GREMLIN Database
PYRDB - Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit
UniProt: Q9UX04 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (274)
Sequences: 5029 (2926)
Seq/√Len: 176.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
234_W268_G3.8281.00
77_K106_V3.7941.00
257_K264_E3.6651.00
3_T8_T3.3561.00
105_E144_V3.0691.00
5_K150_F2.9191.00
135_G168_E2.8791.00
9_L247_L2.7591.00
160_I220_E2.6031.00
135_G169_K2.5551.00
218_Y246_K2.5021.00
210_A240_M2.4871.00
142_K172_D2.4841.00
176_L217_V2.4161.00
232_Y236_D2.4111.00
44_V79_I2.3931.00
207_Y239_G2.3221.00
211_L240_M2.2291.00
150_F173_G2.2151.00
233_D236_D2.1891.00
11_D37_S2.1581.00
142_K149_V2.1461.00
134_I166_A2.1321.00
214_I225_I2.0861.00
279_K282_D2.0381.00
218_Y225_I1.9811.00
207_Y236_D1.9671.00
167_L223_V1.9371.00
11_D266_R1.9311.00
22_D74_P1.8751.00
231_V248_V1.8521.00
89_I113_I1.7941.00
238_I276_K1.7911.00
272_Y276_K1.7531.00
104_V114_I1.7441.00
167_L222_G1.7251.00
175_T228_V1.7191.00
271_S275_E1.6991.00
163_A217_V1.6831.00
250_L265_I1.6661.00
101_K144_V1.6651.00
14_I40_T1.6621.00
207_Y240_M1.6591.00
231_V240_M1.6381.00
28_E85_L1.6311.00
164_G168_E1.6221.00
76_A106_V1.6031.00
237_V265_I1.5921.00
224_D246_K1.5891.00
74_P78_A1.5651.00
235_T239_G1.5551.00
7_I113_I1.5521.00
118_V134_I1.5471.00
158_N161_E1.5351.00
76_A107_V1.5351.00
188_E276_K1.5261.00
235_T272_Y1.5251.00
13_L266_R1.4891.00
177_I180_I1.4871.00
150_F226_I1.4871.00
241_L280_F1.4781.00
92_V103_V1.4501.00
97_I136_D1.4491.00
14_I38_A1.4371.00
45_T93_G1.4361.00
180_I209_I1.4341.00
160_I216_D1.4281.00
108_Q145_T1.4241.00
92_V104_V1.4201.00
174_L221_Y1.4131.00
104_V141_V1.4101.00
182_G209_I1.4021.00
108_Q146_K1.4011.00
214_I227_G1.3961.00
237_V248_V1.3741.00
90_V111_A1.3541.00
131_S161_E1.3521.00
253_V261_V1.3331.00
273_L278_L1.3281.00
101_K140_S1.3271.00
142_K145_T1.3251.00
237_V269_L1.3241.00
13_L265_I1.3051.00
238_I272_Y1.2981.00
132_K136_D1.2941.00
185_I243_A1.2921.00
43_T93_G1.2911.00
270_Q274_L1.2791.00
46_L95_S1.2771.00
31_C86_C1.2751.00
116_I141_V1.2711.00
102_E106_V1.2701.00
135_G139_E1.2681.00
43_T91_S1.2621.00
227_G240_M1.2511.00
102_E105_E1.2511.00
40_T249_G1.2471.00
141_V149_V1.2461.00
165_K169_K1.2451.00
238_I269_L1.2371.00
46_L103_V1.2331.00
4_I247_L1.2311.00
207_Y211_L1.2251.00
41_T90_V1.2231.00
107_V114_I1.2101.00
57_V69_I1.1991.00
82_I85_L1.1981.00
76_A103_V1.1951.00
97_I101_K1.1791.00
263_E267_K1.1781.00
212_R216_D1.1771.00
238_I242_A1.1661.00
13_L231_V1.1591.00
264_E268_G1.1571.00
188_E275_E1.1531.00
234_W238_I1.1441.00
164_G220_E1.1391.00
228_V249_G1.1341.00
97_I140_S1.1271.00
266_R270_Q1.1231.00
138_I151_V1.1211.00
74_P81_E1.1031.00
114_I147_L1.1031.00
14_I249_G1.0991.00
233_D261_V1.0931.00
45_T49_L1.0881.00
226_I247_L1.0771.00
104_V145_T1.0761.00
3_T6_N1.0741.00
96_S99_E1.0721.00
60_L63_G1.0711.00
272_Y275_E1.0711.00
272_Y278_L1.0681.00
151_V171_A1.0671.00
204_R232_Y1.0641.00
180_I206_L1.0631.00
41_T79_I1.0621.00
16_A251_G1.0511.00
63_G189_T1.0481.00
120_S123_R1.0441.00
36_P262_I1.0431.00
101_K105_E1.0270.99
139_E169_K1.0210.99
187_V238_I1.0210.99
232_Y253_V1.0100.99
153_L217_V1.0030.99
80_N83_G1.0000.99
211_L243_A1.0000.99
214_I240_M0.9980.99
235_T268_G0.9980.99
23_V79_I0.9960.99
234_W265_I0.9930.99
26_Y30_I0.9920.99
267_K271_S0.9910.99
140_S143_S0.9890.99
5_K173_G0.9850.99
69_I73_N0.9830.99
234_W272_Y0.9760.99
30_I39_I0.9700.99
260_S264_E0.9700.99
136_D139_E0.9650.99
136_D140_S0.9580.99
159_V217_V0.9550.99
14_I247_L0.9490.99
250_L261_V0.9420.99
7_I87_P0.9410.99
150_F175_T0.9400.99
10_N86_C0.9360.99
108_Q147_L0.9350.99
67_N179_T0.9260.99
179_T202_S0.9240.99
94_G115_E0.9200.99
177_I210_A0.9190.99
176_L213_I0.9170.99
4_I150_F0.9110.99
65_Y252_T0.9070.99
268_G272_Y0.9060.99
63_G186_D0.9020.99
139_E143_S0.8980.99
71_L93_G0.8960.99
116_I151_V0.8880.98
90_V107_V0.8870.98
271_S274_L0.8860.98
204_R207_Y0.8840.98
133_L136_D0.8740.98
16_A249_G0.8690.98
177_I206_L0.8670.98
35_K267_K0.8670.98
98_N102_E0.8490.98
242_A276_K0.8440.98
15_I36_P0.8430.98
4_I226_I0.8410.98
74_P79_I0.8340.98
46_L102_E0.8310.98
15_I262_I0.8220.97
267_K270_Q0.8190.97
163_A221_Y0.8170.97
208_P212_R0.8160.97
209_I212_R0.8160.97
101_K143_S0.8150.97
166_A174_L0.8140.97
35_K263_E0.8070.97
145_T149_V0.8020.97
210_A227_G0.8010.97
254_L262_I0.8010.97
96_S124_K0.7960.97
160_I217_V0.7930.97
216_D220_E0.7900.97
257_K260_S0.7900.97
238_I268_G0.7890.97
13_L250_L0.7870.97
25_N81_E0.7860.97
108_Q114_I0.7800.96
95_S103_V0.7790.96
242_A272_Y0.7790.96
214_I243_A0.7750.96
70_G73_N0.7710.96
69_I72_G0.7690.96
47_N95_S0.7670.96
157_D160_I0.7650.96
159_V213_I0.7640.96
40_T175_T0.7630.96
164_G167_L0.7620.96
120_S127_G0.7610.96
40_T91_S0.7600.96
261_V265_I0.7590.96
78_A81_E0.7570.96
49_L95_S0.7550.96
186_D189_T0.7530.96
174_L217_V0.7520.96
51_P75_G0.7470.95
132_K135_G0.7470.95
160_I164_G0.7440.95
13_L248_V0.7420.95
273_L280_F0.7360.95
198_T215_K0.7330.95
123_R127_G0.7320.95
140_S144_V0.7310.95
131_S165_K0.7270.95
250_L253_V0.7270.95
4_I246_K0.7260.95
43_T92_V0.7230.95
186_D193_I0.7220.95
270_Q273_L0.7160.94
153_L174_L0.7150.94
167_L221_Y0.7140.94
110_K147_L0.7090.94
184_I187_V0.7060.94
161_E165_K0.7050.94
218_Y222_G0.7050.94
87_P112_K0.7040.94
130_L158_N0.7030.94
49_L93_G0.7020.94
107_V110_K0.6990.94
174_L225_I0.6960.93
179_T200_G0.6930.93
13_L237_V0.6910.93
182_G185_I0.6900.93
204_R236_D0.6880.93
177_I213_I0.6880.93
212_R215_K0.6870.93
237_V268_G0.6830.93
9_L38_A0.6830.93
46_L99_E0.6830.93
57_V65_Y0.6800.93
17_S42_K0.6790.93
92_V116_I0.6790.93
104_V108_Q0.6790.93
237_V241_L0.6780.93
181_K216_D0.6770.92
77_K80_N0.6750.92
9_L113_I0.6740.92
159_V220_E0.6660.92
67_N71_L0.6630.92
47_N102_E0.6620.92
118_V151_V0.6590.91
83_G109_S0.6570.91
98_N101_K0.6550.91
121_P200_G0.6540.91
9_L14_I0.6500.91
217_V221_Y0.6490.91
26_Y29_T0.6450.91
80_N84_V0.6440.91
79_I107_V0.6440.91
166_A225_I0.6420.90
101_K141_V0.6390.90
257_K261_V0.6390.90
113_I249_G0.6390.90
25_N74_P0.6380.90
104_V144_V0.6360.90
38_A249_G0.6350.90
142_K169_K0.6350.90
63_G188_E0.6340.90
4_I9_L0.6330.90
129_S154_G0.6330.90
104_V137_I0.6300.90
207_Y214_I0.6300.90
120_S126_Y0.6290.89
22_D25_N0.6290.89
81_E85_L0.6260.89
216_D219_E0.6230.89
175_T249_G0.6210.89
189_T193_I0.6210.89
149_V172_D0.6200.89
52_H56_T0.6200.89
153_L213_I0.6180.89
19_I255_I0.6160.88
82_I88_L0.6150.88
241_L273_L0.6140.88
101_K137_I0.6130.88
211_L214_I0.6120.88
215_K219_E0.6100.88
111_A114_I0.6080.88
5_K113_I0.6070.88
260_S263_E0.6040.87
67_N73_N0.5980.87
269_L273_L0.5970.87
31_C39_I0.5970.87
185_I188_E0.5970.87
60_L201_V0.5940.87
36_P266_R0.5930.87
15_I30_I0.5910.86
4_I224_D0.5910.86
66_M194_L0.5910.86
21_P42_K0.5910.86
77_K102_E0.5900.86
28_E32_E0.5900.86
47_N77_K0.5890.86
138_I171_A0.5850.86
241_L248_V0.5850.86
114_I145_T0.5840.86
211_L227_G0.5810.85
194_L199_G0.5810.85
113_I175_T0.5800.85
70_G121_P0.5800.85
188_E235_T0.5780.85
172_D224_D0.5770.85
184_I207_Y0.5770.85
123_R126_Y0.5760.85
262_I266_R0.5750.85
20_I27_V0.5750.85
87_P113_I0.5720.85
67_N200_G0.5720.85
119_S200_G0.5710.84
124_K127_G0.5700.84
91_S115_E0.5690.84
83_G110_K0.5670.84
174_L223_V0.5670.84
273_L281_E0.5660.84
45_T73_N0.5650.84
104_V147_L0.5640.84
161_E164_G0.5610.83
65_Y255_I0.5580.83
181_K198_T0.5580.83
96_S120_S0.5560.83
38_A87_P0.5560.83
6_N148_P0.5540.83
115_E175_T0.5530.83
38_A247_L0.5530.83
85_L88_L0.5510.82
25_N78_A0.5510.82
70_G117_N0.5510.82
231_V237_V0.5500.82
265_I268_G0.5460.82
68_A72_G0.5460.82
242_A278_L0.5440.82
119_S122_N0.5440.82
215_K239_G0.5420.81
213_I217_V0.5400.81
15_I20_I0.5380.81
184_I239_G0.5380.81
67_N72_G0.5380.81
127_G154_G0.5360.81
106_V109_S0.5330.80
278_L282_D0.5320.80
142_K171_A0.5310.80
134_I138_I0.5300.80
153_L176_L0.5280.80
184_I193_I0.5270.79
71_L126_Y0.5250.79
76_A79_I0.5240.79
162_L166_A0.5240.79
39_I86_C0.5240.79
155_P178_N0.5230.79
27_V85_L0.5220.79
43_T113_I0.5210.79
41_T44_V0.5200.79
232_Y257_K0.5150.78
211_L215_K0.5140.78
79_I90_V0.5130.78
134_I137_I0.5130.78
9_L87_P0.5130.78
269_L272_Y0.5120.77
97_I133_L0.5110.77
60_L66_M0.5110.77
66_M182_G0.5090.77
68_A197_G0.5070.77
73_N79_I0.5070.77
250_L262_I0.5070.77
52_H73_N0.5070.77
113_I150_F0.5060.77
51_P70_G0.5050.77
200_G203_G0.5040.76
40_T228_V0.5040.76
31_C262_I0.5030.76
157_D162_L0.5020.76
207_Y210_A0.5020.76
18_G251_G0.5020.76
43_T71_L0.5020.76
14_I89_I0.5010.76
120_S200_G0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cq8A 1 0.9724 100 0.383 Contact Map
1tv5A 3 0.969 100 0.397 Contact Map
4ef8A 2 0.9931 100 0.417 Contact Map
4oqvA 1 0.9517 100 0.423 Contact Map
1ep3A 2 0.9897 100 0.434 Contact Map
1jubA 2 0.9931 100 0.466 Contact Map
2e6fA 2 0.9931 100 0.468 Contact Map
3oixA 3 0.9724 100 0.481 Contact Map
1gteA 4 0.9931 100 0.494 Contact Map
1f76A 1 0.9103 100 0.509 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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