551.00
219_H224_D0.7551.00
145_E186_Y0.7501.00
11_Y304_V0.7501.00
126_K129_K0.7491.00
88_N93_V0.7491.00
102_K105_E0.7461.00
274_I277_P0.7461.00
22_N25_R0.7451.00
3_I36_P0.7451.00
177_I180_E0.7421.00
243_R248_Q0.7421.00
273_E276_P0.7401.00
50_A307_I0.7401.00
74_E78_G0.7391.00
163_V166_A0.7381.00
73_S77_Y0.7371.00
286_V289_I0.7371.00
253_V258_S0.7351.00
150_V154_M0.7351.00
201_I205_R0.7331.00
82_L115_F0.7281.00
32_S35_K0.7281.00
265_S269_Q0.7281.00
189_G194_H0.7271.00
13_S301_D0.7241.00
222_L227_K0.7231.00
219_H225_R0.7201.00
239_D245_W0.7201.00
147_T150_V0.7191.00
355_F358_R0.7181.00
285_T290_L0.7161.00
13_S305_E0.7151.00
192_N196_T0.7121.00
284_F287_P0.7101.00
8_G330_F0.7091.00
217_T221_L0.7081.00
168_R171_R0.7081.00
131_P134_G0.7071.00
276_P279_I0.7061.00
213_T216_I0.7061.00
115_F122_K0.7061.00
135_Y138_F0.7051.00
201_I206_L0.7031.00
198_A241_N0.7031.00
41_P44_T0.7031.00
205_R208_K0.7011.00
116_V120_V0.6991.00
263_H268_K0.6951.00
217_T222_L0.6951.00
66_E71_G0.6941.00
8_G43_G0.6921.00
124_L127_V0.6921.00
108_Y111_R0.6921.00
177_I181_I0.6911.00
285_T288_F0.6881.00
222_L225_R0.6851.00
215_D220_H0.6851.00
284_F290_L0.6841.00
160_H163_V0.6831.00
11_Y301_D0.6831.00
13_S16_I0.6801.00
180_E184_L0.6801.00
287_P291_T0.6801.00
74_E77_Y0.6791.00
213_T219_H0.6781.00
264_A267_E0.6751.00
283_S290_L0.6741.00
165_L168_R0.6741.00
132_I139_P0.6721.00
45_L300_I0.6711.00
164_P168_R0.6701.00
255_T260_H0.6691.00
9_K336_K0.6681.00
160_H166_A0.6681.00
309_T326_N0.6671.00
191_Q195_I0.6661.00
20_C34_C0.6651.00
113_D119_G0.6651.00
265_S268_K0.6651.00
244_L250_I0.6651.00
260_H263_H0.6641.00
215_D221_L0.6631.00
89_S92_F0.6611.00
257_V260_H0.6601.00
162_E166_A0.6601.00
114_Y118_S0.6601.00
230_L233_V0.6551.00
97_E100_T0.6531.00
240_T246_L0.6521.00
291_T294_S0.6461.00
4_L38_I0.6461.00
177_I200_N0.6431.00
184_L190_Y0.6421.00
201_I204_V0.6401.00
251_N259_D0.6401.00
17_R322_I0.6391.00
331_T364_T0.6381.00
110_S114_Y0.6361.00
72_T76_S0.6351.00
244_L249_A0.6341.00
44_T363_M0.6331.00
207_A210_L0.6331.00
68_V72_T0.6331.00
158_I162_E0.6331.00
333_I361_I0.6311.00
137_I141_D0.6311.00
312_A320_G0.6301.00
231_T235_P0.6281.00
194_H198_A0.6271.00
159_L162_E0.6261.00
161_P167_L0.6251.00
131_P141_D0.6241.00
196_T199_T0.6241.00
64_Y67_D0.6241.00
53_L314_I0.6231.00
283_S289_I0.6221.00
75_A80_I0.6221.00
66_E69_V0.6221.00
321_E324_E0.6211.00
131_P135_Y0.6201.00
157_K160_H0.6191.00
256_V259_D0.6181.00
216_I221_L0.6181.00
241_N246_L0.6181.00
156_L316_N0.6171.00
136_K140_E0.6171.00
251_N254_D0.6171.00
242_E249_A0.6171.00
233_V236_P0.6131.00
221_L226_E0.6131.00
162_E165_L0.6121.00
258_S261_A0.6111.00
279_I282_L0.6111.00
131_P139_P0.6111.00
92_F95_T0.6111.00
339_R360_S0.6091.00
162_E167_L0.6081.00
181_I184_L0.6081.00
82_L329_N0.6071.00
281_A284_F0.6071.00
262_P265_S0.6061.00
279_I283_S0.6051.00
179_Y182_G0.6051.00
275_C279_I0.6041.00
59_G63_A0.6041.00
102_K106_F0.6031.00
133_A138_F0.6031.00
289_I303_A0.6021.00
133_A136_K0.6011.00
149_E153_S0.6011.00
278_G282_L0.6001.00
113_D120_V0.5991.00
113_D329_N0.5991.00
13_S321_E0.5971.00
113_D116_V0.5971.00
131_P136_K0.5961.00
145_E150_V0.5951.00
132_I135_Y0.5931.00
229_C235_P0.5931.00
234_N237_I0.5931.00
104_R107_E0.5931.00
89_S93_V0.5911.00
67_D70_S0.5891.00
232_K236_P0.5891.00
183_A186_Y0.5891.00
178_W206_L0.5871.00
167_L170_N0.5841.00
111_R114_Y0.5841.00
116_V119_G0.5811.00
300_I338_W0.5811.00
236_P239_D0.5801.00
113_D118_S0.5791.00
221_L225_R0.5771.00
13_S304_V0.5761.00
261_A264_A0.5751.00
135_Y139_P0.5741.00
76_S364_T0.5741.00
204_V207_A0.5721.00
68_V71_G0.5681.00
134_G138_F0.5671.00
98_T102_K0.5661.00
220_H223_V0.5621.00
66_E70_S0.5601.00
151_L157_K0.5601.00
193_V198_A0.5591.00
158_I161_P0.5591.00
130_F140_E0.5581.00
148_L157_K0.5571.00
132_I138_F0.5571.00
283_S288_F0.5551.00
193_V197_H0.5541.00
251_N260_H0.5541.00
59_G72_T0.5541.00
229_C232_K0.5541.00
256_V306_L0.5531.00
80_I285_T0.5531.00
145_E148_L0.5501.00
191_Q196_T0.5501.00
69_V109_Y0.5491.00
166_A171_R0.5481.00
253_V257_V0.5471.00
228_E231_T0.5461.00
19_V30_I0.5431.00
52_D55_T0.5421.00
19_V27_I0.5411.00
337_D340_Y0.5401.00
280_A284_F0.5391.00
241_N247_L0.5371.00
167_L171_R0.5361.00
262_P267_E0.5351.00
235_P239_D0.5341.00
5_W332_I0.5311.00
258_S262_P0.5301.00
62_L65_K0.5281.00
161_P164_P0.5281.00
12_L16_I0.5281.00
112_V115_F0.5271.00
208_K254_D0.5261.00
277_P280_A0.5261.00
239_D246_L0.5261.00
302_R310_N0.5261.00
233_V237_I0.5251.00
45_L333_I0.5251.00
65_K69_V0.5251.00
88_N95_T0.5241.00
204_V208_K0.5241.00
199_T202_R0.5241.00
262_P268_K0.5211.00
229_C233_V0.5181.00
84_G115_F0.5181.00
178_W181_I0.5171.00
281_A286_V0.5171.00
166_A170_N0.5161.00
221_L224_D0.5151.00
253_V260_H0.5141.00
216_I219_H0.5131.00
161_P166_A0.5121.00
307_I311_P0.5121.00
208_K211_G0.5121.00
335_F359_A0.5081.00
128_D154_M0.5061.00
190_Y196_T0.5061.00
252_E257_V0.5051.00
298_I302_R0.5031.00
298_I303_A0.5031.00
29_E34_C0.5021.00
102_K107_E0.5001.00
263_H267_E0.5001.00
114_Y119_G0.5001.00
123_D127_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ftyA 3 0.9974 100 0.289 Contact Map
3dc8A 3 0.9897 100 0.289 Contact Map
1gkrA 3 0.9949 100 0.298 Contact Map
1nfgA 3 0.9974 100 0.303 Contact Map
3e74A 3 0.9795 100 0.304 Contact Map
1gkpA 4 0.9949 100 0.304 Contact Map
2ftwA 3 0.9974 100 0.305 Contact Map
4lcqA 3 0.9974 100 0.307 Contact Map
3sfwA 3 0.9974 100 0.308 Contact Map
2vm8A 3 0.9974 100 0.323 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0113 seconds.